MCL coexpression mm9:2236

Phase1 CAGE Peaks

	Short description
Mm9::chr18:36675421..36675441,-	p1@Hbegf
Mm9::chr2:157252140..157252163,+	p@chr2:157252140..157252163 +
Mm9::chr4:140857143..140857165,+	p1@Epha2
Mm9::chr4:140857174..140857191,+	p2@Epha2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.00445576646397867
GO:0051547	regulation of keratinocyte migration	0.00445576646397867
GO:0051549	positive regulation of keratinocyte migration	0.00445576646397867
GO:0007167	enzyme linked receptor protein signaling pathway	0.00445576646397867
GO:0035313	wound healing, spreading of epidermal cells	0.00445576646397867
GO:0051546	keratinocyte migration	0.00445576646397867
GO:0048660	regulation of smooth muscle cell proliferation	0.00501259994799517
GO:0048661	positive regulation of smooth muscle cell proliferation	0.00501259994799517
GO:0048013	ephrin receptor signaling pathway	0.00594069644327627
GO:0048659	smooth muscle cell proliferation	0.00668310040004472
GO:0005154	epidermal growth factor receptor binding	0.0085052980762432
GO:0007173	epidermal growth factor receptor signaling pathway	0.0115815017255876
GO:0033002	muscle cell proliferation	0.0115815017255876
GO:0001832	blastocyst growth	0.0115815017255876
GO:0030335	positive regulation of cell migration	0.0115815017255876
GO:0005003	ephrin receptor activity	0.011692541896481
GO:0051272	positive regulation of cell motility	0.0118774867822091
GO:0040017	positive regulation of locomotion	0.0118774867822091
GO:0001824	blastocyst development	0.0217924773575434
GO:0008016	regulation of heart contraction	0.0240387276318145
GO:0060047	heart contraction	0.0267038382121677
GO:0003015	heart process	0.0267038382121677
GO:0048589	developmental growth	0.0278618177049497
GO:0030334	regulation of cell migration	0.0289228106436236
GO:0008201	heparin binding	0.0300261630548748
GO:0051270	regulation of cell motility	0.0300261630548748
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0300261630548748
GO:0040012	regulation of locomotion	0.0300261630548748
GO:0019199	transmembrane receptor protein kinase activity	0.0318460985768946
GO:0048731	system development	0.0318460985768946
GO:0005539	glycosaminoglycan binding	0.0318460985768946
GO:0042060	wound healing	0.0327396349799411
GO:0030247	polysaccharide binding	0.0327396349799411
GO:0001871	pattern binding	0.0333422625437847
GO:0008015	blood circulation	0.0351849469234926
GO:0003013	circulatory system process	0.0351849469234926
GO:0048856	anatomical structure development	0.0358607299173444
GO:0005615	extracellular space	0.0373803585216228
GO:0001701	in utero embryonic development	0.0398940445984346
GO:0044421	extracellular region part	0.0398940445984346
GO:0007275	multicellular organismal development	0.0405409865804409
GO:0001525	angiogenesis	0.042809770135942
GO:0008083	growth factor activity	0.0461327160541062
GO:0004713	protein-tyrosine kinase activity	0.047494422583449
GO:0007166	cell surface receptor linked signal transduction	0.0491461654119847
GO:0048514	blood vessel morphogenesis	0.0498176652640601
GO:0008284	positive regulation of cell proliferation	0.0498176652640601

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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