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MCL coexpression mm9:1893: Difference between revisions

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{{MCL_coexpression_mm9
{{MCL_coexpression_mm9
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|gostat_on_MCL_coexpression=GO:0004862;cAMP-dependent protein kinase inhibitor activity;0.0121617179066112;18768!GO:0004860;protein kinase inhibitor activity;0.0256501195402001;18768!GO:0019210;kinase inhibitor activity;0.0256501195402001;18768!GO:0006469;negative regulation of protein kinase activity;0.0256501195402001;18768!GO:0033673;negative regulation of kinase activity;0.0256501195402001;18768!GO:0051348;negative regulation of transferase activity;0.0256501195402001;18768!GO:0043086;negative regulation of catalytic activity;0.0271862726864854;18768!GO:0019887;protein kinase regulator activity;0.0318720337344778;18768!GO:0019207;kinase regulator activity;0.0332672814824209;18768!GO:0045859;regulation of protein kinase activity;0.0454415183000368;18768!GO:0043549;regulation of kinase activity;0.0454415183000368;18768!GO:0051338;regulation of transferase activity;0.0454415183000368;18768!
|gostat_on_MCL_coexpression=GO:0004862;cAMP-dependent protein kinase inhibitor activity;0.0121617179066112;18768!GO:0004860;protein kinase inhibitor activity;0.0256501195402001;18768!GO:0019210;kinase inhibitor activity;0.0256501195402001;18768!GO:0006469;negative regulation of protein kinase activity;0.0256501195402001;18768!GO:0033673;negative regulation of kinase activity;0.0256501195402001;18768!GO:0051348;negative regulation of transferase activity;0.0256501195402001;18768!GO:0043086;negative regulation of catalytic activity;0.0271862726864854;18768!GO:0019887;protein kinase regulator activity;0.0318720337344778;18768!GO:0019207;kinase regulator activity;0.0332672814824209;18768!GO:0045859;regulation of protein kinase activity;0.0454415183000368;18768!GO:0043549;regulation of kinase activity;0.0454415183000368;18768!GO:0051338;regulation of transferase activity;0.0454415183000368;18768!
}}
}}

Revision as of 13:04, 11 October 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr10:57351852..57351866,+p3@Pkib
Mm9::chr10:57351868..57351907,+p1@Pkib
Mm9::chr10:57351914..57351926,+p5@Pkib
Mm9::chr12:99813245..99813258,-p6@Kcnk10


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004862cAMP-dependent protein kinase inhibitor activity0.0121617179066112
GO:0004860protein kinase inhibitor activity0.0256501195402001
GO:0019210kinase inhibitor activity0.0256501195402001
GO:0006469negative regulation of protein kinase activity0.0256501195402001
GO:0033673negative regulation of kinase activity0.0256501195402001
GO:0051348negative regulation of transferase activity0.0256501195402001
GO:0043086negative regulation of catalytic activity0.0271862726864854
GO:0019887protein kinase regulator activity0.0318720337344778
GO:0019207kinase regulator activity0.0332672814824209
GO:0045859regulation of protein kinase activity0.0454415183000368
GO:0043549regulation of kinase activity0.0454415183000368
GO:0051338regulation of transferase activity0.0454415183000368



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}

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