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Coexpression cluster:C2886

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Full id: C2886_Hepatocyte_liver_Macrophage_CD14_Monocytederived_normal_kidney



Phase1 CAGE Peaks

Hg19::chr7:150497406..150497501,-p1@TMEM176B
Hg19::chr7:150497491..150497530,+p5@TMEM176A
Hg19::chr7:150497535..150497562,+p3@TMEM176A
Hg19::chr7:150497569..150497631,+p2@TMEM176A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
monopoietic cell3.73e-3459
monocyte3.73e-3459
monoblast3.73e-3459
promonocyte3.73e-3459
macrophage dendritic cell progenitor3.46e-3261
defensive cell3.98e-3148
phagocyte3.98e-3148
myeloid lineage restricted progenitor cell5.45e-3166
myeloid leukocyte3.90e-3072
granulocyte monocyte progenitor cell3.91e-3067
classical monocyte7.80e-2742
CD14-positive, CD16-negative classical monocyte7.80e-2742
myeloid cell2.14e-17108
common myeloid progenitor2.14e-17108
stuff accumulating cell8.82e-1687
leukocyte2.43e-14136
nongranular leukocyte1.18e-13115
hematopoietic lineage restricted progenitor cell1.20e-11120
hematopoietic stem cell1.17e-08168
angioblastic mesenchymal cell1.17e-08168
hematopoietic oligopotent progenitor cell7.09e-08161
hematopoietic multipotent progenitor cell7.09e-08161
hematopoietic cell2.30e-07177
Uber Anatomy
Ontology termp-valuen
adult organism3.40e-41114
hematopoietic system5.94e-2898
blood island5.94e-2898
hemolymphoid system2.75e-26108
bone marrow3.04e-2476
immune system1.61e-2293
bone element2.79e-2182
skeletal element8.17e-1890
skeletal system6.90e-15100
organ3.99e-14503
germ layer2.19e-13560
germ layer / neural crest2.19e-13560
embryonic tissue2.19e-13560
presumptive structure2.19e-13560
germ layer / neural crest derived structure2.19e-13560
epiblast (generic)2.19e-13560
embryonic structure2.97e-13564
embryo4.37e-13592
developing anatomical structure8.30e-13581
multi-cellular organism2.38e-11656
anatomical system1.24e-10624
anatomical group1.68e-10625
neural tube7.77e-1056
neural rod7.77e-1056
future spinal cord7.77e-1056
neural keel7.77e-1056
intestine1.08e-0917
tissue2.23e-09773
gastrointestinal system7.88e-0925
regional part of nervous system1.16e-0853
regional part of brain1.16e-0853
musculoskeletal system3.87e-08167
lateral plate mesoderm2.04e-07203
regional part of forebrain3.01e-0741
forebrain3.01e-0741
anterior neural tube3.01e-0741
future forebrain3.01e-0741
mesoderm6.03e-07315
mesoderm-derived structure6.03e-07315
presumptive mesoderm6.03e-07315
neural plate7.30e-0782
presumptive neural plate7.30e-0782
neurectoderm8.34e-0786


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.15.41581
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.12.02223
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.11.54523
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.11.29536
MA0105.15.38386
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.14.04391
MA0146.11.75643
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.11.06783
MA0163.11.90765
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.657636
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.