MCL coexpression mm9:1019

Phase1 CAGE Peaks

	Short description
Mm9::chr10:29030794..29030801,+	p@chr10:29030794..29030801 +
Mm9::chr16:23268489..23268505,+	p@chr16:23268489..23268505 +
Mm9::chr16:23268536..23268552,+	p@chr16:23268536..23268552 +
Mm9::chr16:23268568..23268612,+	p@chr16:23268568..23268612 +
Mm9::chr17:34745931..34745934,+	p17@Agpat1
Mm9::chr17:34745942..34745966,+	p4@Agpat1
Mm9::chr7:148477887..148477932,+	p1@Drd4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001593	dopamine D4 receptor activity	0.00677000561866695
GO:0060081	membrane hyperpolarization	0.00677000561866695
GO:0060080	regulation of inhibitory postsynaptic membrane potential	0.00677000561866695
GO:0001591	dopamine D2 receptor-like receptor activity	0.00677000561866695
GO:0007195	dopamine receptor, adenylate cyclase inhibiting pathway	0.00677000561866695
GO:0004952	dopamine receptor activity	0.00677000561866695
GO:0035240	dopamine binding	0.00677000561866695
GO:0042053	regulation of dopamine metabolic process	0.00677000561866695
GO:0042069	regulation of catecholamine metabolic process	0.00677000561866695
GO:0048148	behavioral response to cocaine	0.00677000561866695
GO:0014075	response to amine stimulus	0.00677000561866695
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	0.00677000561866695
GO:0042220	response to cocaine	0.00677000561866695
GO:0014073	response to tropane	0.00677000561866695
GO:0001975	response to amphetamine	0.00677000561866695
GO:0060078	regulation of postsynaptic membrane potential	0.00796405778689728
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.00796405778689728
GO:0016411	acylglycerol O-acyltransferase activity	0.00814818768945032
GO:0042596	fear response	0.00890643765665583
GO:0014070	response to organic cyclic substance	0.00902494282549825
GO:0043279	response to alkaloid	0.00913213234335016
GO:0007212	dopamine receptor signaling pathway	0.00922954925352844
GO:0042417	dopamine metabolic process	0.00980864510055752
GO:0033555	multicellular organismal response to stress	0.0117483292008871
GO:0010033	response to organic substance	0.0120823395000664
GO:0006584	catecholamine metabolic process	0.0120823395000664
GO:0018958	phenol metabolic process	0.0120823395000664
GO:0008374	O-acyltransferase activity	0.0120823395000664
GO:0042133	neurotransmitter metabolic process	0.0143849442504756
GO:0008344	adult locomotory behavior	0.0151478667030246
GO:0042391	regulation of membrane potential	0.0151478667030246
GO:0008227	amine receptor activity	0.0151478667030246
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.01857576292548
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.01857576292548
GO:0008654	phospholipid biosynthetic process	0.01857576292548
GO:0019933	cAMP-mediated signaling	0.01857576292548
GO:0030534	adult behavior	0.01857576292548
GO:0019935	cyclic-nucleotide-mediated signaling	0.0186789159297366
GO:0046467	membrane lipid biosynthetic process	0.0202749573683329
GO:0006576	biogenic amine metabolic process	0.0202749573683329
GO:0006575	amino acid derivative metabolic process	0.0225178370794055
GO:0030594	neurotransmitter receptor activity	0.0225178370794055
GO:0001505	regulation of neurotransmitter levels	0.0225178370794055
GO:0042165	neurotransmitter binding	0.0225178370794055
GO:0006725	aromatic compound metabolic process	0.0282529866546731
GO:0006644	phospholipid metabolic process	0.0283702256005521
GO:0019932	second-messenger-mediated signaling	0.0294365110287574
GO:0055082	cellular chemical homeostasis	0.0334935527425336
GO:0006873	cellular ion homeostasis	0.0334935527425336
GO:0006643	membrane lipid metabolic process	0.0339431119605927
GO:0050801	ion homeostasis	0.0362431522515591
GO:0008415	acyltransferase activity	0.0362431522515591
GO:0016747	transferase activity, transferring groups other than amino-acyl groups	0.0362431522515591
GO:0016746	transferase activity, transferring acyl groups	0.0370210120705414
GO:0007268	synaptic transmission	0.0387855068118376
GO:0007626	locomotory behavior	0.0404853938843609
GO:0048878	chemical homeostasis	0.0408208277965453
GO:0019725	cellular homeostasis	0.0408208277965453
GO:0019226	transmission of nerve impulse	0.0427750273268692
GO:0008610	lipid biosynthetic process	0.0441051034305814
GO:0006066	alcohol metabolic process	0.0466676985301054

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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