MCL coexpression mm9:1450

Phase1 CAGE Peaks

	Short description
Mm9::chr2:9809357..9809371,-	p2@Gata3
Mm9::chr2:9809374..9809396,-	p4@Gata3
Mm9::chr2:9809402..9809422,-	p5@Gata3
Mm9::chr2:9809579..9809627,-	p7@Gata3
Mm9::chr2:9811653..9811662,-	p8@Gata3
Mm9::chr6:84543910..84543916,-	p3@Cyp26b1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0001709	cell fate determination	0.000230308074329499
GO:0042445	hormone metabolic process	0.0013518082623688
GO:0045165	cell fate commitment	0.00137684174870896
GO:0032753	positive regulation of interleukin-4 production	0.00380759327233879
GO:0032673	regulation of interleukin-4 production	0.00609198234583313
GO:0048485	sympathetic nervous system development	0.00652694513134735
GO:0042421	norepinephrine biosynthetic process	0.00652694513134735
GO:0042415	norepinephrine metabolic process	0.00761435209513292
GO:0048384	retinoic acid receptor signaling pathway	0.00761435209513292
GO:0032633	interleukin-4 production	0.00761435209513292
GO:0048483	autonomic nervous system development	0.00969046256227709
GO:0042573	retinoic acid metabolic process	0.0101510787109361
GO:0007140	male meiosis	0.0101510787109361
GO:0009954	proximal/distal pattern formation	0.0101510787109361
GO:0042423	catecholamine biosynthetic process	0.0101510787109361
GO:0042136	neurotransmitter biosynthetic process	0.0123706101935708
GO:0006776	vitamin A metabolic process	0.0143285785579013
GO:0030522	intracellular receptor-mediated signaling pathway	0.0152232802682254
GO:0001819	positive regulation of cytokine production	0.0160236271775587
GO:0006775	fat-soluble vitamin metabolic process	0.0167437725060497
GO:0042401	biogenic amine biosynthetic process	0.0173951736223902
GO:0042398	amino acid derivative biosynthetic process	0.0182619282851489
GO:0018958	phenol metabolic process	0.0182619282851489
GO:0006584	catecholamine metabolic process	0.0182619282851489
GO:0001817	regulation of cytokine production	0.0182619282851489
GO:0042446	hormone biosynthetic process	0.02085066892257
GO:0042133	neurotransmitter metabolic process	0.02085066892257
GO:0042035	regulation of cytokine biosynthetic process	0.026680634111376
GO:0009309	amine biosynthetic process	0.026680634111376
GO:0042089	cytokine biosynthetic process	0.026680634111376
GO:0042107	cytokine metabolic process	0.026680634111376
GO:0006766	vitamin metabolic process	0.026680634111376
GO:0030326	embryonic limb morphogenesis	0.026680634111376
GO:0035113	embryonic appendage morphogenesis	0.026680634111376
GO:0006576	biogenic amine metabolic process	0.026680634111376
GO:0051327	M phase of meiotic cell cycle	0.026680634111376
GO:0007126	meiosis	0.026680634111376
GO:0051321	meiotic cell cycle	0.026680634111376
GO:0035107	appendage morphogenesis	0.026680634111376
GO:0035108	limb morphogenesis	0.026680634111376
GO:0044271	nitrogen compound biosynthetic process	0.026680634111376
GO:0048869	cellular developmental process	0.026680634111376
GO:0030154	cell differentiation	0.026680634111376
GO:0060173	limb development	0.026680634111376
GO:0048736	appendage development	0.026680634111376
GO:0006575	amino acid derivative metabolic process	0.0284484799788564
GO:0001505	regulation of neurotransmitter levels	0.0284484799788564
GO:0001816	cytokine production	0.0308517453939281
GO:0048856	anatomical structure development	0.0308517453939281
GO:0006725	aromatic compound metabolic process	0.034315035247569
GO:0007275	multicellular organismal development	0.0371332501642451
GO:0006417	regulation of translation	0.0382321834006277
GO:0031326	regulation of cellular biosynthetic process	0.0397928047893852
GO:0046914	transition metal ion binding	0.0400064471977561
GO:0003002	regionalization	0.0405438248376606
GO:0009889	regulation of biosynthetic process	0.0419776548845426
GO:0016563	transcription activator activity	0.0473309004601403
GO:0007268	synaptic transmission	0.0492356523214464
GO:0007283	spermatogenesis	0.0492356523214464
GO:0048232	male gamete generation	0.0492356523214464
GO:0048598	embryonic morphogenesis	0.0499103697559423

Relative expression of the co-expression cluster over median <br>Analyst:

---

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}