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UBERON:0002523

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Name:tunica intima
Definition:"The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted]." [Wikipedia:Tunica_intima]
Xrefs:
links:

BTO:0002012
FMA:55589
GAID:523
[1]
[2]
MA:0002861
MESH:A.07.231.330.800
ncithesaurus:Tunica_Intima

SCTID:8361002
Synonyms: "tunica intima vasorum" RELATED [BTO:0002012]
Comments:todo - check BTO
Alt_id: UBERON:MA_0002861-FMA_55589
Subset: uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0004797(blood vessel layer)



Children

is a:UBERON:0002165 (endocardium)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002523 (tunica intima), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
5.41e-147FFCP PHASE1:Hg19::chr7:25815812..25815822,-#_f6fab473274db3db7b78677e847f575bp@chr7:25815812..25815822, -
5.41e-147FFCP PHASE2:Hg19::chr7:25815812..25815822,-#_f6fab473274db3db7b78677e847f575bp@chr7:25815812..25815822, -
8.98e-131FFCP PHASE2:Hg19::chr12:3373147..3373149,-#_528106190cadde447a792a906e944976p@chr12:3373147..3373149, -
8.98e-131FFCP PHASE1:Hg19::chr12:3373147..3373149,-#_528106190cadde447a792a906e944976p@chr12:3373147..3373149, -
7.78e-118FFCP PHASE2:Hg19::chr1:20355975..20355980,-#_6c782d3b57bcdd325c6b4defcacc5bf4p@chr1:20355975..20355980, -
7.78e-118FFCP PHASE1:Hg19::chr1:20355975..20355980,-#_6c782d3b57bcdd325c6b4defcacc5bf4p@chr1:20355975..20355980, -
5.69e-99FFCP PHASE1:Hg19::chr1:237331032..237331036,+#_a6b32bf20bc163c1cac382c9d4c2a847p@chr1:237331032..237331036, +
5.69e-99FFCP PHASE2:Hg19::chr1:237331032..237331036,+#_a6b32bf20bc163c1cac382c9d4c2a847p@chr1:237331032..237331036, +
1.52e-87FFCP PHASE1:Hg19::chr6:6739548..6739577,-#_b0ea8010f49274d7cc69650ceda4b608p@chr6:6739548..6739577, -
1.52e-87FFCP PHASE1:Hg19::chr1:11907265..11907271,-#_b0ea8010f49274d7cc69650ceda4b608p9@NPPA
1.52e-87FFCP PHASE2:Hg19::chr1:11907265..11907271,-#_b0ea8010f49274d7cc69650ceda4b608p9@NPPA
1.52e-87FFCP PHASE2:Hg19::chr6:6739548..6739577,-#_b0ea8010f49274d7cc69650ceda4b608p@chr6:6739548..6739577, -
1.52e-87FFCP PHASE1:Hg19::chr2:18116344..18116353,+#_b0ea8010f49274d7cc69650ceda4b608p@chr2:18116344..18116353, +
1.52e-87FFCP PHASE2:Hg19::chr2:18116344..18116353,+#_b0ea8010f49274d7cc69650ceda4b608p@chr2:18116344..18116353, +
7.21e-85FFCP PHASE1:Hg19::chrX:112324334..112324339,-#_7fd44b8e70160439dde61816838139a4p@chrX:112324334..112324339, -
7.21e-85FFCP PHASE2:Hg19::chrX:112324334..112324339,-#_7fd44b8e70160439dde61816838139a4p@chrX:112324334..112324339, -
1.71e-84FFCP PHASE1:Hg19::chr2:220491902..220491915,+#_b669dafa8c89ccc356469dcf429eb27ep11@SLC4A3
1.71e-84FFCP PHASE2:Hg19::chr2:220491902..220491915,+#_b669dafa8c89ccc356469dcf429eb27ep11@SLC4A3
2.27e-84FFCP PHASE1:Hg19::chr2:179533457..179533461,-#_b14098c1c3564d770b9e8ac2ad464ae6p@chr2:179533457..179533461, -
2.27e-84FFCP PHASE2:Hg19::chr2:179533457..179533461,-#_b14098c1c3564d770b9e8ac2ad464ae6p@chr2:179533457..179533461, -
3.03e-84FFCP PHASE2:Hg19::chr2:179398102..179398109,-#_6dde09a1db4a0e9aafa21718d39f7948p@chr2:179398102..179398109, -
3.03e-84FFCP PHASE1:Hg19::chr2:179398102..179398109,-#_6dde09a1db4a0e9aafa21718d39f7948p@chr2:179398102..179398109, -
7.81e-75FFCP PHASE1:Hg19::chr5:123739302..123739319,-#_96d9e3511fdf0c59fa0047c4b5828588p@chr5:123739302..123739319, -
7.81e-75FFCP PHASE2:Hg19::chr5:123739302..123739319,-#_96d9e3511fdf0c59fa0047c4b5828588p@chr5:123739302..123739319, -
1.01e-74FFCP PHASE1:Hg19::chr18:64271475..64271484,-#_4f2788d91c2659a96935e2e0b6cc0c20p6@CDH19
1.01e-74FFCP PHASE2:Hg19::chr18:64271475..64271484,-#_4f2788d91c2659a96935e2e0b6cc0c20p6@CDH19
1.29e-74FFCP PHASE1:Hg19::chr7:35286774..35286778,-#_df2b14278dfc10087b5b82847e6226dfp@chr7:35286774..35286778, -
1.29e-74FFCP PHASE2:Hg19::chr7:35286774..35286778,-#_df2b14278dfc10087b5b82847e6226dfp@chr7:35286774..35286778, -
1.66e-74FFCP PHASE1:Hg19::chr6:129355052..129355056,+#_5e6e9da1b49e04045c339d2a3196c3cfp@chr6:129355052..129355056, +
1.66e-74FFCP PHASE2:Hg19::chr6:129355052..129355056,+#_5e6e9da1b49e04045c339d2a3196c3cfp@chr6:129355052..129355056, +
2.75e-74FFCP PHASE2:Hg19::chr3:16940540..16940554,+#_b0896d9af2288452d93720a88aa02ffep@chr3:16940540..16940554, +
2.75e-74FFCP PHASE1:Hg19::chr3:16940540..16940554,+#_b0896d9af2288452d93720a88aa02ffep@chr3:16940540..16940554, +
3.54e-74FFCP PHASE1:Hg19::chr1:201328779..201328797,-#_76f2e020f55d86c59948e19239cd86f3p@chr1:201328779..201328797, -
3.54e-74FFCP PHASE1:Hg19::chr3:131523446..131523459,-#_76f2e020f55d86c59948e19239cd86f3p@chr3:131523446..131523459, -
3.54e-74FFCP PHASE2:Hg19::chr1:201328779..201328797,-#_76f2e020f55d86c59948e19239cd86f3p@chr1:201328779..201328797, -
3.54e-74FFCP PHASE1:Hg19::chr20:33565465..33565475,+#_76f2e020f55d86c59948e19239cd86f3p9@MYH7B
3.54e-74FFCP PHASE2:Hg19::chr3:131523446..131523459,-#_76f2e020f55d86c59948e19239cd86f3p@chr3:131523446..131523459, -
3.54e-74FFCP PHASE1:Hg19::chr19:55661803..55661807,-#_76f2e020f55d86c59948e19239cd86f3p@chr19:55661803..55661807, -
3.54e-74FFCP PHASE2:Hg19::chr20:33565465..33565475,+#_76f2e020f55d86c59948e19239cd86f3p9@MYH7B
3.54e-74FFCP PHASE2:Hg19::chr19:55661803..55661807,-#_76f2e020f55d86c59948e19239cd86f3p@chr19:55661803..55661807, -
5.84e-74FFCP PHASE1:Hg19::chr6:36812121..36812130,-#_ea18713b354928ea056f927cc9c3467cp@chr6:36812121..36812130, -
5.84e-74FFCP PHASE2:Hg19::chr6:36812121..36812130,-#_ea18713b354928ea056f927cc9c3467cp@chr6:36812121..36812130, -
7.51e-74FFCP PHASE1:Hg19::chr14:105939326..105939337,+#_648e750f3494e2f5351b2eeed34a1c11p16@CRIP2
7.51e-74FFCP PHASE2:Hg19::chr14:105939326..105939337,+#_648e750f3494e2f5351b2eeed34a1c11p16@CRIP2
9.64e-74FFCP PHASE2:Hg19::chr1:206838422..206838456,+#_cfe258eb19b86dc345e2792c7c66d5e2p@chr1:206838422..206838456, +
9.64e-74FFCP PHASE1:Hg19::chr1:206838422..206838456,+#_cfe258eb19b86dc345e2792c7c66d5e2p@chr1:206838422..206838456, +
1.24e-73FFCP PHASE1:Hg19::chr1:231983543..231983554,-#_f5ec424e8966253731ddee12c29dfc11p@chr1:231983543..231983554, -
1.24e-73FFCP PHASE2:Hg19::chr1:231983543..231983554,-#_f5ec424e8966253731ddee12c29dfc11p@chr1:231983543..231983554, -
1.54e-66FFCP PHASE2:Hg19::chr1:201328328..201328343,-#_f905db0c98eedf6647f220ca3ea4b519p@chr1:201328328..201328343, -
1.54e-66FFCP PHASE1:Hg19::chr1:201328328..201328343,-#_f905db0c98eedf6647f220ca3ea4b519p@chr1:201328328..201328343, -
1.71e-66FFCP PHASE2:Hg19::chr11:47367243..47367257,-#_9caa4a1d9024fcb04de4fcd3eeb36959p@chr11:47367243..47367257, -
1.71e-66FFCP PHASE1:Hg19::chr1:237214095..237214115,+#_9caa4a1d9024fcb04de4fcd3eeb36959p@chr1:237214095..237214115, +
1.71e-66FFCP PHASE2:Hg19::chr1:237214095..237214115,+#_9caa4a1d9024fcb04de4fcd3eeb36959p@chr1:237214095..237214115, +
1.71e-66FFCP PHASE1:Hg19::chr11:47367243..47367257,-#_9caa4a1d9024fcb04de4fcd3eeb36959p@chr11:47367243..47367257, -
2.39e-66FFCP PHASE1:Hg19::chr15:86272097..86272099,+#_f6d2759796065c56aa05683d4ebaa7aep@chr15:86272097..86272099, +
2.39e-66FFCP PHASE1:Hg19::chr10:92678409..92678410,-#_f6d2759796065c56aa05683d4ebaa7aep@chr10:92678409..92678410, -
2.39e-66FFCP PHASE1:Hg19::chr5:99390735..99390743,-#_f6d2759796065c56aa05683d4ebaa7aep@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr15:86272097..86272099,+#_f6d2759796065c56aa05683d4ebaa7aep@chr15:86272097..86272099, +
2.39e-66FFCP PHASE2:Hg19::chr5:99390735..99390743,-#_f6d2759796065c56aa05683d4ebaa7aep@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr10:92678409..92678410,-#_f6d2759796065c56aa05683d4ebaa7aep@chr10:92678409..92678410, -
2.4e-66FFCP PHASE1:Hg19::chr2:159976509..159976519,+#_b79e848dd1d633f6561803ee42662c0dp@chr2:159976509..159976519, +
2.4e-66FFCP PHASE2:Hg19::chr12:4735761..4735787,-#_b79e848dd1d633f6561803ee42662c0dp@chr12:4735761..4735787, -
2.4e-66FFCP PHASE1:Hg19::chr12:114886577..114886589,-#_b79e848dd1d633f6561803ee42662c0dp@chr12:114886577..114886589, -
2.4e-66FFCP PHASE1:Hg19::chr1:237996521..237996532,+#_b79e848dd1d633f6561803ee42662c0dp@chr1:237996521..237996532, +
2.4e-66FFCP PHASE2:Hg19::chr2:159976509..159976519,+#_b79e848dd1d633f6561803ee42662c0dp@chr2:159976509..159976519, +
2.4e-66FFCP PHASE2:Hg19::chr1:237996521..237996532,+#_b79e848dd1d633f6561803ee42662c0dp@chr1:237996521..237996532, +
2.4e-66FFCP PHASE1:Hg19::chr12:4735761..4735787,-#_b79e848dd1d633f6561803ee42662c0dp@chr12:4735761..4735787, -
2.4e-66FFCP PHASE2:Hg19::chr12:114886577..114886589,-#_b79e848dd1d633f6561803ee42662c0dp@chr12:114886577..114886589, -
2.41e-66FFCP PHASE1:Hg19::chr1:237207955..237207959,+#_e518dd1239e481b9b0ad1a98ae9c9aa5p@chr1:237207955..237207959, +
2.41e-66FFCP PHASE1:Hg19::chr2:40480968..40480972,-#_e518dd1239e481b9b0ad1a98ae9c9aa5p@chr2:40480968..40480972, -
2.41e-66FFCP PHASE2:Hg19::chr1:237207955..237207959,+#_e518dd1239e481b9b0ad1a98ae9c9aa5p@chr1:237207955..237207959, +
2.41e-66FFCP PHASE2:Hg19::chr2:40480968..40480972,-#_e518dd1239e481b9b0ad1a98ae9c9aa5p@chr2:40480968..40480972, -
3.01e-66FFCP PHASE1:Hg19::chr4:62999501..62999517,+#_f02d43d55d444a98e7dfc7385040ef98p@chr4:62999501..62999517, +
3.01e-66FFCP PHASE2:Hg19::chr4:62999501..62999517,+#_f02d43d55d444a98e7dfc7385040ef98p@chr4:62999501..62999517, +
3.35e-66FFCP PHASE1:Hg19::chr7:44178491..44178498,-#_4836ed21a32f81e59839fd6d4142a024p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE2:Hg19::chr7:35253487..35253489,-#_4836ed21a32f81e59839fd6d4142a024p@chr7:35253487..35253489, -
3.35e-66FFCP PHASE2:Hg19::chr7:44178491..44178498,-#_4836ed21a32f81e59839fd6d4142a024p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE1:Hg19::chr9:38650254..38650266,+#_4836ed21a32f81e59839fd6d4142a024p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE1:Hg19::chr7:44179972..44179982,-#_4836ed21a32f81e59839fd6d4142a024p2@MYL7
3.35e-66FFCP PHASE1:Hg19::chr5:65736120..65736128,-#_4836ed21a32f81e59839fd6d4142a024p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE1:Hg19::chr1:11905830..11905839,-#_4836ed21a32f81e59839fd6d4142a024p@chr1:11905830..11905839, -
3.35e-66FFCP PHASE2:Hg19::chr9:38650254..38650266,+#_4836ed21a32f81e59839fd6d4142a024p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE2:Hg19::chr7:44179972..44179982,-#_4836ed21a32f81e59839fd6d4142a024p2@MYL7
3.35e-66FFCP PHASE2:Hg19::chr1:11905830..11905839,-#_4836ed21a32f81e59839fd6d4142a024p@chr1:11905830..11905839, -
3.35e-66FFCP PHASE2:Hg19::chr5:65736120..65736128,-#_4836ed21a32f81e59839fd6d4142a024p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE1:Hg19::chr7:35253487..35253489,-#_4836ed21a32f81e59839fd6d4142a024p@chr7:35253487..35253489, -
4.68e-66FFCP PHASE1:Hg19::chr10:112524543..112524547,+#_249ff41200b3af8fe79e238a420c1555p@chr10:112524543..112524547, +
4.68e-66FFCP PHASE2:Hg19::chr10:112524543..112524547,+#_249ff41200b3af8fe79e238a420c1555p@chr10:112524543..112524547, +
4.68e-66FFCP PHASE1:Hg19::chr7:44180643..44180652,-#_249ff41200b3af8fe79e238a420c1555p3@MYL7
4.68e-66FFCP PHASE2:Hg19::chr7:44180643..44180652,-#_249ff41200b3af8fe79e238a420c1555p3@MYL7
5.88e-66FFCP PHASE1:Hg19::chr6:36812225..36812238,-#_bf3c08d74ecb1293eae0f20921407f97p@chr6:36812225..36812238, -
5.88e-66FFCP PHASE2:Hg19::chr6:36812225..36812238,-#_bf3c08d74ecb1293eae0f20921407f97p@chr6:36812225..36812238, -
6.53e-66FFCP PHASE2:Hg19::chr4:62999459..62999462,+#_4021f8481e82a7b7b8e489196a8f785fp@chr4:62999459..62999462, +
6.53e-66FFCP PHASE1:Hg19::chr2:168104544..168104551,+#_4021f8481e82a7b7b8e489196a8f785fp52@XIRP2
6.53e-66FFCP PHASE2:Hg19::chr2:168104544..168104551,+#_4021f8481e82a7b7b8e489196a8f785fp52@XIRP2
6.53e-66FFCP PHASE1:Hg19::chr4:62999459..62999462,+#_4021f8481e82a7b7b8e489196a8f785fp@chr4:62999459..62999462, +
1.15e-65FFCP PHASE1:Hg19::chr7:123302841..123302854,+#_ff48457c81f4049bade5bfcc9d515635p@chr7:123302841..123302854, +
1.15e-65FFCP PHASE2:Hg19::chrX:121555838..121555874,+#_ff48457c81f4049bade5bfcc9d515635p@chrX:121555838..121555874, +
1.15e-65FFCP PHASE2:Hg19::chr10:127569398..127569410,-#_ff48457c81f4049bade5bfcc9d515635p5@DHX32
1.15e-65FFCP PHASE2:Hg19::chr7:123302841..123302854,+#_ff48457c81f4049bade5bfcc9d515635p@chr7:123302841..123302854, +

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