MCL coexpression mm9:1702

Phase1 CAGE Peaks

	Short description
Mm9::chr16:88290431..88290442,-	p3@Grik1
Mm9::chr16:88290444..88290471,-	p1@Grik1
Mm9::chr2:113839356..113839374,-	p1@Gjd2
Mm9::chr5:46030532..46030550,-	p2@Fam184b
Mm9::chr7:48153974..48153989,-	p1@A230077H06Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007268	synaptic transmission	0.0035803288377154
GO:0048172	regulation of short-term neuronal synaptic plasticity	0.0035803288377154
GO:0019226	transmission of nerve impulse	0.0035803288377154
GO:0015277	kainate selective glutamate receptor activity	0.00388966498699777
GO:0007267	cell-cell signaling	0.00389749695633027
GO:0022803	passive transmembrane transporter activity	0.00389749695633027
GO:0015267	channel activity	0.00389749695633027
GO:0030054	cell junction	0.00389749695633027
GO:0008328	ionotropic glutamate receptor complex	0.00777741194068963
GO:0065008	regulation of biological quality	0.00777741194068963
GO:0048169	regulation of long-term neuronal synaptic plasticity	0.00777741194068963
GO:0048168	regulation of neuronal synaptic plasticity	0.00808773078604848
GO:0005234	extracellular-glutamate-gated ion channel activity	0.00808773078604848
GO:0005243	gap junction channel activity	0.00808773078604848
GO:0004970	ionotropic glutamate receptor activity	0.00808773078604848
GO:0022829	wide pore channel activity	0.00808773078604848
GO:0005922	connexon complex	0.00808773078604848
GO:0022857	transmembrane transporter activity	0.00808773078604848
GO:0048167	regulation of synaptic plasticity	0.00859373140231635
GO:0050803	regulation of synapse structure and activity	0.00894108274739065
GO:0005921	gap junction	0.00962521884196859
GO:0001508	regulation of action potential	0.0130708738798452
GO:0005231	excitatory extracellular ligand-gated ion channel activity	0.0139862988667611
GO:0008066	glutamate receptor activity	0.0139862988667611
GO:0014704	intercalated disc	0.0139862988667611
GO:0044459	plasma membrane part	0.0174841030919808
GO:0005230	extracellular ligand-gated ion channel activity	0.0184633996099129
GO:0043234	protein complex	0.0184633996099129
GO:0043235	receptor complex	0.0192771606715988
GO:0050877	neurological system process	0.0201328630300659
GO:0015276	ligand-gated ion channel activity	0.0201328630300659
GO:0022834	ligand-gated channel activity	0.0201328630300659
GO:0003008	system process	0.0216390967647873
GO:0005886	plasma membrane	0.0224257707744585
GO:0032991	macromolecular complex	0.0226559776580504
GO:0045211	postsynaptic membrane	0.0226559776580504
GO:0007601	visual perception	0.0226559776580504
GO:0050953	sensory perception of light stimulus	0.0226559776580504
GO:0044456	synapse part	0.024057186837918
GO:0005911	intercellular junction	0.0290542086819516
GO:0042802	identical protein binding	0.0324832506934418
GO:0005261	cation channel activity	0.0445290510818903
GO:0022836	gated channel activity	0.0465269977220717
GO:0046873	metal ion transmembrane transporter activity	0.0496500648514648

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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