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MCL coexpression mm9:1287

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:48805759..48805781,-p3@Tgtp1
p3@Tgtp2
Mm9::chr2:167766298..167766302,+p@chr2:167766298..167766302
+
Mm9::chr4:149075690..149075711,-p2@Pik3cd
Mm9::chr5:122683421..122683445,+p@chr5:122683421..122683445
+
Mm9::chr8:90812977..90812990,+p8@Adcy7
Mm9::chrX:50113602..50113611,+p@chrX:50113602..50113611
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0019932second-messenger-mediated signaling0.0041889307110198
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity0.0101825686755877
GO:0046854phosphoinositide phosphorylation0.0101825686755877
GO:0035004phosphoinositide 3-kinase activity0.0101825686755877
GO:00163031-phosphatidylinositol-3-kinase activity0.0101825686755877
GO:0005942phosphoinositide 3-kinase complex0.0101825686755877
GO:0001782B cell homeostasis0.0101825686755877
GO:0046834lipid phosphorylation0.0101825686755877
GO:0004016adenylate cyclase activity0.0101825686755877
GO:0007190adenylate cyclase activation0.0101825686755877
GO:0031281positive regulation of cyclase activity0.0101825686755877
GO:0051349positive regulation of lyase activity0.0101825686755877
GO:0045762positive regulation of adenylate cyclase activity0.0101825686755877
GO:0045761regulation of adenylate cyclase activity0.0101825686755877
GO:0006171cAMP biosynthetic process0.0101825686755877
GO:0031279regulation of cyclase activity0.0101825686755877
GO:0051339regulation of lyase activity0.0101825686755877
GO:0002260lymphocyte homeostasis0.0101825686755877
GO:0046058cAMP metabolic process0.0101825686755877
GO:0001727lipid kinase activity0.0101825686755877
GO:0009975cyclase activity0.0101825686755877
GO:0016849phosphorus-oxygen lyase activity0.0101825686755877
GO:0030258lipid modification0.0101825686755877
GO:0001776leukocyte homeostasis0.0101825686755877
GO:0007242intracellular signaling cascade0.0101825686755877
GO:0009190cyclic nucleotide biosynthetic process0.0101825686755877
GO:0048872homeostasis of number of cells0.0101825686755877
GO:0004428inositol or phosphatidylinositol kinase activity0.0101825686755877
GO:0007189G-protein signaling, adenylate cyclase activating pathway0.0122869486827826
GO:0009187cyclic nucleotide metabolic process0.0125554027972597
GO:0048015phosphoinositide-mediated signaling0.0139948906204137
GO:0030384phosphoinositide metabolic process0.0139948906204137
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.016860093186008
GO:0006650glycerophospholipid metabolic process0.016860093186008
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.016860093186008
GO:0019933cAMP-mediated signaling0.0169560597719931
GO:0019935cyclic-nucleotide-mediated signaling0.0173212513502202
GO:0042113B cell activation0.0227412066789144
GO:0044445cytosolic part0.0244981950385326
GO:0006644phospholipid metabolic process0.0294582099803791
GO:0009165nucleotide biosynthetic process0.0302212702873356
GO:0043085positive regulation of catalytic activity0.0323928369149597
GO:0006643membrane lipid metabolic process0.0350565684588753
GO:0016829lyase activity0.0350565684588753
GO:0007166cell surface receptor linked signal transduction0.0374638801911031
GO:0009117nucleotide metabolic process0.0398981395349427
GO:0046649lymphocyte activation0.0407661960117566
GO:0055086nucleobase, nucleoside and nucleotide metabolic process0.040967261749857
GO:0045321leukocyte activation0.0425994543014596
GO:0001775cell activation0.0447688215167534



Relative expression of the co-expression cluster over median <br>Analyst:



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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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