Coexpression cluster:C3532

Full id: C3532_tubular_signet_smallcell_argyrophil_prostate_tonsil_somatostatinoma

Phase1 CAGE Peaks

Hg19::chr16:1117848..1117886,-	p@chr16:1117848..1117886 -
Hg19::chr16:1128614..1128627,-	p1@LOC146336
Hg19::chr16:1128813..1128840,+	p1@SSTR5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004994	somatostatin receptor activity	0.00405480984340045
GO:0050796	regulation of insulin secretion	0.00405480984340045
GO:0030073	insulin secretion	0.00405480984340045
GO:0042593	glucose homeostasis	0.00405480984340045
GO:0033500	carbohydrate homeostasis	0.00405480984340045
GO:0030072	peptide hormone secretion	0.00405480984340045
GO:0002790	peptide secretion	0.00405480984340045
GO:0046883	regulation of hormone secretion	0.00405480984340045
GO:0046879	hormone secretion	0.00644975600821592
GO:0015833	peptide transport	0.00665842458495231
GO:0008188	neuropeptide receptor activity	0.00697142745005691
GO:0042923	neuropeptide binding	0.00697142745005691
GO:0051046	regulation of secretion	0.00774846253475713
GO:0003001	generation of a signal involved in cell-cell signaling	0.00853644177557989
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0126339338278582
GO:0019935	cyclic-nucleotide-mediated signaling	0.0126339338278582
GO:0030594	neurotransmitter receptor activity	0.0126339338278582
GO:0042165	neurotransmitter binding	0.0126339338278582
GO:0001653	peptide receptor activity	0.0126339338278582
GO:0008528	peptide receptor activity, G-protein coupled	0.0126339338278582
GO:0042277	peptide binding	0.0169102846601963
GO:0008285	negative regulation of cell proliferation	0.017460903631868
GO:0019932	second-messenger-mediated signaling	0.0198936208335253
GO:0048878	chemical homeostasis	0.0214833784685427
GO:0046903	secretion	0.0262239491345814
GO:0042127	regulation of cell proliferation	0.0303517929798396
GO:0042592	homeostatic process	0.0303517929798396
GO:0007267	cell-cell signaling	0.0390237338312223
GO:0008283	cell proliferation	0.043859649122807

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
throat	7.26e-08	2

Disease

Ontology term	p-value	n
carcinoma	1.18e-12	106
cell type cancer	9.63e-11	143
cancer	1.44e-08	235
disease of cellular proliferation	3.13e-08	239
signet ring cell adenocarcinoma	4.31e-08	2
adenocarcinoma	6.77e-08	25
cervical cancer	4.29e-07	5

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BHLHE40#8553	2	29.9145423646516	0.00146748352710614	0.00939511506696737
BRCA1#672	2	13.4561537621492	0.00711980771608456	0.0296190240215158
FOSL2#2355	2	11.2868004030411	0.010053458697312	0.0376671990273924
FOXA2#3170	2	16.4203091684435	0.00481068235210548	0.0225848626347004
GATA3#2625	2	18.1576775714707	0.00394454681927962	0.0189452529436074
RXRA#6256	2	13.3830780927555	0.00719643442946573	0.029823753635926
SMC3#9126	2	10.0299552299552	0.012665637976747	0.0457284393353435

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.