Coexpression cluster:C356
From FANTOM5_SSTAR
Full id: C356_renal_Smooth_Chondrocyte_thyroid_serous_Small_mesenchymal
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 1.74727516305728e-06 | 0.00110602517821526 | 3 | 71 | PPAR signaling pathway (KEGG):03320 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042127 | regulation of cell proliferation | 0.0151338388640772 |
| GO:0001525 | angiogenesis | 0.0151338388640772 |
| GO:0048514 | blood vessel morphogenesis | 0.0151338388640772 |
| GO:0008283 | cell proliferation | 0.0151338388640772 |
| GO:0048646 | anatomical structure formation | 0.0151338388640772 |
| GO:0009967 | positive regulation of signal transduction | 0.0151338388640772 |
| GO:0001568 | blood vessel development | 0.0151338388640772 |
| GO:0001944 | vasculature development | 0.0151338388640772 |
| GO:0005155 | epidermal growth factor receptor activating ligand activity | 0.0151338388640772 |
| GO:0050840 | extracellular matrix binding | 0.0151338388640772 |
| GO:0005172 | vascular endothelial growth factor receptor binding | 0.0151338388640772 |
| GO:0045741 | positive regulation of epidermal growth factor receptor activity | 0.0151338388640772 |
| GO:0004768 | stearoyl-CoA 9-desaturase activity | 0.0151338388640772 |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 0.0151338388640772 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0155861889547463 |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 0.0165509309304655 |
| GO:0008284 | positive regulation of cell proliferation | 0.0168920544335655 |
| GO:0001948 | glycoprotein binding | 0.0176415992128267 |
| GO:0008083 | growth factor activity | 0.0176415992128267 |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | 0.0176415992128267 |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 0.0176415992128267 |
| GO:0050930 | induction of positive chemotaxis | 0.0176415992128267 |
| GO:0007176 | regulation of epidermal growth factor receptor activity | 0.0176415992128267 |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0176415992128267 |
| GO:0005154 | epidermal growth factor receptor binding | 0.0176415992128267 |
| GO:0048531 | beta-1,3-galactosyltransferase activity | 0.0176415992128267 |
| GO:0050926 | regulation of positive chemotaxis | 0.0176415992128267 |
| GO:0050927 | positive regulation of positive chemotaxis | 0.0176415992128267 |
| GO:0050918 | positive chemotaxis | 0.0176415992128267 |
| GO:0004708 | MAP kinase kinase activity | 0.0176415992128267 |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 0.0176415992128267 |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 0.0176415992128267 |
| GO:0050921 | positive regulation of chemotaxis | 0.0176415992128267 |
| GO:0050920 | regulation of chemotaxis | 0.0176415992128267 |
| GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 0.0176415992128267 |
| GO:0045840 | positive regulation of mitosis | 0.0176415992128267 |
| GO:0009887 | organ morphogenesis | 0.0181039866972444 |
| GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 0.0181039866972444 |
| GO:0035250 | UDP-galactosyltransferase activity | 0.0230579040204921 |
| GO:0050679 | positive regulation of epithelial cell proliferation | 0.023220920115621 |
| GO:0001570 | vasculogenesis | 0.023220920115621 |
| GO:0045787 | positive regulation of progression through cell cycle | 0.0302053811995919 |
| GO:0031177 | phosphopantetheine binding | 0.0324452868894586 |
| GO:0005615 | extracellular space | 0.0324452868894586 |
| GO:0050678 | regulation of epithelial cell proliferation | 0.035217840976197 |
| GO:0005504 | fatty acid binding | 0.035596977264209 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | 0.0360018094262514 |
| GO:0050673 | epithelial cell proliferation | 0.0360018094262514 |
| GO:0042221 | response to chemical stimulus | 0.0360018094262514 |
| GO:0010038 | response to metal ion | 0.0369596962407415 |
| GO:0016020 | membrane | 0.039237620499413 |
| GO:0008378 | galactosyltransferase activity | 0.0405941435874171 |
| GO:0010035 | response to inorganic substance | 0.0418110153633352 |
| GO:0001666 | response to hypoxia | 0.0468701625904609 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br><br>
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
