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MCL coexpression mm9:3102: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0009569!2.51e-08!66;UBERON:0005177!3.02e-08!79;UBERON:0002100!9.05e-07!90
|ontology_enrichment_uberon=UBERON:0009569!2.51e-08!66;UBERON:0005177!3.02e-08!79;UBERON:0002100!9.05e-07!90
|tfbs_overrepresentation_for_novel_motifs=0.752782,0.564138,0.722405,0.801166,0.587814,0.81763,0.919454,0.467321,0.479531,0.235304,0.870507,0.906098,0.467629,0.933025,0.608226,0,1.14208,0.578045,0.448066,0.876292,0.679146,0.275782,0.932027,0.585919,0.731217,0.963352,1.1146,0.841386,1.55113,0.99159,0.825437,1.24901,0.575271,0.411696,0.608816,3.47215,1.38481,0.902078,0.536514,2.16143,0.582863,0.831295,0.724277,0.610669,0.156582,0.788421,1.05665,0.859154,0.663409,0.646474,1.12346,0.99279,0.371606,1.3966,1.41464,0.940919,0.657156,0.891887,0.425455,0.938668,1.22795,1.00308,0.494668,1.11142,0.953187,1.15459,1.55483,1.90983,1.22303,1.7608,2.80886,0.474956,0.284975,1.44925,1.07031,0.402065,0.411601,1.04436,1.20986,0.684144,0.476502,1.16055,1.00151,0.459035,1.32978,0.535545,0.195254,0.380977,1.06194,2.07346,1.62608,1.33496,1.26245,0.595071,0.531443,0.509215,0.464141,1.26539,1.05692,0.928366,0.563856,1.24872,1.37854,1.12409,1.12297,0.830796,1.18646,0.854628,1.649,1.63106,0.744607,1.38039,0.685481,2.03346,1.63327,0.580657,1.1471,0.805461,1.14346,0.559153,1.45481,1.08896,0.965352,1.04338,1.68841,1.21376,0.928483,1.25534,1.55328,0.598722,1.36093,1.862,1.52297,0.955954,1.65529,0.751419,0.762499,0.832891,1.60513,2.44352,2.04137,1.55966,0.978551,1.26,1.11604,0.831808,1.06002,2.40374,0.765221,0.589976,0.999018,0.260379,1.39822,0.516739,0.954936,1.48249,2.2736,0.622823,0.749933,0.762177,1.61484,1.32889,1.21423,1.75703,1.11251,0.94678,0.562367,0.904334,0.421338
}}
}}

Revision as of 22:24, 26 November 2012


Phase1 CAGE Peaks

 Short description
Mm9::chr17:46169315..46169332,-p1@Vegfa
Mm9::chr17:87153440..87153451,+p4@Epas1
Mm9::chr17:87153462..87153473,+p3@Epas1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0048875chemical homeostasis within a tissue4.03417333827088e-06
GO:0043129surfactant homeostasis4.03417333827088e-06
GO:0001894tissue homeostasis0.000109258861244836
GO:0048871multicellular organismal homeostasis0.000109258861244836
GO:0030324lung development0.0004661711413113
GO:0030323respiratory tube development0.0004661711413113
GO:0048469cell maturation0.000518871532698554
GO:0021700developmental maturation0.000688330825842467
GO:0001525angiogenesis0.00135144806832074
GO:0048514blood vessel morphogenesis0.00200068103089314
GO:0048646anatomical structure formation0.00202813261994261
GO:0035295tube development0.00202813261994261
GO:0001568blood vessel development0.00202813261994261
GO:0001944vasculature development0.00202813261994261
GO:0043618regulation of transcription from RNA polymerase II promoter in response to stress0.00306790477847712
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress0.00306790477847712
GO:0042592homeostatic process0.00409042764426564
GO:0043620regulation of transcription in response to stress0.00409042764426564
GO:0001938positive regulation of endothelial cell proliferation0.00516671442176228
GO:0042415norepinephrine metabolic process0.00613530528528696
GO:0009790embryonic development0.00638302273860601
GO:0001936regulation of endothelial cell proliferation0.00669287693970676
GO:0009887organ morphogenesis0.0072353775816092
GO:0001935endothelial cell proliferation0.00817951056408521
GO:0010464regulation of mesenchymal cell proliferation0.00817951056408521
GO:0002053positive regulation of mesenchymal cell proliferation0.00817951056408521
GO:0010463mesenchymal cell proliferation0.00817951056408521
GO:0002027regulation of heart rate0.00861296007720831
GO:0065008regulation of biological quality0.00861296007720831
GO:0001892embryonic placenta development0.00899696855486349
GO:0042462eye photoreceptor cell development0.0105147846509646
GO:0048010vascular endothelial growth factor receptor signaling pathway0.0105147846509646
GO:0048522positive regulation of cellular process0.0105147846509646
GO:0050679positive regulation of epithelial cell proliferation0.0105147846509646
GO:0001974blood vessel remodeling0.0105147846509646
GO:0001754eye photoreceptor cell differentiation0.0109039222918641
GO:0033554cellular response to stress0.0109753578291056
GO:0042461photoreceptor cell development0.0109753578291056
GO:0048593camera-type eye morphogenesis0.0110396161945117
GO:0001541ovarian follicle development0.0110396161945117
GO:0048518positive regulation of biological process0.0112837140197725
GO:0051716cellular response to stimulus0.0116814931941915
GO:0046530photoreceptor cell differentiation0.0117077211422082
GO:0001666response to hypoxia0.0117077211422082
GO:0001569patterning of blood vessels0.0119923422585296
GO:0050678regulation of epithelial cell proliferation0.01279745022204
GO:0001890placenta development0.0140896508010745
GO:0018958phenol metabolic process0.0142245489797209
GO:0022601menstrual cycle phase0.0142245489797209
GO:0006584catecholamine metabolic process0.0142245489797209
GO:0022602menstrual cycle process0.0144261247562186
GO:0050673epithelial cell proliferation0.0146199217581502
GO:0048468cell development0.0148726082844325
GO:0009653anatomical structure morphogenesis0.0148726082844325
GO:0008585female gonad development0.0148726082844325
GO:0008016regulation of heart contraction0.0148726082844325
GO:0046545development of primary female sexual characteristics0.0148726082844325
GO:0030855epithelial cell differentiation0.0148726082844325
GO:0046660female sex differentiation0.0148726082844325
GO:0042133neurotransmitter metabolic process0.0148726082844325
GO:0030218erythrocyte differentiation0.0148726082844325
GO:0009880embryonic pattern specification0.0155667863259309
GO:0042698menstrual cycle0.0155667863259309
GO:0048592eye morphogenesis0.0163433326762993
GO:0003015heart process0.0163433326762993
GO:0060047heart contraction0.0163433326762993
GO:0006979response to oxidative stress0.0164648462589577
GO:0048513organ development0.0172936112099897
GO:0007498mesoderm development0.0174068148255559
GO:0008406gonad development0.0178574988060467
GO:0048608reproductive structure development0.0182954117040198
GO:0048754branching morphogenesis of a tube0.01947019157141
GO:0045137development of primary sexual characteristics0.01947019157141
GO:0008201heparin binding0.0195377013687176
GO:0046982protein heterodimerization activity0.0196033929751042
GO:0001763morphogenesis of a branching structure0.0203110542148593
GO:0007005mitochondrion organization and biogenesis0.0213177769322386
GO:0048609reproductive process in a multicellular organism0.0218387624449888
GO:0032504multicellular organism reproduction0.0218387624449888
GO:0006576biogenic amine metabolic process0.0218387624449888
GO:0007548sex differentiation0.0218387624449888
GO:0048731system development0.0218387624449888
GO:0005539glycosaminoglycan binding0.0218387624449888
GO:0043010camera-type eye development0.0218697819513702
GO:0048869cellular developmental process0.0219584691782932
GO:0030154cell differentiation0.0219584691782932
GO:0006916anti-apoptosis0.0219584691782932
GO:0042445hormone metabolic process0.0222887623661562
GO:0030247polysaccharide binding0.0222887623661562
GO:0001871pattern binding0.0231270192653428
GO:0003006reproductive developmental process0.0231413334383844
GO:0006575amino acid derivative metabolic process0.023155321817181
GO:0001505regulation of neurotransmitter levels0.0231689949112246
GO:0030099myeloid cell differentiation0.0239618165718334
GO:0008015blood circulation0.0242257011604375
GO:0003013circulatory system process0.0242257011604375
GO:0048856anatomical structure development0.0251152382588263
GO:0001654eye development0.0259731056860296
GO:0007601visual perception0.0271616453275106
GO:0050953sensory perception of light stimulus0.0271616453275106
GO:0006725aromatic compound metabolic process0.0273757671324719
GO:0001701in utero embryonic development0.0285420004890074
GO:0048771tissue remodeling0.0287383541933614
GO:0002009morphogenesis of an epithelium0.0289308801447683
GO:0007275multicellular organismal development0.0290654504882724
GO:0016043cellular component organization and biogenesis0.0334148233593887
GO:0035239tube morphogenesis0.0334148233593887
GO:0008083growth factor activity0.0334148233593887
GO:0043066negative regulation of apoptosis0.0334148233593887
GO:0043069negative regulation of programmed cell death0.0335536499522187
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0358820092731061
GO:0008284positive regulation of cell proliferation0.0383841027444397
GO:0000904cellular morphogenesis during differentiation0.0397071754564827
GO:0007423sensory organ development0.0397071754564827
GO:0008134transcription factor binding0.0397071754564827
GO:0007268synaptic transmission0.0399930903851556
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.040961594372507
GO:0046983protein dimerization activity0.040961594372507
GO:0022414reproductive process0.0422491741585634
GO:0030097hemopoiesis0.0423015347904407
GO:0032502developmental process0.0436736049305149
GO:0043009chordate embryonic development0.0441927376156917
GO:0009792embryonic development ending in birth or egg hatching0.0442620389251412
GO:0019226transmission of nerve impulse0.0442620389251412
GO:0048534hemopoietic or lymphoid organ development0.0452652321650547
GO:0007389pattern specification process0.0452906074995594
GO:0045893positive regulation of transcription, DNA-dependent0.0453155408689713
GO:0002520immune system development0.0474212033197068
GO:0006066alcohol metabolic process0.0479918290596343
GO:0030246carbohydrate binding0.0494754610980777
GO:0007167enzyme linked receptor protein signaling pathway0.0494754610980777



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
subdivision of trunk2.51e-0866
trunk region element3.02e-0879
trunk9.05e-0790


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}