Coexpression cluster:C779

Full id: C779_testis_medial_occipital_brain_temporal_postcentral_insula

Phase1 CAGE Peaks

Hg19::chr10:134145640..134145724,+	p1@LRRC27
Hg19::chr11:72504681..72504716,-	p6@STARD10
Hg19::chr11:73882263..73882276,+	p5@PPME1
Hg19::chr11:73882283..73882309,+	p3@PPME1
Hg19::chr12:121341939..121341985,-	p3@SPPL3
Hg19::chr12:50101500..50101550,+	p23@TMBIM6
Hg19::chr13:37006398..37006417,+	p5@CCNA1
Hg19::chr14:105767100..105767153,+	p3@PACS2
Hg19::chr15:33486929..33486977,-	p5@FMN1
Hg19::chr9:34665983..34666063,-	p1@ENST00000416454 p1@ENST00000421828 p1@ENST00000544078 p1@ENST00000556719

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0051722	protein C-terminal methylesterase activity	0.00735856827869091
GO:0051723	protein methylesterase activity	0.00735856827869091
GO:0006482	protein amino acid demethylation	0.00735856827869091
GO:0008214	protein amino acid dealkylation	0.00735856827869091
GO:0007141	male meiosis I	0.00882976206266084
GO:0051721	protein phosphatase 2A binding	0.00981026913500083
GO:0007140	male meiosis	0.0147128048027599
GO:0019903	protein phosphatase binding	0.0312463083769772
GO:0019902	phosphatase binding	0.0359328864606653
GO:0004864	protein phosphatase inhibitor activity	0.0428416640546203
GO:0019212	phosphatase inhibitor activity	0.0428416640546203
GO:0008601	protein phosphatase type 2A regulator activity	0.0428416640546203

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.