MCL coexpression mm9:2899

Phase1 CAGE Peaks

	Short description
Mm9::chr14:29317751..29317791,+	p2@Wnt5a
Mm9::chr7:114710938..114710954,+	p1@Olfml1
Mm9::chr7:114710959..114710975,+	p3@Olfml1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	0.0145580054088245
GO:0007254	JNK cascade	0.0145580054088245
GO:0031098	stress-activated protein kinase signaling pathway	0.0145580054088245
GO:0030326	embryonic limb morphogenesis	0.0145580054088245
GO:0035113	embryonic appendage morphogenesis	0.0145580054088245
GO:0030324	lung development	0.0145580054088245
GO:0030323	respiratory tube development	0.0145580054088245
GO:0035107	appendage morphogenesis	0.0145580054088245
GO:0035108	limb morphogenesis	0.0145580054088245
GO:0048736	appendage development	0.0145580054088245
GO:0060173	limb development	0.0145580054088245
GO:0000165	MAPKKK cascade	0.0188672884120208
GO:0016055	Wnt receptor signaling pathway	0.0188672884120208
GO:0048598	embryonic morphogenesis	0.0271626581931737
GO:0035295	tube development	0.0271626581931737
GO:0007243	protein kinase cascade	0.0277454391059004
GO:0005578	proteinaceous extracellular matrix	0.0332676981382593
GO:0007267	cell-cell signaling	0.0365997674659264
GO:0009790	embryonic development	0.047689348830906

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	8.43e-12	333
tissue	1.36e-07	349
embryo	3.04e-07	320

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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