Novel motif:8

name:	motif8_CCATGN

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0031960	response to corticosteroid stimulus	2.006896e-22
GO:0051384	response to glucocorticoid stimulus	5.518635e-19
GO:0003008	system process	3.275161e-14
GO:0065008	regulation of biological quality	6.539789e-14
GO:0014050	negative regulation of glutamate secretion	7.197006e-14
GO:0000302	response to reactive oxygen species	1.229971e-13
GO:0009612	response to mechanical stimulus	4.551314e-13
GO:0016064	immunoglobulin mediated immune response	4.761941e-13
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	5.994668e-13
GO:0006956	complement activation	6.702598e-13
GO:0002455	humoral immune response mediated by circulating immunoglobulin	1.522366e-12
GO:0006629	lipid metabolic process	1.881331e-12
GO:0072376	protein activation cascade	2.031312e-12
GO:0019724	B cell mediated immunity	2.671003e-12
GO:0008203	cholesterol metabolic process	3.295822e-12
GO:0006955	immune response	3.533453e-12
GO:0051346	negative regulation of hydrolase activity	2.930543e-11
GO:0002439	chronic inflammatory response to antigenic stimulus	3.004160e-11
GO:0009628	response to abiotic stimulus	3.319353e-11
GO:0007586	digestion	3.606403e-11
GO:0050877	neurological system process	4.415767e-11
GO:0002544	chronic inflammatory response	5.448263e-11
GO:0034369	plasma lipoprotein particle remodeling	6.494248e-11
GO:0002449	lymphocyte mediated immunity	6.522467e-11
GO:0007601	visual perception	8.688325e-11
GO:0016125	sterol metabolic process	9.580293e-11
GO:0050953	sensory perception of light stimulus	1.266488e-10
GO:0006958	complement activation, classical pathway	1.415565e-10
GO:0030198	extracellular matrix organization	1.697890e-10
GO:0007506	gonadal mesoderm development	1.895377e-10
GO:0007600	sensory perception	2.005270e-10
GO:0032501	multicellular organismal process	2.386611e-10
GO:0010466	negative regulation of peptidase activity	2.499818e-10
GO:0044281	small molecule metabolic process	6.922951e-10
GO:0006707	cholesterol catabolic process	1.063924e-9
GO:0032101	regulation of response to external stimulus	1.385138e-9
GO:0002526	acute inflammatory response	1.423852e-9
GO:0042060	wound healing	1.430482e-9
GO:0051293	establishment of spindle localization	1.441653e-9
GO:0009408	response to heat	1.534943e-9
GO:0032368	regulation of lipid transport	1.605871e-9
GO:0071827	plasma lipoprotein particle organization	1.714201e-9
GO:0051234	establishment of localization	2.085862e-9
GO:0051704	multi-organism process	2.763430e-9
GO:0006953	acute-phase response	2.789514e-9
GO:0010035	response to inorganic substance	3.071195e-9
GO:0006979	response to oxidative stress	3.448321e-9
GO:0006810	transport	3.611923e-9
GO:0071732	cellular response to nitric oxide	4.252086e-9
GO:0008202	steroid metabolic process	4.304220e-9
GO:0002443	leukocyte mediated immunity	4.715288e-9
GO:0006950	response to stress	4.765181e-9
GO:0002250	adaptive immune response	4.884078e-9
GO:0042157	lipoprotein metabolic process	5.574171e-9
GO:0034374	low-density lipoprotein particle remodeling	5.623945e-9
GO:0050776	regulation of immune response	7.447676e-9
GO:0009611	response to wounding	8.408656e-9
GO:0050878	regulation of body fluid levels	9.216039e-9
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1.101223e-8
GO:0052547	regulation of peptidase activity	1.128304e-8
GO:0010872	regulation of cholesterol esterification	1.270925e-8
GO:0014048	regulation of glutamate secretion	1.437936e-8
GO:0051179	localization	1.487196e-8
GO:0051271	negative regulation of cellular component movement	1.521322e-8
GO:0050994	regulation of lipid catabolic process	1.544418e-8
GO:0071702	organic substance transport	1.795711e-8
GO:0032964	collagen biosynthetic process	1.899178e-8
GO:0006959	humoral immune response	1.932149e-8
GO:0015914	phospholipid transport	2.710804e-8
GO:0002253	activation of immune response	3.286221e-8
GO:0002252	immune effector process	3.303092e-8
GO:0044236	multicellular organismal metabolic process	3.484010e-8
GO:0006952	defense response	4.002528e-8
GO:0051049	regulation of transport	4.350967e-8
GO:0017144	drug metabolic process	4.427558e-8
GO:0002432	granuloma formation	4.648397e-8
GO:0050896	response to stimulus	4.688043e-8
GO:0006982	response to lipid hydroperoxide	5.090385e-8
GO:0008078	mesodermal cell migration	5.830889e-8
GO:0070587	regulation of cell-cell adhesion involved in gastrulation	6.074433e-8
GO:0034114	regulation of heterotypic cell-cell adhesion	6.074433e-8
GO:0031581	hemidesmosome assembly	6.090388e-8
GO:0050778	positive regulation of immune response	6.104313e-8
GO:0000132	establishment of mitotic spindle orientation	6.194340e-8
GO:0050996	positive regulation of lipid catabolic process	8.220674e-8
GO:0042592	homeostatic process	9.254471e-8
GO:0009582	detection of abiotic stimulus	9.419038e-8
GO:0009620	response to fungus	9.948149e-8
GO:0040001	establishment of mitotic spindle localization	1.022625e-7
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	1.060326e-7
GO:0044089	positive regulation of cellular component biogenesis	1.064416e-7
GO:0090189	regulation of branching involved in ureteric bud morphogenesis	1.077650e-7
GO:0007568	aging	1.081711e-7
GO:0006766	vitamin metabolic process	1.086046e-7
GO:0015918	sterol transport	1.168917e-7
GO:0045590	negative regulation of regulatory T cell differentiation	1.186367e-7
GO:0030301	cholesterol transport	1.511494e-7
GO:0009607	response to biotic stimulus	1.533978e-7
GO:0007602	phototransduction	1.547913e-7
GO:0030168	platelet activation	1.627913e-7
GO:0006811	ion transport	1.651319e-7
GO:0030157	pancreatic juice secretion	1.698333e-7
GO:0051048	negative regulation of secretion	1.731903e-7
GO:0006702	androgen biosynthetic process	1.820852e-7
GO:0006869	lipid transport	1.846033e-7
GO:0060047	heart contraction	2.033310e-7
GO:0044057	regulation of system process	2.110622e-7
GO:0002682	regulation of immune system process	2.184886e-7
GO:0010876	lipid localization	2.205441e-7
GO:0051336	regulation of hydrolase activity	2.339986e-7
GO:0030336	negative regulation of cell migration	2.545785e-7
GO:0097006	regulation of plasma lipoprotein particle levels	2.598107e-7
GO:0006200	ATP catabolic process	2.748165e-7
GO:0022414	reproductive process	2.763643e-7
GO:0034115	negative regulation of heterotypic cell-cell adhesion	2.778917e-7
GO:0022038	corpus callosum development	2.876904e-7
GO:2000146	negative regulation of cell motility	2.999169e-7
GO:0050727	regulation of inflammatory response	3.213275e-7
GO:0000003	reproduction	3.240747e-7
GO:0051707	response to other organism	3.396511e-7
GO:0033273	response to vitamin	3.427850e-7
GO:0032374	regulation of cholesterol transport	3.514907e-7
GO:0045112	integrin biosynthetic process	3.788898e-7
GO:0042744	hydrogen peroxide catabolic process	3.814741e-7
GO:0007522	visceral muscle development	4.007766e-7
GO:0032879	regulation of localization	4.015227e-7
GO:0043086	negative regulation of catalytic activity	4.085303e-7
GO:0042730	fibrinolysis	4.444696e-7
GO:0046034	ATP metabolic process	4.555670e-7
GO:0002478	antigen processing and presentation of exogenous peptide antigen	4.996323e-7
GO:0006706	steroid catabolic process	5.322887e-7
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.396088e-7
GO:0006565	L-serine catabolic process	5.690428e-7
GO:0003012	muscle system process	6.358450e-7
GO:0071482	cellular response to light stimulus	6.865175e-7
GO:0032370	positive regulation of lipid transport	7.108110e-7
GO:2000659	regulation of interleukin-1-mediated signaling pathway	7.500348e-7
GO:0019884	antigen processing and presentation of exogenous antigen	7.822045e-7
GO:0051128	regulation of cellular component organization	8.367337e-7
GO:0060048	cardiac muscle contraction	8.893343e-7
GO:0007599	hemostasis	9.141398e-7
GO:0031667	response to nutrient levels	9.263044e-7
GO:0070098	chemokine-mediated signaling pathway	9.932689e-7
GO:0008544	epidermis development	9.954938e-7
GO:0043691	reverse cholesterol transport	1.057654e-6
GO:0042866	pyruvate biosynthetic process	1.072775e-6
GO:0032094	response to food	1.076920e-6
GO:0016043	cellular component organization	1.193290e-6
GO:0033344	cholesterol efflux	1.220242e-6
GO:0007596	blood coagulation	1.248251e-6
GO:0016042	lipid catabolic process	1.250698e-6
GO:0071840	cellular component organization or biogenesis	1.253686e-6
GO:0010470	regulation of gastrulation	1.308005e-6
GO:0002237	response to molecule of bacterial origin	1.309931e-6
GO:0033189	response to vitamin A	1.331822e-6
GO:0002376	immune system process	1.394518e-6
GO:0001659	temperature homeostasis	1.430081e-6
GO:0009583	detection of light stimulus	1.450195e-6
GO:0009069	serine family amino acid metabolic process	1.459057e-6
GO:0007154	cell communication	1.471620e-6
GO:0007584	response to nutrient	1.531563e-6
GO:0040013	negative regulation of locomotion	1.657173e-6
GO:0048878	chemical homeostasis	1.712714e-6
GO:0001936	regulation of endothelial cell proliferation	1.758446e-6
GO:0032526	response to retinoic acid	1.798743e-6
GO:0015874	norepinephrine transport	1.914387e-6
GO:0034104	negative regulation of tissue remodeling	1.976651e-6
GO:0007320	insemination	1.997361e-6
GO:0080134	regulation of response to stress	2.155552e-6
GO:0033198	response to ATP	2.197311e-6
GO:0060252	positive regulation of glial cell proliferation	2.229939e-6
GO:0009991	response to extracellular stimulus	2.269081e-6
GO:0052697	xenobiotic glucuronidation	2.345216e-6
GO:0070980	biphenyl catabolic process	2.345216e-6
GO:0051552	flavone metabolic process	2.345216e-6
GO:0006789	bilirubin conjugation	2.345216e-6
GO:0052696	flavonoid glucuronidation	2.345216e-6
GO:0051965	positive regulation of synapse assembly	2.374833e-6
GO:0009259	ribonucleotide metabolic process	2.380988e-6
GO:0042542	response to hydrogen peroxide	2.420507e-6
GO:0019538	protein metabolic process	2.437169e-6
GO:0006457	protein folding	2.488891e-6
GO:0018350	protein esterification	2.767789e-6
GO:0044258	intestinal lipid catabolic process	2.767789e-6
GO:0052548	regulation of endopeptidase activity	2.865925e-6
GO:0033700	phospholipid efflux	2.944140e-6
GO:0018298	protein-chromophore linkage	2.953227e-6
GO:0002684	positive regulation of immune system process	2.991993e-6
GO:0043069	negative regulation of programmed cell death	3.017546e-6
GO:0045414	regulation of interleukin-8 biosynthetic process	3.087641e-6
GO:0006954	inflammatory response	3.103651e-6
GO:0043066	negative regulation of apoptosis	3.287870e-6
GO:0007186	G-protein coupled receptor protein signaling pathway	3.367835e-6
GO:0010873	positive regulation of cholesterol esterification	4.985529e-6
GO:0010625	positive regulation of Schwann cell proliferation	5.059838e-6
GO:0016056	rhodopsin mediated signaling pathway	5.132821e-6
GO:0001938	positive regulation of endothelial cell proliferation	5.473931e-6
GO:0090140	regulation of mitochondrial fission	5.748253e-6
GO:0070482	response to oxygen levels	5.834971e-6
GO:0009617	response to bacterium	6.004242e-6
GO:0090026	positive regulation of monocyte chemotaxis	6.005962e-6
GO:0009113	purine base biosynthetic process	6.005962e-6
GO:0050881	musculoskeletal movement	6.147682e-6
GO:0045471	response to ethanol	6.164731e-6
GO:0090181	regulation of cholesterol metabolic process	6.843653e-6
GO:0009314	response to radiation	6.860173e-6
GO:0032496	response to lipopolysaccharide	6.887549e-6
GO:0023052	signaling	7.058085e-6
GO:0050679	positive regulation of epithelial cell proliferation	7.063542e-6
GO:0032463	negative regulation of protein homooligomerization	7.151630e-6
GO:0018879	biphenyl metabolic process	7.228638e-6
GO:0009266	response to temperature stimulus	7.306843e-6
GO:0032689	negative regulation of interferon-gamma production	7.602801e-6
GO:0042256	mature ribosome assembly	7.821640e-6
GO:0014805	smooth muscle adaptation	7.975446e-6
GO:0070232	regulation of T cell apoptosis	8.046469e-6
GO:0071300	cellular response to retinoic acid	8.353461e-6
GO:0060548	negative regulation of cell death	8.788644e-6
GO:0002685	regulation of leukocyte migration	8.905372e-6
GO:0050433	regulation of catecholamine secretion	8.974628e-6
GO:0090130	tissue migration	9.370631e-6
GO:0044092	negative regulation of molecular function	9.500635e-6
GO:0002437	inflammatory response to antigenic stimulus	9.546277e-6
GO:0007162	negative regulation of cell adhesion	9.687593e-6
GO:0009150	purine ribonucleotide metabolic process	9.791899e-6
GO:0042632	cholesterol homeostasis	1.029384e-5
GO:0007509	mesoderm migration involved in gastrulation	1.064799e-5
GO:0010817	regulation of hormone levels	1.066897e-5
GO:0044259	multicellular organismal macromolecule metabolic process	1.075528e-5
GO:0032411	positive regulation of transporter activity	1.076759e-5
GO:0007267	cell-cell signaling	1.082989e-5
GO:0051716	cellular response to stimulus	1.084715e-5
GO:0009071	serine family amino acid catabolic process	1.084748e-5
GO:0009144	purine nucleoside triphosphate metabolic process	1.127077e-5
GO:0050995	negative regulation of lipid catabolic process	1.137476e-5
GO:0048583	regulation of response to stimulus	1.154401e-5
GO:0030300	regulation of intestinal cholesterol absorption	1.183911e-5
GO:0002679	respiratory burst involved in defense response	1.384061e-5
GO:0042221	response to chemical stimulus	1.404550e-5
GO:0048545	response to steroid hormone stimulus	1.414958e-5
GO:0001666	response to hypoxia	1.422914e-5
GO:0034614	cellular response to reactive oxygen species	1.518561e-5
GO:0048844	artery morphogenesis	1.550668e-5
GO:0044240	multicellular organismal lipid catabolic process	1.563177e-5
GO:0043542	endothelial cell migration	1.643215e-5
GO:0002019	regulation of renal output by angiotensin	1.651739e-5
GO:0007166	cell surface receptor linked signaling pathway	1.655951e-5
GO:0051014	actin filament severing	1.657805e-5
GO:0006916	anti-apoptosis	1.712307e-5
GO:0014070	response to organic cyclic compound	1.748811e-5
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	1.752931e-5
GO:0070228	regulation of lymphocyte apoptosis	1.822787e-5
GO:0050807	regulation of synapse organization	1.875168e-5
GO:0006897	endocytosis	1.905786e-5
GO:0043534	blood vessel endothelial cell migration	1.917866e-5
GO:2000107	negative regulation of leukocyte apoptosis	1.945415e-5
GO:0009416	response to light stimulus	1.967858e-5
GO:0050906	detection of stimulus involved in sensory perception	1.991920e-5
GO:0000088	mitotic prophase	2.020402e-5
GO:0044241	lipid digestion	2.040364e-5
GO:0045765	regulation of angiogenesis	2.077999e-5
GO:0010951	negative regulation of endopeptidase activity	2.122526e-5
GO:0034762	regulation of transmembrane transport	2.175772e-5
GO:0033129	positive regulation of histone phosphorylation	2.185722e-5
GO:0043113	receptor clustering	2.190742e-5
GO:0003084	positive regulation of systemic arterial blood pressure	2.216386e-5
GO:0002697	regulation of immune effector process	2.230592e-5
GO:0003009	skeletal muscle contraction	2.237056e-5
GO:0072522	purine-containing compound biosynthetic process	2.250440e-5
GO:0070243	regulation of thymocyte apoptosis	2.288890e-5
GO:0051051	negative regulation of transport	2.297089e-5
GO:0050848	regulation of calcium-mediated signaling	2.379643e-5
GO:0048243	norepinephrine secretion	2.396573e-5
GO:0006163	purine nucleotide metabolic process	2.469945e-5
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	2.488789e-5
GO:0019226	transmission of nerve impulse	2.518272e-5
GO:0043269	regulation of ion transport	2.565612e-5
GO:0009605	response to external stimulus	2.616350e-5
GO:0032103	positive regulation of response to external stimulus	2.836102e-5
GO:0043243	positive regulation of protein complex disassembly	2.844315e-5
GO:0010243	response to organic nitrogen	2.873695e-5
GO:0006164	purine nucleotide biosynthetic process	2.888423e-5
GO:0006066	alcohol metabolic process	2.909606e-5
GO:0051606	detection of stimulus	3.007709e-5
GO:2000649	regulation of sodium ion transmembrane transporter activity	3.055218e-5
GO:0032963	collagen metabolic process	3.064420e-5
GO:0009141	nucleoside triphosphate metabolic process	3.081318e-5
GO:0070229	negative regulation of lymphocyte apoptosis	3.101642e-5
GO:0001508	regulation of action potential	3.203474e-5
GO:0043270	positive regulation of ion transport	3.278774e-5
GO:0006775	fat-soluble vitamin metabolic process	3.294406e-5
GO:0060014	granulosa cell differentiation	3.316453e-5
GO:0010812	negative regulation of cell-substrate adhesion	3.358578e-5
GO:0045540	regulation of cholesterol biosynthetic process	3.364986e-5
GO:0010193	response to ozone	3.814402e-5
GO:0002238	response to molecule of fungal origin	3.856002e-5
GO:0071299	cellular response to vitamin A	3.869455e-5
GO:0046390	ribose phosphate biosynthetic process	3.894826e-5
GO:0009260	ribonucleotide biosynthetic process	3.920229e-5
GO:0018904	organic ether metabolic process	3.957011e-5
GO:0070301	cellular response to hydrogen peroxide	4.129291e-5
GO:0019221	cytokine-mediated signaling pathway	4.175253e-5
GO:0000413	protein peptidyl-prolyl isomerization	4.225821e-5
GO:0051580	regulation of neurotransmitter uptake	4.283026e-5
GO:0071496	cellular response to external stimulus	4.352454e-5
GO:0001775	cell activation	4.469798e-5
GO:0032972	regulation of muscle filament sliding speed	4.543069e-5
GO:0002149	hypochlorous acid biosynthetic process	4.562813e-5
GO:0009205	purine ribonucleoside triphosphate metabolic process	4.723552e-5
GO:0032959	inositol trisphosphate biosynthetic process	4.734316e-5
GO:0060167	regulation of adenosine receptor signaling pathway	4.795853e-5
GO:0002315	marginal zone B cell differentiation	4.795853e-5
GO:0045064	T-helper 2 cell differentiation	4.795853e-5
GO:0090205	positive regulation of cholesterol metabolic process	4.866236e-5
GO:0051963	regulation of synapse assembly	4.920465e-5
GO:0072593	reactive oxygen species metabolic process	4.987991e-5
GO:0009146	purine nucleoside triphosphate catabolic process	4.990340e-5
GO:0071385	cellular response to glucocorticoid stimulus	5.011853e-5
GO:0007398	ectoderm development	5.070136e-5
GO:0043983	histone H4-K12 acetylation	5.264035e-5
GO:0002673	regulation of acute inflammatory response	5.326079e-5
GO:0045589	regulation of regulatory T cell differentiation	5.347823e-5
GO:0002028	regulation of sodium ion transport	5.350056e-5
GO:0010874	regulation of cholesterol efflux	5.353400e-5
GO:0016192	vesicle-mediated transport	5.390214e-5
GO:0009165	nucleotide biosynthetic process	5.482144e-5
GO:0071260	cellular response to mechanical stimulus	5.544182e-5
GO:0032456	endocytic recycling	5.632801e-5
GO:2000106	regulation of leukocyte apoptosis	5.696160e-5
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	5.894493e-5
GO:0009199	ribonucleoside triphosphate metabolic process	5.903797e-5
GO:0009895	negative regulation of catabolic process	5.910675e-5
GO:0010933	positive regulation of macrophage tolerance induction	6.037863e-5
GO:0009143	nucleoside triphosphate catabolic process	6.237799e-5
GO:0046070	dGTP metabolic process	6.264109e-5
GO:0031444	slow-twitch skeletal muscle fiber contraction	6.264109e-5
GO:0055086	nucleobase-containing small molecule metabolic process	6.284177e-5
GO:0022617	extracellular matrix disassembly	6.322710e-5
GO:0060840	artery development	6.378807e-5
GO:0002906	negative regulation of mature B cell apoptosis	6.491762e-5
GO:0051967	negative regulation of synaptic transmission, glutamatergic	6.511815e-5
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	6.700364e-5
GO:0046122	purine deoxyribonucleoside metabolic process	7.122746e-5
GO:0009207	purine ribonucleoside triphosphate catabolic process	7.134417e-5
GO:0002891	positive regulation of immunoglobulin mediated immune response	7.212561e-5
GO:0032649	regulation of interferon-gamma production	7.268894e-5
GO:0006703	estrogen biosynthetic process	7.296779e-5
GO:0010896	regulation of triglyceride catabolic process	7.394966e-5
GO:0043206	fibril organization	7.439438e-5
GO:0001867	complement activation, lectin pathway	7.752069e-5
GO:2000651	positive regulation of sodium ion transmembrane transporter activity	8.381735e-5
GO:0006812	cation transport	8.747433e-5
GO:0046903	secretion	8.904414e-5
GO:0055114	oxidation-reduction process	9.097590e-5
GO:0009261	ribonucleotide catabolic process	9.136274e-5
GO:0061024	membrane organization	9.372393e-5
GO:0008015	blood circulation	9.766795e-5
GO:0009154	purine ribonucleotide catabolic process	9.781174e-5
GO:0051241	negative regulation of multicellular organismal process	9.915062e-5
GO:0031347	regulation of defense response	9.951505e-5
GO:0060333	interferon-gamma-mediated signaling pathway	1.000975e-4
GO:2000193	positive regulation of fatty acid transport	1.013169e-4
GO:0051092	positive regulation of NF-kappaB transcription factor activity	1.023933e-4
GO:0001101	response to acid	1.024372e-4
GO:0006544	glycine metabolic process	1.046362e-4
GO:0032414	positive regulation of ion transmembrane transporter activity	1.062571e-4
GO:0070884	regulation of calcineurin-NFAT signaling pathway	1.081724e-4
GO:0046100	hypoxanthine metabolic process	1.081724e-4
GO:0009117	nucleotide metabolic process	1.109766e-4
GO:0002712	regulation of B cell mediated immunity	1.128702e-4
GO:0060319	primitive erythrocyte differentiation	1.159494e-4
GO:0002575	basophil chemotaxis	1.159494e-4
GO:0034378	chylomicron assembly	1.208481e-4
GO:0061049	cell growth involved in cardiac muscle cell development	1.208481e-4
GO:0046491	L-methylmalonyl-CoA metabolic process	1.208481e-4
GO:0014873	response to muscle activity involved in regulation of muscle adaptation	1.208481e-4
GO:0003331	positive regulation of extracellular matrix constituent secretion	1.208481e-4
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	1.208481e-4
GO:0032308	positive regulation of prostaglandin secretion	1.220276e-4
GO:0010885	regulation of cholesterol storage	1.224993e-4
GO:0006936	muscle contraction	1.226771e-4
GO:0010038	response to metal ion	1.262185e-4
GO:0048167	regulation of synaptic plasticity	1.292940e-4
GO:0071206	establishment of protein localization to juxtaparanode region of axon	1.315562e-4
GO:0060168	positive regulation of adenosine receptor signaling pathway	1.315562e-4
GO:0009581	detection of external stimulus	1.326584e-4
GO:0001660	fever generation	1.330750e-4
GO:0032958	inositol phosphate biosynthetic process	1.360014e-4
GO:0040012	regulation of locomotion	1.370684e-4
GO:0035176	social behavior	1.380200e-4
GO:0006348	chromatin silencing at telomere	1.382637e-4
GO:0000917	barrier septum formation	1.382637e-4
GO:0045087	innate immune response	1.385683e-4
GO:0072521	purine-containing compound metabolic process	1.433251e-4
GO:0060346	bone trabecula formation	1.453327e-4
GO:0002686	negative regulation of leukocyte migration	1.466159e-4
GO:0003051	angiotensin-mediated drinking behavior	1.467200e-4
GO:0003015	heart process	1.492441e-4
GO:2000191	regulation of fatty acid transport	1.494391e-4
GO:0034654	nucleobase-containing compound biosynthetic process	1.521920e-4
GO:0010959	regulation of metal ion transport	1.562550e-4
GO:0060992	response to fungicide	1.569889e-4
GO:0006638	neutral lipid metabolic process	1.586552e-4
GO:0043933	macromolecular complex subunit organization	1.626634e-4
GO:0007165	signal transduction	1.631662e-4
GO:0018026	peptidyl-lysine monomethylation	1.639184e-4
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	1.642038e-4
GO:0055009	atrial cardiac muscle tissue morphogenesis	1.645768e-4
GO:0016044	cellular membrane organization	1.661127e-4
GO:0046851	negative regulation of bone remodeling	1.666146e-4
GO:0046165	alcohol biosynthetic process	1.701772e-4
GO:0009151	purine deoxyribonucleotide metabolic process	1.725646e-4
GO:0007618	mating	1.731162e-4
GO:0051928	positive regulation of calcium ion transport	1.731650e-4
GO:0060744	mammary gland branching involved in thelarche	1.768867e-4
GO:0008210	estrogen metabolic process	1.783015e-4
GO:0051270	regulation of cellular component movement	1.783062e-4
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	1.805859e-4
GO:0046101	hypoxanthine biosynthetic process	1.805996e-4
GO:0050832	defense response to fungus	1.835775e-4
GO:0009264	deoxyribonucleotide catabolic process	1.854617e-4
GO:0045542	positive regulation of cholesterol biosynthetic process	1.859326e-4
GO:0035814	negative regulation of renal sodium excretion	1.859326e-4
GO:0014059	regulation of dopamine secretion	1.890235e-4
GO:0051952	regulation of amine transport	1.894766e-4
GO:0006898	receptor-mediated endocytosis	1.902631e-4
GO:0006941	striated muscle contraction	1.905014e-4
GO:0007268	synaptic transmission	1.927967e-4
GO:0045779	negative regulation of bone resorption	1.950787e-4
GO:0019725	cellular homeostasis	1.955220e-4
GO:0033194	response to hydroperoxide	1.967355e-4
GO:0002889	regulation of immunoglobulin mediated immune response	2.015990e-4
GO:0001568	blood vessel development	2.022205e-4
GO:0019233	sensory perception of pain	2.030614e-4
GO:0009394	2'-deoxyribonucleotide metabolic process	2.055725e-4
GO:0048609	multicellular organismal reproductive process	2.066230e-4
GO:0032729	positive regulation of interferon-gamma production	2.078942e-4
GO:0046483	heterocycle metabolic process	2.100183e-4
GO:0015992	proton transport	2.101177e-4
GO:0070327	thyroid hormone transport	2.118545e-4
GO:0002675	positive regulation of acute inflammatory response	2.131451e-4
GO:0006879	cellular iron ion homeostasis	2.235272e-4
GO:0001922	B-1 B cell homeostasis	2.263099e-4
GO:0006725	cellular aromatic compound metabolic process	2.268774e-4
GO:0044243	multicellular organismal catabolic process	2.322028e-4
GO:0018022	peptidyl-lysine methylation	2.345617e-4
GO:0071214	cellular response to abiotic stimulus	2.367630e-4
GO:0006749	glutathione metabolic process	2.448864e-4
GO:0090141	positive regulation of mitochondrial fission	2.482835e-4
GO:0042756	drinking behavior	2.508613e-4
GO:0051259	protein oligomerization	2.513747e-4
GO:0035313	wound healing, spreading of epidermal cells	2.519616e-4
GO:0050851	antigen receptor-mediated signaling pathway	2.524998e-4
GO:0003013	circulatory system process	2.529401e-4
GO:0007155	cell adhesion	2.533255e-4
GO:0006641	triglyceride metabolic process	2.543569e-4
GO:0070244	negative regulation of thymocyte apoptosis	2.544757e-4
GO:0019228	regulation of action potential in neuron	2.572368e-4
GO:0007492	endoderm development	2.584339e-4
GO:0051323	metaphase	2.594586e-4
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	2.602412e-4
GO:0002768	immune response-regulating cell surface receptor signaling pathway	2.685851e-4
GO:2000145	regulation of cell motility	2.761273e-4
GO:0002429	immune response-activating cell surface receptor signaling pathway	2.787818e-4
GO:0009262	deoxyribonucleotide metabolic process	2.796576e-4
GO:0009152	purine ribonucleotide biosynthetic process	2.811147e-4
GO:0042445	hormone metabolic process	2.886191e-4
GO:0072334	UDP-galactose transmembrane transport	2.888654e-4
GO:0034599	cellular response to oxidative stress	2.918802e-4
GO:0048584	positive regulation of response to stimulus	2.941605e-4
GO:0015670	carbon dioxide transport	2.949050e-4
GO:0070508	cholesterol import	2.978172e-4
GO:0070164	negative regulation of adiponectin secretion	3.003538e-4
GO:0035505	positive regulation of myosin light chain kinase activity	3.003538e-4
GO:0060355	positive regulation of cell adhesion molecule production	3.003538e-4
GO:0002268	follicular dendritic cell differentiation	3.021938e-4
GO:0042116	macrophage activation	3.074611e-4
GO:0033504	floor plate development	3.079403e-4
GO:0051656	establishment of organelle localization	3.108160e-4
GO:0007208	activation of phospholipase C activity by serotonin receptor signaling pathway	3.169066e-4
GO:0060020	Bergmann glial cell differentiation	3.182214e-4
GO:0007589	body fluid secretion	3.187952e-4
GO:0048514	blood vessel morphogenesis	3.219535e-4
GO:0006821	chloride transport	3.265944e-4
GO:0006639	acylglycerol metabolic process	3.319566e-4
GO:0007566	embryo implantation	3.357020e-4
GO:0032892	positive regulation of organic acid transport	3.412210e-4
GO:0033127	regulation of histone phosphorylation	3.416627e-4
GO:0072205	metanephric collecting duct development	3.430646e-4
GO:0085018	maintenance of symbiont-containing vacuole via substance secreted by host	3.471004e-4
GO:0035378	carbon dioxide transmembrane transport	3.471004e-4
GO:0030950	establishment or maintenance of actin cytoskeleton polarity	3.471004e-4
GO:0035377	transepithelial water transport	3.471004e-4
GO:0070234	positive regulation of T cell apoptosis	3.495517e-4
GO:0031133	regulation of axon diameter	3.536573e-4
GO:0071472	cellular response to salt stress	3.546328e-4
GO:0072488	ammonium transmembrane transport	3.546328e-4
GO:0034097	response to cytokine stimulus	3.569554e-4
GO:0018027	peptidyl-lysine dimethylation	3.587989e-4
GO:0048610	cellular process involved in reproduction	3.606112e-4

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0008202	steroid metabolic process	1.294353e-21
GO:0055114	oxidation-reduction process	4.105637e-16
GO:0006629	lipid metabolic process	1.139984e-15
GO:0033344	cholesterol efflux	4.252235e-15
GO:0008203	cholesterol metabolic process	4.324978e-15
GO:0034369	plasma lipoprotein particle remodeling	7.843236e-15
GO:0071827	plasma lipoprotein particle organization	1.337642e-14
GO:0016125	sterol metabolic process	1.662210e-14
GO:0044281	small molecule metabolic process	3.095416e-14
GO:0097006	regulation of plasma lipoprotein particle levels	4.203478e-12
GO:0030301	cholesterol transport	4.450404e-12
GO:0008610	lipid biosynthetic process	1.235996e-11
GO:0044255	cellular lipid metabolic process	1.254223e-11
GO:0006082	organic acid metabolic process	1.588314e-11
GO:0019752	carboxylic acid metabolic process	1.987761e-11
GO:0042632	cholesterol homeostasis	2.662451e-11
GO:0042180	cellular ketone metabolic process	3.373265e-11
GO:0032374	regulation of cholesterol transport	1.416482e-10
GO:0044242	cellular lipid catabolic process	2.499421e-10
GO:0015914	phospholipid transport	7.306334e-10
GO:0042446	hormone biosynthetic process	7.837817e-10
GO:0043691	reverse cholesterol transport	7.959664e-10
GO:0006066	alcohol metabolic process	1.761658e-9
GO:0018904	organic ether metabolic process	3.002830e-9
GO:0030300	regulation of intestinal cholesterol absorption	4.080547e-9
GO:0006869	lipid transport	5.028507e-9
GO:0009308	amine metabolic process	5.749884e-9
GO:0006639	acylglycerol metabolic process	6.932190e-9
GO:0033700	phospholipid efflux	9.099804e-9
GO:0070328	triglyceride homeostasis	1.198577e-8
GO:0006694	steroid biosynthetic process	1.423470e-8
GO:0046464	acylglycerol catabolic process	1.760722e-8
GO:0032368	regulation of lipid transport	1.837469e-8
GO:0042157	lipoprotein metabolic process	2.086063e-8
GO:0000305	response to oxygen radical	2.360465e-8
GO:0055088	lipid homeostasis	3.231675e-8
GO:0006641	triglyceride metabolic process	3.354205e-8
GO:0046474	glycerophospholipid biosynthetic process	3.375261e-8
GO:0006662	glycerol ether metabolic process	4.674081e-8
GO:0006638	neutral lipid metabolic process	4.959808e-8
GO:0006952	defense response	5.079276e-8
GO:0006642	triglyceride mobilization	5.095177e-8
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	6.721052e-8
GO:0022410	circadian sleep/wake cycle process	7.741872e-8
GO:0046503	glycerolipid catabolic process	8.525548e-8
GO:0019433	triglyceride catabolic process	9.291667e-8
GO:0008207	C21-steroid hormone metabolic process	9.807232e-8
GO:0010876	lipid localization	1.000714e-7
GO:0042745	circadian sleep/wake cycle	1.136500e-7
GO:0042744	hydrogen peroxide catabolic process	1.278439e-7
GO:0031424	keratinization	1.389726e-7
GO:0051659	maintenance of mitochondrion location	1.513076e-7
GO:0045589	regulation of regulatory T cell differentiation	1.812611e-7
GO:0046486	glycerolipid metabolic process	1.895337e-7
GO:0044106	cellular amine metabolic process	1.971370e-7
GO:0045017	glycerolipid biosynthetic process	2.445592e-7
GO:0010038	response to metal ion	2.540358e-7
GO:0042304	regulation of fatty acid biosynthetic process	2.548008e-7
GO:0010872	regulation of cholesterol esterification	2.792581e-7
GO:0044283	small molecule biosynthetic process	3.012605e-7
GO:0034375	high-density lipoprotein particle remodeling	3.572476e-7
GO:0016042	lipid catabolic process	3.655911e-7
GO:0006690	icosanoid metabolic process	3.715156e-7
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	3.775752e-7
GO:0044058	regulation of digestive system process	4.009780e-7
GO:0032375	negative regulation of cholesterol transport	5.988593e-7
GO:0009310	amine catabolic process	6.183682e-7
GO:0034381	plasma lipoprotein particle clearance	7.831652e-7
GO:0006636	unsaturated fatty acid biosynthetic process	8.773225e-7
GO:0006603	phosphocreatine metabolic process	8.979668e-7
GO:0034442	regulation of lipoprotein oxidation	9.458595e-7
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	1.123711e-6
GO:0002227	innate immune response in mucosa	1.179772e-6
GO:0046394	carboxylic acid biosynthetic process	1.250921e-6
GO:0000303	response to superoxide	1.665783e-6
GO:0006954	inflammatory response	1.677857e-6
GO:0019370	leukotriene biosynthetic process	1.689904e-6
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	1.952489e-6
GO:0070508	cholesterol import	2.100792e-6
GO:0046456	icosanoid biosynthetic process	2.208021e-6
GO:0042445	hormone metabolic process	2.235043e-6
GO:0045717	negative regulation of fatty acid biosynthetic process	2.281642e-6
GO:0008654	phospholipid biosynthetic process	2.293141e-6
GO:0022900	electron transport chain	2.446661e-6
GO:0010873	positive regulation of cholesterol esterification	2.722017e-6
GO:0010984	regulation of lipoprotein particle clearance	2.828923e-6
GO:0051657	maintenance of organelle location	3.403281e-6
GO:0010982	regulation of high-density lipoprotein particle clearance	3.588723e-6
GO:0042178	xenobiotic catabolic process	3.697875e-6
GO:0032490	detection of molecule of bacterial origin	3.973519e-6
GO:0051234	establishment of localization	4.387200e-6
GO:0010035	response to inorganic substance	4.994391e-6
GO:0071870	cellular response to catecholamine stimulus	5.559875e-6
GO:0006420	arginyl-tRNA aminoacylation	5.825092e-6
GO:0009063	cellular amino acid catabolic process	6.484243e-6
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	7.195168e-6
GO:0006810	transport	7.210696e-6
GO:0032237	activation of store-operated calcium channel activity	7.706025e-6
GO:0010985	negative regulation of lipoprotein particle clearance	7.863684e-6
GO:0006661	phosphatidylinositol biosynthetic process	8.368478e-6
GO:0032787	monocarboxylic acid metabolic process	8.563253e-6
GO:0006700	C21-steroid hormone biosynthetic process	1.039301e-5
GO:0050704	regulation of interleukin-1 secretion	1.063541e-5
GO:0065005	protein-lipid complex assembly	1.149700e-5
GO:0045590	negative regulation of regulatory T cell differentiation	1.218857e-5
GO:0042448	progesterone metabolic process	1.267854e-5
GO:0018924	mandelate metabolic process	1.418919e-5
GO:0006691	leukotriene metabolic process	1.458996e-5
GO:0046689	response to mercury ion	1.495814e-5
GO:0044282	small molecule catabolic process	1.574343e-5
GO:0051005	negative regulation of lipoprotein lipase activity	1.711944e-5
GO:0042742	defense response to bacterium	1.755210e-5
GO:0006707	cholesterol catabolic process	1.914712e-5
GO:0045940	positive regulation of steroid metabolic process	2.017735e-5
GO:0043476	pigment accumulation	2.041256e-5
GO:0006941	striated muscle contraction	2.243869e-5
GO:0032236	positive regulation of calcium ion transport via store-operated calcium channel activity	2.403596e-5
GO:0019884	antigen processing and presentation of exogenous antigen	2.448704e-5
GO:0042747	circadian sleep/wake cycle, REM sleep	2.473245e-5
GO:0045187	regulation of circadian sleep/wake cycle, sleep	2.519386e-5
GO:0006520	cellular amino acid metabolic process	2.525748e-5
GO:0050748	negative regulation of lipoprotein metabolic process	2.693700e-5
GO:0006805	xenobiotic metabolic process	2.874285e-5
GO:0051346	negative regulation of hydrolase activity	2.994074e-5
GO:0006399	tRNA metabolic process	3.044832e-5
GO:0006957	complement activation, alternative pathway	3.131536e-5
GO:0046034	ATP metabolic process	3.398357e-5
GO:0010987	negative regulation of high-density lipoprotein particle clearance	3.452607e-5
GO:0010897	negative regulation of triglyceride catabolic process	3.452607e-5
GO:0050706	regulation of interleukin-1 beta secretion	3.636832e-5
GO:0006982	response to lipid hydroperoxide	3.874052e-5
GO:0042158	lipoprotein biosynthetic process	4.003333e-5
GO:0046395	carboxylic acid catabolic process	4.057375e-5
GO:0034382	chylomicron remnant clearance	4.062070e-5
GO:0050746	regulation of lipoprotein metabolic process	4.431031e-5
GO:0006631	fatty acid metabolic process	4.689070e-5
GO:0006725	cellular aromatic compound metabolic process	4.697673e-5
GO:0010466	negative regulation of peptidase activity	5.442430e-5
GO:0032497	detection of lipopolysaccharide	5.806833e-5
GO:0006506	GPI anchor biosynthetic process	6.151858e-5
GO:0044271	cellular nitrogen compound biosynthetic process	6.441285e-5
GO:0060620	regulation of cholesterol import	6.579608e-5
GO:0008033	tRNA processing	6.892379e-5
GO:0046755	non-lytic virus budding	6.930830e-5
GO:0042938	dipeptide transport	6.930830e-5
GO:0010269	response to selenium ion	7.258316e-5
GO:0019430	removal of superoxide radicals	7.739989e-5
GO:0055090	acylglycerol homeostasis	7.784156e-5
GO:0033198	response to ATP	7.992918e-5
GO:0010193	response to ozone	8.793224e-5
GO:0034754	cellular hormone metabolic process	1.008377e-4
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	1.009221e-4
GO:0043482	cellular pigment accumulation	1.048311e-4
GO:0007159	leukocyte cell-cell adhesion	1.065051e-4
GO:0007586	digestion	1.134046e-4
GO:0051336	regulation of hydrolase activity	1.142335e-4
GO:0051707	response to other organism	1.192749e-4
GO:0060988	lipid tube assembly	1.201612e-4
GO:0009617	response to bacterium	1.221213e-4
GO:0002478	antigen processing and presentation of exogenous peptide antigen	1.221765e-4
GO:0046130	purine ribonucleoside catabolic process	1.225618e-4
GO:0002407	dendritic cell chemotaxis	1.225618e-4
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.261809e-4
GO:0006633	fatty acid biosynthetic process	1.297523e-4
GO:0051704	multi-organism process	1.417816e-4
GO:0019836	hemolysis by symbiont of host erythrocytes	1.524101e-4
GO:0032418	lysosome localization	1.528306e-4
GO:0050873	brown fat cell differentiation	1.552755e-4
GO:0090207	regulation of triglyceride metabolic process	1.553318e-4
GO:0006547	histidine metabolic process	1.684621e-4
GO:0002253	activation of immune response	1.703883e-4
GO:0032369	negative regulation of lipid transport	1.765570e-4
GO:0010896	regulation of triglyceride catabolic process	1.779992e-4
GO:0000266	mitochondrial fission	1.781829e-4
GO:0060192	negative regulation of lipase activity	1.796836e-4
GO:0006515	misfolded or incompletely synthesized protein catabolic process	1.824455e-4
GO:0006811	ion transport	1.902607e-4
GO:0006754	ATP biosynthetic process	1.982423e-4
GO:0046470	phosphatidylcholine metabolic process	2.076800e-4
GO:0050863	regulation of T cell activation	2.154437e-4
GO:0090076	relaxation of skeletal muscle	2.158272e-4
GO:0032470	elevation of endoplasmic reticulum calcium ion concentration	2.158272e-4
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	2.175763e-4
GO:0046483	heterocycle metabolic process	2.195170e-4
GO:0015920	lipopolysaccharide transport	2.195537e-4
GO:0030889	negative regulation of B cell proliferation	2.219629e-4
GO:0070541	response to platinum ion	2.364226e-4
GO:0046314	phosphocreatine biosynthetic process	2.421007e-4
GO:0010949	negative regulation of intestinal phytosterol absorption	2.421007e-4
GO:0045796	negative regulation of intestinal cholesterol absorption	2.421007e-4
GO:0050711	negative regulation of interleukin-1 secretion	2.440670e-4
GO:0009607	response to biotic stimulus	2.502156e-4
GO:0042743	hydrogen peroxide metabolic process	2.535561e-4
GO:0046013	regulation of T cell homeostatic proliferation	2.591674e-4
GO:0002385	mucosal immune response	2.623528e-4
GO:0050872	white fat cell differentiation	2.701654e-4
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	2.726945e-4
GO:0006546	glycine catabolic process	2.754727e-4
GO:0050778	positive regulation of immune response	2.814048e-4
GO:0019637	organophosphate metabolic process	2.826109e-4
GO:0045651	positive regulation of macrophage differentiation	2.875112e-4
GO:0051875	pigment granule localization	2.877454e-4
GO:0002335	mature B cell differentiation	2.924079e-4
GO:0045922	negative regulation of fatty acid metabolic process	3.039207e-4
GO:0042439	ethanolamine-containing compound metabolic process	3.049248e-4
GO:0046466	membrane lipid catabolic process	3.146961e-4
GO:0006172	ADP biosynthetic process	3.286058e-4
GO:0033239	negative regulation of cellular amine metabolic process	3.291283e-4
GO:0051788	response to misfolded protein	3.311353e-4
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	3.336684e-4
GO:0071712	ER-associated misfolded protein catabolic process	3.348825e-4
GO:0006702	androgen biosynthetic process	3.428534e-4
GO:0002251	organ or tissue specific immune response	3.972014e-4
GO:0032853	positive regulation of Ran GTPase activity	4.109135e-4
GO:0009201	ribonucleoside triphosphate biosynthetic process	4.178835e-4
GO:0006705	mineralocorticoid biosynthetic process	4.180787e-4
GO:0010951	negative regulation of endopeptidase activity	4.181288e-4
GO:0045066	regulatory T cell differentiation	4.236020e-4
GO:0050953	sensory perception of light stimulus	4.237038e-4
GO:0009415	response to water	4.312590e-4
GO:0014819	regulation of skeletal muscle contraction	4.413797e-4
GO:0002764	immune response-regulating signaling pathway	4.431885e-4
GO:0019307	mannose biosynthetic process	4.728871e-4
GO:0032321	positive regulation of Rho GTPase activity	4.785775e-4
GO:0009260	ribonucleotide biosynthetic process	4.825521e-4
GO:0010900	negative regulation of phosphatidylcholine catabolic process	5.007891e-4
GO:0009145	purine nucleoside triphosphate biosynthetic process	5.100609e-4
GO:0010565	regulation of cellular ketone metabolic process	5.183277e-4
GO:0042752	regulation of circadian rhythm	5.195209e-4
GO:0006953	acute-phase response	5.224801e-4
GO:0031295	T cell costimulation	5.232077e-4
GO:0010817	regulation of hormone levels	5.247541e-4
GO:0007341	penetration of zona pellucida	5.250300e-4
GO:0034374	low-density lipoprotein particle remodeling	5.489512e-4
GO:0015824	proline transport	5.532391e-4
GO:0002238	response to molecule of fungal origin	5.690446e-4
GO:0006164	purine nucleotide biosynthetic process	5.775266e-4
GO:0006544	glycine metabolic process	5.780608e-4
GO:0007601	visual perception	5.791314e-4
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	5.864786e-4
GO:0035315	hair cell differentiation	5.957188e-4
GO:0034435	cholesterol esterification	6.014715e-4
GO:0010989	negative regulation of low-density lipoprotein particle clearance	6.294292e-4
GO:0009152	purine ribonucleotide biosynthetic process	6.376780e-4
GO:0016098	monoterpenoid metabolic process	6.377980e-4
GO:0006663	platelet activating factor biosynthetic process	6.377980e-4
GO:0009595	detection of biotic stimulus	6.490292e-4
GO:0043249	erythrocyte maturation	6.518391e-4
GO:0006704	glucocorticoid biosynthetic process	6.518391e-4
GO:0072362	regulation of glycolysis by negative regulation of transcription from RNA polymerase II promoter	6.773815e-4
GO:0070627	ferrous iron import	6.773815e-4
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	6.773815e-4
GO:0015676	vanadium ion transport	6.773815e-4
GO:0008057	eye pigment granule organization	6.773815e-4
GO:0015692	lead ion transport	6.773815e-4
GO:0035964	COPI-coated vesicle budding	6.774925e-4
GO:0006650	glycerophospholipid metabolic process	6.962168e-4
GO:0060621	negative regulation of cholesterol import	7.012920e-4
GO:0071872	cellular response to epinephrine stimulus	7.103558e-4
GO:0009235	cobalamin metabolic process	7.103558e-4
GO:0000715	nucleotide-excision repair, DNA damage recognition	7.324136e-4
GO:0071702	organic substance transport	7.328378e-4
GO:0006505	GPI anchor metabolic process	7.672258e-4
GO:0050900	leukocyte migration	7.807578e-4
GO:0002316	follicular B cell differentiation	7.841748e-4
GO:0018130	heterocycle biosynthetic process	8.013252e-4
GO:0009142	nucleoside triphosphate biosynthetic process	8.053857e-4
GO:0009117	nucleotide metabolic process	8.166182e-4
GO:0031640	killing of cells of other organism	8.230732e-4
GO:0006548	histidine catabolic process	8.261131e-4
GO:0015876	acetyl-CoA transport	8.597636e-4
GO:0051092	positive regulation of NF-kappaB transcription factor activity	8.693013e-4
GO:0046164	alcohol catabolic process	8.774792e-4
GO:0008206	bile acid metabolic process	8.788717e-4
GO:0014894	response to denervation involved in regulation of muscle adaptation	8.974297e-4
GO:0042730	fibrinolysis	9.054931e-4
GO:0002313	mature B cell differentiation involved in immune response	9.367391e-4
GO:0090026	positive regulation of monocyte chemotaxis	9.452007e-4
GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	9.649977e-4
GO:0032526	response to retinoic acid	9.708248e-4
GO:0019882	antigen processing and presentation	9.724510e-4
GO:0090209	negative regulation of triglyceride metabolic process	9.735305e-4
GO:0071421	manganese ion transmembrane transport	1.013585e-3
GO:0006644	phospholipid metabolic process	1.022415e-3
GO:0045988	negative regulation of striated muscle contraction	1.038834e-3
GO:0009620	response to fungus	1.041291e-3
GO:0032652	regulation of interleukin-1 production	1.053130e-3
GO:0050713	negative regulation of interleukin-1 beta secretion	1.076129e-3
GO:0015840	urea transport	1.076129e-3
GO:0006412	translation	1.090064e-3
GO:0000038	very long-chain fatty acid metabolic process	1.125151e-3
GO:0000302	response to reactive oxygen species	1.128383e-3
GO:0019218	regulation of steroid metabolic process	1.139350e-3
GO:0006654	phosphatidic acid biosynthetic process	1.144977e-3
GO:0042404	thyroid hormone catabolic process	1.153581e-3
GO:0050729	positive regulation of inflammatory response	1.158247e-3
GO:0070059	apoptosis in response to endoplasmic reticulum stress	1.169915e-3
GO:0051883	killing of cells in other organism involved in symbiotic interaction	1.181262e-3
GO:0006497	protein lipidation	1.187346e-3
GO:0032367	intracellular cholesterol transport	1.194529e-3
GO:0030216	keratinocyte differentiation	1.203309e-3
GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning	1.211068e-3
GO:0046949	fatty-acyl-CoA biosynthetic process	1.211068e-3
GO:0061302	smooth muscle cell-matrix adhesion	1.211068e-3
GO:0043163	cell envelope organization	1.211068e-3
GO:0002221	pattern recognition receptor signaling pathway	1.213311e-3
GO:0002684	positive regulation of immune system process	1.215583e-3
GO:0071874	cellular response to norepinephrine stimulus	1.234022e-3
GO:0031349	positive regulation of defense response	1.242103e-3
GO:0008211	glucocorticoid metabolic process	1.244398e-3
GO:0071608	macrophage inflammatory protein-1 alpha production	1.251767e-3
GO:2000363	positive regulation of prostaglandin-E synthase activity	1.251767e-3
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	1.251767e-3
GO:0032701	negative regulation of interleukin-18 production	1.251767e-3
GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	1.251767e-3
GO:0032498	detection of muramyl dipeptide	1.251767e-3
GO:0052547	regulation of peptidase activity	1.252438e-3
GO:0042346	positive regulation of NF-kappaB import into nucleus	1.258187e-3
GO:0048711	positive regulation of astrocyte differentiation	1.268795e-3
GO:0051561	elevation of mitochondrial calcium ion concentration	1.279273e-3
GO:0032488	Cdc42 protein signal transduction	1.279273e-3
GO:0048535	lymph node development	1.279700e-3
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	1.289899e-3
GO:0046434	organophosphate catabolic process	1.307729e-3
GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	1.318712e-3
GO:0032094	response to food	1.343544e-3
GO:0001845	phagolysosome assembly	1.372472e-3
GO:0042219	cellular modified amino acid catabolic process	1.380842e-3
GO:0009165	nucleotide biosynthetic process	1.382342e-3
GO:0015938	coenzyme A catabolic process	1.442142e-3
GO:0031081	nuclear pore distribution	1.442142e-3
GO:0097026	dendritic cell dendrite assembly	1.466795e-3
GO:0016559	peroxisome fission	1.466795e-3
GO:0009414	response to water deprivation	1.479651e-3
GO:0002579	positive regulation of antigen processing and presentation	1.480570e-3
GO:0002757	immune response-activating signal transduction	1.506474e-3
GO:0050869	negative regulation of B cell activation	1.511816e-3
GO:0019371	cyclooxygenase pathway	1.545980e-3
GO:0006435	threonyl-tRNA aminoacylation	1.568169e-3
GO:0035104	positive regulation of transcription via sterol regulatory element binding	1.584056e-3
GO:0060457	negative regulation of digestive system process	1.599489e-3
GO:0045415	negative regulation of interleukin-8 biosynthetic process	1.613070e-3
GO:0043550	regulation of lipid kinase activity	1.631941e-3
GO:0019369	arachidonic acid metabolic process	1.634877e-3
GO:0055085	transmembrane transport	1.640614e-3
GO:0002682	regulation of immune system process	1.650115e-3
GO:0071356	cellular response to tumor necrosis factor	1.650285e-3
GO:0015936	coenzyme A metabolic process	1.732109e-3
GO:0051222	positive regulation of protein transport	1.735138e-3
GO:0006812	cation transport	1.744550e-3
GO:0002861	regulation of inflammatory response to antigenic stimulus	1.763910e-3
GO:0048512	circadian behavior	1.790763e-3
GO:0003032	detection of oxygen	1.799852e-3
GO:0042396	phosphagen biosynthetic process	1.816026e-3
GO:0043901	negative regulation of multi-organism process	1.835169e-3
GO:0030149	sphingolipid catabolic process	1.844703e-3
GO:0042345	regulation of NF-kappaB import into nucleus	1.857002e-3
GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	1.876575e-3
GO:0042537	benzene-containing compound metabolic process	1.876828e-3
GO:0034380	high-density lipoprotein particle assembly	1.918763e-3
GO:0032959	inositol trisphosphate biosynthetic process	1.948633e-3
GO:0010830	regulation of myotube differentiation	1.957239e-3
GO:0009437	carnitine metabolic process	1.964653e-3
GO:0070509	calcium ion import	1.981181e-3
GO:0016074	snoRNA metabolic process	1.981181e-3
GO:0043547	positive regulation of GTPase activity	2.018215e-3
GO:0045591	positive regulation of regulatory T cell differentiation	2.024840e-3
GO:0002376	immune system process	2.073227e-3
GO:0050870	positive regulation of T cell activation	2.092979e-3
GO:0050862	positive regulation of T cell receptor signaling pathway	2.106957e-3
GO:0006098	pentose-phosphate shunt	2.131267e-3
GO:0006720	isoprenoid metabolic process	2.142589e-3
GO:0002758	innate immune response-activating signal transduction	2.194632e-3
GO:0051249	regulation of lymphocyte activation	2.210199e-3
GO:0042993	positive regulation of transcription factor import into nucleus	2.221364e-3
GO:0097039	protein linear polyubiquitination	2.248567e-3
GO:0009913	epidermal cell differentiation	2.290348e-3
GO:0010572	positive regulation of platelet activation	2.317823e-3
GO:0019217	regulation of fatty acid metabolic process	2.328954e-3
GO:0046890	regulation of lipid biosynthetic process	2.397474e-3
GO:0006959	humoral immune response	2.402126e-3
GO:0019319	hexose biosynthetic process	2.416713e-3
GO:0010288	response to lead ion	2.460514e-3
GO:0032320	positive regulation of Ras GTPase activity	2.467080e-3
GO:0042990	regulation of transcription factor import into nucleus	2.489265e-3
GO:0002740	negative regulation of cytokine secretion involved in immune response	2.599270e-3
GO:0070574	cadmium ion transmembrane transport	2.626014e-3
GO:0034694	response to prostaglandin stimulus	2.627089e-3
GO:0001817	regulation of cytokine production	2.664887e-3
GO:0045933	positive regulation of muscle contraction	2.723436e-3
GO:0042891	antibiotic transport	2.727526e-3
GO:0051668	localization within membrane	2.746345e-3
GO:0072522	purine-containing compound biosynthetic process	2.807326e-3
GO:0060992	response to fungicide	2.844537e-3
GO:0045580	regulation of T cell differentiation	2.929930e-3
GO:0042403	thyroid hormone metabolic process	2.940048e-3
GO:0033037	polysaccharide localization	2.951813e-3
GO:0097022	lymphocyte migration into lymph node	2.969721e-3
GO:0034441	plasma lipoprotein particle oxidation	2.969721e-3
GO:0072610	interleukin-12 secretion	2.969721e-3
GO:0071218	cellular response to misfolded protein	2.970994e-3
GO:0017004	cytochrome complex assembly	2.970994e-3
GO:0071322	cellular response to carbohydrate stimulus	3.016101e-3
GO:0032319	regulation of Rho GTPase activity	3.016375e-3
GO:0006801	superoxide metabolic process	3.032622e-3
GO:0033085	negative regulation of T cell differentiation in thymus	3.093307e-3
GO:0032088	negative regulation of NF-kappaB transcription factor activity	3.118764e-3
GO:0048002	antigen processing and presentation of peptide antigen	3.142912e-3
GO:0042697	menopause	3.198316e-3
GO:0072530	purine-containing compound transmembrane transport	3.206062e-3
GO:0006818	hydrogen transport	3.262720e-3
GO:0032651	regulation of interleukin-1 beta production	3.322164e-3
GO:0023035	CD40 signaling pathway	3.425611e-3
GO:0090257	regulation of muscle system process	3.479230e-3
GO:0009583	detection of light stimulus	3.491941e-3
GO:0009593	detection of chemical stimulus	3.503087e-3
GO:2000110	negative regulation of macrophage apoptosis	3.558201e-3
GO:0050776	regulation of immune response	3.559844e-3
GO:0042984	regulation of amyloid precursor protein biosynthetic process	3.567753e-3
GO:0090218	positive regulation of lipid kinase activity	3.612709e-3
GO:0015931	nucleobase-containing compound transport	3.626300e-3
GO:0050994	regulation of lipid catabolic process	3.667577e-3
GO:0070301	cellular response to hydrogen peroxide	3.670224e-3
GO:0006955	immune response	3.717421e-3
GO:0006937	regulation of muscle contraction	3.744575e-3
GO:2000412	positive regulation of thymocyte migration	3.781484e-3
GO:0032400	melanosome localization	3.800780e-3
GO:0006599	phosphagen metabolic process	3.800780e-3
GO:0051882	mitochondrial depolarization	3.813191e-3
GO:0017126	nucleologenesis	3.813191e-3
GO:0033342	negative regulation of collagen binding	3.813191e-3
GO:0045214	sarcomere organization	3.824004e-3
GO:0046824	positive regulation of nucleocytoplasmic transport	3.824714e-3
GO:0002709	regulation of T cell mediated immunity	3.824899e-3
GO:0001935	endothelial cell proliferation	3.861995e-3
GO:0035524	proline transmembrane transport	3.900166e-3
GO:0009071	serine family amino acid catabolic process	3.907273e-3
GO:0044003	modification by symbiont of host morphology or physiology	3.934108e-3
GO:0051186	cofactor metabolic process	3.976751e-3
GO:0015842	synaptic vesicle amine transport	4.094381e-3
GO:0042761	very long-chain fatty acid biosynthetic process	4.097545e-3
GO:0003229	ventricular cardiac muscle tissue development	4.300116e-3
GO:0007602	phototransduction	4.300442e-3
GO:0003062	regulation of heart rate by chemical signal	4.322826e-3
GO:0051701	interaction with host	4.415149e-3
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	4.433420e-3
GO:0009133	nucleoside diphosphate biosynthetic process	4.477786e-3
GO:0048247	lymphocyte chemotaxis	4.477786e-3
GO:0007584	response to nutrient	4.482534e-3
GO:0050718	positive regulation of interleukin-1 beta secretion	4.572974e-3
GO:0055010	ventricular cardiac muscle tissue morphogenesis	4.577825e-3
GO:0034614	cellular response to reactive oxygen species	4.614819e-3
GO:0010886	positive regulation of cholesterol storage	4.656934e-3
GO:0008016	regulation of heart contraction	4.671635e-3
GO:0008612	peptidyl-lysine modification to hypusine	4.677911e-3
GO:0006576	cellular biogenic amine metabolic process	4.756013e-3
GO:0035444	nickel ion transmembrane transport	4.760107e-3
GO:0070932	histone H3 deacetylation	4.760107e-3
GO:0009313	oligosaccharide catabolic process	4.760107e-3
GO:0002697	regulation of immune effector process	4.786010e-3
GO:0072376	protein activation cascade	4.830383e-3
GO:2000107	negative regulation of leukocyte apoptosis	4.841981e-3
GO:0045619	regulation of lymphocyte differentiation	5.016872e-3
GO:0045087	innate immune response	5.047691e-3
GO:0009649	entrainment of circadian clock	5.098721e-3
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	5.161543e-3
GO:0034654	nucleobase-containing compound biosynthetic process	5.175232e-3
GO:0006689	ganglioside catabolic process	5.307607e-3
GO:0006695	cholesterol biosynthetic process	5.361145e-3
GO:0010226	response to lithium ion	5.404167e-3
GO:0071577	zinc ion transmembrane transport	5.444616e-3
GO:0032732	positive regulation of interleukin-1 production	5.528886e-3
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	5.579745e-3
GO:0015991	ATP hydrolysis coupled proton transport	5.597423e-3
GO:0010884	positive regulation of lipid storage	5.597423e-3
GO:0051928	positive regulation of calcium ion transport	5.636520e-3
GO:0044130	negative regulation of growth of symbiont in host	5.653911e-3
GO:0002540	leukotriene production involved in inflammatory response	5.798455e-3
GO:0006739	NADP metabolic process	5.807903e-3
GO:0034377	plasma lipoprotein particle assembly	5.848414e-3
GO:0030157	pancreatic juice secretion	5.866328e-3
GO:0046684	response to pyrethroid	5.866328e-3
GO:0002768	immune response-regulating cell surface receptor signaling pathway	5.879610e-3
GO:0071394	cellular response to testosterone stimulus	5.883362e-3
GO:0008535	respiratory chain complex IV assembly	5.929843e-3
GO:0034372	very-low-density lipoprotein particle remodeling	5.993744e-3
GO:0030497	fatty acid elongation	6.045463e-3
GO:0015684	ferrous iron transport	6.078634e-3
GO:0001765	membrane raft assembly	6.078634e-3
GO:0045332	phospholipid translocation	6.195184e-3
GO:0051606	detection of stimulus	6.284539e-3
GO:0009236	cobalamin biosynthetic process	6.296885e-3
GO:0015939	pantothenate metabolic process	6.296885e-3
GO:0001309	age-dependent telomere shortening	6.296885e-3
GO:0006409	tRNA export from nucleus	6.296885e-3
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	6.296885e-3
GO:0009581	detection of external stimulus	6.356952e-3
GO:0042866	pyruvate biosynthetic process	6.470220e-3
GO:0033121	regulation of purine nucleotide catabolic process	6.479302e-3
GO:0007522	visceral muscle development	6.489641e-3