MCL coexpression mm9:2386

Phase1 CAGE Peaks

	Short description
Mm9::chr3:92377648..92377664,-	p1@Ivl
Mm9::chr3:92377667..92377678,-	p2@Ivl
Mm9::chr3:92377789..92377793,-	p3@Ivl
Mm9::chr5:102193870..102193883,+	p7@Cds1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016024	CDP-diacylglycerol biosynthetic process	0.00361584397085411
GO:0046341	CDP-diacylglycerol metabolic process	0.00361584397085411
GO:0004605	phosphatidate cytidylyltransferase activity	0.00482099322332118
GO:0006651	diacylglycerol biosynthetic process	0.0064269343952206
GO:0046460	neutral lipid biosynthetic process	0.0064269343952206
GO:0046463	acylglycerol biosynthetic process	0.0064269343952206
GO:0046339	diacylglycerol metabolic process	0.0064269343952206
GO:0046504	glycerol ether biosynthetic process	0.0064269343952206
GO:0045017	glycerolipid biosynthetic process	0.0064269343952206
GO:0001533	cornified envelope	0.0121947814690103
GO:0030216	keratinocyte differentiation	0.0121947814690103
GO:0006639	acylglycerol metabolic process	0.0121947814690103
GO:0046486	glycerolipid metabolic process	0.0121947814690103
GO:0006638	neutral lipid metabolic process	0.0121947814690103
GO:0006662	glycerol ether metabolic process	0.0121947814690103
GO:0031424	keratinization	0.0121947814690103
GO:0009913	epidermal cell differentiation	0.0148749018209019
GO:0048730	epidermis morphogenesis	0.0196603756735073
GO:0008654	phospholipid biosynthetic process	0.022041208409552
GO:0046467	membrane lipid biosynthetic process	0.025775100156972
GO:0048729	tissue morphogenesis	0.025775100156972
GO:0008544	epidermis development	0.0314743322299509
GO:0007398	ectoderm development	0.0316695480076329
GO:0016779	nucleotidyltransferase activity	0.0318480830814946
GO:0006644	phospholipid metabolic process	0.0334493223003014
GO:0006643	membrane lipid metabolic process	0.0418268369940089

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
respiratory tract	2.80e-07	41
zone of skin	5.45e-07	5
skin epidermis	5.45e-07	5
skin of body	5.45e-07	5
integument	5.45e-07	5
surface	5.45e-07	5
outer epithelium	5.45e-07	5
integumental system	5.45e-07	5
enveloping layer of ectoderm	5.45e-07	5
respiratory system	6.03e-07	42

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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