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|id=CL:0000767
|id=CL:0000767
|name=basophil
|name=basophil
|namespace=efo
|namespace=cell;;efo
|def="Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081]
|def="Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081]
|xref=BTO:0000129;;FMA:62862
|xref=BTO:0000129;;FMA:62862
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|obo_creation_date=
|obo_creation_date=
|subset=
|subset=
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
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|located_in=
|located_in=
|part_of=
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.obo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 17:26, 26 June 2012

Name:basophil
Namespace:cell;;efo
Definition:"Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081]
Xrefs:
links:

BTO:0000129

FMA:62862
Synonyms: "basophilic leucocyte" EXACT []
"basophilic leukocyte" EXACT []
"polymorphonuclear leucocyte" BROAD []
"polymorphonuclear leukocyte" BROAD []
Comments:Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000094(granulocyte)



Children


derives from:FF:0000013 (human basophil sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000767 (basophil), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.79e-195FFCP PHASE2:Hg19::chr11:2961841..2961848,-#_ca011a2e46da3e58070599a017fbf2eep@chr11:2961841..2961848, -
2.79e-195FFCP PHASE1:Hg19::chr11:2961841..2961848,-#_ca011a2e46da3e58070599a017fbf2eep@chr11:2961841..2961848, -
3.27e-147FFCP PHASE1:Hg19::chr6:159271714..159271721,+#_aa8e2d694081f7706e2d1e6d4087296bp@chr6:159271714..159271721, +
3.27e-147FFCP PHASE2:Hg19::chr6:159271714..159271721,+#_aa8e2d694081f7706e2d1e6d4087296bp@chr6:159271714..159271721, +
3.27e-147FFCP PHASE1:Hg19::chr13:47538203..47538205,-#_aa8e2d694081f7706e2d1e6d4087296bp@chr13:47538203..47538205, -
3.27e-147FFCP PHASE2:Hg19::chr13:47538203..47538205,-#_aa8e2d694081f7706e2d1e6d4087296bp@chr13:47538203..47538205, -
1.47e-146FFCP PHASE1:Hg19::chr8:102167891..102167895,+#_178752d67250761a871fb8730f4bbef8p@chr8:102167891..102167895, +
1.47e-146FFCP PHASE2:Hg19::chr8:102167891..102167895,+#_178752d67250761a871fb8730f4bbef8p@chr8:102167891..102167895, +
8.98e-131FFCP PHASE1:Hg19::chr4:47475231..47475236,-#_0acd15b2b5a9114e39bbb12895c0347fp@chr4:47475231..47475236, -
8.98e-131FFCP PHASE2:Hg19::chr11:128186999..128187003,+#_0acd15b2b5a9114e39bbb12895c0347fp@chr11:128186999..128187003, +
8.98e-131FFCP PHASE1:Hg19::chr11:128186999..128187003,+#_0acd15b2b5a9114e39bbb12895c0347fp@chr11:128186999..128187003, +
8.98e-131FFCP PHASE1:Hg19::chr13:74039989..74040003,+#_0acd15b2b5a9114e39bbb12895c0347fp@chr13:74039989..74040003, +
8.98e-131FFCP PHASE2:Hg19::chr13:74039989..74040003,+#_0acd15b2b5a9114e39bbb12895c0347fp@chr13:74039989..74040003, +
8.98e-131FFCP PHASE2:Hg19::chr4:47475231..47475236,-#_0acd15b2b5a9114e39bbb12895c0347fp@chr4:47475231..47475236, -
5.2e-118FFCP PHASE1:Hg19::chr10:17242471..17242477,-#_d18f6c25745917aac6c10c4fe2aceb74p@chr10:17242471..17242477, -
5.2e-118FFCP PHASE2:Hg19::chr4:47487155..47487166,-#_d18f6c25745917aac6c10c4fe2aceb74p@chr4:47487155..47487166, -
5.2e-118FFCP PHASE1:Hg19::chr4:47487155..47487166,-#_d18f6c25745917aac6c10c4fe2aceb74p@chr4:47487155..47487166, -
5.2e-118FFCP PHASE2:Hg19::chr10:17242471..17242477,-#_d18f6c25745917aac6c10c4fe2aceb74p@chr10:17242471..17242477, -
7.78e-118FFCP PHASE2:Hg19::chr2:85932253..85932262,+#_7ea746e9b3eb3a3080a5ae88e482cec4p@chr2:85932253..85932262, +
7.78e-118FFCP PHASE1:Hg19::chr2:85932253..85932262,+#_7ea746e9b3eb3a3080a5ae88e482cec4p@chr2:85932253..85932262, +
7.95e-99FFCP PHASE2:Hg19::chr4:47465894..47465904,+#_5014819755f7a49d61cd0bd4d2984fccp@chr4:47465894..47465904, +
7.95e-99FFCP PHASE1:Hg19::chr4:47465894..47465904,+#_5014819755f7a49d61cd0bd4d2984fccp@chr4:47465894..47465904, +
2.17e-98FFCP PHASE2:Hg19::chr4:130015616..130015630,-#_47bde682c0890f4b865563e50eec285cp@chr4:130015616..130015630, -
2.17e-98FFCP PHASE1:Hg19::chr4:130015616..130015630,-#_47bde682c0890f4b865563e50eec285cp@chr4:130015616..130015630, -
6.24e-88FFCP PHASE1:Hg19::chr2:98547746..98547784,-#_f12d6bd0ec067d97a62ebe75a6b09e1ap@chr2:98547746..98547784, -
6.24e-88FFCP PHASE2:Hg19::chr2:98547746..98547784,-#_f12d6bd0ec067d97a62ebe75a6b09e1ap@chr2:98547746..98547784, -
6.24e-88FFCP PHASE2:Hg19::chr10:124304122..124304160,-#_f12d6bd0ec067d97a62ebe75a6b09e1ap@chr10:124304122..124304160, -
6.24e-88FFCP PHASE1:Hg19::chr10:124304122..124304160,-#_f12d6bd0ec067d97a62ebe75a6b09e1ap@chr10:124304122..124304160, -
9.74e-88FFCP PHASE1:Hg19::chr21:15957203..15957206,-#_86fd1504dc16eb0fddd03a5f474fde6fp@chr21:15957203..15957206, -
9.74e-88FFCP PHASE2:Hg19::chr21:15957203..15957206,-#_86fd1504dc16eb0fddd03a5f474fde6fp@chr21:15957203..15957206, -
1.52e-87FFCP PHASE1:Hg19::chr4:175579439..175579451,-#_b9b7cb0fb1b864f3eccf3de75b1b1667p@chr4:175579439..175579451, -
1.52e-87FFCP PHASE2:Hg19::chr4:175579439..175579451,-#_b9b7cb0fb1b864f3eccf3de75b1b1667p@chr4:175579439..175579451, -
1.28e-84FFCP PHASE2:Hg19::chr10:129681159..129681175,-#_c32dd0332a2fdb7fee0bf874c0d396e9p@chr10:129681159..129681175, -
1.28e-84FFCP PHASE1:Hg19::chr10:129681159..129681175,-#_c32dd0332a2fdb7fee0bf874c0d396e9p@chr10:129681159..129681175, -
2.27e-84FFCP PHASE2:Hg19::chr13:73908778..73908786,+#_3a8d1dcbc71ba6f709ebcd1bcf480b2cp@chr13:73908778..73908786, +
2.27e-84FFCP PHASE1:Hg19::chr13:73908778..73908786,+#_3a8d1dcbc71ba6f709ebcd1bcf480b2cp@chr13:73908778..73908786, +
3.03e-84FFCP PHASE2:Hg19::chr5:131758672..131758682,+#_932aec986c7b39034be0474cfb0dac5ep@chr5:131758672..131758682, +
3.03e-84FFCP PHASE1:Hg19::chr5:131758672..131758682,+#_932aec986c7b39034be0474cfb0dac5ep@chr5:131758672..131758682, +
5.37e-84FFCP PHASE1:Hg19::chr11:121356186..121356201,+#_e979d630beb313284a76032cdf5061f9p@chr11:121356186..121356201, +
5.37e-84FFCP PHASE2:Hg19::chr11:121356186..121356201,+#_e979d630beb313284a76032cdf5061f9p@chr11:121356186..121356201, +
4.72e-75FFCP PHASE2:Hg19::chr1:15545407..15545411,+#_83dd435f81eebd61bea447bbc4edec82p@chr1:15545407..15545411, +
4.72e-75FFCP PHASE1:Hg19::chr1:15545407..15545411,+#_83dd435f81eebd61bea447bbc4edec82p@chr1:15545407..15545411, +
6.07e-75FFCP PHASE2:Hg19::chr5:169831446..169831478,-#_f80dcc094df6e4009c2b200851c2d18fp@chr5:169831446..169831478, -
6.07e-75FFCP PHASE1:Hg19::chr5:169831446..169831478,-#_f80dcc094df6e4009c2b200851c2d18fp@chr5:169831446..169831478, -
6.07e-75FFCP PHASE1:Hg19::chr4:124538142..124538152,-#_f80dcc094df6e4009c2b200851c2d18fp@chr4:124538142..124538152, -
6.07e-75FFCP PHASE2:Hg19::chr4:124538142..124538152,-#_f80dcc094df6e4009c2b200851c2d18fp@chr4:124538142..124538152, -
1.01e-74FFCP PHASE2:Hg19::chr1:247712219..247712230,+#_4727ec1003c3b089eafccf347e88aaeep5@C1orf150
1.01e-74FFCP PHASE1:Hg19::chr1:247712219..247712230,+#_4727ec1003c3b089eafccf347e88aaeep5@C1orf150
1.29e-74FFCP PHASE1:Hg19::chr5:106725747..106725757,+#_7944c49e6867a790ee9b33552736d7a3p@chr5:106725747..106725757, +
1.29e-74FFCP PHASE2:Hg19::chr5:106725747..106725757,+#_7944c49e6867a790ee9b33552736d7a3p@chr5:106725747..106725757, +
2.14e-74FFCP PHASE1:Hg19::chr6:167504549..167504554,-#_4525e05b6fdf1bf3bdc0c4f5527e011bp@chr6:167504549..167504554, -
2.14e-74FFCP PHASE2:Hg19::chr6:167504549..167504554,-#_4525e05b6fdf1bf3bdc0c4f5527e011bp@chr6:167504549..167504554, -
2.75e-74FFCP PHASE1:Hg19::chr6:25006945..25006954,-#_82065180a87e81f779429a6a908dcc4bp@chr6:25006945..25006954, -
2.75e-74FFCP PHASE2:Hg19::chr6:25006945..25006954,-#_82065180a87e81f779429a6a908dcc4bp@chr6:25006945..25006954, -
2.75e-74FFCP PHASE1:Hg19::chr6:170773733..170773744,+#_82065180a87e81f779429a6a908dcc4bp@chr6:170773733..170773744, +
2.75e-74FFCP PHASE2:Hg19::chr6:170773733..170773744,+#_82065180a87e81f779429a6a908dcc4bp@chr6:170773733..170773744, +
4.55e-74FFCP PHASE2:Hg19::chr12:92271427..92271444,+#_d69986aefda76491f695c6722541550ep@chr12:92271427..92271444, +
4.55e-74FFCP PHASE1:Hg19::chr12:92271427..92271444,+#_d69986aefda76491f695c6722541550ep@chr12:92271427..92271444, +
9.64e-74FFCP PHASE2:Hg19::chr3:4790645..4790663,+#_4f899352159ca0dad5b6a7d7e8e187d8p@chr3:4790645..4790663, +
9.64e-74FFCP PHASE1:Hg19::chr3:4790645..4790663,+#_4f899352159ca0dad5b6a7d7e8e187d8p@chr3:4790645..4790663, +
1.24e-73FFCP PHASE2:Hg19::chr8:125860500..125860504,+#_6b252e1c28511177712c9bdbc9b2f7f9p6@ENST00000525292
1.24e-73FFCP PHASE1:Hg19::chr12:129296519..129296565,+#_6b252e1c28511177712c9bdbc9b2f7f9p@chr12:129296519..129296565, +
1.24e-73FFCP PHASE1:Hg19::chr8:125860500..125860504,+#_6b252e1c28511177712c9bdbc9b2f7f9p6@ENST00000525292
1.24e-73FFCP PHASE2:Hg19::chr12:129296519..129296565,+#_6b252e1c28511177712c9bdbc9b2f7f9p@chr12:129296519..129296565, +
6.27e-67FFCP PHASE2:Hg19::chr6:20326681..20326699,+#_ca0c5f02c44e8b9876c227fffade1587p@chr6:20326681..20326699, +
6.27e-67FFCP PHASE1:Hg19::chr6:20326681..20326699,+#_ca0c5f02c44e8b9876c227fffade1587p@chr6:20326681..20326699, +
7.85e-67FFCP PHASE2:Hg19::chr10:48482432..48482435,+#_48d59d999164efd970ed9fe2656357b0p@chr10:48482432..48482435, +
7.85e-67FFCP PHASE1:Hg19::chr10:48482432..48482435,+#_48d59d999164efd970ed9fe2656357b0p@chr10:48482432..48482435, +
9.82e-67FFCP PHASE1:Hg19::chr2:216614478..216614489,-#_3c47dbf75163c789fc9c1d7214492b99p@chr2:216614478..216614489, -
9.82e-67FFCP PHASE2:Hg19::chr2:216614478..216614489,-#_3c47dbf75163c789fc9c1d7214492b99p@chr2:216614478..216614489, -
2.39e-66FFCP PHASE1:Hg19::chr12:12537737..12537747,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr12:12537737..12537747, +
2.39e-66FFCP PHASE2:Hg19::chr5:171595590..171595593,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr5:171595590..171595593, +
2.39e-66FFCP PHASE1:Hg19::chr2:28148771..28148776,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr2:28148771..28148776, -
2.39e-66FFCP PHASE1:Hg19::chr4:3946864..3946865,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:3946864..3946865, +
2.39e-66FFCP PHASE2:Hg19::chr12:12537737..12537747,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr12:12537737..12537747, +
2.39e-66FFCP PHASE1:Hg19::chr5:171595590..171595593,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr5:171595590..171595593, +
2.39e-66FFCP PHASE2:Hg19::chr4:3946864..3946865,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:3946864..3946865, +
2.39e-66FFCP PHASE1:Hg19::chr4:47477135..47477138,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:47477135..47477138, +
2.39e-66FFCP PHASE1:Hg19::chr16:86052259..86052261,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr16:86052259..86052261, -
2.39e-66FFCP PHASE2:Hg19::chr16:86052259..86052261,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr16:86052259..86052261, -
2.39e-66FFCP PHASE1:Hg19::chr18:50772425..50772426,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr18:50772425..50772426, +
2.39e-66FFCP PHASE2:Hg19::chr1:212101868..212101870,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:212101868..212101870, +
2.39e-66FFCP PHASE2:Hg19::chr4:47477135..47477138,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:47477135..47477138, +
2.39e-66FFCP PHASE1:Hg19::chr22:25463318..25463319,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr22:25463318..25463319, -
2.39e-66FFCP PHASE2:Hg19::chr18:50772425..50772426,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr18:50772425..50772426, +
2.39e-66FFCP PHASE2:Hg19::chr2:28148771..28148776,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr2:28148771..28148776, -
2.39e-66FFCP PHASE2:Hg19::chr20:809889..809897,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr20:809889..809897, +
2.39e-66FFCP PHASE1:Hg19::chr4:3371692..3371695,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:3371692..3371695, -
2.39e-66FFCP PHASE2:Hg19::chr1:30128875..30128876,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:30128875..30128876, +
2.39e-66FFCP PHASE1:Hg19::chr1:212101868..212101870,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:212101868..212101870, +
2.39e-66FFCP PHASE1:Hg19::chr4:47477113..47477121,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:47477113..47477121, +
2.39e-66FFCP PHASE1:Hg19::chr1:154720840..154720844,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:154720840..154720844, -
2.39e-66FFCP PHASE1:Hg19::chr15:26341798..26341807,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr15:26341798..26341807, -
2.39e-66FFCP PHASE1:Hg19::chr20:809889..809897,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr20:809889..809897, +
2.39e-66FFCP PHASE2:Hg19::chr1:154720840..154720844,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:154720840..154720844, -
2.39e-66FFCP PHASE1:Hg19::chrX:51490163..51490164,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chrX:51490163..51490164, -
2.39e-66FFCP PHASE1:Hg19::chr1:30128875..30128876,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr1:30128875..30128876, +
2.39e-66FFCP PHASE2:Hg19::chr15:26341798..26341807,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr15:26341798..26341807, -
2.39e-66FFCP PHASE2:Hg19::chr4:3371692..3371695,-#_0ad0d3a1cbd7bc754b377b35eae4192bp@chr4:3371692..3371695, -
2.39e-66FFCP PHASE1:Hg19::chrX:119444947..119444949,+#_0ad0d3a1cbd7bc754b377b35eae4192bp@chrX:119444947..119444949, +

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