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{{CL
{{CL
|id=CL:0000623
|alt_id=
|name=natural killer cell
|namespace=cell;;efo
|def="A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
|xref=BTO:0000914;;BTO:0004716;;FMA:63147;;FMA:83601
|is_a=CL:0000542
|synonym="large granular lymphocyte" BROAD [];;"NK cell" EXACT [];;"null cell" BROAD []
|comment=
|comment=
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000825
|develops_from=CL:0000825
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000623
|is_a=CL:0000542
|is_obsolete=
|located_in=
|located_in=
|name=natural killer cell
|namespace=cell;;efo
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="large granular lymphocyte" BROAD [];;"NK cell" EXACT [];;"null cell" BROAD []
|union_of=
|xref=BTO:0000914;;BTO:0004716;;FMA:63147;;FMA:83601
}}
}}

Revision as of 10:19, 12 September 2014

Name:natural killer cell
Namespace:cell;;efo
Definition:"A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
Xrefs:
links:

BTO:0000914
BTO:0004716
FMA:63147

FMA:83601
Synonyms: "large granular lymphocyte" BROAD []
"NK cell" EXACT []
"null cell" BROAD []


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000542(lymphocyte)
develops_from:CL:0000825(pro-NK cell)



Children


disjoint from:CL:0000084 (T cell)
derives from:FF:0000119 (human natural killer cell sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000623 (natural killer cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.79e-195FFCP PHASE1:Hg19::chr11:115085875..115085888,+#_a428f1fa76d08f93945cd96e423756fdp@chr11:115085875..115085888, +
2.79e-195FFCP PHASE1:Hg19::chr3:4892090..4892095,-#_a428f1fa76d08f93945cd96e423756fdp@chr3:4892090..4892095, -
2.79e-195FFCP PHASE1:Hg19::chr8:103110281..103110286,+#_a428f1fa76d08f93945cd96e423756fdp@chr8:103110281..103110286, +
2.79e-195FFCP PHASE2:Hg19::chr11:115085875..115085888,+#_a428f1fa76d08f93945cd96e423756fdp@chr11:115085875..115085888, +
2.79e-195FFCP PHASE2:Hg19::chr3:4892090..4892095,-#_a428f1fa76d08f93945cd96e423756fdp@chr3:4892090..4892095, -
2.79e-195FFCP PHASE2:Hg19::chr8:103110281..103110286,+#_a428f1fa76d08f93945cd96e423756fdp@chr8:103110281..103110286, +
3.27e-147FFCP PHASE1:Hg19::chr2:145267967..145267972,-#_1a317224837b1a65b5dc279c6c28d81dp@chr2:145267967..145267972, -
3.27e-147FFCP PHASE2:Hg19::chr8:103126233..103126242,-#_1a317224837b1a65b5dc279c6c28d81dp@chr8:103126233..103126242, -
3.27e-147FFCP PHASE1:Hg19::chr18:46360601..46360610,+#_1a317224837b1a65b5dc279c6c28d81dp@chr18:46360601..46360610, +
3.27e-147FFCP PHASE1:Hg19::chr2:240467130..240467134,+#_1a317224837b1a65b5dc279c6c28d81dp@chr2:240467130..240467134, +
3.27e-147FFCP PHASE1:Hg19::chr7:38357449..38357458,+#_1a317224837b1a65b5dc279c6c28d81dp@chr7:38357449..38357458, +
3.27e-147FFCP PHASE2:Hg19::chr8:103120766..103120771,+#_1a317224837b1a65b5dc279c6c28d81dp@chr8:103120766..103120771, +
3.27e-147FFCP PHASE2:Hg19::chr22:38597578..38597586,-#_1a317224837b1a65b5dc279c6c28d81dp@chr22:38597578..38597586, -
3.27e-147FFCP PHASE2:Hg19::chr7:38357449..38357458,+#_1a317224837b1a65b5dc279c6c28d81dp@chr7:38357449..38357458, +
3.27e-147FFCP PHASE2:Hg19::chr11:65401401..65401406,+#_1a317224837b1a65b5dc279c6c28d81dp@chr11:65401401..65401406, +
3.27e-147FFCP PHASE1:Hg19::chr8:103126233..103126242,-#_1a317224837b1a65b5dc279c6c28d81dp@chr8:103126233..103126242, -
3.27e-147FFCP PHASE2:Hg19::chr19:45953439..45953444,+#_1a317224837b1a65b5dc279c6c28d81dp@chr19:45953439..45953444, +
3.27e-147FFCP PHASE2:Hg19::chr8:66750085..66750091,+#_1a317224837b1a65b5dc279c6c28d81dp@chr8:66750085..66750091, +
3.27e-147FFCP PHASE1:Hg19::chr19:45953439..45953444,+#_1a317224837b1a65b5dc279c6c28d81dp@chr19:45953439..45953444, +
3.27e-147FFCP PHASE1:Hg19::chr8:103120766..103120771,+#_1a317224837b1a65b5dc279c6c28d81dp@chr8:103120766..103120771, +
3.27e-147FFCP PHASE2:Hg19::chr2:145267967..145267972,-#_1a317224837b1a65b5dc279c6c28d81dp@chr2:145267967..145267972, -
3.27e-147FFCP PHASE2:Hg19::chr9:136007795..136007801,-#_1a317224837b1a65b5dc279c6c28d81dp@chr9:136007795..136007801, -
3.27e-147FFCP PHASE1:Hg19::chr8:66750085..66750091,+#_1a317224837b1a65b5dc279c6c28d81dp@chr8:66750085..66750091, +
3.27e-147FFCP PHASE2:Hg19::chr18:46360601..46360610,+#_1a317224837b1a65b5dc279c6c28d81dp@chr18:46360601..46360610, +
3.27e-147FFCP PHASE1:Hg19::chr22:38597578..38597586,-#_1a317224837b1a65b5dc279c6c28d81dp@chr22:38597578..38597586, -
3.27e-147FFCP PHASE2:Hg19::chr2:240467130..240467134,+#_1a317224837b1a65b5dc279c6c28d81dp@chr2:240467130..240467134, +
3.27e-147FFCP PHASE1:Hg19::chr9:136007795..136007801,-#_1a317224837b1a65b5dc279c6c28d81dp@chr9:136007795..136007801, -
3.27e-147FFCP PHASE1:Hg19::chr11:65401401..65401406,+#_1a317224837b1a65b5dc279c6c28d81dp@chr11:65401401..65401406, +
8.93e-147FFCP PHASE2:Hg19::chr7:38320712..38320736,+#_4c1ca0598070f231b04b441724c1cf1dp@chr7:38320712..38320736, +
8.93e-147FFCP PHASE1:Hg19::chr1:167420291..167420294,+#_4c1ca0598070f231b04b441724c1cf1dp@chr1:167420291..167420294, +
8.93e-147FFCP PHASE2:Hg19::chr1:167400749..167400756,-#_4c1ca0598070f231b04b441724c1cf1dp2@EF079882
8.93e-147FFCP PHASE2:Hg19::chr1:167420291..167420294,+#_4c1ca0598070f231b04b441724c1cf1dp@chr1:167420291..167420294, +
8.93e-147FFCP PHASE1:Hg19::chr1:167400749..167400756,-#_4c1ca0598070f231b04b441724c1cf1dp2@EF079882
8.93e-147FFCP PHASE1:Hg19::chr7:38320712..38320736,+#_4c1ca0598070f231b04b441724c1cf1dp@chr7:38320712..38320736, +
8.98e-131FFCP PHASE2:Hg19::chr6:37019056..37019063,-#_22b494a5520b948f94bb6d6a8e37f288p@chr6:37019056..37019063, -
8.98e-131FFCP PHASE1:Hg19::chr12:9994967..9994968,+#_22b494a5520b948f94bb6d6a8e37f288p@chr12:9994967..9994968, +
8.98e-131FFCP PHASE1:Hg19::chr6:2940707..2940710,+#_22b494a5520b948f94bb6d6a8e37f288p@chr6:2940707..2940710, +
8.98e-131FFCP PHASE2:Hg19::chr5:172281403..172281405,-#_22b494a5520b948f94bb6d6a8e37f288p@chr5:172281403..172281405, -
8.98e-131FFCP PHASE2:Hg19::chr12:9994967..9994968,+#_22b494a5520b948f94bb6d6a8e37f288p@chr12:9994967..9994968, +
8.98e-131FFCP PHASE1:Hg19::chr18:74804978..74804993,+#_22b494a5520b948f94bb6d6a8e37f288p@chr18:74804978..74804993, +
8.98e-131FFCP PHASE1:Hg19::chr6:37019056..37019063,-#_22b494a5520b948f94bb6d6a8e37f288p@chr6:37019056..37019063, -
8.98e-131FFCP PHASE2:Hg19::chr18:74804978..74804993,+#_22b494a5520b948f94bb6d6a8e37f288p@chr18:74804978..74804993, +
8.98e-131FFCP PHASE2:Hg19::chr22:38597593..38597598,-#_22b494a5520b948f94bb6d6a8e37f288p@chr22:38597593..38597598, -
8.98e-131FFCP PHASE1:Hg19::chr22:38597593..38597598,-#_22b494a5520b948f94bb6d6a8e37f288p@chr22:38597593..38597598, -
8.98e-131FFCP PHASE2:Hg19::chr6:2940707..2940710,+#_22b494a5520b948f94bb6d6a8e37f288p@chr6:2940707..2940710, +
8.98e-131FFCP PHASE1:Hg19::chr5:172281403..172281405,-#_22b494a5520b948f94bb6d6a8e37f288p@chr5:172281403..172281405, -
2.33e-118FFCP PHASE1:Hg19::chr22:39474405..39474438,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr22:39474405..39474438, -
2.33e-118FFCP PHASE1:Hg19::chr5:169705868..169705875,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr5:169705868..169705875, -
2.33e-118FFCP PHASE1:Hg19::chr2:111610415..111610439,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr2:111610415..111610439, +
2.33e-118FFCP PHASE2:Hg19::chr17:33776655..33776667,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr17:33776655..33776667, -
2.33e-118FFCP PHASE1:Hg19::chr11:121353266..121353274,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr11:121353266..121353274, -
2.33e-118FFCP PHASE1:Hg19::chr17:33776655..33776667,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr17:33776655..33776667, -
2.33e-118FFCP PHASE1:Hg19::chr1:167458837..167458845,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:167458837..167458845, -
2.33e-118FFCP PHASE2:Hg19::chr11:67037100..67037109,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr11:67037100..67037109, +
2.33e-118FFCP PHASE2:Hg19::chr7:38320586..38320596,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr7:38320586..38320596, +
2.33e-118FFCP PHASE2:Hg19::chr1:167458837..167458845,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:167458837..167458845, -
2.33e-118FFCP PHASE1:Hg19::chr11:67037100..67037109,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr11:67037100..67037109, +
2.33e-118FFCP PHASE1:Hg19::chr4:48116513..48116522,-#_5bff6ff16f029389f9e84a5e9cacacdfp9@TXK
2.33e-118FFCP PHASE2:Hg19::chr19:41804394..41804429,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr19:41804394..41804429, +
2.33e-118FFCP PHASE2:Hg19::chr12:129281246..129281271,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr12:129281246..129281271, +
2.33e-118FFCP PHASE2:Hg19::chr11:121353266..121353274,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr11:121353266..121353274, -
2.33e-118FFCP PHASE1:Hg19::chr2:145263300..145263311,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr2:145263300..145263311, -
2.33e-118FFCP PHASE2:Hg19::chr2:145263300..145263311,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr2:145263300..145263311, -
2.33e-118FFCP PHASE1:Hg19::chr7:38320586..38320596,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr7:38320586..38320596, +
2.33e-118FFCP PHASE1:Hg19::chr1:19275176..19275185,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:19275176..19275185, +
2.33e-118FFCP PHASE2:Hg19::chr10:98431336..98431339,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr10:98431336..98431339, -
2.33e-118FFCP PHASE1:Hg19::chr18:46341777..46341782,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr18:46341777..46341782, +
2.33e-118FFCP PHASE2:Hg19::chr5:169705868..169705875,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr5:169705868..169705875, -
2.33e-118FFCP PHASE1:Hg19::chr1:162518235..162518252,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:162518235..162518252, +
2.33e-118FFCP PHASE1:Hg19::chr10:98431336..98431339,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr10:98431336..98431339, -
2.33e-118FFCP PHASE2:Hg19::chr17:34401981..34401994,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr17:34401981..34401994, +
2.33e-118FFCP PHASE1:Hg19::chr19:41804394..41804429,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr19:41804394..41804429, +
2.33e-118FFCP PHASE2:Hg19::chr18:46341777..46341782,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr18:46341777..46341782, +
2.33e-118FFCP PHASE1:Hg19::chr22:23480066..23480080,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr22:23480066..23480080, -
2.33e-118FFCP PHASE1:Hg19::chr17:34401981..34401994,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr17:34401981..34401994, +
2.33e-118FFCP PHASE2:Hg19::chr2:111610415..111610439,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr2:111610415..111610439, +
2.33e-118FFCP PHASE1:Hg19::chr12:129281246..129281271,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr12:129281246..129281271, +
2.33e-118FFCP PHASE2:Hg19::chr1:19275176..19275185,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:19275176..19275185, +
2.33e-118FFCP PHASE2:Hg19::chr1:162518235..162518252,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr1:162518235..162518252, +
2.33e-118FFCP PHASE1:Hg19::chr7:50428238..50428247,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr7:50428238..50428247, +
2.33e-118FFCP PHASE2:Hg19::chr4:48116513..48116522,-#_5bff6ff16f029389f9e84a5e9cacacdfp9@TXK
2.33e-118FFCP PHASE2:Hg19::chr22:39474405..39474438,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr22:39474405..39474438, -
2.33e-118FFCP PHASE2:Hg19::chr22:23480066..23480080,-#_5bff6ff16f029389f9e84a5e9cacacdfp@chr22:23480066..23480080, -
2.33e-118FFCP PHASE2:Hg19::chr7:50428238..50428247,+#_5bff6ff16f029389f9e84a5e9cacacdfp@chr7:50428238..50428247, +
3.48e-118FFCP PHASE1:Hg19::chr19:10213257..10213267,+#_e7137141ed38fcee58f4cafddfb4bc0dp@chr19:10213257..10213267, +
3.48e-118FFCP PHASE1:Hg19::chr1:172502793..172502831,-#_e7137141ed38fcee58f4cafddfb4bc0dp3@BC034700
3.48e-118FFCP PHASE2:Hg19::chr19:10213257..10213267,+#_e7137141ed38fcee58f4cafddfb4bc0dp@chr19:10213257..10213267, +
3.48e-118FFCP PHASE1:Hg19::chr18:74804800..74804840,-#_e7137141ed38fcee58f4cafddfb4bc0dp@chr18:74804800..74804840, -
3.48e-118FFCP PHASE2:Hg19::chr1:172502793..172502831,-#_e7137141ed38fcee58f4cafddfb4bc0dp3@BC034700
3.48e-118FFCP PHASE2:Hg19::chr18:74804800..74804840,-#_e7137141ed38fcee58f4cafddfb4bc0dp@chr18:74804800..74804840, -
3.48e-118FFCP PHASE1:Hg19::chr1:100494394..100494399,-#_e7137141ed38fcee58f4cafddfb4bc0dp@chr1:100494394..100494399, -
3.48e-118FFCP PHASE2:Hg19::chr1:100494394..100494399,-#_e7137141ed38fcee58f4cafddfb4bc0dp@chr1:100494394..100494399, -
5.2e-118FFCP PHASE2:Hg19::chr4:103421745..103421751,+#_e249bbf32d1f82790fe8fdd62d7db2f8p@chr4:103421745..103421751, +
5.2e-118FFCP PHASE1:Hg19::chr4:103421745..103421751,+#_e249bbf32d1f82790fe8fdd62d7db2f8p@chr4:103421745..103421751, +
7.78e-118FFCP PHASE1:Hg19::chr14:64108359..64108365,-#_3fd24065d3812ff4149c345c8732a3b3p9@WDR89
7.78e-118FFCP PHASE1:Hg19::chr18:43268301..43268305,-#_3fd24065d3812ff4149c345c8732a3b3p@chr18:43268301..43268305, -
7.78e-118FFCP PHASE2:Hg19::chr14:64108359..64108365,-#_3fd24065d3812ff4149c345c8732a3b3p9@WDR89
7.78e-118FFCP PHASE2:Hg19::chr18:43268301..43268305,-#_3fd24065d3812ff4149c345c8732a3b3p@chr18:43268301..43268305, -
4.06e-99FFCP PHASE1:Hg19::chr7:38320426..38320429,-#_daeeaf77e193fca6144e154223269365p@chr7:38320426..38320429, -
4.06e-99FFCP PHASE1:Hg19::chr9:116281787..116281792,-#_daeeaf77e193fca6144e154223269365p@chr9:116281787..116281792, -

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