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Coexpression cluster:C176

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Full id: C176_Eosinophils_Neutrophils_Mast_CD14_CD4_Basophils_CD19



Phase1 CAGE Peaks

Hg19::chr10:124768300..124768334,-p1@IKZF5
Hg19::chr10:28821674..28821715,+p2@WAC
Hg19::chr10:32636106..32636150,-p3@EPC1
Hg19::chr10:69644404..69644425,+p1@SIRT1
Hg19::chr10:76586348..76586366,+p1@KAT6B
Hg19::chr10:98592009..98592061,+p1@C10orf12
p1@LCOR
Hg19::chr11:118661828..118661886,-p1@DDX6
Hg19::chr11:13299319..13299424,+p1@ARNTL
Hg19::chr11:65265141..65265306,+p4@MALAT1
Hg19::chr11:9482551..9482580,+p1@ZNF143
Hg19::chr12:132195617..132195648,+p1@SFSWAP
Hg19::chr12:46384334..46384366,-p1@SCAF11
Hg19::chr12:498415..498492,-p1@KDM5A
Hg19::chr12:72057607..72057636,-p1@ZFC3H1
Hg19::chr12:72057639..72057678,-p2@ZFC3H1
Hg19::chr12:76953542..76953561,-p1@OSBPL8
Hg19::chr13:108870714..108870780,+p2@ABHD13
Hg19::chr13:28712299..28712376,+p1@PAN3
Hg19::chr13:41557016..41557041,-p@chr13:41557016..41557041
-
Hg19::chr14:50319482..50319564,-p1@NEMF
Hg19::chr14:58765217..58765301,+p1@ARID4A
Hg19::chr14:70233822..70233868,+p1@SRSF5
Hg19::chr14:73525229..73525260,+p1@RBM25
Hg19::chr15:50716576..50716624,+p1@USP8
Hg19::chr15:68346646..68346665,+p1@PIAS1
Hg19::chr15:72766651..72766680,+p1@ARIH1
Hg19::chr16:3930681..3930721,-p1@CREBBP
Hg19::chr16:9185450..9185516,+p1@C16orf72
Hg19::chr17:29641057..29641079,-p1@EVI2B
Hg19::chr17:34900745..34900821,+p1@GGNBP2
Hg19::chr17:42264322..42264376,+p2@TMUB2
Hg19::chr17:62502399..62502411,-p1@DDX5
Hg19::chr17:7737518..7737579,+p@chr17:7737518..7737579
+
Hg19::chr18:19180606..19180673,-p1@ESCO1
Hg19::chr18:60190226..60190314,+p1@ZCCHC2
Hg19::chr18:72265084..72265143,+p1@ZNF407
Hg19::chr18:9136763..9136852,+p1@ANKRD12
Hg19::chr19:52490043..52490113,-p1@ZNF350
Hg19::chr1:109289279..109289331,+p1@STXBP3
Hg19::chr1:14075903..14075940,+p1@PRDM2
Hg19::chr1:1655723..1655803,-p1@CDK11A
p1@CDK11B
Hg19::chr1:173991434..173991556,-p1@RC3H1
Hg19::chr1:226187013..226187071,-p1@C1orf55
Hg19::chr1:231473578..231473619,-p1@EXOC8
Hg19::chr1:235491462..235491510,-p1@ARID4B
Hg19::chr1:40627038..40627071,+p1@RLF
Hg19::chr1:67395922..67395976,+p2@MIER1
Hg19::chr1:89458415..89458463,-p1@RBMXL1
p2@CCBL2
Hg19::chr20:34330129..34330195,-p1@RBM39
Hg19::chr21:34915337..34915397,+p1@SON
Hg19::chr21:38739111..38739164,+p3@DYRK1A
Hg19::chr21:43430440..43430485,-p1@ZNF295
Hg19::chr22:39101927..39101990,+p1@GTPBP1
Hg19::chr22:41487711..41487798,+p1@EP300
Hg19::chr2:109065634..109065692,+p1@GCC2
Hg19::chr2:109335929..109336002,+p1@RANBP2
Hg19::chr2:136499179..136499228,+p3@UBXN4
Hg19::chr2:149402275..149402341,+p1@EPC2
Hg19::chr2:160568978..160569064,+p1@MARCH7
Hg19::chr2:198299726..198299776,-p1@SF3B1
Hg19::chr2:48133576..48133693,-p@chr2:48133576..48133693
-
Hg19::chr2:86668464..86668529,+p1@KDM3A
Hg19::chr3:135915086..135915144,-p2@MSL2
Hg19::chr3:14693235..14693246,+p3@C3orf19
Hg19::chr3:156877955..156877974,-p2@CCNL1
Hg19::chr3:156877978..156877987,-p3@CCNL1
Hg19::chr3:38206975..38207101,+p1@OXSR1
Hg19::chr3:53381539..53381577,-p1@DCP1A
Hg19::chr3:69101413..69101457,-p1@TMF1
Hg19::chr4:69215699..69215815,-p1@YTHDC1
Hg19::chr5:130970848..130970965,-p1@RAPGEF6
Hg19::chr5:137368726..137368784,-p1@FAM13B
Hg19::chr5:139781393..139781435,+p1@ANKHD1-EIF4EBP3
p1@ANKHD1
Hg19::chr5:142784003..142784065,-p2@NR3C1
Hg19::chr5:172483347..172483407,+p1@C5orf41
Hg19::chr5:176433693..176433812,-p1@UIMC1
Hg19::chr5:36876833..36876894,+p2@NIPBL
Hg19::chr5:36876926..36876994,+p1@NIPBL
Hg19::chr5:39074479..39074515,-p1@RICTOR
Hg19::chr5:56469958..56469966,+p8@GPBP1
Hg19::chr5:86708636..86708665,-p2@CCNH
Hg19::chr5:86708670..86708766,-p1@CCNH
Hg19::chr5:98264581..98264689,-p@chr5:98264581..98264689
-
Hg19::chr6:139456200..139456225,+p2@HECA
Hg19::chr6:155054530..155054561,+p1@SCAF8
Hg19::chr6:160148525..160148576,+p1@WTAP
Hg19::chr6:33378517..33378564,+p3@PHF1
Hg19::chr6:42749679..42749713,+p3@KIAA0240
Hg19::chr6:87865262..87865311,+p1@ZNF292
Hg19::chr7:104653471..104653515,-p1@ENST00000445184
p1@ENST00000450686
Hg19::chr7:104654623..104654669,+p1@MLL5
Hg19::chr7:130792893..130792908,-p2@ENST00000429901
Hg19::chr7:152133620..152133652,-p@chr7:152133620..152133652
-
Hg19::chr7:155437341..155437405,+p1@RBM33
Hg19::chr8:41909496..41909512,-p1@KAT6A
Hg19::chr8:68256003..68256034,-p1@ARFGEF1
Hg19::chr9:135230336..135230398,-p1@SETX
Hg19::chrX:123094564..123094581,+p5@STAG2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016070RNA metabolic process2.04805303337828e-16
GO:0005634nucleus5.91057991685637e-16
GO:0005654nucleoplasm7.36093040758252e-12
GO:0044428nuclear part1.65553376857781e-11
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process1.9791392473282e-11
GO:0043283biopolymer metabolic process7.54138067960235e-11
GO:0006355regulation of transcription, DNA-dependent7.93606534422575e-11
GO:0031981nuclear lumen1.4487896449597e-10
GO:0044451nucleoplasm part1.4487896449597e-10
GO:0006351transcription, DNA-dependent1.4487896449597e-10
GO:0032774RNA biosynthetic process1.4487896449597e-10
GO:0043233organelle lumen1.07378294608341e-09
GO:0031974membrane-enclosed lumen1.07378294608341e-09
GO:0045449regulation of transcription1.20411774222063e-09
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process2.07478549350105e-09
GO:0010467gene expression3.23347342085246e-09
GO:0043231intracellular membrane-bound organelle3.89486616805506e-09
GO:0043227membrane-bound organelle3.89486616805506e-09
GO:0006350transcription4.01781254181114e-09
GO:0010468regulation of gene expression5.09781748222147e-09
GO:0016607nuclear speck5.39835757687086e-09
GO:0044424intracellular part5.58612787508296e-09
GO:0031323regulation of cellular metabolic process1.12509981391023e-08
GO:0003677DNA binding2.93357379289555e-08
GO:0016604nuclear body2.93357379289555e-08
GO:0019222regulation of metabolic process6.3952309874976e-08
GO:0003676nucleic acid binding1.00348876840398e-07
GO:0050794regulation of cellular process5.85585363872622e-07
GO:0005622intracellular5.98883247284247e-07
GO:0043229intracellular organelle1.61683472984701e-06
GO:0043226organelle1.61683472984701e-06
GO:0044446intracellular organelle part3.17560673516358e-06
GO:0044422organelle part3.29559932897327e-06
GO:0016071mRNA metabolic process3.98629041141266e-06
GO:0050789regulation of biological process4.84705507682382e-06
GO:0065007biological regulation1.44141419662829e-05
GO:0043170macromolecule metabolic process1.88498361909312e-05
GO:0006325establishment and/or maintenance of chromatin architecture2.78098088741691e-05
GO:0006323DNA packaging2.98809127512521e-05
GO:0006259DNA metabolic process4.37513673725924e-05
GO:0016568chromatin modification4.47292275502309e-05
GO:0008380RNA splicing5.09901043828198e-05
GO:0051276chromosome organization and biogenesis8.84265175142438e-05
GO:0018076N-terminal peptidyl-lysine acetylation0.000109206058845818
GO:0018394peptidyl-lysine acetylation0.000109206058845818
GO:0008270zinc ion binding0.000122435686528734
GO:0006397mRNA processing0.000136985932640894
GO:0045941positive regulation of transcription0.000151644506336996
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.000181131400730647
GO:0003724RNA helicase activity0.0002380279519532
GO:0044237cellular metabolic process0.000260749868446827
GO:0006366transcription from RNA polymerase II promoter0.000260749868446827
GO:0044238primary metabolic process0.000322919765554256
GO:0006396RNA processing0.000546972447298479
GO:0045893positive regulation of transcription, DNA-dependent0.000577921422521647
GO:0031325positive regulation of cellular metabolic process0.000580837189861837
GO:0006474N-terminal protein amino acid acetylation0.0006005290158013
GO:0009893positive regulation of metabolic process0.000817596507976426
GO:0018205peptidyl-lysine modification0.000992124687775453
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00113536569907426
GO:0017053transcriptional repressor complex0.0011980133531595
GO:0016481negative regulation of transcription0.00177456209167396
GO:0000123histone acetyltransferase complex0.00197189449901821
GO:0016573histone acetylation0.00197189449901821
GO:0018409peptide or protein amino-terminal blocking0.00226235410115885
GO:0046914transition metal ion binding0.00239710015130057
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.00250271221666721
GO:0003723RNA binding0.00356557517576573
GO:0031365N-terminal protein amino acid modification0.00356557517576573
GO:0005515protein binding0.00362308024683212
GO:0006473protein amino acid acetylation0.00467267787776979
GO:0000184mRNA catabolic process, nonsense-mediated decay0.00467267787776979
GO:0016564transcription repressor activity0.00478296814858988
GO:0031324negative regulation of cellular metabolic process0.00505553640616498
GO:0004468lysine N-acetyltransferase activity0.00629279275980798
GO:0004402histone acetyltransferase activity0.00629279275980798
GO:0045814negative regulation of gene expression, epigenetic0.00672036348106831
GO:0006887exocytosis0.00746455895371333
GO:0006357regulation of transcription from RNA polymerase II promoter0.00753245338880945
GO:0006402mRNA catabolic process0.00805062666196582
GO:0009892negative regulation of metabolic process0.00839215155288564
GO:0003682chromatin binding0.00846323818811058
GO:0043543protein amino acid acylation0.00886539050646993
GO:0018193peptidyl-amino acid modification0.00887745789516632
GO:0043425bHLH transcription factor binding0.00978168405706219
GO:0051577MyoD binding0.00978168405706219
GO:0043426MRF binding0.00978168405706219
GO:0004883glucocorticoid receptor activity0.00978168405706219
GO:0031932TORC 2 complex0.00978168405706219
GO:0004386helicase activity0.0100200006009732
GO:0044464cell part0.0104811135956777
GO:0006950response to stress0.0111099691207288
GO:0048522positive regulation of cellular process0.0111447540751904
GO:0016043cellular component organization and biogenesis0.0114322406403173
GO:0006996organelle organization and biogenesis0.011529206903564
GO:0003712transcription cofactor activity0.0128320861573194
GO:0016563transcription activator activity0.0137873544696713
GO:0031965nuclear membrane0.0142219074408801
GO:0030323respiratory tube development0.0142219074408801
GO:0043687post-translational protein modification0.014700746057638
GO:0006401RNA catabolic process0.0159192083747378
GO:0006464protein modification process0.0164906416690819
GO:0042975peroxisome proliferator activated receptor binding0.0164906416690819
GO:0051896regulation of protein kinase B signaling cascade0.0164906416690819
GO:0016570histone modification0.0164906416690819
GO:0001666response to hypoxia0.0164906416690819
GO:0006512ubiquitin cycle0.0171365002087408
GO:0048518positive regulation of biological process0.0173445567288284
GO:0016569covalent chromatin modification0.0173730484453595
GO:0009952anterior/posterior pattern formation0.0207410997161865
GO:0008026ATP-dependent helicase activity0.0217252221298926
GO:0007049cell cycle0.0217252221298926
GO:0003713transcription coactivator activity0.022472748674848
GO:0007243protein kinase cascade0.0233284123103522
GO:0043412biopolymer modification0.0233284123103522
GO:0005635nuclear envelope0.0240200551782881
GO:0006281DNA repair0.0262042156577
GO:0040029regulation of gene expression, epigenetic0.0265266456191394
GO:0045892negative regulation of transcription, DNA-dependent0.0265266456191394
GO:0007519skeletal muscle development0.0276633383013126
GO:0003700transcription factor activity0.0283948889122752
GO:0005667transcription factor complex0.0283948889122752
GO:0000377RNA splicing, via transesterification reactions with bulged adenosine as nucleophile0.0289101437357237
GO:0000398nuclear mRNA splicing, via spliceosome0.0289101437357237
GO:0000375RNA splicing, via transesterification reactions0.0289101437357237
GO:0008080N-acetyltransferase activity0.0310977097245966
GO:0008134transcription factor binding0.0331028901367043
GO:0043491protein kinase B signaling cascade0.0331028901367043
GO:0017016Ras GTPase binding0.0331496531642673
GO:0006974response to DNA damage stimulus0.0367141147123424
GO:0045045secretory pathway0.0374313327026615
GO:0043285biopolymer catabolic process0.0378322604307343
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex0.0382270460094718
GO:0031267small GTPase binding0.038589881052216
GO:0003002regionalization0.0392664956444353
GO:0016407acetyltransferase activity0.0392664956444353
GO:0008415acyltransferase activity0.0392664956444353
GO:0014706striated muscle development0.0395550349984727
GO:0016747transferase activity, transferring groups other than amino-acyl groups0.0395550349984727
GO:0016410N-acyltransferase activity0.0400757210967511
GO:0006359regulation of transcription from RNA polymerase III promoter0.0417907099392139
GO:0051020GTPase binding0.0465388385645271
GO:0031532actin cytoskeleton reorganization0.0467486869842573
GO:0017022myosin binding0.0467486869842573
GO:0006333chromatin assembly or disassembly0.0474676277540671



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

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