MCL coexpression mm9:2602

Phase1 CAGE Peaks

	Short description
Mm9::chr10:90545781..90545820,+	p1@Ikbip
Mm9::chr10:90545826..90545848,+	p2@Ikbip
Mm9::chr11:120434136..120434156,-	p2@P4hb

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019511	peptidyl-proline hydroxylation	0.00177505067660111
GO:0031545	peptidyl-proline 4-dioxygenase activity	0.00177505067660111
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	0.00177505067660111
GO:0019471	4-hydroxyproline metabolic process	0.00177505067660111
GO:0004656	procollagen-proline 4-dioxygenase activity	0.00177505067660111
GO:0018208	peptidyl-proline modification	0.00197227852955679
GO:0019798	procollagen-proline dioxygenase activity	0.00207089245603463
GO:0031543	peptidyl-proline dioxygenase activity	0.00207089245603463
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	0.00207089245603463
GO:0003756	protein disulfide isomerase activity	0.00207089245603463
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.00215157657769831
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.00616337040486496
GO:0045454	cell redox homeostasis	0.00908656893974376
GO:0016860	intramolecular oxidoreductase activity	0.00908656893974376
GO:0046483	heterocycle metabolic process	0.0130170382950748
GO:0006575	amino acid derivative metabolic process	0.0160863967566975
GO:0018193	peptidyl-amino acid modification	0.0161842855807748
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0205445680162165
GO:0016853	isomerase activity	0.0221176949386011
GO:0005792	microsome	0.0221176949386011
GO:0042598	vesicular fraction	0.0221176949386011
GO:0019725	cellular homeostasis	0.0283739161183965
GO:0006519	amino acid and derivative metabolic process	0.0362727746957618
GO:0042592	homeostatic process	0.0388144414616776
GO:0009308	amine metabolic process	0.0388144414616776
GO:0006807	nitrogen compound metabolic process	0.0401662108230891
GO:0005624	membrane fraction	0.0488686791212404

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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