CL:0000135: Difference between revisions
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|located_in= | |located_in= | ||
|name=fibrocyte | |name=fibrocyte | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of= | |part_of= | ||
Latest revision as of 16:30, 12 September 2014
| Name: | fibrocyte | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999] | ||
| Xrefs: |
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| Comments: | Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, VEGF-A, and type I collagen. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000499(stromal cell) |
|---|---|
| develops_from: | CL:0000057(fibroblast) |
Children
| is a: | CL:0000388 (tendon cell) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11763-123H8 (tenocyte, donor1)
- 11765-123I1 (tenocyte, donor2)
- 11768-123I4 (tenocyte, donor3)
Mouse (Mus musculus)
- 11763-123H8 (tenocyte, donor1)
- 11765-123I1 (tenocyte, donor2)
- 11768-123I4 (tenocyte, donor3)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000135 (fibrocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 9.74e-88 | FFCP PHASE1:Hg19::chr1:203150041..203150049,-#_e06a7acb0cd63bbf5222a6fb13341051 | p@chr1:203150041..203150049, - |
| 9.74e-88 | FFCP PHASE2:Hg19::chr1:203150041..203150049,-#_e06a7acb0cd63bbf5222a6fb13341051 | p@chr1:203150041..203150049, - |
| 2.75e-74 | FFCP PHASE2:Hg19::chr5:79375755..79375801,+#_28734fc3b1b5b270da7b556e88db8734 | p@chr5:79375755..79375801, + |
| 2.75e-74 | FFCP PHASE1:Hg19::chr5:79375755..79375801,+#_28734fc3b1b5b270da7b556e88db8734 | p@chr5:79375755..79375801, + |
| 2.39e-66 | FFCP PHASE1:Hg19::chr7:43016260..43016261,+#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr7:43016260..43016261, + |
| 2.39e-66 | FFCP PHASE1:Hg19::chr11:27541356..27541360,+#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr11:27541356..27541360, + |
| 2.39e-66 | FFCP PHASE1:Hg19::chr4:4396380..4396381,-#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr4:4396380..4396381, - |
| 2.39e-66 | FFCP PHASE2:Hg19::chr7:43016260..43016261,+#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr7:43016260..43016261, + |
| 2.39e-66 | FFCP PHASE2:Hg19::chr11:27541356..27541360,+#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr11:27541356..27541360, + |
| 2.39e-66 | FFCP PHASE2:Hg19::chr4:4396380..4396381,-#_665dc4e2e6e6b85f5e2d0f36a2cb8660 | p@chr4:4396380..4396381, - |
| 2.4e-66 | FFCP PHASE2:Hg19::chr1:203150031..203150040,-#_51a70970a57fecc913b287e36859a8ef | p@chr1:203150031..203150040, - |
| 2.4e-66 | FFCP PHASE1:Hg19::chr1:203150031..203150040,-#_51a70970a57fecc913b287e36859a8ef | p@chr1:203150031..203150040, - |
| 2.41e-66 | FFCP PHASE2:Hg19::chr8:120608233..120608244,-#_15bf093b24156e8aabcdb9ea1fe0085b | p@chr8:120608233..120608244, - |
| 2.41e-66 | FFCP PHASE1:Hg19::chr8:120608233..120608244,-#_15bf093b24156e8aabcdb9ea1fe0085b | p@chr8:120608233..120608244, - |
| 1.22e-59 | FFCP PHASE1:Hg19::chr7:80373118..80373135,-#_165e9ab4aece570f8351f3b159866b99 | p21@SEMA3C |
| 1.22e-59 | FFCP PHASE2:Hg19::chr7:80373118..80373135,-#_165e9ab4aece570f8351f3b159866b99 | p21@SEMA3C |
| 3.13e-54 | FFCP PHASE1:Hg19::chr8:57353995..57354004,-#_1e48411084d10453adcb20dd7b30569e | p@chr8:57353995..57354004, - |
| 3.13e-54 | FFCP PHASE2:Hg19::chr8:57353995..57354004,-#_1e48411084d10453adcb20dd7b30569e | p@chr8:57353995..57354004, - |
| 9.77e-45 | FFCP PHASE2:Hg19::chr6:159660765..159660776,+#_8107df191602c074a7a223d8d5f9577f | p@chr6:159660765..159660776, + |
| 9.77e-45 | FFCP PHASE1:Hg19::chr6:159660765..159660776,+#_8107df191602c074a7a223d8d5f9577f | p@chr6:159660765..159660776, + |
| 6.64e-41 | FFCP PHASE1:Hg19::chr1:56962127..56962135,-#_c27a6cb2b45bbbafdb4fc44463341901 | p@chr1:56962127..56962135, - |
| 6.64e-41 | FFCP PHASE2:Hg19::chr1:56962127..56962135,-#_c27a6cb2b45bbbafdb4fc44463341901 | p@chr1:56962127..56962135, - |
| 2.93e-40 | FFCP PHASE1:Hg19::chr4:26492048..26492059,-#_33aa53b972a57459a684cb97d792254b | p3@CCKAR |
| 2.93e-40 | FFCP PHASE2:Hg19::chr4:26492048..26492059,-#_33aa53b972a57459a684cb97d792254b | p3@CCKAR |
| 9.77e-40 | FFCP PHASE2:Hg19::chr8:57354119..57354137,+#_a0de3e82e017f9765af8ab177f137a8c | p@chr8:57354119..57354137, + |
| 9.77e-40 | FFCP PHASE1:Hg19::chr8:57354119..57354137,+#_a0de3e82e017f9765af8ab177f137a8c | p@chr8:57354119..57354137, + |
| 1.46e-39 | FFCP PHASE1:Hg19::chr19:18895742..18895757,-#_7e5a2c0dde3299cecd01c70c32023f34 | p@chr19:18895742..18895757, - |
| 1.46e-39 | FFCP PHASE2:Hg19::chr19:18895742..18895757,-#_7e5a2c0dde3299cecd01c70c32023f34 | p@chr19:18895742..18895757, - |
| 6.91e-39 | FFCP PHASE1:Hg19::chr7:15725581..15725587,-#_01295efa77ac33427f758742133c75b7 | p13@MEOX2 |
| 6.91e-39 | FFCP PHASE2:Hg19::chr7:15725581..15725587,-#_01295efa77ac33427f758742133c75b7 | p13@MEOX2 |
| 8.37e-39 | FFCP PHASE2:Hg19::chr1:203149809..203149816,-#_8c640c7e88637814c829febc0eb97de6 | p@chr1:203149809..203149816, - |
| 8.37e-39 | FFCP PHASE1:Hg19::chr1:203149809..203149816,-#_8c640c7e88637814c829febc0eb97de6 | p@chr1:203149809..203149816, - |
| 1.01e-38 | FFCP PHASE1:Hg19::chr1:203152872..203152879,-#_c7171fce1f8d58f7a6f95eb01600c9f2 | p@chr1:203152872..203152879, - |
| 1.01e-38 | FFCP PHASE2:Hg19::chr1:203152872..203152879,-#_c7171fce1f8d58f7a6f95eb01600c9f2 | p@chr1:203152872..203152879, - |
| 3.19e-38 | FFCP PHASE2:Hg19::chr18:61495529..61495546,+#_dfa0d150b2477930e28b05edee8bb58c | p@chr18:61495529..61495546, + |
| 3.19e-38 | FFCP PHASE1:Hg19::chr18:61495529..61495546,+#_dfa0d150b2477930e28b05edee8bb58c | p@chr18:61495529..61495546, + |
| 8.41e-38 | FFCP PHASE2:Hg19::chr8:110346720..110346722,-#_c77f4b8c191465439e3d3cee19e55ff1 | p5@NUDCD1 |
| 8.41e-38 | FFCP PHASE1:Hg19::chr8:110346720..110346722,-#_c77f4b8c191465439e3d3cee19e55ff1 | p5@NUDCD1 |
| 2.95e-37 | FFCP PHASE2:Hg19::chr10:28033776..28033788,+#_9a84536e4b483af26b0355fb8018c7a3 | p1@ENST00000419777 |
| 2.95e-37 | FFCP PHASE1:Hg19::chr10:28033776..28033788,+#_9a84536e4b483af26b0355fb8018c7a3 | p1@ENST00000419777 |
| 1.39e-34 | FFCP PHASE2:Hg19::chr1:203148394..203148401,-#_94a07ddf98079bf37279dffe68279745 | p10@CHI3L1 |
| 1.39e-34 | FFCP PHASE1:Hg19::chr1:203148394..203148401,-#_94a07ddf98079bf37279dffe68279745 | p10@CHI3L1 |
| 2.19e-34 | FFCP PHASE1:Hg19::chr12:91502776..91502785,-#_d88bc37b54143983707de36857c134dd | p15@LUM |
| 2.19e-34 | FFCP PHASE1:Hg19::chr7:87906696..87906704,-#_d88bc37b54143983707de36857c134dd | p@chr7:87906696..87906704, - |
| 2.19e-34 | FFCP PHASE2:Hg19::chr12:91502776..91502785,-#_d88bc37b54143983707de36857c134dd | p15@LUM |
| 2.19e-34 | FFCP PHASE2:Hg19::chr7:87906696..87906704,-#_d88bc37b54143983707de36857c134dd | p@chr7:87906696..87906704, - |
| 4.27e-34 | FFCP PHASE2:Hg19::chr1:203153416..203153419,-#_d69db016f4dc7278474a3dc9576c9dc4 | p@chr1:203153416..203153419, - |
| 4.27e-34 | FFCP PHASE1:Hg19::chr1:203153416..203153419,-#_d69db016f4dc7278474a3dc9576c9dc4 | p@chr1:203153416..203153419, - |
| 5.96e-34 | FFCP PHASE2:Hg19::chr1:110471879..110471901,+#_37d0d1b252e63de400a89cfb77849fe3 | p@chr1:110471879..110471901, + |
| 5.96e-34 | FFCP PHASE1:Hg19::chr10:127350469..127350475,-#_37d0d1b252e63de400a89cfb77849fe3 | p@chr10:127350469..127350475, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr1:110471879..110471901,+#_37d0d1b252e63de400a89cfb77849fe3 | p@chr1:110471879..110471901, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr10:127350469..127350475,-#_37d0d1b252e63de400a89cfb77849fe3 | p@chr10:127350469..127350475, - |
| 8.46e-34 | FFCP PHASE2:Hg19::chr1:56320708..56320728,-#_05743d96fa539cd64c11be068242ab1e | p@chr1:56320708..56320728, - |
| 8.46e-34 | FFCP PHASE1:Hg19::chr1:56320708..56320728,-#_05743d96fa539cd64c11be068242ab1e | p@chr1:56320708..56320728, - |
| 9.1e-34 | FFCP PHASE1:Hg19::chr8:57354463..57354473,+#_61ff63221f26967096fd83b845cc5d13 | p@chr8:57354463..57354473, + |
| 9.1e-34 | FFCP PHASE2:Hg19::chr8:57354463..57354473,+#_61ff63221f26967096fd83b845cc5d13 | p@chr8:57354463..57354473, + |
| 2.31e-33 | FFCP PHASE1:Hg19::chr18:43418712..43418734,+#_ae3ce033d9f62517babfe153cc8d388b | p7@SIGLEC15 |
| 2.31e-33 | FFCP PHASE2:Hg19::chr18:43418712..43418734,+#_ae3ce033d9f62517babfe153cc8d388b | p7@SIGLEC15 |
| 7.76e-32 | FFCP PHASE2:Hg19::chr19:18899448..18899459,-#_baaba1921ace7794c2da1d9719c06154 | p@chr19:18899448..18899459, - |
| 7.76e-32 | FFCP PHASE1:Hg19::chr19:18899448..18899459,-#_baaba1921ace7794c2da1d9719c06154 | p@chr19:18899448..18899459, - |
| 1.32e-31 | FFCP PHASE2:Hg19::chr3:100494130..100494141,-#_25968184ba00a9a15287ce0326bdaedd | p@chr3:100494130..100494141, - |
| 1.32e-31 | FFCP PHASE1:Hg19::chr3:100494130..100494141,-#_25968184ba00a9a15287ce0326bdaedd | p@chr3:100494130..100494141, - |
| 9.03e-31 | FFCP PHASE2:Hg19::chr19:18900031..18900054,+#_f486607db526b1f2df2c3f9a0403069b | p@chr19:18900031..18900054, + |
| 9.03e-31 | FFCP PHASE1:Hg19::chr19:18900031..18900054,+#_f486607db526b1f2df2c3f9a0403069b | p@chr19:18900031..18900054, + |
| 1.09e-30 | FFCP PHASE2:Hg19::chr1:161969956..161969963,-#_c41c1de2130e69e65674d4749d7f86cd | p@chr1:161969956..161969963, - |
| 1.09e-30 | FFCP PHASE1:Hg19::chr1:161969956..161969963,-#_c41c1de2130e69e65674d4749d7f86cd | p@chr1:161969956..161969963, - |
| 2.48e-30 | FFCP PHASE2:Hg19::chr19:18896512..18896527,-#_27d431c7a033078aeac049e207bbda51 | p@chr19:18896512..18896527, - |
| 2.48e-30 | FFCP PHASE1:Hg19::chr19:18896512..18896527,-#_27d431c7a033078aeac049e207bbda51 | p@chr19:18896512..18896527, - |
| 2.67e-30 | FFCP PHASE1:Hg19::chr5:79351765..79351792,+#_7b079bc737ca5f16d58ee0d6be814f98 | p@chr5:79351765..79351792, + |
| 2.67e-30 | FFCP PHASE2:Hg19::chr5:79351765..79351792,+#_7b079bc737ca5f16d58ee0d6be814f98 | p@chr5:79351765..79351792, + |
| 5.0e-30 | FFCP PHASE1:Hg19::chr20:48140767..48140776,-#_9ce1e8d123ddb6fa178894ea559fb6cb | p@chr20:48140767..48140776, - |
| 5.0e-30 | FFCP PHASE2:Hg19::chr20:48140767..48140776,-#_9ce1e8d123ddb6fa178894ea559fb6cb | p@chr20:48140767..48140776, - |
| 2.91e-29 | FFCP PHASE2:Hg19::chr19:18895812..18895830,-#_557ac451c2cc0679d98d012b60489e76 | p@chr19:18895812..18895830, - |
| 2.91e-29 | FFCP PHASE1:Hg19::chr19:18895812..18895830,-#_557ac451c2cc0679d98d012b60489e76 | p@chr19:18895812..18895830, - |
| 5.18e-29 | FFCP PHASE2:Hg19::chr15:81243109..81243120,+#_0cf4e3fb5af8bd10cecf90bc82cfd870 | p@chr15:81243109..81243120, + |
| 5.18e-29 | FFCP PHASE1:Hg19::chr15:81243109..81243120,+#_0cf4e3fb5af8bd10cecf90bc82cfd870 | p@chr15:81243109..81243120, + |
| 1.11e-28 | FFCP PHASE1:Hg19::chr19:18896642..18896656,-#_cc43106f561a6abec9cc953f26a7d468 | p@chr19:18896642..18896656, - |
| 1.11e-28 | FFCP PHASE2:Hg19::chr19:18896642..18896656,-#_cc43106f561a6abec9cc953f26a7d468 | p@chr19:18896642..18896656, - |
| 1.42e-28 | FFCP PHASE2:Hg19::chr1:56977818..56977827,-#_85df61fefd09601e105063a1d68505e3 | p@chr1:56977818..56977827, - |
| 1.42e-28 | FFCP PHASE1:Hg19::chr1:56977818..56977827,-#_85df61fefd09601e105063a1d68505e3 | p@chr1:56977818..56977827, - |
| 2.06e-28 | FFCP PHASE2:Hg19::chr17:38613300..38613311,-#_4ae2960b9f7532e05b509a58986bb457 | p@chr17:38613300..38613311, - |
| 2.06e-28 | FFCP PHASE1:Hg19::chr17:38613300..38613311,-#_4ae2960b9f7532e05b509a58986bb457 | p@chr17:38613300..38613311, - |
| 3.59e-28 | FFCP PHASE2:Hg19::chr1:203148495..203148505,-#_64ac6d6078bb57182a1ee7b42f156f06 | p13@CHI3L1 |
| 3.59e-28 | FFCP PHASE2:Hg19::chr3:69154031..69154043,+#_64ac6d6078bb57182a1ee7b42f156f06 | p@chr3:69154031..69154043, + |
| 3.59e-28 | FFCP PHASE1:Hg19::chr1:203148495..203148505,-#_64ac6d6078bb57182a1ee7b42f156f06 | p13@CHI3L1 |
| 3.59e-28 | FFCP PHASE1:Hg19::chr3:69154031..69154043,+#_64ac6d6078bb57182a1ee7b42f156f06 | p@chr3:69154031..69154043, + |
| 6.24e-28 | FFCP PHASE1:Hg19::chr8:57354275..57354292,-#_c80acbc11fc4f2e8acabecaf01a34ff4 | p@chr8:57354275..57354292, - |
| 6.24e-28 | FFCP PHASE2:Hg19::chr8:57354275..57354292,-#_c80acbc11fc4f2e8acabecaf01a34ff4 | p@chr8:57354275..57354292, - |
| 9.35e-28 | FFCP PHASE1:Hg19::chr4:26491909..26491918,-#_ca559946b244d13a3c946a7465872ffc | p2@CCKAR |
| 9.35e-28 | FFCP PHASE2:Hg19::chr4:26491909..26491918,-#_ca559946b244d13a3c946a7465872ffc | p2@CCKAR |
| 1.19e-27 | FFCP PHASE2:Hg19::chr3:86992689..86992700,-#_eda155454f382595339e22b3dfa39030 | p@chr3:86992689..86992700, - |
| 1.19e-27 | FFCP PHASE1:Hg19::chr3:86992689..86992700,-#_eda155454f382595339e22b3dfa39030 | p@chr3:86992689..86992700, - |
| 1.39e-27 | FFCP PHASE1:Hg19::chr21:39705323..39705334,-#_2b468045fdc72e7b8a678e4811b22d2e | p2@ENST00000436845 |
| 1.39e-27 | FFCP PHASE2:Hg19::chr21:39705323..39705334,-#_2b468045fdc72e7b8a678e4811b22d2e | p2@ENST00000436845 |
| 2.46e-27 | FFCP PHASE2:Hg19::chr19:18895892..18895911,-#_406d46b7f8bbef35346a2deb3f5ed122 | p@chr19:18895892..18895911, - |
| 2.46e-27 | FFCP PHASE1:Hg19::chr19:18895892..18895911,-#_406d46b7f8bbef35346a2deb3f5ed122 | p@chr19:18895892..18895911, - |
| 3.11e-27 | FFCP PHASE2:Hg19::chr3:29966392..29966406,+#_c94ee2e3ee3a31b85f7356ed28151b0c | p22@RBMS3 |
| 3.11e-27 | FFCP PHASE1:Hg19::chr3:29966392..29966406,+#_c94ee2e3ee3a31b85f7356ed28151b0c | p22@RBMS3 |
| 3.89e-27 | FFCP PHASE2:Hg19::chr1:203151934..203151947,-#_e0cce13e7925b9ddfafaf932539c7eba | p7@CHI3L1 |
| 3.89e-27 | FFCP PHASE1:Hg19::chr1:203151934..203151947,-#_e0cce13e7925b9ddfafaf932539c7eba | p7@CHI3L1 |
