MCL coexpression mm9:3036

Phase1 CAGE Peaks

	Short description
Mm9::chr16:20673268..20673318,+	p4@Eif4g1
Mm9::chr16:20673337..20673435,+	p2@Eif4g1
Mm9::chr7:27980918..27980934,+	p1@BC024978

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006446	regulation of translational initiation	0.0435202432476853
GO:0006413	translational initiation	0.0435202432476853
GO:0022618	protein-RNA complex assembly	0.0435202432476853
GO:0003743	translation initiation factor activity	0.0435202432476853
GO:0008135	translation factor activity, nucleic acid binding	0.0435202432476853
GO:0006417	regulation of translation	0.0435202432476853
GO:0031326	regulation of cellular biosynthetic process	0.0435202432476853
GO:0009889	regulation of biosynthetic process	0.0435202432476853
GO:0022613	ribonucleoprotein complex biogenesis and assembly	0.0471703281652331

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
exocrine gland	1.70e-07	25
exocrine system	1.70e-07	25
digestive tract diverticulum	7.08e-07	23
sac	7.08e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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