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{{Coexpression_clusters
{{Coexpression_clusters
|full_id=C336_left_heart_skeletal_breast_lung_mature_adipose
|full_id=C336_left_heart_skeletal_breast_lung_mature_adipose
|gostat_on_coexpression_clusters=GO:0003988!acetyl-CoA C-acyltransferase activity!6.92129505418527e-05!3030;3032$GO:0004300!enoyl-CoA hydratase activity!6.92129505418527e-05!3030;3032$GO:0003857!3-hydroxyacyl-CoA dehydrogenase activity!6.92129505418527e-05!3030;3032$GO:0016408!C-acyltransferase activity!0.000228214532956531!3030;3032$GO:0006635!fatty acid beta-oxidation!0.00052500760191928!3030;3032$GO:0006631!fatty acid metabolic process!0.000530362812756355!3030;3032;948$GO:0019395!fatty acid oxidation!0.000800337080983666!3030;3032$GO:0032787!monocarboxylic acid metabolic process!0.00118596621311143!3030;3032;948$GO:0008016!regulation of heart contraction!0.00118596621311143!7168;4625$GO:0008307!structural constituent of muscle!0.00118596621311143!7168;4625$GO:0003015!heart process!0.00119419938607684!7168;4625$GO:0060047!heart contraction!0.00119419938607684!7168;4625$GO:0030017!sarcomere!0.00119419938607684!7168;4625$GO:0030016!myofibril!0.00135373569175321!7168;4625$GO:0044449!contractile fiber part!0.00162135059197157!7168;4625$GO:0043292!contractile fiber!0.00173032124461943!7168;4625$GO:0003779!actin binding!0.00220390170700477!7168;4625;667$GO:0016836!hydro-lyase activity!0.00280062572538729!3030;3032$GO:0016508!long-chain-enoyl-CoA hydratase activity!0.00280062572538729!3030$GO:0016507!fatty acid beta-oxidation multienzyme complex!0.00280062572538729!3030$GO:0016509!long-chain-3-hydroxyacyl-CoA dehydrogenase activity!0.00280062572538729!3030$GO:0016835!carbon-oxygen lyase activity!0.00313629135527366!3030;3032$GO:0008092!cytoskeletal protein binding!0.00416575764242442!7168;4625;667$GO:0005516!calmodulin binding!0.00509004928055831!5137;4625$GO:0016616!oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor!0.00509004928055831!3030;3032$GO:0008015!blood circulation!0.00509004928055831!7168;4625$GO:0003013!circulatory system process!0.00509004928055831!7168;4625$GO:0006200!ATP catabolic process!0.00509004928055831!4625$GO:0009207!purine ribonucleoside triphosphate catabolic process!0.00509004928055831!4625$GO:0009146!purine nucleoside triphosphate catabolic process!0.00509004928055831!4625$GO:0004117!calmodulin-dependent cyclic-nucleotide phosphodiesterase activity!0.00509004928055831!5137$GO:0003985!acetyl-CoA C-acetyltransferase activity!0.00509004928055831!3030$GO:0009203!ribonucleoside triphosphate catabolic process!0.00509004928055831!4625$GO:0016614!oxidoreductase activity, acting on CH-OH group of donors!0.00509004928055831!3030;3032$GO:0003012!muscle system process!0.00509004928055831!7168;4625$GO:0006936!muscle contraction!0.00509004928055831!7168;4625$GO:0044255!cellular lipid metabolic process!0.00523876299108885!3030;3032;948$GO:0019752!carboxylic acid metabolic process!0.00534476070800211!3030;3032;948$GO:0006082!organic acid metabolic process!0.00534476070800211!3030;3032;948$GO:0009154!purine ribonucleotide catabolic process!0.00534476070800211!4625$GO:0009143!nucleoside triphosphate catabolic process!0.00534476070800211!4625$GO:0006195!purine nucleotide catabolic process!0.00534476070800211!4625$GO:0005862!muscle thin filament tropomyosin!0.00534476070800211!7168$GO:0030898!actin-dependent ATPase activity!0.00534476070800211!4625$GO:0016453!C-acetyltransferase activity!0.00625377080234083!3030$GO:0033275!actin-myosin filament sliding!0.00625377080234083!4625$GO:0030049!muscle filament sliding!0.00625377080234083!4625$GO:0009261!ribonucleotide catabolic process!0.00707946691661464!4625$GO:0002027!regulation of heart rate!0.00707946691661464!4625$GO:0006629!lipid metabolic process!0.00707946691661464!3030;3032;948$GO:0055010!ventricular cardiac muscle morphogenesis!0.00777643195140338!4625$GO:0007512!adult heart development!0.00777643195140338!4625$GO:0008415!acyltransferase activity!0.00777643195140338!3030;3032$GO:0016747!transferase activity, transferring groups other than amino-acyl groups!0.00777643195140338!3030;3032$GO:0005515!protein binding!0.00788231127580342!7168;5137;84529;4625;202333;667;948$GO:0048644!muscle morphogenesis!0.00824767501883972!4625$GO:0055008!cardiac muscle morphogensis!0.00824767501883972!4625$GO:0051239!regulation of multicellular organismal process!0.0087020181146306!7168;4625$GO:0016829!lyase activity!0.0087020181146306!3030;3032$GO:0015629!actin cytoskeleton!0.00952041531412415!7168;4625$GO:0016746!transferase activity, transferring acyl groups!0.00952041531412415!3030;3032$GO:0005865!striated muscle thin filament!0.01028524455451!7168$GO:0005743!mitochondrial inner membrane!0.01028524455451!3030;3032$GO:0019866!organelle inner membrane!0.0112964660841367!3030;3032$GO:0045104!intermediate filament cytoskeleton organization and biogenesis!0.012648071284402!667$GO:0045103!intermediate filament-based process!0.0131454347830111!667$GO:0000146!microfilament motor activity!0.0131454347830111!4625$GO:0030048!actin filament-based movement!0.0134192831021231!4625$GO:0032982!myosin filament!0.0134192831021231!4625$GO:0005863!striated muscle thick filament!0.0134192831021231!4625$GO:0031966!mitochondrial membrane!0.0153170358144426!3030;3032$GO:0005856!cytoskeleton!0.0155226771801919!7168;4625;667$GO:0000062!acyl-CoA binding!0.0160771851772659!3030$GO:0005740!mitochondrial envelope!0.016423777393706!3030;3032$GO:0005859!muscle myosin complex!0.0192918421568587!4625$GO:0009166!nucleotide catabolic process!0.0192918421568587!4625$GO:0016460!myosin II complex!0.0198006200548218!4625$GO:0000302!response to reactive oxygen species!0.0202961757118159!4625$GO:0005504!fatty acid binding!0.0229972128803536!3030$GO:0006941!striated muscle contraction!0.0269794578053047!4625$GO:0044429!mitochondrial part!0.0269794578053047!3030;3032$GO:0042221!response to chemical stimulus!0.0269794578053047!3030;4625$GO:0006937!regulation of muscle contraction!0.0275117531679227!7168$GO:0031967!organelle envelope!0.0290746276768742!3030;3032$GO:0031975!envelope!0.0290746276768742!3030;3032$GO:0004114!3',5'-cyclic-nucleotide phosphodiesterase activity!0.0306153492651917!5137$GO:0004112!cyclic-nucleotide phosphodiesterase activity!0.0316010541811552!5137$GO:0007010!cytoskeleton organization and biogenesis!0.0336575397112977!4625;667$GO:0044446!intracellular organelle part!0.0404207849669413!7168;3030;4625;3032$GO:0044422!organelle part!0.0404207849669413!7168;3030;4625;3032$GO:0042493!response to drug!0.0404207849669413!3030$GO:0051287!NAD binding!0.0456447248263079!3030
|id=C336
|id=C336
}}
}}

Revision as of 17:38, 18 May 2012


Full id: C336_left_heart_skeletal_breast_lung_mature_adipose



Phase1 CAGE Peaks

Hg19::chr10:21112200..21112221,-p@chr10:21112200..21112221
-
Hg19::chr11:111781125..111781137,-p@chr11:111781125..111781137
-
Hg19::chr12:111348835..111348847,-p@chr12:111348835..111348847
-
Hg19::chr12:56091538..56091540,-p@chr12:56091538..56091540
-
Hg19::chr14:23886391..23886400,-p@chr14:23886391..23886400
-
Hg19::chr14:23893155..23893171,-p7@MYH7
Hg19::chr15:36887069..36887086,+p3@C15orf41
Hg19::chr15:63353097..63353109,+p16@TPM1
Hg19::chr19:2273037..2273052,+p@chr19:2273037..2273052
+
Hg19::chr1:145441220..145441237,+p@chr1:145441220..145441237
+
Hg19::chr1:145441715..145441724,+p@chr1:145441715..145441724
+
Hg19::chr1:16342059..16342090,+p@chr1:16342059..16342090
+
Hg19::chr20:62120363..62120378,-p@chr20:62120363..62120378
-
Hg19::chr22:36003307..36003317,-p@chr22:36003307..36003317
-
Hg19::chr2:26467557..26467568,-p3@HADHA
Hg19::chr2:26467825..26467841,+p2@HADHB
Hg19::chr3:37061825..37061832,+p@chr3:37061825..37061832
+
Hg19::chr3:46902281..46902288,-p@chr3:46902281..46902288
-
Hg19::chr3:96337038..96337083,-p@chr3:96337038..96337083
-
Hg19::chr4:186066197..186066221,+p@chr4:186066197..186066221
+
Hg19::chr5:79030927..79030935,+p49@CMYA5
Hg19::chr5:79946820..79946857,-p2@MTRNR2L2
Hg19::chr5:80555040..80555044,+p@chr5:80555040..80555044
+
Hg19::chr6:123760865..123760870,+p5@ENST00000427828
p5@ENST00000434768
Hg19::chr6:140400645..140400650,+p@chr6:140400645..140400650
+
Hg19::chr6:56323932..56323936,-p67@DST
Hg19::chr7:148638575..148638586,+p2@RNY5
Hg19::chr7:32110543..32110557,-p11@PDE1C
Hg19::chr7:80231530..80231551,+p8@CD36
Hg19::chr7:80231563..80231585,+p6@CD36
Hg19::chr7:80231609..80231627,+p11@CD36
Hg19::chr7:95221375..95221386,-p@chr7:95221375..95221386
-
Hg19::chr8:23584449..23584459,-p@chr8:23584449..23584459
-
Hg19::chrX:5225192..5225203,-p1@ENST00000434972


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003988acetyl-CoA C-acyltransferase activity6.92129505418527e-05
GO:0004300enoyl-CoA hydratase activity6.92129505418527e-05
GO:00038573-hydroxyacyl-CoA dehydrogenase activity6.92129505418527e-05
GO:0016408C-acyltransferase activity0.000228214532956531
GO:0006635fatty acid beta-oxidation0.00052500760191928
GO:0006631fatty acid metabolic process0.000530362812756355
GO:0019395fatty acid oxidation0.000800337080983666
GO:0032787monocarboxylic acid metabolic process0.00118596621311143
GO:0008016regulation of heart contraction0.00118596621311143
GO:0008307structural constituent of muscle0.00118596621311143
GO:0003015heart process0.00119419938607684
GO:0060047heart contraction0.00119419938607684
GO:0030017sarcomere0.00119419938607684
GO:0030016myofibril0.00135373569175321
GO:0044449contractile fiber part0.00162135059197157
GO:0043292contractile fiber0.00173032124461943
GO:0003779actin binding0.00220390170700477
GO:0016836hydro-lyase activity0.00280062572538729
GO:0016508long-chain-enoyl-CoA hydratase activity0.00280062572538729
GO:0016507fatty acid beta-oxidation multienzyme complex0.00280062572538729
GO:0016509long-chain-3-hydroxyacyl-CoA dehydrogenase activity0.00280062572538729
GO:0016835carbon-oxygen lyase activity0.00313629135527366
GO:0008092cytoskeletal protein binding0.00416575764242442
GO:0005516calmodulin binding0.00509004928055831
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.00509004928055831
GO:0008015blood circulation0.00509004928055831
GO:0003013circulatory system process0.00509004928055831
GO:0006200ATP catabolic process0.00509004928055831
GO:0009207purine ribonucleoside triphosphate catabolic process0.00509004928055831
GO:0009146purine nucleoside triphosphate catabolic process0.00509004928055831
GO:0004117calmodulin-dependent cyclic-nucleotide phosphodiesterase activity0.00509004928055831
GO:0003985acetyl-CoA C-acetyltransferase activity0.00509004928055831
GO:0009203ribonucleoside triphosphate catabolic process0.00509004928055831
GO:0016614oxidoreductase activity, acting on CH-OH group of donors0.00509004928055831
GO:0003012muscle system process0.00509004928055831
GO:0006936muscle contraction0.00509004928055831
GO:0044255cellular lipid metabolic process0.00523876299108885
GO:0019752carboxylic acid metabolic process0.00534476070800211
GO:0006082organic acid metabolic process0.00534476070800211
GO:0009154purine ribonucleotide catabolic process0.00534476070800211
GO:0009143nucleoside triphosphate catabolic process0.00534476070800211
GO:0006195purine nucleotide catabolic process0.00534476070800211
GO:0005862muscle thin filament tropomyosin0.00534476070800211
GO:0030898actin-dependent ATPase activity0.00534476070800211
GO:0016453C-acetyltransferase activity0.00625377080234083
GO:0033275actin-myosin filament sliding0.00625377080234083
GO:0030049muscle filament sliding0.00625377080234083
GO:0009261ribonucleotide catabolic process0.00707946691661464
GO:0002027regulation of heart rate0.00707946691661464
GO:0006629lipid metabolic process0.00707946691661464
GO:0055010ventricular cardiac muscle morphogenesis0.00777643195140338
GO:0007512adult heart development0.00777643195140338
GO:0008415acyltransferase activity0.00777643195140338
GO:0016747transferase activity, transferring groups other than amino-acyl groups0.00777643195140338
GO:0005515protein binding0.00788231127580342
GO:0048644muscle morphogenesis0.00824767501883972
GO:0055008cardiac muscle morphogensis0.00824767501883972
GO:0051239regulation of multicellular organismal process0.0087020181146306
GO:0016829lyase activity0.0087020181146306
GO:0015629actin cytoskeleton0.00952041531412415
GO:0016746transferase activity, transferring acyl groups0.00952041531412415
GO:0005865striated muscle thin filament0.01028524455451
GO:0005743mitochondrial inner membrane0.01028524455451
GO:0019866organelle inner membrane0.0112964660841367
GO:0045104intermediate filament cytoskeleton organization and biogenesis0.012648071284402
GO:0045103intermediate filament-based process0.0131454347830111
GO:0000146microfilament motor activity0.0131454347830111
GO:0030048actin filament-based movement0.0134192831021231
GO:0032982myosin filament0.0134192831021231
GO:0005863striated muscle thick filament0.0134192831021231
GO:0031966mitochondrial membrane0.0153170358144426
GO:0005856cytoskeleton0.0155226771801919
GO:0000062acyl-CoA binding0.0160771851772659
GO:0005740mitochondrial envelope0.016423777393706
GO:0005859muscle myosin complex0.0192918421568587
GO:0009166nucleotide catabolic process0.0192918421568587
GO:0016460myosin II complex0.0198006200548218
GO:0000302response to reactive oxygen species0.0202961757118159
GO:0005504fatty acid binding0.0229972128803536
GO:0006941striated muscle contraction0.0269794578053047
GO:0044429mitochondrial part0.0269794578053047
GO:0042221response to chemical stimulus0.0269794578053047
GO:0006937regulation of muscle contraction0.0275117531679227
GO:0031967organelle envelope0.0290746276768742
GO:0031975envelope0.0290746276768742
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0306153492651917
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0316010541811552
GO:0007010cytoskeleton organization and biogenesis0.0336575397112977
GO:0044446intracellular organelle part0.0404207849669413
GO:0044422organelle part0.0404207849669413
GO:0042493response to drug0.0404207849669413
GO:0051287NAD binding0.0456447248263079



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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