MCL coexpression mm9:1966

Phase1 CAGE Peaks

	Short description
Mm9::chr11:43287783..43287842,+	p1@C1qtnf2
Mm9::chr13:49639848..49639902,+	p1@Aspn
Mm9::chr13:49639994..49640005,+	p2@Aspn
Mm9::chr17:8020154..8020175,-	p1@Fndc1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046320	regulation of fatty acid oxidation	0.00268449022078563
GO:0045725	positive regulation of glycogen biosynthetic process	0.00268449022078563
GO:0046321	positive regulation of fatty acid oxidation	0.00268449022078563
GO:0005979	regulation of glycogen biosynthetic process	0.00268449022078563
GO:0046326	positive regulation of glucose import	0.00429506668986796
GO:0045923	positive regulation of fatty acid metabolic process	0.0053682450453898
GO:0045913	positive regulation of carbohydrate metabolic process	0.0053682450453898
GO:0043255	regulation of carbohydrate biosynthetic process	0.0053682450453898
GO:0045834	positive regulation of lipid metabolic process	0.0053682450453898
GO:0006109	regulation of carbohydrate metabolic process	0.0053682450453898
GO:0046323	glucose import	0.0053682450453898
GO:0046324	regulation of glucose import	0.0053682450453898
GO:0019217	regulation of fatty acid metabolic process	0.00578102857893454
GO:0009250	glucan biosynthetic process	0.00787234748550556
GO:0005978	glycogen biosynthetic process	0.00787234748550556
GO:0033692	cellular polysaccharide biosynthetic process	0.0112686815993754
GO:0019216	regulation of lipid metabolic process	0.0112686815993754
GO:0000271	polysaccharide biosynthetic process	0.0112686815993754
GO:0019395	fatty acid oxidation	0.0112686815993754
GO:0051260	protein homooligomerization	0.0112686815993754
GO:0015758	glucose transport	0.0127924315383814
GO:0008645	hexose transport	0.0127924315383814
GO:0015749	monosaccharide transport	0.0127924315383814
GO:0051259	protein oligomerization	0.0127924315383814
GO:0006073	glucan metabolic process	0.0127924315383814
GO:0005977	glycogen metabolic process	0.0127924315383814
GO:0051050	positive regulation of transport	0.0131126695480243
GO:0006112	energy reserve metabolic process	0.0133171017971613
GO:0000187	activation of MAPK activity	0.0133171017971613
GO:0043406	positive regulation of MAP kinase activity	0.0146591325437936
GO:0031328	positive regulation of cellular biosynthetic process	0.0148774537991498
GO:0005976	polysaccharide metabolic process	0.0152741876027265
GO:0044264	cellular polysaccharide metabolic process	0.0152741876027265
GO:0009891	positive regulation of biosynthetic process	0.0167147419428269
GO:0043405	regulation of MAP kinase activity	0.0183781809141602
GO:0008643	carbohydrate transport	0.0184622518725425
GO:0043284	biopolymer biosynthetic process	0.0186169336431586
GO:0015980	energy derivation by oxidation of organic compounds	0.0186169336431586
GO:0016051	carbohydrate biosynthetic process	0.0217047770579539
GO:0045860	positive regulation of protein kinase activity	0.0219497034466616
GO:0051049	regulation of transport	0.0219497034466616
GO:0033674	positive regulation of kinase activity	0.0221715039405213
GO:0051347	positive regulation of transferase activity	0.0221715039405213
GO:0005615	extracellular space	0.0259322755466698
GO:0000165	MAPKKK cascade	0.0278661181086713
GO:0044421	extracellular region part	0.0278661181086713
GO:0006461	protein complex assembly	0.0283127897558507
GO:0045859	regulation of protein kinase activity	0.0283127897558507
GO:0043549	regulation of kinase activity	0.0283196743618672
GO:0043085	positive regulation of catalytic activity	0.0283196743618672
GO:0051338	regulation of transferase activity	0.0283196743618672
GO:0031326	regulation of cellular biosynthetic process	0.0285948849026102
GO:0009889	regulation of biosynthetic process	0.0312709881914443
GO:0006631	fatty acid metabolic process	0.0316775990696353
GO:0032787	monocarboxylic acid metabolic process	0.0413436845112987
GO:0007243	protein kinase cascade	0.0417423164216104
GO:0044262	cellular carbohydrate metabolic process	0.0464034268004006
GO:0050790	regulation of catalytic activity	0.0490714453924019

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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