MCL coexpression mm9:2257

Phase1 CAGE Peaks

	Short description
Mm9::chr19:32832066..32832077,+	p2@Pten
Mm9::chr19:32832094..32832127,+	p1@Pten
Mm9::chr19:32894609..32894613,+	p@chr19:32894609..32894613 +
Mm9::chr3:99966377..99966459,+	p1@Gdap2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	0.00476633977976223
GO:0051898	negative regulation of protein kinase B signaling cascade	0.00748996251105494
GO:0051896	regulation of protein kinase B signaling cascade	0.00748996251105494
GO:0043542	endothelial cell migration	0.00748996251105494
GO:0048738	cardiac muscle development	0.00748996251105494
GO:0042577	lipid phosphatase activity	0.00748996251105494
GO:0043491	protein kinase B signaling cascade	0.00748996251105494
GO:0004437	inositol or phosphatidylinositol phosphatase activity	0.0178737741741084
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	0.0185357658101864
GO:0009968	negative regulation of signal transduction	0.0314225363258399
GO:0006470	protein amino acid dephosphorylation	0.0314225363258399
GO:0045786	negative regulation of progression through cell cycle	0.0314225363258399
GO:0008285	negative regulation of cell proliferation	0.0314225363258399
GO:0016311	dephosphorylation	0.0314225363258399
GO:0014706	striated muscle development	0.0314225363258399
GO:0006917	induction of apoptosis	0.0314225363258399
GO:0012502	induction of programmed cell death	0.0314225363258399
GO:0001525	angiogenesis	0.0314225363258399
GO:0004721	phosphoprotein phosphatase activity	0.0314225363258399
GO:0043066	negative regulation of apoptosis	0.0314225363258399
GO:0043069	negative regulation of programmed cell death	0.0314225363258399
GO:0043065	positive regulation of apoptosis	0.0314225363258399
GO:0043068	positive regulation of programmed cell death	0.0314225363258399
GO:0007517	muscle development	0.0314225363258399
GO:0007507	heart development	0.0314225363258399
GO:0048514	blood vessel morphogenesis	0.0314225363258399
GO:0000074	regulation of progression through cell cycle	0.0314225363258399
GO:0048646	anatomical structure formation	0.0316621142512777
GO:0001568	blood vessel development	0.0327288664877007
GO:0001944	vasculature development	0.0327288664877007
GO:0007243	protein kinase cascade	0.0333643784583356
GO:0016791	phosphoric monoester hydrolase activity	0.0333643784583356
GO:0007417	central nervous system development	0.0333643784583356
GO:0016477	cell migration	0.0382709047022085
GO:0042578	phosphoric ester hydrolase activity	0.038811623920921
GO:0042127	regulation of cell proliferation	0.0404527812077256
GO:0051674	localization of cell	0.0404527812077256
GO:0006928	cell motility	0.0404527812077256
GO:0009966	regulation of signal transduction	0.0404527812077256
GO:0051726	regulation of cell cycle	0.0417054730729195
GO:0042981	regulation of apoptosis	0.0427835737373896
GO:0043067	regulation of programmed cell death	0.0427835737373896

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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