MCL coexpression mm9:94
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0001525 | angiogenesis | 2.64970444448411e-07 |
| GO:0001568 | blood vessel development | 2.64970444448411e-07 |
| GO:0001944 | vasculature development | 2.64970444448411e-07 |
| GO:0048514 | blood vessel morphogenesis | 7.68267412900292e-07 |
| GO:0048646 | anatomical structure formation | 1.15816321019475e-06 |
| GO:0030334 | regulation of cell migration | 1.75991235573691e-06 |
| GO:0051270 | regulation of cell motility | 3.27871066159407e-06 |
| GO:0040012 | regulation of locomotion | 4.28166690385124e-06 |
| GO:0016477 | cell migration | 1.73105689814255e-05 |
| GO:0030695 | GTPase regulator activity | 2.82126103631599e-05 |
| GO:0006928 | cell motility | 5.42941595411039e-05 |
| GO:0051674 | localization of cell | 5.42941595411039e-05 |
| GO:0001570 | vasculogenesis | 0.000104605505114981 |
| GO:0009887 | organ morphogenesis | 0.000208432256221841 |
| GO:0007266 | Rho protein signal transduction | 0.000251837197467868 |
| GO:0007265 | Ras protein signal transduction | 0.00035974989084525 |
| GO:0030336 | negative regulation of cell migration | 0.00039999458665454 |
| GO:0007264 | small GTPase mediated signal transduction | 0.00046830674708023 |
| GO:0007242 | intracellular signaling cascade | 0.000499921987789595 |
| GO:0005886 | plasma membrane | 0.000499921987789595 |
| GO:0051271 | negative regulation of cell motility | 0.000719006685210945 |
| GO:0040013 | negative regulation of locomotion | 0.000792956971360994 |
| GO:0007165 | signal transduction | 0.000792956971360994 |
| GO:0007154 | cell communication | 0.000801955348402792 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.00112529569665157 |
| GO:0005083 | small GTPase regulator activity | 0.00308498417294489 |
| GO:0009653 | anatomical structure morphogenesis | 0.00519796578704105 |
| GO:0045446 | endothelial cell differentiation | 0.0093711924225644 |
| GO:0048856 | anatomical structure development | 0.0119143106461027 |
| GO:0050794 | regulation of cellular process | 0.0121106230981079 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0133648339015022 |
| GO:0009966 | regulation of signal transduction | 0.0133648339015022 |
| GO:0007275 | multicellular organismal development | 0.0133648339015022 |
| GO:0065007 | biological regulation | 0.0133648339015022 |
| GO:0035023 | regulation of Rho protein signal transduction | 0.0133893416143907 |
| GO:0005100 | Rho GTPase activator activity | 0.0146130059143952 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0147484590382442 |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 0.0165880198089054 |
| GO:0007160 | cell-matrix adhesion | 0.0169306529174035 |
| GO:0048513 | organ development | 0.0169465815918363 |
| GO:0050789 | regulation of biological process | 0.0182255107439308 |
| GO:0031589 | cell-substrate adhesion | 0.0187864104115868 |
| GO:0048731 | system development | 0.0194999062713668 |
| GO:0005096 | GTPase activator activity | 0.0199902578160445 |
| GO:0019199 | transmembrane receptor protein kinase activity | 0.0224436331355046 |
| GO:0042060 | wound healing | 0.0275221362160585 |
| GO:0044459 | plasma membrane part | 0.0333316775834401 |
| GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity | 0.0355733437042172 |
| GO:0045602 | negative regulation of endothelial cell differentiation | 0.0355733437042172 |
| GO:0022610 | biological adhesion | 0.0355733437042172 |
| GO:0007155 | cell adhesion | 0.0355733437042172 |
| GO:0032502 | developmental process | 0.0398278839144057 |
| GO:0045765 | regulation of angiogenesis | 0.0456072135681949 |
| GO:0046578 | regulation of Ras protein signal transduction | 0.0456072135681949 |
| GO:0008047 | enzyme activator activity | 0.0456072135681949 |
| GO:0016337 | cell-cell adhesion | 0.049659269781546 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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