MCL coexpression mm9:3187

Phase1 CAGE Peaks

	Short description
Mm9::chr19:34723708..34723728,+	p@chr19:34723708..34723728 +
Mm9::chr7:29678757..29678782,-	p@chr7:29678757..29678782 -
Mm9::chr9:80129298..80129306,+	p@chr9:80129298..80129306 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0051015	actin filament binding	0.000275044175098539
GO:0010324	membrane invagination	0.00259839869767005
GO:0006897	endocytosis	0.00259839869767005
GO:0015629	actin cytoskeleton	0.00259839869767005
GO:0048549	positive regulation of pinocytosis	0.00259839869767005
GO:0031143	pseudopodium	0.00259839869767005
GO:0048548	regulation of pinocytosis	0.00259839869767005
GO:0016044	membrane organization and biogenesis	0.00322889017312741
GO:0003779	actin binding	0.00322889017312741
GO:0006907	pinocytosis	0.00503803742470515
GO:0008092	cytoskeletal protein binding	0.00503803742470515
GO:0042995	cell projection	0.00548643371740944
GO:0014047	glutamate secretion	0.00559609110104334
GO:0016192	vesicle-mediated transport	0.00570873261979886
GO:0007010	cytoskeleton organization and biogenesis	0.00662238609130374
GO:0044430	cytoskeletal part	0.00840454279614965
GO:0051017	actin filament bundle formation	0.0136341191362705
GO:0051272	positive regulation of cell motility	0.0136341191362705
GO:0040017	positive regulation of locomotion	0.0136341191362705
GO:0030863	cortical cytoskeleton	0.0136341191362705
GO:0051271	negative regulation of cell motility	0.0136341191362705
GO:0007416	synaptogenesis	0.0136341191362705
GO:0040013	negative regulation of locomotion	0.0136341191362705
GO:0001725	stress fiber	0.0136341191362705
GO:0032432	actin filament bundle	0.0136341191362705
GO:0005856	cytoskeleton	0.0136341191362705
GO:0045807	positive regulation of endocytosis	0.0136341191362705
GO:0048167	regulation of synaptic plasticity	0.0136341191362705
GO:0042491	auditory receptor cell differentiation	0.0139363355499235
GO:0050803	regulation of synapse structure and activity	0.0139363355499235
GO:0060113	inner ear receptor cell differentiation	0.0158305667554699
GO:0044448	cell cortex part	0.0159034204314959
GO:0005905	coated pit	0.0166989144017156
GO:0042490	mechanoreceptor differentiation	0.0166989144017156
GO:0051050	positive regulation of transport	0.0166989144017156
GO:0006996	organelle organization and biogenesis	0.0166989144017156
GO:0030100	regulation of endocytosis	0.0166989144017156
GO:0048471	perinuclear region of cytoplasm	0.0167372300393083
GO:0016358	dendrite development	0.0181693584147975
GO:0007015	actin filament organization	0.0181693584147975
GO:0050808	synapse organization and biogenesis	0.0194966847562648
GO:0005938	cell cortex	0.0203284741709756
GO:0007269	neurotransmitter secretion	0.0213639918189818
GO:0042472	inner ear morphogenesis	0.0213639918189818
GO:0012506	vesicle membrane	0.0213639918189818
GO:0016459	myosin complex	0.0213639918189818
GO:0043025	cell soma	0.0213639918189818
GO:0043232	intracellular non-membrane-bound organelle	0.0213639918189818
GO:0043228	non-membrane-bound organelle	0.0213639918189818
GO:0051270	regulation of cell motility	0.0213639918189818
GO:0042471	ear morphogenesis	0.0213639918189818
GO:0030424	axon	0.0215198814487726
GO:0040012	regulation of locomotion	0.0215198814487726
GO:0045055	regulated secretory pathway	0.0215198814487726
GO:0048839	inner ear development	0.0231056131877493
GO:0043583	ear development	0.0246340710194913
GO:0051049	regulation of transport	0.026743587837089
GO:0003001	generation of a signal involved in cell-cell signaling	0.0270643873667891
GO:0001505	regulation of neurotransmitter levels	0.0270643873667891
GO:0007605	sensory perception of sound	0.0278199542996197
GO:0050954	sensory perception of mechanical stimulus	0.0288470957388275
GO:0043062	extracellular structure organization and biogenesis	0.0289654209217246
GO:0042803	protein homodimerization activity	0.0290799264774273
GO:0005516	calmodulin binding	0.0303210822497826
GO:0043005	neuron projection	0.0323577360247671
GO:0006810	transport	0.0382960575974159
GO:0044446	intracellular organelle part	0.0382960575974159
GO:0044422	organelle part	0.0382960575974159
GO:0016043	cellular component organization and biogenesis	0.0382960575974159
GO:0051234	establishment of localization	0.0382960575974159
GO:0030036	actin cytoskeleton organization and biogenesis	0.0392863886657246
GO:0030029	actin filament-based process	0.0414953798889983
GO:0042802	identical protein binding	0.0426550268608075
GO:0045045	secretory pathway	0.0428090017683298
GO:0007423	sensory organ development	0.0440229525732857
GO:0006605	protein targeting	0.0440229525732857
GO:0051179	localization	0.0440229525732857
GO:0007268	synaptic transmission	0.0440229525732857
GO:0031988	membrane-bound vesicle	0.0440229525732857
GO:0031175	neurite development	0.0440229525732857
GO:0046983	protein dimerization activity	0.0440229525732857
GO:0048598	embryonic morphogenesis	0.0440229525732857
GO:0007626	locomotory behavior	0.0440229525732857
GO:0032940	secretion by cell	0.0443553457870037
GO:0048666	neuron development	0.0463715920723049
GO:0019226	transmission of nerve impulse	0.0472949444162742

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}