MCL coexpression mm9:106
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005615 | extracellular space | 0.0132416920853748 |
| GO:0044421 | extracellular region part | 0.0132416920853748 |
| GO:0004263 | chymotrypsin activity | 0.0322211873847222 |
| GO:0004295 | trypsin activity | 0.0322211873847222 |
| GO:0007507 | heart development | 0.0322211873847222 |
| GO:0002651 | positive regulation of tolerance induction to self antigen | 0.0322211873847222 |
| GO:0002649 | regulation of tolerance induction to self antigen | 0.0322211873847222 |
| GO:0004996 | thyroid-stimulating hormone receptor activity | 0.0322211873847222 |
| GO:0002663 | positive regulation of B cell tolerance induction | 0.0322211873847222 |
| GO:0001880 | Mullerian duct regression | 0.0322211873847222 |
| GO:0002514 | B cell tolerance induction | 0.0322211873847222 |
| GO:0045616 | regulation of keratinocyte differentiation | 0.0322211873847222 |
| GO:0002661 | regulation of B cell tolerance induction | 0.0322211873847222 |
| GO:0045617 | negative regulation of keratinocyte differentiation | 0.0322211873847222 |
| GO:0048382 | mesendoderm development | 0.0322211873847222 |
| GO:0004702 | receptor signaling protein serine/threonine kinase activity | 0.0348346947515786 |
| GO:0030097 | hemopoiesis | 0.0366462529633387 |
| GO:0008283 | cell proliferation | 0.0366462529633387 |
| GO:0009309 | amine biosynthetic process | 0.0366462529633387 |
| GO:0002666 | positive regulation of T cell tolerance induction | 0.0366462529633387 |
| GO:0002643 | regulation of tolerance induction | 0.0366462529633387 |
| GO:0004084 | branched-chain-amino-acid transaminase activity | 0.0366462529633387 |
| GO:0002664 | regulation of T cell tolerance induction | 0.0366462529633387 |
| GO:0002645 | positive regulation of tolerance induction | 0.0366462529633387 |
| GO:0009082 | branched chain family amino acid biosynthetic process | 0.0366462529633387 |
| GO:0002517 | T cell tolerance induction | 0.0366462529633387 |
| GO:0040012 | regulation of locomotion | 0.0366462529633387 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0366462529633387 |
| GO:0048518 | positive regulation of biological process | 0.0366462529633387 |
| GO:0002520 | immune system development | 0.0426192840597251 |
| GO:0060033 | anatomical structure regression | 0.0452589307795212 |
| GO:0002513 | tolerance induction to self antigen | 0.0452589307795212 |
| GO:0044271 | nitrogen compound biosynthetic process | 0.0455018767054064 |
| GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 0.0459508849158139 |
| GO:0007411 | axon guidance | 0.0459508849158139 |
| GO:0005057 | receptor signaling protein activity | 0.0459508849158139 |
| GO:0002507 | tolerance induction | 0.0459508849158139 |
| GO:0009950 | dorsal/ventral axis specification | 0.0459508849158139 |
| GO:0051138 | positive regulation of NK T cell differentiation | 0.0459508849158139 |
| GO:0001865 | NK T cell differentiation | 0.0459508849158139 |
| GO:0042416 | dopamine biosynthetic process | 0.0459508849158139 |
| GO:0051136 | regulation of NK T cell differentiation | 0.0459508849158139 |
| GO:0005102 | receptor binding | 0.0463596873818624 |
| GO:0030098 | lymphocyte differentiation | 0.0495436465649074 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| embryonic uterus | 1.60e-49 | 4 |
| uterus | 1.60e-49 | 4 |
| internal female genitalia | 7.27e-40 | 5 |
| female reproductive organ | 2.39e-25 | 8 |
| uterus or analog | 3.06e-23 | 1 |
| internal genitalia | 1.19e-22 | 9 |
| female reproductive system | 1.19e-22 | 9 |
| female organism | 1.00e-18 | 11 |
| placenta | 3.12e-12 | 2 |
| chorion | 3.12e-12 | 2 |
| allantois | 3.12e-12 | 2 |
| reproductive organ | 4.35e-09 | 24 |
| extraembryonic membrane | 1.34e-08 | 3 |
| extraembryonic structure | 1.34e-08 | 3 |
| membranous layer | 1.34e-08 | 3 |
| reproductive structure | 1.87e-08 | 26 |
| reproductive system | 1.87e-08 | 26 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
