MCL coexpression mm9:1092

Phase1 CAGE Peaks

	Short description
Mm9::chr11:85644728..85644768,+	p@chr11:85644728..85644768 +
Mm9::chr11:85645796..85645812,-	p1@ENSMUST00000136117 p1@uc007krx.1 p1@uc007kry.1
Mm9::chr11:85646263..85646278,+	p2@Tbx2
Mm9::chr11:85646303..85646329,+	p1@Tbx2
Mm9::chr11:85646341..85646352,+	p3@Tbx2
Mm9::chr11:85646427..85646451,+	p4@Tbx2
Mm9::chr11:85646469..85646488,+	p5@Tbx2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007521	muscle cell fate determination	0.00427327014737304
GO:0042693	muscle cell fate commitment	0.00427327014737304
GO:0048738	cardiac muscle development	0.0128198104421191
GO:0007569	cell aging	0.0138881279789624
GO:0030879	mammary gland development	0.0170930805894921
GO:0001709	cell fate determination	0.0170930805894921
GO:0007568	aging	0.0170930805894921
GO:0003007	heart morphogenesis	0.0181613981263354
GO:0042692	muscle cell differentiation	0.0299128910316112
GO:0048732	gland development	0.0316221990905605
GO:0045165	cell fate commitment	0.038847910430664
GO:0014706	striated muscle development	0.0434449131649592
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	0.0454034953158385
GO:0016564	transcription repressor activity	0.0454034953158385
GO:0007517	muscle development	0.0454034953158385
GO:0007507	heart development	0.0454034953158385
GO:0045892	negative regulation of transcription, DNA-dependent	0.0470059716211034

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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