MCL coexpression mm9:49
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0007049 | cell cycle | 0 |
GO:0022402 | cell cycle process | 0 |
GO:0006259 | DNA metabolic process | 2.0066440102997e-72 |
GO:0051301 | cell division | 7.33282191702005e-54 |
GO:0022403 | cell cycle phase | 4.48962712688836e-52 |
GO:0000279 | M phase | 3.99935061471844e-51 |
GO:0007067 | mitosis | 2.24275299020316e-48 |
GO:0000087 | M phase of mitotic cell cycle | 2.6139251063463e-48 |
GO:0000278 | mitotic cell cycle | 3.0903794168841e-47 |
GO:0005634 | nucleus | 1.31574129279882e-44 |
GO:0043228 | non-membrane-bound organelle | 3.62789020569374e-38 |
GO:0043232 | intracellular non-membrane-bound organelle | 3.62789020569374e-38 |
GO:0005694 | chromosome | 2.73639652843954e-31 |
GO:0000775 | chromosome, pericentric region | 5.86275135327594e-28 |
GO:0044427 | chromosomal part | 1.25811238265441e-26 |
GO:0044446 | intracellular organelle part | 4.67000487441161e-26 |
GO:0044422 | organelle part | 6.36693669893789e-26 |
GO:0005622 | intracellular | 3.87474890885439e-21 |
GO:0005524 | ATP binding | 5.75558088975734e-21 |
GO:0032559 | adenyl ribonucleotide binding | 1.42775164948528e-20 |
GO:0043229 | intracellular organelle | 3.9752282759242e-20 |
GO:0043226 | organelle | 4.12658593626287e-20 |
GO:0030554 | adenyl nucleotide binding | 4.92816079479252e-19 |
GO:0043231 | intracellular membrane-bound organelle | 2.15263462417784e-18 |
GO:0043227 | membrane-bound organelle | 2.25723314393277e-18 |
GO:0006996 | organelle organization and biogenesis | 2.61782255834896e-18 |
GO:0044424 | intracellular part | 1.95278787773504e-17 |
GO:0006974 | response to DNA damage stimulus | 5.70886503420649e-17 |
GO:0007059 | chromosome segregation | 1.23509887485781e-16 |
GO:0009719 | response to endogenous stimulus | 3.38060137458985e-16 |
GO:0006260 | DNA replication | 6.20957710442414e-16 |
GO:0006281 | DNA repair | 1.5559948958736e-15 |
GO:0015630 | microtubule cytoskeleton | 6.80095258553291e-15 |
GO:0000166 | nucleotide binding | 2.48940826139709e-14 |
GO:0032555 | purine ribonucleotide binding | 3.64611390716958e-14 |
GO:0032553 | ribonucleotide binding | 3.64611390716958e-14 |
GO:0017076 | purine nucleotide binding | 3.75623064213396e-13 |
GO:0005874 | microtubule | 4.0060337995512e-13 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 8.57337346481312e-13 |
GO:0043283 | biopolymer metabolic process | 5.4862900078687e-12 |
GO:0000776 | kinetochore | 2.16861101922964e-11 |
GO:0006950 | response to stress | 1.21281426340099e-10 |
GO:0007017 | microtubule-based process | 1.73465048010574e-10 |
GO:0051726 | regulation of cell cycle | 2.65381892658252e-10 |
GO:0044430 | cytoskeletal part | 3.28416762428007e-10 |
GO:0003777 | microtubule motor activity | 3.49576078580517e-10 |
GO:0003677 | DNA binding | 4.06809715702429e-10 |
GO:0030261 | chromosome condensation | 5.57455300557826e-10 |
GO:0051276 | chromosome organization and biogenesis | 1.01343828165011e-09 |
GO:0005875 | microtubule associated complex | 3.20229939905323e-09 |
GO:0007076 | mitotic chromosome condensation | 1.56785524866687e-08 |
GO:0005819 | spindle | 2.9656399349531e-08 |
GO:0005856 | cytoskeleton | 3.58391702090341e-08 |
GO:0000793 | condensed chromosome | 9.8933311964885e-08 |
GO:0000070 | mitotic sister chromatid segregation | 1.00479356106137e-07 |
GO:0000819 | sister chromatid segregation | 1.00479356106137e-07 |
GO:0000074 | regulation of progression through cell cycle | 1.84164004401226e-07 |
GO:0043170 | macromolecule metabolic process | 4.99397228388735e-07 |
GO:0003676 | nucleic acid binding | 8.74710269684077e-07 |
GO:0007018 | microtubule-based movement | 1.09365486512051e-06 |
GO:0016043 | cellular component organization and biogenesis | 1.76758584232405e-06 |
GO:0043234 | protein complex | 2.61166700201745e-06 |
GO:0004386 | helicase activity | 3.86890102053962e-06 |
GO:0030705 | cytoskeleton-dependent intracellular transport | 4.37075803856758e-06 |
GO:0051327 | M phase of meiotic cell cycle | 4.79978355201302e-06 |
GO:0007126 | meiosis | 4.79978355201302e-06 |
GO:0051321 | meiotic cell cycle | 5.19469652376042e-06 |
GO:0008094 | DNA-dependent ATPase activity | 5.23872588028561e-06 |
GO:0044428 | nuclear part | 9.64054299549575e-06 |
GO:0007010 | cytoskeleton organization and biogenesis | 1.18217196005003e-05 |
GO:0005871 | kinesin complex | 1.69603038091523e-05 |
GO:0006323 | DNA packaging | 2.12441342047488e-05 |
GO:0005657 | replication fork | 2.61714557686475e-05 |
GO:0016568 | chromatin modification | 3.69905362396676e-05 |
GO:0006261 | DNA-dependent DNA replication | 4.33764847554113e-05 |
GO:0006310 | DNA recombination | 5.9939443932324e-05 |
GO:0006270 | DNA replication initiation | 6.74967996762051e-05 |
GO:0045120 | pronucleus | 6.74967996762051e-05 |
GO:0050794 | regulation of cellular process | 6.74967996762051e-05 |
GO:0032991 | macromolecular complex | 6.81472500710803e-05 |
GO:0006325 | establishment and/or maintenance of chromatin architecture | 8.00280475170027e-05 |
GO:0044238 | primary metabolic process | 0.000114197007027286 |
GO:0044237 | cellular metabolic process | 0.000134975286361835 |
GO:0007098 | centrosome cycle | 0.000253477040318315 |
GO:0044454 | nuclear chromosome part | 0.000347204849998549 |
GO:0003684 | damaged DNA binding | 0.000347204849998549 |
GO:0016538 | cyclin-dependent protein kinase regulator activity | 0.000347204849998549 |
GO:0051297 | centrosome organization and biogenesis | 0.000382218542080462 |
GO:0031023 | microtubule organizing center organization and biogenesis | 0.000563626543198586 |
GO:0042054 | histone methyltransferase activity | 0.000584973007393438 |
GO:0000910 | cytokinesis | 0.000677769979001985 |
GO:0008608 | attachment of spindle microtubules to kinetochore | 0.000720984437635715 |
GO:0000785 | chromatin | 0.000720984437635715 |
GO:0000228 | nuclear chromosome | 0.000743084517195092 |
GO:0050789 | regulation of biological process | 0.000940830586568273 |
GO:0008283 | cell proliferation | 0.000949040521769148 |
GO:0004674 | protein serine/threonine kinase activity | 0.00113885690700605 |
GO:0008276 | protein methyltransferase activity | 0.00191767146350192 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00192284548533968 |
GO:0030496 | midbody | 0.00193872079149924 |
GO:0016728 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | 0.00193872079149924 |
GO:0004748 | ribonucleoside-diphosphate reductase activity | 0.00193872079149924 |
GO:0051298 | centrosome duplication | 0.00193872079149924 |
GO:0051053 | negative regulation of DNA metabolic process | 0.00201371363449296 |
GO:0042770 | DNA damage response, signal transduction | 0.0022735981824686 |
GO:0018024 | histone-lysine N-methyltransferase activity | 0.00356206341490605 |
GO:0016278 | lysine N-methyltransferase activity | 0.00356206341490605 |
GO:0016279 | protein-lysine N-methyltransferase activity | 0.00356206341490605 |
GO:0000777 | condensed chromosome kinetochore | 0.00357383186213541 |
GO:0040020 | regulation of meiosis | 0.00357383186213541 |
GO:0000089 | mitotic metaphase | 0.00357383186213541 |
GO:0005658 | alpha DNA polymerase:primase complex | 0.00357383186213541 |
GO:0043414 | biopolymer methylation | 0.00432319652125231 |
GO:0003678 | DNA helicase activity | 0.00476811600802742 |
GO:0031323 | regulation of cellular metabolic process | 0.00489822149599812 |
GO:0031570 | DNA integrity checkpoint | 0.00545605956193634 |
GO:0032259 | methylation | 0.00545605956193634 |
GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | 0.00564645515964749 |
GO:0051052 | regulation of DNA metabolic process | 0.0062086723863188 |
GO:0017111 | nucleoside-triphosphatase activity | 0.00674402003557085 |
GO:0065007 | biological regulation | 0.0067661355505471 |
GO:0044464 | cell part | 0.00716291626523161 |
GO:0005623 | cell | 0.00716291626523161 |
GO:0004519 | endonuclease activity | 0.00768737655136651 |
GO:0051323 | metaphase | 0.0078724945639034 |
GO:0010369 | chromocenter | 0.0078724945639034 |
GO:0000779 | condensed chromosome, pericentric region | 0.0078724945639034 |
GO:0042623 | ATPase activity, coupled | 0.00793641549025517 |
GO:0004672 | protein kinase activity | 0.00843544640443569 |
GO:0006333 | chromatin assembly or disassembly | 0.00889792336539769 |
GO:0016462 | pyrophosphatase activity | 0.00948026668182306 |
GO:0004518 | nuclease activity | 0.00948026668182306 |
GO:0019222 | regulation of metabolic process | 0.00948039777244114 |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.00984817039746807 |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 0.00989959760523752 |
GO:0010468 | regulation of gene expression | 0.00989959760523752 |
GO:0007405 | neuroblast proliferation | 0.0102420167467546 |
GO:0000075 | cell cycle checkpoint | 0.0102420167467546 |
GO:0006350 | transcription | 0.0115599414788777 |
GO:0000724 | double-strand break repair via homologous recombination | 0.0129332798457672 |
GO:0000725 | recombinational repair | 0.0129332798457672 |
GO:0042393 | histone binding | 0.0129332798457672 |
GO:0008156 | negative regulation of DNA replication | 0.0129332798457672 |
GO:0051651 | maintenance of cellular localization | 0.0129332798457672 |
GO:0003682 | chromatin binding | 0.0130755390969123 |
GO:0045449 | regulation of transcription | 0.0135583869660049 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0150766306164611 |
GO:0019887 | protein kinase regulator activity | 0.0150766306164611 |
GO:0001824 | blastocyst development | 0.0150766306164611 |
GO:0043601 | nuclear replisome | 0.0150766306164611 |
GO:0005876 | spindle microtubule | 0.0150766306164611 |
GO:0006268 | DNA unwinding during replication | 0.0150766306164611 |
GO:0032508 | DNA duplex unwinding | 0.0150766306164611 |
GO:0030894 | replisome | 0.0150766306164611 |
GO:0007140 | male meiosis | 0.0150766306164611 |
GO:0000922 | spindle pole | 0.0150766306164611 |
GO:0032392 | DNA geometric change | 0.0150766306164611 |
GO:0018105 | peptidyl-serine phosphorylation | 0.0150766306164611 |
GO:0018209 | peptidyl-serine modification | 0.0150766306164611 |
GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0152057036345092 |
GO:0016887 | ATPase activity | 0.0161586016235131 |
GO:0032774 | RNA biosynthetic process | 0.0168676325667711 |
GO:0008170 | N-methyltransferase activity | 0.0175595855609345 |
GO:0043596 | nuclear replication fork | 0.0179934764524165 |
GO:0004520 | endodeoxyribonuclease activity | 0.0179934764524165 |
GO:0004003 | ATP-dependent DNA helicase activity | 0.0179934764524165 |
GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 0.020191058761672 |
GO:0006275 | regulation of DNA replication | 0.0216142127403844 |
GO:0000792 | heterochromatin | 0.0217666916227282 |
GO:0045786 | negative regulation of progression through cell cycle | 0.0222811623518706 |
GO:0016569 | covalent chromatin modification | 0.0232689624267824 |
GO:0019207 | kinase regulator activity | 0.0239489736563508 |
GO:0006730 | one-carbon compound metabolic process | 0.0274159640499316 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.0274177856365633 |
GO:0046907 | intracellular transport | 0.028670491613808 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0289777416022248 |
GO:0051325 | interphase | 0.0298421130667059 |
GO:0051329 | interphase of mitotic cell cycle | 0.0298421130667059 |
GO:0008026 | ATP-dependent helicase activity | 0.0302138806081412 |
GO:0005813 | centrosome | 0.0315052879335337 |
GO:0043687 | post-translational protein modification | 0.031639475213507 |
GO:0006351 | transcription, DNA-dependent | 0.0320894327479285 |
GO:0040029 | regulation of gene expression, epigenetic | 0.0331234515049716 |
GO:0031981 | nuclear lumen | 0.0336222035336408 |
GO:0051641 | cellular localization | 0.0338761722539801 |
GO:0006305 | DNA alkylation | 0.0338761722539801 |
GO:0006306 | DNA methylation | 0.0338761722539801 |
GO:0051235 | maintenance of localization | 0.0338761722539801 |
GO:0016571 | histone methylation | 0.0338761722539801 |
GO:0004527 | exonuclease activity | 0.0338761722539801 |
GO:0008017 | microtubule binding | 0.0338761722539801 |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.0338761722539801 |
GO:0031508 | centric heterochromatin formation | 0.0338761722539801 |
GO:0008054 | cyclin catabolic process | 0.0338761722539801 |
GO:0051661 | maintenance of centrosome localization | 0.0338761722539801 |
GO:0021873 | forebrain neuroblast division | 0.0338761722539801 |
GO:0043486 | histone exchange | 0.0338761722539801 |
GO:0045836 | positive regulation of meiosis | 0.0338761722539801 |
GO:0007056 | spindle assembly involved in female meiosis | 0.0338761722539801 |
GO:0051383 | kinetochore organization and biogenesis | 0.0338761722539801 |
GO:0007057 | spindle assembly involved in female meiosis I | 0.0338761722539801 |
GO:0043140 | ATP-dependent 3'-5' DNA helicase activity | 0.0338761722539801 |
GO:0009786 | regulation of asymmetric cell division | 0.0338761722539801 |
GO:0051438 | regulation of ubiquitin-protein ligase activity | 0.0338761722539801 |
GO:0015616 | DNA translocase activity | 0.0338761722539801 |
GO:0051352 | negative regulation of ligase activity | 0.0338761722539801 |
GO:0019046 | reactivation of latent virus | 0.0338761722539801 |
GO:0043138 | 3'-5' DNA helicase activity | 0.0338761722539801 |
GO:0040001 | establishment of mitotic spindle localization | 0.0338761722539801 |
GO:0051642 | centrosome localization | 0.0338761722539801 |
GO:0051440 | regulation of ubiquitin-protein ligase activity during meiotic cell cycle | 0.0338761722539801 |
GO:0048256 | flap endonuclease activity | 0.0338761722539801 |
GO:0043044 | ATP-dependent chromatin remodeling | 0.0338761722539801 |
GO:0051442 | negative regulation of ubiquitin-protein ligase activity during meiotic cell cycle | 0.0338761722539801 |
GO:0043515 | kinetochore binding | 0.0338761722539801 |
GO:0005971 | ribonucleoside-diphosphate reductase complex | 0.0338761722539801 |
GO:0045769 | negative regulation of asymmetric cell division | 0.0338761722539801 |
GO:0051154 | negative regulation of striated muscle cell differentiation | 0.0338761722539801 |
GO:0051444 | negative regulation of ubiquitin-protein ligase activity | 0.0338761722539801 |
GO:0031055 | chromatin remodeling at centromere | 0.0338761722539801 |
GO:0019042 | latent virus infection | 0.0338761722539801 |
GO:0051782 | negative regulation of cell division | 0.0338761722539801 |
GO:0031616 | spindle pole centrosome | 0.0338761722539801 |
GO:0055057 | neuroblast division | 0.0338761722539801 |
GO:0006468 | protein amino acid phosphorylation | 0.0351860676439668 |
GO:0043566 | structure-specific DNA binding | 0.0366444649444473 |
GO:0000077 | DNA damage checkpoint | 0.0383787665238965 |
GO:0016772 | transferase activity, transferring phosphorus-containing groups | 0.0383787665238965 |
GO:0048523 | negative regulation of cellular process | 0.0392138305582723 |
GO:0000795 | synaptonemal complex | 0.0419746203330027 |
GO:0006304 | DNA modification | 0.0419746203330027 |
GO:0004536 | deoxyribonuclease activity | 0.0419746203330027 |
GO:0009892 | negative regulation of metabolic process | 0.04374587211578 |
GO:0005815 | microtubule organizing center | 0.04374587211578 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0458738727126457 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |