Coexpression cluster:C173
From FANTOM5_SSTAR
Full id: C173_Adipocyte_mature_skin_left_Hepatocyte_Osteoblast_adipose
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0032787 | monocarboxylic acid metabolic process | 1.73275744464493e-05 |
GO:0006629 | lipid metabolic process | 3.68303076272497e-05 |
GO:0006090 | pyruvate metabolic process | 0.000158056992643084 |
GO:0006631 | fatty acid metabolic process | 0.00093611946455349 |
GO:0044255 | cellular lipid metabolic process | 0.00093611946455349 |
GO:0019752 | carboxylic acid metabolic process | 0.00093611946455349 |
GO:0006082 | organic acid metabolic process | 0.00093611946455349 |
GO:0005737 | cytoplasm | 0.00274374696519734 |
GO:0008610 | lipid biosynthetic process | 0.00388723994990565 |
GO:0044444 | cytoplasmic part | 0.00524267132803325 |
GO:0006094 | gluconeogenesis | 0.00547635957551173 |
GO:0015758 | glucose transport | 0.00661975714474225 |
GO:0005975 | carbohydrate metabolic process | 0.00661975714474225 |
GO:0008645 | hexose transport | 0.00661975714474225 |
GO:0015749 | monosaccharide transport | 0.00661975714474225 |
GO:0019319 | hexose biosynthetic process | 0.00738804011175958 |
GO:0006006 | glucose metabolic process | 0.00738804011175958 |
GO:0046165 | alcohol biosynthetic process | 0.00738804011175958 |
GO:0046364 | monosaccharide biosynthetic process | 0.00738804011175958 |
GO:0005783 | endoplasmic reticulum | 0.00763820596210189 |
GO:0044262 | cellular carbohydrate metabolic process | 0.00763820596210189 |
GO:0000250 | lanosterol synthase activity | 0.0119816319321794 |
GO:0031559 | oxidosqualene cyclase activity | 0.0119816319321794 |
GO:0015755 | fructose transport | 0.0119816319321794 |
GO:0005967 | mitochondrial pyruvate dehydrogenase complex | 0.0119816319321794 |
GO:0019318 | hexose metabolic process | 0.0143270588232775 |
GO:0005996 | monosaccharide metabolic process | 0.0145494156568869 |
GO:0009058 | biosynthetic process | 0.0178195177213405 |
GO:0006633 | fatty acid biosynthetic process | 0.017823864636361 |
GO:0045254 | pyruvate dehydrogenase complex | 0.018714962284046 |
GO:0003989 | acetyl-CoA carboxylase activity | 0.018714962284046 |
GO:0045721 | negative regulation of gluconeogenesis | 0.018714962284046 |
GO:0016053 | organic acid biosynthetic process | 0.0196013790796282 |
GO:0046394 | carboxylic acid biosynthetic process | 0.0196013790796282 |
GO:0006694 | steroid biosynthetic process | 0.0218552600591857 |
GO:0004075 | biotin carboxylase activity | 0.0219027833096744 |
GO:0030523 | dihydrolipoamide S-acyltransferase activity | 0.0219027833096744 |
GO:0005353 | fructose transmembrane transporter activity | 0.0219027833096744 |
GO:0006085 | acetyl-CoA biosynthetic process | 0.0219027833096744 |
GO:0004742 | dihydrolipoyllysine-residue acetyltransferase activity | 0.0219027833096744 |
GO:0045912 | negative regulation of carbohydrate metabolic process | 0.0219027833096744 |
GO:0008643 | carbohydrate transport | 0.0260205847257939 |
GO:0006111 | regulation of gluconeogenesis | 0.0260205847257939 |
GO:0016418 | S-acetyltransferase activity | 0.0260205847257939 |
GO:0046326 | positive regulation of glucose import | 0.0260205847257939 |
GO:0004768 | stearoyl-CoA 9-desaturase activity | 0.0260205847257939 |
GO:0005886 | plasma membrane | 0.031762335050145 |
GO:0006066 | alcohol metabolic process | 0.0322854011259591 |
GO:0005813 | centrosome | 0.0322854011259591 |
GO:0005789 | endoplasmic reticulum membrane | 0.0322854011259591 |
GO:0042175 | nuclear envelope-endoplasmic reticulum network | 0.0322854011259591 |
GO:0016421 | CoA carboxylase activity | 0.0322854011259591 |
GO:0045923 | positive regulation of fatty acid metabolic process | 0.0322854011259591 |
GO:0050811 | GABA receptor binding | 0.0322854011259591 |
GO:0043255 | regulation of carbohydrate biosynthetic process | 0.0322854011259591 |
GO:0016051 | carbohydrate biosynthetic process | 0.0322854011259591 |
GO:0005815 | microtubule organizing center | 0.0352497886411914 |
GO:0030135 | coated vesicle | 0.0352497886411914 |
GO:0016885 | ligase activity, forming carbon-carbon bonds | 0.0354666323447513 |
GO:0006109 | regulation of carbohydrate metabolic process | 0.0363860662134483 |
GO:0005869 | dynactin complex | 0.0363860662134483 |
GO:0019217 | regulation of fatty acid metabolic process | 0.0363860662134483 |
GO:0046323 | glucose import | 0.0363860662134483 |
GO:0046324 | regulation of glucose import | 0.0363860662134483 |
GO:0044446 | intracellular organelle part | 0.0363860662134483 |
GO:0044432 | endoplasmic reticulum part | 0.0363860662134483 |
GO:0044422 | organelle part | 0.0363860662134483 |
GO:0016417 | S-acyltransferase activity | 0.0409081858716647 |
GO:0045834 | positive regulation of lipid metabolic process | 0.0409081858716647 |
GO:0004467 | long-chain-fatty-acid-CoA ligase activity | 0.0409081858716647 |
GO:0005811 | lipid particle | 0.0409081858716647 |
GO:0015645 | fatty-acid ligase activity | 0.0409081858716647 |
GO:0030212 | hyaluronan metabolic process | 0.0409081858716647 |
GO:0044424 | intracellular part | 0.0415672940808074 |
GO:0031405 | lipoic acid binding | 0.0415672940808074 |
GO:0009746 | response to hexose stimulus | 0.0415672940808074 |
GO:0050729 | positive regulation of inflammatory response | 0.0415672940808074 |
GO:0009749 | response to glucose stimulus | 0.0415672940808074 |
GO:0031349 | positive regulation of defense response | 0.0415672940808074 |
GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 0.044211523486239 |
GO:0004303 | estradiol 17-beta-dehydrogenase activity | 0.044211523486239 |
GO:0031406 | carboxylic acid binding | 0.049790421721825 |
GO:0004245 | neprilysin activity | 0.049790421721825 |
GO:0009308 | amine metabolic process | 0.049790421721825 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
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