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{{MCL_coexpression_mm9|gostat_on_MCL_coexpression=GO:0045010;actin nucleation;0.0102266294125167;14026!GO:0005522;profilin binding;0.0102266294125167;14026!GO:0017124;SH3 domain binding;0.0102266294125167;14026!GO:0030168;platelet activation;0.0102266294125167;14026!GO:0030048;actin filament-based movement;0.0102266294125167;14026!GO:0051016;barbed-end actin filament capping;0.0102266294125167;14026!GO:0051693;actin filament capping;0.0102266294125167;14026!GO:0030835;negative regulation of actin filament depolymerization;0.0102266294125167;14026!GO:0030834;regulation of actin filament depolymerization;0.0102266294125167;14026!GO:0030042;actin filament depolymerization;0.0102266294125167;14026!GO:0005925;focal adhesion;0.0102266294125167;14026!GO:0008064;regulation of actin polymerization and/or depolymerization;0.0102266294125167;14026!GO:0005924;cell-substrate adherens junction;0.0102266294125167;14026!GO:0051261;protein depolymerization;0.0102266294125167;14026!GO:0032535;regulation of cellular component size;0.0102266294125167;14026!GO:0032956;regulation of actin cytoskeleton organization and biogenesis;0.0102266294125167;14026!GO:0030832;regulation of actin filament length;0.0102266294125167;14026!GO:0051493;regulation of cytoskeleton organization and biogenesis;0.0102266294125167;14026!GO:0033043;regulation of organelle organization and biogenesis;0.0102266294125167;14026!GO:0051129;negative regulation of cellular component organization and biogenesis;0.0102266294125167;14026!GO:0030055;cell-matrix junction;0.0102266294125167;14026!GO:0008154;actin polymerization and/or depolymerization;0.0111563229954727;14026!GO:0030027;lamellipodium;0.0118336711773407;14026!GO:0007596;blood coagulation;0.0118336711773407;14026!GO:0019904;protein domain specific binding;0.0118336711773407;14026!GO:0051128;regulation of cellular component organization and biogenesis;0.0118336711773407;14026!GO:0007599;hemostasis;0.0118336711773407;14026!GO:0050817;coagulation;0.0118336711773407;14026!GO:0005912;adherens junction;0.0129067116033831;14026!GO:0051248;negative regulation of protein metabolic process;0.0134224511039281;14026!GO:0016323;basolateral plasma membrane;0.0134224511039281;14026!GO:0050878;regulation of body fluid levels;0.0134224511039281;14026!GO:0031252;leading edge;0.0138497781186654;14026!GO:0007411;axon guidance;0.0138497781186654;14026!GO:0042060;wound healing;0.0138497781186654;14026!GO:0030705;cytoskeleton-dependent intracellular transport;0.0167034947071106;14026!GO:0007409;axonogenesis;0.0246935685814427;14026!GO:0030036;actin cytoskeleton organization and biogenesis;0.0246935685814427;14026!GO:0048667;neuron morphogenesis during differentiation;0.0246935685814427;14026!GO:0048812;neurite morphogenesis;0.0246935685814427;14026!GO:0030029;actin filament-based process;0.0246935685814427;14026!GO:0000904;cellular morphogenesis during differentiation;0.0270275205902226;14026!GO:0031175;neurite development;0.0278259451456849;14026!GO:0048666;neuron development;0.0301344680022158;14026!GO:0001775;cell activation;0.0301344680022158;14026!GO:0051246;regulation of protein metabolic process;0.03067988823755;14026!GO:0003779;actin binding;0.0315937572488813;14026!GO:0032990;cell part morphogenesis;0.0326858809300052;14026!GO:0030030;cell projection organization and biogenesis;0.0326858809300052;14026!GO:0048858;cell projection morphogenesis;0.0326858809300052;14026!GO:0016477;cell migration;0.0326858809300052;14026!GO:0030182;neuron differentiation;0.0326858809300052;14026!GO:0009611;response to wounding;0.033342670990243;14026!GO:0048699;generation of neurons;0.0351518719467522;14026!GO:0051674;localization of cell;0.0351518719467522;14026!GO:0006928;cell motility;0.0351518719467522;14026!GO:0009892;negative regulation of metabolic process;0.0351518719467522;14026!GO:0008092;cytoskeletal protein binding;0.0351518719467522;14026!GO:0022008;neurogenesis;0.0351518719467522;14026!GO:0042995;cell projection;0.0372249310615607;14026!GO:0030054;cell junction;0.0385258924425628;14026!GO:0009605;response to external stimulus;0.0433477130582158;14026!GO:0007010;cytoskeleton organization and biogenesis;0.0434238418131477;14026!GO:0000902;cell morphogenesis;0.0434238418131477;14026!GO:0032989;cellular structure morphogenesis;0.0434238418131477;14026!}}
{{MCL_coexpression_mm9
|coexpression_dpi_cluster_scores_mean=-0.0806275020613823,-0.162020663842813,-0.153805980365432,-0.165830222255537,-0.150434041429478,-0.0875368944718734,-0.0256274394863926,1.18898299755986,0.464012171159769,0.396948632498714,0.484517295721371,0.504512448819462,1.2869044575471,1.2605476360346,0.472543030963358,0.555970771364043,0.29404198077389,1.1443382063384,1.05930898857362,0.887730582835561,0.200814292032793,0.584726281470334,0.476280256156702,0.346710255660925,0.396682807439122,-0.145254490359419,-0.155629822958831,-0.0939577600782081,0.207684714578691,0.195043819494317,0.194717510395438,0.0220546937974254,0.0579044758941294,0.112116499813917,0.0798363409269227,0.0279125128895188,0.0304574918995069,0.18490597325827,0.268714993824595,0.231231928691531,0.0329737961394505,-0.0332834022765735,0.212104732999852,-0.11207119942034,-0.113043360043211,-0.194521671938351,-0.131770905819068,-0.194521671938351,-0.172959645957858,-0.144631575504125,-0.167721483071593,-0.194521671938351,0.683022160481,0.816827579374151,0.936201450823385,-0.0550260498665801,0.107927080862443,-0.0278446560937108,-0.143021122662408,-0.045222469742795,-0.141219862118238,-0.162839134627939,-0.125446739851304,0.953057003988145,1.11105853913247,1.10083540662703,0.581284523488351,0.567609357567029,-0.149171686567785,-0.115003358433013,-0.0873827043893236,-0.0370580617211375,0.0415224369576243,-0.114016690025664,-0.101467372592416,-0.194521671938351,0.0582105305427061,-0.00705958036898888,-0.0132635215468155,-0.116313944493619,-0.104998585084669,-0.194521671938351,-0.0230762879601647,-0.0007085688313321,-0.0400810253590613,-0.0730061894285028,-0.0276734412537669,-0.0431631610366953,-0.08948915858996,-0.17132951380705,-0.0293233860318465,0.365682417301749,-0.194521671938351,-0.100803166928338,0.0406562971179508,-0.002650323275819,0.264733015424078,-0.194521671938351,-0.169447477109977,-0.161669976515381,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.170002725987256,-0.194521671938351,0.173798114824188,1.04162453680016,0.197953812880646,-0.0433668894163539,-0.0206939197286961,-0.0123087630443101,-0.022340169793704,0.0188631786402676,-0.00160819443091804,-0.110301921622243,0.273365433732936,0.371307451300722,0.0489252148887114,0.306888726295882,0.400650175090507,-0.0258560889377524,-0.0824693323917745,-0.0637935443659025,0.323640713851505,0.307761327877899,0.284842426378373,0.329313065501326,-0.0866871041590115,0.084019368289942,-0.120667584745315,0.0371371599321503,0.00691145171693793,0.0265973200241762,-0.0151399762779076,0.0233010414256173,0.255386562192,0.125052050572646,-0.00995542498569797,-0.126829883301227,-0.0554689591606489,-0.0734446563600196,-0.0681378743250682,-0.133487757544651,-0.0633108126013072,-0.0938082489518089,-0.0678112866831429,-0.140367788224999,-0.0944800894051489,-0.0659477412438857,-0.0845478048536109,-0.0234984238659014,-0.0423968607899446,0.0659550893453606,-0.0436539188347671,0.317337879826549,0.272987868406979,0.234909954172844,-0.14205064865715,-0.0890515204345071,-0.105973693510014,-0.0475412001566488,-0.0313757329333564,-0.0916676458777261,-0.100424984390453,-0.0353879240157064,-0.0754343430216001,-0.0537737728613292,-0.0057489013383466,-0.0386943856739311,0.0153616934080549,0.118396058567199,0.0340571226958126,-0.00409110023065533,-0.0696348723801332,0.236314613090819,0.17225409780095,-0.0567665626310663,0.0158020816403398,0.0313147735973465,0.137472839331887,0.172416230264869,0.0893927986705141,0.21337580188203,0.0747869339014129,0.238008251411549,0.20566276246121,0.182767525585704,0.210689768441855,0.256209929444519,0.24507007083996,-0.0790465788686111,-0.0894486907485377,-0.0306300297160836,-0.157424795134504,-0.0656166863017468,-0.0858258673495441,-0.0687539579064794,-0.0173756988874362,-0.0436980581159145,-0.0832418923268472,0.141850234648264,0.0766884519317086,0.124761968080618,0.213176005772417,0.158975134577727,0.220522061968098,0.213188284843071,0.275994798913827,0.327927081220757,0.197394967075606,0.338553602827026,0.329852062403745,0.28367952111047,0.0740076636470109,0.121936451510333,0.222809371053968,0.411177855967027,-0.0533884759975248,-0.0462308571829589,-0.0292233466425787,-0.0991011718894749,-0.0689975025889873,0.0541113973225542,0.0860005609805056,0.208049426044808,0.226918855092862,0.183713412283683,0.434525196337664,0.444237223150616,0.371696871165214,1.03011138545815,1.19529448301685,0.176930094366256,0.325608320646225,0.00356720306049975,-0.0713381954773676,-0.194521671938351,0.0635200551047317,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.194521671938351,-0.166684544553377,-0.194521671938351,-0.0469814811614405,0.122790513151059,-0.00685577848256117,-0.0992189626415795,0.286614989061932,-0.0110813629101111,-0.0537533408065631,-0.0371738363633139,-0.0661087207083418,-0.0020783563906407,-0.00725140347862437,0.122909683635023,0.179453167984006,0.0960987860197594,0.1701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|gostat_on_MCL_coexpression=GO:0045010;actin nucleation;0.0102266294125167;14026!GO:0005522;profilin binding;0.0102266294125167;14026!GO:0017124;SH3 domain binding;0.0102266294125167;14026!GO:0030168;platelet activation;0.0102266294125167;14026!GO:0030048;actin filament-based movement;0.0102266294125167;14026!GO:0051016;barbed-end actin filament capping;0.0102266294125167;14026!GO:0051693;actin filament capping;0.0102266294125167;14026!GO:0030835;negative regulation of actin filament depolymerization;0.0102266294125167;14026!GO:0030834;regulation of actin filament depolymerization;0.0102266294125167;14026!GO:0030042;actin filament depolymerization;0.0102266294125167;14026!GO:0005925;focal adhesion;0.0102266294125167;14026!GO:0008064;regulation of actin polymerization and/or depolymerization;0.0102266294125167;14026!GO:0005924;cell-substrate adherens junction;0.0102266294125167;14026!GO:0051261;protein depolymerization;0.0102266294125167;14026!GO:0032535;regulation of cellular component size;0.0102266294125167;14026!GO:0032956;regulation of actin cytoskeleton organization and biogenesis;0.0102266294125167;14026!GO:0030832;regulation of actin filament length;0.0102266294125167;14026!GO:0051493;regulation of cytoskeleton organization and biogenesis;0.0102266294125167;14026!GO:0033043;regulation of organelle organization and biogenesis;0.0102266294125167;14026!GO:0051129;negative regulation of cellular component organization and biogenesis;0.0102266294125167;14026!GO:0030055;cell-matrix junction;0.0102266294125167;14026!GO:0008154;actin polymerization and/or depolymerization;0.0111563229954727;14026!GO:0030027;lamellipodium;0.0118336711773407;14026!GO:0007596;blood coagulation;0.0118336711773407;14026!GO:0019904;protein domain specific binding;0.0118336711773407;14026!GO:0051128;regulation of cellular component organization and biogenesis;0.0118336711773407;14026!GO:0007599;hemostasis;0.0118336711773407;14026!GO:0050817;coagulation;0.0118336711773407;14026!GO:0005912;adherens junction;0.0129067116033831;14026!GO:0051248;negative regulation of protein metabolic process;0.0134224511039281;14026!GO:0016323;basolateral plasma membrane;0.0134224511039281;14026!GO:0050878;regulation of body fluid levels;0.0134224511039281;14026!GO:0031252;leading edge;0.0138497781186654;14026!GO:0007411;axon guidance;0.0138497781186654;14026!GO:0042060;wound healing;0.0138497781186654;14026!GO:0030705;cytoskeleton-dependent intracellular transport;0.0167034947071106;14026!GO:0007409;axonogenesis;0.0246935685814427;14026!GO:0030036;actin cytoskeleton organization and biogenesis;0.0246935685814427;14026!GO:0048667;neuron morphogenesis during differentiation;0.0246935685814427;14026!GO:0048812;neurite morphogenesis;0.0246935685814427;14026!GO:0030029;actin filament-based process;0.0246935685814427;14026!GO:0000904;cellular morphogenesis during differentiation;0.0270275205902226;14026!GO:0031175;neurite development;0.0278259451456849;14026!GO:0048666;neuron development;0.0301344680022158;14026!GO:0001775;cell activation;0.0301344680022158;14026!GO:0051246;regulation of protein metabolic process;0.03067988823755;14026!GO:0003779;actin binding;0.0315937572488813;14026!GO:0032990;cell part morphogenesis;0.0326858809300052;14026!GO:0030030;cell projection organization and biogenesis;0.0326858809300052;14026!GO:0048858;cell projection morphogenesis;0.0326858809300052;14026!GO:0016477;cell migration;0.0326858809300052;14026!GO:0030182;neuron differentiation;0.0326858809300052;14026!GO:0009611;response to wounding;0.033342670990243;14026!GO:0048699;generation of neurons;0.0351518719467522;14026!GO:0051674;localization of cell;0.0351518719467522;14026!GO:0006928;cell motility;0.0351518719467522;14026!GO:0009892;negative regulation of metabolic process;0.0351518719467522;14026!GO:0008092;cytoskeletal protein binding;0.0351518719467522;14026!GO:0022008;neurogenesis;0.0351518719467522;14026!GO:0042995;cell projection;0.0372249310615607;14026!GO:0030054;cell junction;0.0385258924425628;14026!GO:0009605;response to external stimulus;0.0433477130582158;14026!GO:0007010;cytoskeleton organization and biogenesis;0.0434238418131477;14026!GO:0000902;cell morphogenesis;0.0434238418131477;14026!GO:0032989;cellular structure morphogenesis;0.0434238418131477;14026!
}}

Revision as of 11:29, 11 October 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr10:33847761..33847786,-p1@Fam26f
Mm9::chr12:109873953..109874049,+p3@Evl
Mm9::chr6:125021344..125021363,+p2@Lpar5
Mm9::chr9:108959809..108959823,+p@chr9:108959809..108959823
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0045010actin nucleation0.0102266294125167
GO:0005522profilin binding0.0102266294125167
GO:0017124SH3 domain binding0.0102266294125167
GO:0030168platelet activation0.0102266294125167
GO:0030048actin filament-based movement0.0102266294125167
GO:0051016barbed-end actin filament capping0.0102266294125167
GO:0051693actin filament capping0.0102266294125167
GO:0030835negative regulation of actin filament depolymerization0.0102266294125167
GO:0030834regulation of actin filament depolymerization0.0102266294125167
GO:0030042actin filament depolymerization0.0102266294125167
GO:0005925focal adhesion0.0102266294125167
GO:0008064regulation of actin polymerization and/or depolymerization0.0102266294125167
GO:0005924cell-substrate adherens junction0.0102266294125167
GO:0051261protein depolymerization0.0102266294125167
GO:0032535regulation of cellular component size0.0102266294125167
GO:0032956regulation of actin cytoskeleton organization and biogenesis0.0102266294125167
GO:0030832regulation of actin filament length0.0102266294125167
GO:0051493regulation of cytoskeleton organization and biogenesis0.0102266294125167
GO:0033043regulation of organelle organization and biogenesis0.0102266294125167
GO:0051129negative regulation of cellular component organization and biogenesis0.0102266294125167
GO:0030055cell-matrix junction0.0102266294125167
GO:0008154actin polymerization and/or depolymerization0.0111563229954727
GO:0030027lamellipodium0.0118336711773407
GO:0007596blood coagulation0.0118336711773407
GO:0019904protein domain specific binding0.0118336711773407
GO:0051128regulation of cellular component organization and biogenesis0.0118336711773407
GO:0007599hemostasis0.0118336711773407
GO:0050817coagulation0.0118336711773407
GO:0005912adherens junction0.0129067116033831
GO:0051248negative regulation of protein metabolic process0.0134224511039281
GO:0016323basolateral plasma membrane0.0134224511039281
GO:0050878regulation of body fluid levels0.0134224511039281
GO:0031252leading edge0.0138497781186654
GO:0007411axon guidance0.0138497781186654
GO:0042060wound healing0.0138497781186654
GO:0030705cytoskeleton-dependent intracellular transport0.0167034947071106
GO:0007409axonogenesis0.0246935685814427
GO:0030036actin cytoskeleton organization and biogenesis0.0246935685814427
GO:0048667neuron morphogenesis during differentiation0.0246935685814427
GO:0048812neurite morphogenesis0.0246935685814427
GO:0030029actin filament-based process0.0246935685814427
GO:0000904cellular morphogenesis during differentiation0.0270275205902226
GO:0031175neurite development0.0278259451456849
GO:0048666neuron development0.0301344680022158
GO:0001775cell activation0.0301344680022158
GO:0051246regulation of protein metabolic process0.03067988823755
GO:0003779actin binding0.0315937572488813
GO:0032990cell part morphogenesis0.0326858809300052
GO:0030030cell projection organization and biogenesis0.0326858809300052
GO:0048858cell projection morphogenesis0.0326858809300052
GO:0016477cell migration0.0326858809300052
GO:0030182neuron differentiation0.0326858809300052
GO:0009611response to wounding0.033342670990243
GO:0048699generation of neurons0.0351518719467522
GO:0051674localization of cell0.0351518719467522
GO:0006928cell motility0.0351518719467522
GO:0009892negative regulation of metabolic process0.0351518719467522
GO:0008092cytoskeletal protein binding0.0351518719467522
GO:0022008neurogenesis0.0351518719467522
GO:0042995cell projection0.0372249310615607
GO:0030054cell junction0.0385258924425628
GO:0009605response to external stimulus0.0433477130582158
GO:0007010cytoskeleton organization and biogenesis0.0434238418131477
GO:0000902cell morphogenesis0.0434238418131477
GO:0032989cellular structure morphogenesis0.0434238418131477



Relative expression of the co-expression cluster over median <br>Analyst:



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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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