MCL coexpression mm9:2479

Phase1 CAGE Peaks

	Short description
Mm9::chr8:131256722..131256746,+	p@chr8:131256722..131256746 +
Mm9::chr8:131256759..131256778,+	p@chr8:131256759..131256778 +
Mm9::chr8:26061312..26061316,-	p@chr8:26061312..26061316 -
Mm9::chr8:74676495..74676509,+	p@chr8:74676495..74676509 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042685	cardioblast cell fate specification	0.00657426176518929
GO:0042684	cardioblast cell fate commitment	0.00657426176518929
GO:0010002	cardioblast differentiation	0.00986085235671182
GO:0002102	podosome	0.00986085235671182
GO:0031941	filamentous actin	0.0165981967165556
GO:0045214	sarcomere organization	0.0165981967165556
GO:0031594	neuromuscular junction	0.0165981967165556
GO:0030239	myofibril assembly	0.0165981967165556
GO:0055002	striated muscle cell development	0.0165981967165556
GO:0055001	muscle cell development	0.0165981967165556
GO:0035051	cardiac cell differentiation	0.0165981967165556
GO:0030863	cortical cytoskeleton	0.0165981967165556
GO:0031032	actomyosin structure organization and biogenesis	0.0165981967165556
GO:0048628	myoblast maturation	0.0165981967165556
GO:0048627	myoblast development	0.0165981967165556
GO:0005178	integrin binding	0.0165981967165556
GO:0005884	actin filament	0.0165981967165556
GO:0001708	cell fate specification	0.0165981967165556
GO:0000082	G1/S transition of mitotic cell cycle	0.0165981967165556
GO:0042383	sarcolemma	0.0173188502188161
GO:0044448	cell cortex part	0.0173188502188161
GO:0051146	striated muscle cell differentiation	0.0173188502188161
GO:0008305	integrin complex	0.0194193766222151
GO:0045445	myoblast differentiation	0.0197038751080447
GO:0051325	interphase	0.0207114902502578
GO:0051329	interphase of mitotic cell cycle	0.0207114902502578
GO:0005938	cell cortex	0.0228593283850328
GO:0032403	protein complex binding	0.0229796598781254
GO:0019717	synaptosome	0.0235437237573873
GO:0042692	muscle cell differentiation	0.0251245228129955
GO:0007160	cell-matrix adhesion	0.0251245228129955
GO:0048741	skeletal muscle fiber development	0.0251245228129955
GO:0048747	muscle fiber development	0.0251245228129955
GO:0043234	protein complex	0.0251245228129955
GO:0031589	cell-substrate adhesion	0.0251245228129955
GO:0043235	receptor complex	0.0262444587297404
GO:0048469	cell maturation	0.0262444587297404
GO:0045596	negative regulation of cell differentiation	0.0293434924889218
GO:0007229	integrin-mediated signaling pathway	0.029839141300271
GO:0021700	developmental maturation	0.029839141300271
GO:0007519	skeletal muscle development	0.0303876390862631
GO:0045165	cell fate commitment	0.0312211055229063
GO:0051093	negative regulation of developmental process	0.0315284890423223
GO:0032991	macromolecular complex	0.0315284890423223
GO:0001701	in utero embryonic development	0.0346581434509376
GO:0014706	striated muscle development	0.0347565801341027
GO:0045595	regulation of cell differentiation	0.0420080360732898
GO:0030036	actin cytoskeleton organization and biogenesis	0.0420080360732898
GO:0030029	actin filament-based process	0.0434557838213296
GO:0007517	muscle development	0.0434557838213296
GO:0007507	heart development	0.0436255024541881
GO:0008284	positive regulation of cell proliferation	0.0442893493205074
GO:0015629	actin cytoskeleton	0.0468921679718131

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	1.69e-07	23
circulatory system	1.69e-07	23
splanchnic layer of lateral plate mesoderm	3.43e-07	33

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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