Preadipocyte to adipocyte

Series:	IN_VITRO DIFFERENTIATION SERIES
Species:	Human (Homo sapiens)
Genomic View:	Zenbu
Expression table:	[{{{tet_config}}} FILE]
Link to TET:	[{{{tet_file}}} TET]
Sample providers :	Peter Arner
Germ layer:	{{{germ_layer}}}
Primary cells or cell line:	{{{primary_cells}}}
Time span:	{{{time_span}}}
Number of time points:	{{{number_time_points}}}

Overview

Adipose tissue can account for between 5% (lean athletes) and 60% (morbidly obese) of total body mass, making it one of the most plastic organs in the body [8]. In response to changed nutritional status, both adipocyte cell number and size change and even under stable conditions as much as 10% of the adipocytes are turned over annually [1,2]. Thus the birth of new adipocytes from precursor cells (adipogenesis) is central for a functional fat tissue. References: [1] Dynamics of fat cell turnover in humans. Spalding KL et al, Nature, 2008, vol 453, p783-787. PMID:18454136 [2] Adipocyte turnover:relevance to human adiopose tissue morphology- Arner E et al, Diabetes, 2010,59(1):105-9. PMID:19846802

Sample description
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Quality control
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Profiled time course samples

Only samples that passed quality controls (Arner et al. 2015) are shown here. The entire set of samples are downloadable from FANTOM5 human / mouse samples

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13019-139D4	Adipocyte differentiation	day04	donor1
13020-139D5	Adipocyte differentiation	day08	donor1
13021-139D6	Adipocyte differentiation	day12	donor1
13022-139D7	Adipocyte differentiation	day04	donor2
13023-139D8	Adipocyte differentiation	day08	donor2
13024-139D9	Adipocyte differentiation	day12	donor2
13025-139E1	Adipocyte differentiation	day04	donor3
13026-139E2	Adipocyte differentiation	day08	donor3
13027-139E3	Adipocyte differentiation	day12	donor3
13028-139E4	Adipocyte differentiation	day04	donor4
13029-139E5	Adipocyte differentiation	day08	donor4
13030-139E6	Adipocyte differentiation	day12	donor4