FFCP PHASE1:Hg19::chr3:77088946..77088957,+: Difference between revisions
From FANTOM5_SSTAR
No edit summary |
No edit summary |
||
(10 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
{{FFCP | {{FFCP | ||
|DHSsupport=supported | |||
|DPIdataset=robust | |||
|EntrezGene=6092 | |EntrezGene=6092 | ||
|GencodeV16b_All_Build2_RSEM10_CPAT_consensus=gencodeV16_protein_coding | |||
|HGNC=10250 | |HGNC=10250 | ||
|TSSclassifier=strong | |||
|UniProt=Q9HCK4 | |UniProt=Q9HCK4 | ||
|association_with_transcript=-79bp_to_ENST00000461745_5end | |association_with_transcript=-79bp_to_ENST00000461745_5end | ||
|cluster_id=chr3:77088946..77088957,+ | |||
|coexpression_cluster_id=C2753 | |||
|description=CAGE_peak_11_at_ROBO2_5end | |description=CAGE_peak_11_at_ROBO2_5end | ||
|id=chr3:77088946..77088957,+ | |id=chr3:77088946..77088957,+ | ||
|ontology_enrichment_celltype=CL:0000047!1.32e-08!8 | |ontology_enrichment_celltype=CL:0000047!1.32e-08!8 | ||
|ontology_enrichment_celltype_v019= | |||
|ontology_enrichment_celltype_v019_2=CL:0000047,4.57e-09,8 | |||
|ontology_enrichment_development_v019=UBERON:0003099;1.42e-08;1!UBERON:0003852;1.42e-08;1 | |||
|ontology_enrichment_disease=DOID:5409!7.73e-08!4;DOID:171!8.08e-08!10 | |||
|ontology_enrichment_disease_v019=DOID:8552;1.42e-08;1!DOID:5409;1.50e-08;4 | |||
|ontology_enrichment_disease_v019_2=DOID:8552,9.74e-09,1;DOID:5409,1.48e-08,4 | |||
|ontology_enrichment_uberon=UBERON:0001017!1.87e-33!82;UBERON:0005743!4.81e-33!86;UBERON:0000073!5.81e-33!94;UBERON:0001016!5.81e-33!94;UBERON:0001049!2.14e-30!57;UBERON:0005068!2.14e-30!57;UBERON:0006241!2.14e-30!57;UBERON:0007135!2.14e-30!57;UBERON:0002346!1.36e-27!90;UBERON:0002020!1.26e-25!34;UBERON:0003528!1.26e-25!34;UBERON:0001869!4.37e-25!32;UBERON:0002616!4.43e-25!59;UBERON:0000924!8.77e-25!173;UBERON:0006601!8.77e-25!173;UBERON:0000955!2.49e-24!69;UBERON:0006238!2.49e-24!69;UBERON:0002780!2.59e-24!41;UBERON:0001890!2.59e-24!41;UBERON:0006240!2.59e-24!41;UBERON:0003080!1.49e-23!42;UBERON:0001893!3.13e-23!34;UBERON:0003075!4.53e-23!86;UBERON:0007284!4.53e-23!86;UBERON:0002791!3.50e-22!33;UBERON:0004121!3.15e-21!169;UBERON:0003056!6.24e-18!61;UBERON:0000956!4.00e-16!25;UBERON:0000203!4.00e-16!25;UBERON:0000153!8.21e-16!129;UBERON:0007811!8.21e-16!129;UBERON:0007023!1.62e-15!115;UBERON:0000033!2.97e-15!123;UBERON:0002619!1.80e-14!22;UBERON:0001950!3.74e-14!20;UBERON:0002308!1.54e-11!9;UBERON:0000125!1.54e-11!9;UBERON:0002420!4.86e-09!9;UBERON:0007245!4.86e-09!9;UBERON:0010009!4.86e-09!9;UBERON:0010011!4.86e-09!9;UBERON:0000454!4.86e-09!9;UBERON:0009663!7.92e-09!7;UBERON:0003076!5.56e-08!15;UBERON:0003057!5.56e-08!15;UBERON:0001871!7.65e-08!7;UBERON:0000369!1.60e-07!4;UBERON:0002435!1.60e-07!4;UBERON:0000204!1.60e-07!4;UBERON:0010082!1.60e-07!4;UBERON:0000025!6.43e-07!194;UBERON:0000922!7.22e-07!612 | |ontology_enrichment_uberon=UBERON:0001017!1.87e-33!82;UBERON:0005743!4.81e-33!86;UBERON:0000073!5.81e-33!94;UBERON:0001016!5.81e-33!94;UBERON:0001049!2.14e-30!57;UBERON:0005068!2.14e-30!57;UBERON:0006241!2.14e-30!57;UBERON:0007135!2.14e-30!57;UBERON:0002346!1.36e-27!90;UBERON:0002020!1.26e-25!34;UBERON:0003528!1.26e-25!34;UBERON:0001869!4.37e-25!32;UBERON:0002616!4.43e-25!59;UBERON:0000924!8.77e-25!173;UBERON:0006601!8.77e-25!173;UBERON:0000955!2.49e-24!69;UBERON:0006238!2.49e-24!69;UBERON:0002780!2.59e-24!41;UBERON:0001890!2.59e-24!41;UBERON:0006240!2.59e-24!41;UBERON:0003080!1.49e-23!42;UBERON:0001893!3.13e-23!34;UBERON:0003075!4.53e-23!86;UBERON:0007284!4.53e-23!86;UBERON:0002791!3.50e-22!33;UBERON:0004121!3.15e-21!169;UBERON:0003056!6.24e-18!61;UBERON:0000956!4.00e-16!25;UBERON:0000203!4.00e-16!25;UBERON:0000153!8.21e-16!129;UBERON:0007811!8.21e-16!129;UBERON:0007023!1.62e-15!115;UBERON:0000033!2.97e-15!123;UBERON:0002619!1.80e-14!22;UBERON:0001950!3.74e-14!20;UBERON:0002308!1.54e-11!9;UBERON:0000125!1.54e-11!9;UBERON:0002420!4.86e-09!9;UBERON:0007245!4.86e-09!9;UBERON:0010009!4.86e-09!9;UBERON:0010011!4.86e-09!9;UBERON:0000454!4.86e-09!9;UBERON:0009663!7.92e-09!7;UBERON:0003076!5.56e-08!15;UBERON:0003057!5.56e-08!15;UBERON:0001871!7.65e-08!7;UBERON:0000369!1.60e-07!4;UBERON:0002435!1.60e-07!4;UBERON:0000204!1.60e-07!4;UBERON:0010082!1.60e-07!4;UBERON:0000025!6.43e-07!194;UBERON:0000922!7.22e-07!612 | ||
|ontology_enrichment_uberon_v019=UBERON:0001905;3.30e-16;2!UBERON:0002757;3.30e-16;2!UBERON:0010134;3.30e-16;2!UBERON:0005408;3.30e-16;2!UBERON:0001899;3.30e-16;2!UBERON:0000922;1.24e-14;49!UBERON:0005705;1.42e-08;1!UBERON:0008193;1.42e-08;1!UBERON:0010912;1.42e-08;1!UBERON:0002514;1.42e-08;1!UBERON:0003457;1.42e-08;1!UBERON:0008907;1.42e-08;1!UBERON:0008001;1.42e-08;1!UBERON:0007213;1.42e-08;1!UBERON:0009891;1.42e-08;1!UBERON:0007914;1.42e-08;1!UBERON:0007375;1.42e-08;1!UBERON:0003323;1.42e-08;1!UBERON:0010258;1.42e-08;1!UBERON:0005253;1.42e-08;1!UBERON:0007842;1.42e-08;1!UBERON:0002397;1.42e-08;1!UBERON:0003113;1.42e-08;1!UBERON:0003277;1.42e-08;1!UBERON:0001709;1.42e-08;1!UBERON:0002244;1.42e-08;1!UBERON:0005620;1.42e-08;1!UBERON:0010364;1.42e-08;1!UBERON:0004288;1.42e-08;1!UBERON:0003296;1.50e-08;4!UBERON:0010133;1.50e-08;4!UBERON:0002784;1.50e-08;4!UBERON:0002346;3.59e-08;4!UBERON:0000923;3.59e-08;4!UBERON:0010316;3.59e-08;4!UBERON:0005291;3.59e-08;4 | |||
|ontology_enrichment_uberon_v019_2=UBERON:0001905,4.31e-16,2;UBERON:0002757,4.31e-16,2;UBERON:0010134,4.31e-16,2;UBERON:0005408,4.31e-16,2;UBERON:0001899,4.31e-16,2;UBERON:0001017,7.93e-13,81;UBERON:0001016,2.44e-11,89;UBERON:0002346,4.41e-10,86;UBERON:0011216,1.79e-09,223;UBERON:0001049,2.98e-09,56;UBERON:0005068,2.98e-09,56;UBERON:0006241,2.98e-09,56;UBERON:0007135,2.98e-09,56;UBERON:0004121,4.56e-09,171;UBERON:0000924,4.56e-09,171;UBERON:0006601,4.56e-09,171;UBERON:0003296,1.72e-08,4;UBERON:0010133,1.72e-08,4;UBERON:0002784,1.72e-08,4;UBERON:0005705,2.06e-08,1;UBERON:0008193,2.06e-08,1;UBERON:0010912,2.06e-08,1;UBERON:0002514,2.06e-08,1;UBERON:0003457,2.06e-08,1;UBERON:0008907,2.06e-08,1;UBERON:0008001,2.06e-08,1;UBERON:0007213,2.06e-08,1;UBERON:0009891,2.06e-08,1;UBERON:0007914,2.06e-08,1;UBERON:0009292,2.06e-08,1;UBERON:0003099,2.06e-08,1;UBERON:0007375,2.06e-08,1;UBERON:0003323,2.06e-08,1;UBERON:0010258,2.06e-08,1;UBERON:0007842,2.06e-08,1;UBERON:0009494,2.06e-08,1;UBERON:0010042,2.06e-08,1;UBERON:0010045,2.06e-08,1;UBERON:0010259,2.06e-08,1;UBERON:0010359,2.06e-08,1;UBERON:0009526,2.06e-08,1;UBERON:0002397,2.06e-08,1;UBERON:0003113,2.06e-08,1;UBERON:0003277,2.06e-08,1;UBERON:0001709,2.06e-08,1;UBERON:0004066,2.06e-08,1;UBERON:0002244,2.06e-08,1;UBERON:0005620,2.06e-08,1;UBERON:0004362,2.06e-08,1;UBERON:0010364,2.06e-08,1;UBERON:0010046,2.06e-08,1;UBERON:0005868,2.06e-08,1;UBERON:0007238,2.06e-08,1;UBERON:0004288,2.06e-08,1;UBERON:0004068,2.06e-08,1;UBERON:0010334,2.06e-08,1;UBERON:0003852,2.06e-08,1;UBERON:0010253,2.06e-08,1;UBERON:0002780,5.01e-08,41;UBERON:0001890,5.01e-08,41;UBERON:0003080,5.01e-08,41;UBERON:0006240,5.01e-08,41;UBERON:0000073,8.12e-08,53;UBERON:0002616,8.12e-08,53;UBERON:0003075,2.57e-07,82;UBERON:0007284,2.57e-07,82;UBERON:0000955,2.63e-07,68;UBERON:0006238,2.63e-07,68 | |||
|phase1_expression=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.286235987131057,0.136874425072884,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.111410456885174,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.196468613246569,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.122834317311768,0,0,0,0,0,0.168336113954066,0.125118519871964,0.277064115484183,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.232387885739037,0.310983165046111,0,0,0,0,0,0,0,0,0,0,0,0,0,0.134831308160164,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.115930404975077,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.142977993658148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.76228387266739,3.90419561572865,3.86644406388848,1.67516265334349,0.637938751653163,0,0,0,0.12269149171914,0,0,0,0.178428988797162,0,0,0,0,0,0,0,0.0868836144680828,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0915694648183434,0,0,0,0,0,0,0,0,0.107420244868274,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.188287601553558,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.278406173895242,2.46174797895425,1.6227340708559,0,2.81974010175699,0,0,0.121360521749513,0,0,0,0,0,0,0.281338832821026,0,0,0,0.19924798825107,0,0,0,0,0,0,0,0,0,0,0,0,0.185536196323703,1.99613798001194,0,0,0,0,0,0,0,0,0.347249989866585,1.77148277162768,0.120596438625408,1.52581736317083,0.110579259931225,0,0.219385397153973,0,0,0.230850775511391,0,0,0,0,0,0,0,0,0,1.99454018280188,0,0,0,0,0.953619473882272,0,0,0,0,0,0,0,0,0,0,0,0,0.234264445725339,0,0,0,0,1.20990716048664,3.97894590119637,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.225980740780532,0,0,0.443175571691151,0,0,0,0,0,5.26868342363212,0,0,0,0,0,0,0,0,0.600420288709789,0.136905378891993,0,0,0,0,0,0,0,0,0,0.0671834724867263,0,0,0,0,0,0,0,0,0.136203406111576,0,0.137539436597234,0,0,0,0.242998226632099,0,0,0.891727998294968,0,0,0,0,0,0,0,0,0,0,0.246277562248017,0,0,0,0,0.258565912723101,0.13223260174269,0,0,0.106787412567695,1.25763444079733,0,0,0,0,0,0,0,0,0,0,0,0,0.1251909307065,0,0.221858103073705,0.124192805882767,0,0,0.303298235083296,0.570930667089935,0,0.936669811613763,1.01444720027578,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.260994291965212,0,0,0,0,0,0,0,0,0,0,0,0,0.138258436151731,0,0,0,0,0,0,0,0,0,0,0,0,0,0.127894371303652,0.107824811396682,0,0.109209638192014,0.169732529954025,1.70059936081346,1.11542187833102,0,0,0,0,1.05802783107205,0,0.321146125482298,0,0,0,6.55386410176467,0.207471757392654,0,0,0,0,0,0,0,0,0,0.0752103283492573,0,0,0,0,0,0.0675375846183947,0.781078098613847,0.206686796501184,0,9.84554656232795,0,0,0.879356221798103,0,3.21421101526972,2.69026977775059,0,0,0,0,0,0.135939465953663,0.0657727735628491,0,0.111231401892069,0.078493092850514,0.157115589916002,0,2.73947616152849,0,0,0.357382720883282,0.316027223465453,0,0,0,0,0,0,0,0,0,0,0,0,0,0.223710863595585,0,0,0,0,0,0,0.233939463462106,0,2.85408217866165,0.11294608203896,3.4081560191083,0.150962843566674,0,0.437119121007915,0,0,0,0.588925401344836,0,1.2679671827502,0,0.187967835959707,0,0,0,0,0,0,0,0,0.788857810965923,0.203974470572744,3.9271562130634,0,0,0,0,0,0,0,0,0,0,0,0.151557396436479,0.267964130156178,0,0,0,0,0.0645889098360061,0.372448285775147,0,0,0,0,0,0,0,0.99798106963804,0,0.106727345877715,0,0,0,0.122241444182866,0.813792356631477,0,0.201273793591026,0 | |phase1_expression=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.286235987131057,0.136874425072884,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.111410456885174,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.196468613246569,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.122834317311768,0,0,0,0,0,0.168336113954066,0.125118519871964,0.277064115484183,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.232387885739037,0.310983165046111,0,0,0,0,0,0,0,0,0,0,0,0,0,0.134831308160164,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.115930404975077,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.142977993658148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.76228387266739,3.90419561572865,3.86644406388848,1.67516265334349,0.637938751653163,0,0,0,0.12269149171914,0,0,0,0.178428988797162,0,0,0,0,0,0,0,0.0868836144680828,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0915694648183434,0,0,0,0,0,0,0,0,0.107420244868274,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.188287601553558,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.278406173895242,2.46174797895425,1.6227340708559,0,2.81974010175699,0,0,0.121360521749513,0,0,0,0,0,0,0.281338832821026,0,0,0,0.19924798825107,0,0,0,0,0,0,0,0,0,0,0,0,0.185536196323703,1.99613798001194,0,0,0,0,0,0,0,0,0.347249989866585,1.77148277162768,0.120596438625408,1.52581736317083,0.110579259931225,0,0.219385397153973,0,0,0.230850775511391,0,0,0,0,0,0,0,0,0,1.99454018280188,0,0,0,0,0.953619473882272,0,0,0,0,0,0,0,0,0,0,0,0,0.234264445725339,0,0,0,0,1.20990716048664,3.97894590119637,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.225980740780532,0,0,0.443175571691151,0,0,0,0,0,5.26868342363212,0,0,0,0,0,0,0,0,0.600420288709789,0.136905378891993,0,0,0,0,0,0,0,0,0,0.0671834724867263,0,0,0,0,0,0,0,0,0.136203406111576,0,0.137539436597234,0,0,0,0.242998226632099,0,0,0.891727998294968,0,0,0,0,0,0,0,0,0,0,0.246277562248017,0,0,0,0,0.258565912723101,0.13223260174269,0,0,0.106787412567695,1.25763444079733,0,0,0,0,0,0,0,0,0,0,0,0,0.1251909307065,0,0.221858103073705,0.124192805882767,0,0,0.303298235083296,0.570930667089935,0,0.936669811613763,1.01444720027578,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.260994291965212,0,0,0,0,0,0,0,0,0,0,0,0,0.138258436151731,0,0,0,0,0,0,0,0,0,0,0,0,0,0.127894371303652,0.107824811396682,0,0.109209638192014,0.169732529954025,1.70059936081346,1.11542187833102,0,0,0,0,1.05802783107205,0,0.321146125482298,0,0,0,6.55386410176467,0.207471757392654,0,0,0,0,0,0,0,0,0,0.0752103283492573,0,0,0,0,0,0.0675375846183947,0.781078098613847,0.206686796501184,0,9.84554656232795,0,0,0.879356221798103,0,3.21421101526972,2.69026977775059,0,0,0,0,0,0.135939465953663,0.0657727735628491,0,0.111231401892069,0.078493092850514,0.157115589916002,0,2.73947616152849,0,0,0.357382720883282,0.316027223465453,0,0,0,0,0,0,0,0,0,0,0,0,0,0.223710863595585,0,0,0,0,0,0,0.233939463462106,0,2.85408217866165,0.11294608203896,3.4081560191083,0.150962843566674,0,0.437119121007915,0,0,0,0.588925401344836,0,1.2679671827502,0,0.187967835959707,0,0,0,0,0,0,0,0,0.788857810965923,0.203974470572744,3.9271562130634,0,0,0,0,0,0,0,0,0,0,0,0.151557396436479,0.267964130156178,0,0,0,0,0.0645889098360061,0.372448285775147,0,0,0,0,0,0,0,0.99798106963804,0,0.106727345877715,0,0,0,0.122241444182866,0.813792356631477,0,0.201273793591026,0 | ||
|short_description=p11@ROBO2 | |short_description=p11@ROBO2 | ||
}} | }} |
Latest revision as of 16:09, 19 September 2015
Short description: | p11@ROBO2 |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | Robust |
TSS-like-by-RIKEN-classifier(Yes/No): | Yes |
DHS support(Yes/No): | Yes |
Description: | CAGE_peak_11_at_ROBO2_5end |
Coexpression cluster: | C2753_parietal_acute_occipital_temporal_small_duodenum_gastric |
Association with transcript: | -79bp_to_ENST00000461745_5end |
EntrezGene: | ROBO2 |
HGNC: | 10250 |
UniProt: | Q9HCK4 |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|---|---|
neuronal stem cell | 4.57e-09 | 8 |
Ontology term | p-value | n |
---|---|---|
chronic myeloid leukemia | 9.74e-09 | 1 |
lung small cell carcinoma | 1.48e-08 | 4 |