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{{CL
{{CL
|id=CL:0002363
|alt_id=
|name=keratocyte
|namespace=cell;;efo
|def="A keratocyte is a specialized fibroblast��residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This��corneal��layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components.  This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5]
|xref=
|is_a=CL:0000057
|synonym="corneal fibroblast" EXACT [];;"corneal keratocyte" EXACT []
|comment=
|comment=
|alt_id=
|disjoint_from=
|union_of=
|created_by=tmeehan
|created_by=tmeehan
|obo_creation_date=2010-09-22T01:57:40Z
|def="A keratocyte is a specialized fibroblast��residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This��corneal��layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components.  This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000008
|develops_from=CL:0000008
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0002363
|is_a=CL:0000005
|is_obsolete=
|located_in=
|located_in=
|name=keratocyte
|namespace=cell;;efo
|obo_creation_date=2010-09-22T01:57:40Z
|part_of=UBERON:0001777
|part_of=UBERON:0001777
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="corneal fibroblast" EXACT [];;"corneal keratocyte" EXACT []
|union_of=
|xref=
}}
}}

Revision as of 10:26, 12 September 2014

Name:keratocyte
Namespace:cell;;efo
Definition:"A keratocyte is a specialized fibroblast��residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This��corneal��layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5]
Synonyms: "corneal fibroblast" EXACT []
"corneal keratocyte" EXACT []
Created by:tmeehan
Creation date:2010-09-22T01:57:40Z


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000005(fibroblast neural crest derived)
develops_from:CL:0000008(migratory cranial neural crest cell)
part_of:UBERON:0001777(substantia propria of cornea)



Children


derives from:FF:0000084 (human keratocyte sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0002363 (keratocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.55e-98FFCP PHASE2:Hg19::chr3:52362029..52362031,+#_035824bd2694378c46a5ce0c38de80bbp@chr3:52362029..52362031, +
1.55e-98FFCP PHASE2:Hg19::chr7:150910973..150910976,-#_035824bd2694378c46a5ce0c38de80bbp@chr7:150910973..150910976, -
1.55e-98FFCP PHASE1:Hg19::chr7:150910973..150910976,-#_035824bd2694378c46a5ce0c38de80bbp@chr7:150910973..150910976, -
1.55e-98FFCP PHASE1:Hg19::chr3:52362029..52362031,+#_035824bd2694378c46a5ce0c38de80bbp@chr3:52362029..52362031, +
4.52e-50FFCP PHASE2:Hg19::chr15:49255230..49255248,-#_2b478c4e21db8bcd992c5e5708589089p16@SHC4
4.52e-50FFCP PHASE2:Hg19::chr8:22932230..22932233,-#_2b478c4e21db8bcd992c5e5708589089p5@ENST00000520840, p5@ENST00000523806
4.52e-50FFCP PHASE1:Hg19::chr10:92617531..92617541,-#_2b478c4e21db8bcd992c5e5708589089p8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr8:22932230..22932233,-#_2b478c4e21db8bcd992c5e5708589089p5@ENST00000520840, p5@ENST00000523806
4.52e-50FFCP PHASE1:Hg19::chr15:49255230..49255248,-#_2b478c4e21db8bcd992c5e5708589089p16@SHC4
4.52e-50FFCP PHASE2:Hg19::chr6:113369869..113369877,+#_2b478c4e21db8bcd992c5e5708589089p@chr6:113369869..113369877, +
4.52e-50FFCP PHASE2:Hg19::chr10:92617531..92617541,-#_2b478c4e21db8bcd992c5e5708589089p8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr6:113369869..113369877,+#_2b478c4e21db8bcd992c5e5708589089p@chr6:113369869..113369877, +
5.04e-34FFCP PHASE1:Hg19::chr21:47410794..47410799,+#_cb5da6128a0d02db408a1e23e7bb4ba1p@chr21:47410794..47410799, +
5.04e-34FFCP PHASE2:Hg19::chr1:44820685..44820695,-#_cb5da6128a0d02db408a1e23e7bb4ba1p10@ERI3
5.04e-34FFCP PHASE2:Hg19::chr6:151770193..151770196,-#_cb5da6128a0d02db408a1e23e7bb4ba1p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE1:Hg19::chr6:151770193..151770196,-#_cb5da6128a0d02db408a1e23e7bb4ba1p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE1:Hg19::chr1:44820685..44820695,-#_cb5da6128a0d02db408a1e23e7bb4ba1p10@ERI3
5.04e-34FFCP PHASE2:Hg19::chr21:47410794..47410799,+#_cb5da6128a0d02db408a1e23e7bb4ba1p@chr21:47410794..47410799, +
7.05e-34FFCP PHASE1:Hg19::chr5:79375654..79375674,+#_849e78bb631ed5fcacef1ae36c3734efp@chr5:79375654..79375674, +
7.05e-34FFCP PHASE2:Hg19::chr15:101459410..101459421,-#_849e78bb631ed5fcacef1ae36c3734efp2@ENST00000560068
7.05e-34FFCP PHASE2:Hg19::chr11:65265332..65265342,+#_849e78bb631ed5fcacef1ae36c3734efp19@MALAT1
7.05e-34FFCP PHASE2:Hg19::chr2:25383828..25383855,-#_849e78bb631ed5fcacef1ae36c3734efp4@POMC
7.05e-34FFCP PHASE2:Hg19::chr10:43133595..43133606,-#_849e78bb631ed5fcacef1ae36c3734efp@chr10:43133595..43133606, -
7.05e-34FFCP PHASE2:Hg19::chr1:9970194..9970195,-#_849e78bb631ed5fcacef1ae36c3734efp14@CTNNBIP1
7.05e-34FFCP PHASE1:Hg19::chr11:65265332..65265342,+#_849e78bb631ed5fcacef1ae36c3734efp19@MALAT1
7.05e-34FFCP PHASE2:Hg19::chr10:74020629..74020634,-#_849e78bb631ed5fcacef1ae36c3734efp@chr10:74020629..74020634, -
7.05e-34FFCP PHASE1:Hg19::chr15:101459410..101459421,-#_849e78bb631ed5fcacef1ae36c3734efp2@ENST00000560068
7.05e-34FFCP PHASE1:Hg19::chr10:43133595..43133606,-#_849e78bb631ed5fcacef1ae36c3734efp@chr10:43133595..43133606, -
7.05e-34FFCP PHASE1:Hg19::chr2:25383828..25383855,-#_849e78bb631ed5fcacef1ae36c3734efp4@POMC
7.05e-34FFCP PHASE2:Hg19::chr5:79375654..79375674,+#_849e78bb631ed5fcacef1ae36c3734efp@chr5:79375654..79375674, +
7.05e-34FFCP PHASE1:Hg19::chr1:9970194..9970195,-#_849e78bb631ed5fcacef1ae36c3734efp14@CTNNBIP1
7.05e-34FFCP PHASE1:Hg19::chr10:74020629..74020634,-#_849e78bb631ed5fcacef1ae36c3734efp@chr10:74020629..74020634, -
6.41e-31FFCP PHASE1:Hg19::chr4:111536534..111536575,-#_65e4aab2358affaaf70e749e709b6953p1@ENST00000503456
6.41e-31FFCP PHASE2:Hg19::chr4:111536534..111536575,-#_65e4aab2358affaaf70e749e709b6953p1@ENST00000503456
4.55e-29FFCP PHASE2:Hg19::chrX:19688475..19688492,-#_566bfb279bad29014d99514b09d24f57p26@SH3KBP1
4.55e-29FFCP PHASE1:Hg19::chrX:19688475..19688492,-#_566bfb279bad29014d99514b09d24f57p26@SH3KBP1
9.18e-26FFCP PHASE2:Hg19::chr1:36024782..36024791,+#_c15cd95a59a7342a014d77681eb34b78p4@AB383919
9.18e-26FFCP PHASE1:Hg19::chr7:6049190..6049209,+#_c15cd95a59a7342a014d77681eb34b78p@chr7:6049190..6049209, +
9.18e-26FFCP PHASE1:Hg19::chr10:86153606..86153623,+#_c15cd95a59a7342a014d77681eb34b78p9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr21:47681190..47681194,-#_c15cd95a59a7342a014d77681eb34b78p@chr21:47681190..47681194, -
9.18e-26FFCP PHASE2:Hg19::chr16:10590513..10590515,-#_c15cd95a59a7342a014d77681eb34b78p@chr16:10590513..10590515, -
9.18e-26FFCP PHASE1:Hg19::chr11:34073641..34073656,-#_c15cd95a59a7342a014d77681eb34b78p@chr11:34073641..34073656, -
9.18e-26FFCP PHASE1:Hg19::chr17:30185971..30185986,-#_c15cd95a59a7342a014d77681eb34b78p7@C17orf79
9.18e-26FFCP PHASE1:Hg19::chr1:93646042..93646043,-#_c15cd95a59a7342a014d77681eb34b78p7@TMED5
9.18e-26FFCP PHASE2:Hg19::chr4:57522753..57522760,-#_c15cd95a59a7342a014d77681eb34b78p18@HOPX
9.18e-26FFCP PHASE1:Hg19::chr20:60758060..60758074,-#_c15cd95a59a7342a014d77681eb34b78p@chr20:60758060..60758074, -
9.18e-26FFCP PHASE2:Hg19::chr15:90344775..90344794,+#_c15cd95a59a7342a014d77681eb34b78p@chr15:90344775..90344794, +
9.18e-26FFCP PHASE2:Hg19::chr7:100806199..100806216,-#_c15cd95a59a7342a014d77681eb34b78p@chr7:100806199..100806216, -
9.18e-26FFCP PHASE1:Hg19::chr4:120546882..120546885,-#_c15cd95a59a7342a014d77681eb34b78p@chr4:120546882..120546885, -
9.18e-26FFCP PHASE2:Hg19::chr2:219540880..219540912,+#_c15cd95a59a7342a014d77681eb34b78p@chr2:219540880..219540912, +
9.18e-26FFCP PHASE1:Hg19::chr1:179335101..179335112,+#_c15cd95a59a7342a014d77681eb34b78p6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr3:9956047..9956079,+#_c15cd95a59a7342a014d77681eb34b78p@chr3:9956047..9956079, +
9.18e-26FFCP PHASE1:Hg19::chr7:100806199..100806216,-#_c15cd95a59a7342a014d77681eb34b78p@chr7:100806199..100806216, -
9.18e-26FFCP PHASE1:Hg19::chr1:151171326..151171337,-#_c15cd95a59a7342a014d77681eb34b78p@chr1:151171326..151171337, -
9.18e-26FFCP PHASE1:Hg19::chr1:36024782..36024791,+#_c15cd95a59a7342a014d77681eb34b78p4@AB383919
9.18e-26FFCP PHASE2:Hg19::chr21:47397571..47397582,-#_c15cd95a59a7342a014d77681eb34b78p@chr21:47397571..47397582, -
9.18e-26FFCP PHASE1:Hg19::chr4:57522753..57522760,-#_c15cd95a59a7342a014d77681eb34b78p18@HOPX
9.18e-26FFCP PHASE1:Hg19::chr21:47681190..47681194,-#_c15cd95a59a7342a014d77681eb34b78p@chr21:47681190..47681194, -
9.18e-26FFCP PHASE1:Hg19::chr16:10590513..10590515,-#_c15cd95a59a7342a014d77681eb34b78p@chr16:10590513..10590515, -
9.18e-26FFCP PHASE2:Hg19::chr4:73434498..73434509,-#_c15cd95a59a7342a014d77681eb34b78p6@ADAMTS3
9.18e-26FFCP PHASE1:Hg19::chr15:90344775..90344794,+#_c15cd95a59a7342a014d77681eb34b78p@chr15:90344775..90344794, +
9.18e-26FFCP PHASE2:Hg19::chr10:86153606..86153623,+#_c15cd95a59a7342a014d77681eb34b78p9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr17:30185971..30185986,-#_c15cd95a59a7342a014d77681eb34b78p7@C17orf79
9.18e-26FFCP PHASE2:Hg19::chr12:53693440..53693450,-#_c15cd95a59a7342a014d77681eb34b78p2@CU687581
9.18e-26FFCP PHASE2:Hg19::chr1:93646042..93646043,-#_c15cd95a59a7342a014d77681eb34b78p7@TMED5
9.18e-26FFCP PHASE2:Hg19::chr11:34073641..34073656,-#_c15cd95a59a7342a014d77681eb34b78p@chr11:34073641..34073656, -
9.18e-26FFCP PHASE2:Hg19::chr1:151171326..151171337,-#_c15cd95a59a7342a014d77681eb34b78p@chr1:151171326..151171337, -
9.18e-26FFCP PHASE1:Hg19::chr2:219540880..219540912,+#_c15cd95a59a7342a014d77681eb34b78p@chr2:219540880..219540912, +
9.18e-26FFCP PHASE2:Hg19::chr20:60758060..60758074,-#_c15cd95a59a7342a014d77681eb34b78p@chr20:60758060..60758074, -
9.18e-26FFCP PHASE1:Hg19::chr21:47397571..47397582,-#_c15cd95a59a7342a014d77681eb34b78p@chr21:47397571..47397582, -
9.18e-26FFCP PHASE2:Hg19::chr7:6049190..6049209,+#_c15cd95a59a7342a014d77681eb34b78p@chr7:6049190..6049209, +
9.18e-26FFCP PHASE2:Hg19::chr4:120546882..120546885,-#_c15cd95a59a7342a014d77681eb34b78p@chr4:120546882..120546885, -
9.18e-26FFCP PHASE2:Hg19::chr1:179335101..179335112,+#_c15cd95a59a7342a014d77681eb34b78p6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr4:73434498..73434509,-#_c15cd95a59a7342a014d77681eb34b78p6@ADAMTS3
9.18e-26FFCP PHASE2:Hg19::chr3:9956047..9956079,+#_c15cd95a59a7342a014d77681eb34b78p@chr3:9956047..9956079, +
9.18e-26FFCP PHASE1:Hg19::chr12:53693440..53693450,-#_c15cd95a59a7342a014d77681eb34b78p2@CU687581
6.02e-24FFCP PHASE1:Hg19::chr1:145589059..145589070,-#_061749fec89f93fe1c4fd73b406882fcp3@NUDT17
6.02e-24FFCP PHASE2:Hg19::chr1:145589059..145589070,-#_061749fec89f93fe1c4fd73b406882fcp3@NUDT17
3.81e-21FFCP PHASE1:Hg19::chr17:19648416..19648426,-#_0fda23e8ca08f545ec9aa2300952f67cp13@ALDH3A1
3.81e-21FFCP PHASE2:Hg19::chr17:19648416..19648426,-#_0fda23e8ca08f545ec9aa2300952f67cp13@ALDH3A1
4.66e-21FFCP PHASE2:Hg19::chr4:52917466..52917498,-#_bc618231684c1951909736cbe31c729ap@chr4:52917466..52917498, -
4.66e-21FFCP PHASE1:Hg19::chr4:52917466..52917498,-#_bc618231684c1951909736cbe31c729ap@chr4:52917466..52917498, -
4.66e-21FFCP PHASE2:Hg19::chr6:41562324..41562340,+#_bc618231684c1951909736cbe31c729ap16@FOXP4
4.66e-21FFCP PHASE1:Hg19::chr6:41562324..41562340,+#_bc618231684c1951909736cbe31c729ap16@FOXP4
5.7e-21FFCP PHASE1:Hg19::chr12:58141331..58141342,+#_3c9ea83d80a3b014892f838dfe9b74c7p@chr12:58141331..58141342, +
5.7e-21FFCP PHASE1:Hg19::chr19:48244695..48244702,+#_3c9ea83d80a3b014892f838dfe9b74c7p14@EHD2
5.7e-21FFCP PHASE1:Hg19::chr5:142254452..142254462,+#_3c9ea83d80a3b014892f838dfe9b74c7p29@ARHGAP26
5.7e-21FFCP PHASE2:Hg19::chr7:73118172..73118185,-#_3c9ea83d80a3b014892f838dfe9b74c7p3@STX1A
5.7e-21FFCP PHASE1:Hg19::chr7:73118172..73118185,-#_3c9ea83d80a3b014892f838dfe9b74c7p3@STX1A
5.7e-21FFCP PHASE2:Hg19::chr8:27686258..27686262,-#_3c9ea83d80a3b014892f838dfe9b74c7p@chr8:27686258..27686262, -
5.7e-21FFCP PHASE2:Hg19::chr19:48244695..48244702,+#_3c9ea83d80a3b014892f838dfe9b74c7p14@EHD2
5.7e-21FFCP PHASE1:Hg19::chr8:27686258..27686262,-#_3c9ea83d80a3b014892f838dfe9b74c7p@chr8:27686258..27686262, -
5.7e-21FFCP PHASE2:Hg19::chr12:58141331..58141342,+#_3c9ea83d80a3b014892f838dfe9b74c7p@chr12:58141331..58141342, +
5.7e-21FFCP PHASE2:Hg19::chr5:142254452..142254462,+#_3c9ea83d80a3b014892f838dfe9b74c7p29@ARHGAP26
6.96e-21FFCP PHASE2:Hg19::chr6:30585100..30585105,-#_f689d9c097231b92c4c946a0fe88fc97p19@PPP1R10
6.96e-21FFCP PHASE1:Hg19::chr15:90348577..90348582,-#_f689d9c097231b92c4c946a0fe88fc97p34@ANPEP
6.96e-21FFCP PHASE2:Hg19::chr17:71283257..71283270,-#_f689d9c097231b92c4c946a0fe88fc97p@chr17:71283257..71283270, -
6.96e-21FFCP PHASE1:Hg19::chr4:111563076..111563124,-#_f689d9c097231b92c4c946a0fe88fc97p8@PITX2
6.96e-21FFCP PHASE2:Hg19::chr9:140348438..140348460,-#_f689d9c097231b92c4c946a0fe88fc97p@chr9:140348438..140348460, -
6.96e-21FFCP PHASE1:Hg19::chr2:37898966..37898999,+#_f689d9c097231b92c4c946a0fe88fc97p@chr2:37898966..37898999, +

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