MCL coexpression mm9:3521

Phase1 CAGE Peaks

	Short description
Mm9::chr5:64551446..64551459,+	p6@LOC677502 p8@Tbc1d1
Mm9::chr5:64551466..64551509,+	p1@LOC677502 p2@Tbc1d1
Mm9::chr5:64551510..64551535,+	p3@LOC677502 p5@Tbc1d1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032313	regulation of Rab GTPase activity	0.012293869500904
GO:0032482	Rab protein signal transduction	0.012293869500904
GO:0032483	regulation of Rab protein signal transduction	0.012293869500904
GO:0005097	Rab GTPase activator activity	0.012293869500904
GO:0032318	regulation of Ras GTPase activity	0.012293869500904
GO:0005099	Ras GTPase activator activity	0.0145912087510729
GO:0043087	regulation of GTPase activity	0.0170304685726808
GO:0046578	regulation of Ras protein signal transduction	0.0216360640400524
GO:0051336	regulation of hydrolase activity	0.0216360640400524
GO:0051056	regulation of small GTPase mediated signal transduction	0.0216360640400524
GO:0007265	Ras protein signal transduction	0.0216360640400524
GO:0005083	small GTPase regulator activity	0.0216360640400524
GO:0005096	GTPase activator activity	0.0216360640400524
GO:0008047	enzyme activator activity	0.0268762082162619
GO:0050790	regulation of catalytic activity	0.0330385488182188
GO:0030695	GTPase regulator activity	0.0330385488182188
GO:0065009	regulation of a molecular function	0.0330385488182188
GO:0009966	regulation of signal transduction	0.0330385488182188
GO:0007264	small GTPase mediated signal transduction	0.0330385488182188

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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