MCL coexpression mm9:151
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006259 | DNA metabolic process | 3.15330458288618e-29 |
GO:0006260 | DNA replication | 4.67286915465219e-28 |
GO:0005634 | nucleus | 3.02905470989514e-27 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 5.40163738216021e-26 |
GO:0006261 | DNA-dependent DNA replication | 3.48768500926499e-15 |
GO:0006974 | response to DNA damage stimulus | 9.59888059389555e-14 |
GO:0043231 | intracellular membrane-bound organelle | 1.55523747148963e-13 |
GO:0043227 | membrane-bound organelle | 1.55523747148963e-13 |
GO:0009719 | response to endogenous stimulus | 1.9269433197973e-13 |
GO:0007049 | cell cycle | 4.51885055575174e-13 |
GO:0043283 | biopolymer metabolic process | 1.09120538839064e-12 |
GO:0006281 | DNA repair | 3.40935821279336e-12 |
GO:0043229 | intracellular organelle | 7.4759722734738e-12 |
GO:0043226 | organelle | 7.4759722734738e-12 |
GO:0022403 | cell cycle phase | 8.92273666493073e-12 |
GO:0008094 | DNA-dependent ATPase activity | 7.53249373032802e-11 |
GO:0003677 | DNA binding | 3.47431366316725e-10 |
GO:0044238 | primary metabolic process | 2.39384059447584e-09 |
GO:0044237 | cellular metabolic process | 2.6730337523508e-09 |
GO:0044424 | intracellular part | 4.58996025933372e-09 |
GO:0006270 | DNA replication initiation | 5.93370041819232e-09 |
GO:0000278 | mitotic cell cycle | 9.73059964308855e-09 |
GO:0043170 | macromolecule metabolic process | 1.20392958804383e-08 |
GO:0000279 | M phase | 1.20392958804383e-08 |
GO:0005622 | intracellular | 1.69463150750947e-08 |
GO:0022402 | cell cycle process | 3.8017592101679e-08 |
GO:0003676 | nucleic acid binding | 3.90710750470063e-08 |
GO:0005694 | chromosome | 4.41308356647323e-08 |
GO:0005657 | replication fork | 8.93675976906425e-08 |
GO:0006950 | response to stress | 1.1074446469447e-07 |
GO:0044427 | chromosomal part | 1.15929074018689e-07 |
GO:0016779 | nucleotidyltransferase activity | 2.34027870778727e-07 |
GO:0006310 | DNA recombination | 7.6252390310501e-07 |
GO:0000166 | nucleotide binding | 9.03616413698726e-07 |
GO:0005658 | alpha DNA polymerase:primase complex | 1.11408830143144e-06 |
GO:0007059 | chromosome segregation | 2.20925730743541e-06 |
GO:0042623 | ATPase activity, coupled | 2.20925730743541e-06 |
GO:0051301 | cell division | 2.90409136668118e-06 |
GO:0016462 | pyrophosphatase activity | 6.03470808329226e-06 |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 6.05610950206653e-06 |
GO:0016887 | ATPase activity | 6.05610950206653e-06 |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 6.05610950206653e-06 |
GO:0051320 | S phase | 7.70946964792907e-06 |
GO:0000084 | S phase of mitotic cell cycle | 7.70946964792907e-06 |
GO:0003887 | DNA-directed DNA polymerase activity | 1.09039358986273e-05 |
GO:0043601 | nuclear replisome | 1.72548783175568e-05 |
GO:0030894 | replisome | 1.72548783175568e-05 |
GO:0000228 | nuclear chromosome | 2.31261049021504e-05 |
GO:0043596 | nuclear replication fork | 2.31261049021504e-05 |
GO:0017111 | nucleoside-triphosphatase activity | 2.92124400973089e-05 |
GO:0006275 | regulation of DNA replication | 3.0516357846238e-05 |
GO:0005524 | ATP binding | 3.38675536102417e-05 |
GO:0032559 | adenyl ribonucleotide binding | 3.82808823314224e-05 |
GO:0007067 | mitosis | 5.80047972604077e-05 |
GO:0000087 | M phase of mitotic cell cycle | 5.89438766237021e-05 |
GO:0030554 | adenyl nucleotide binding | 6.36289417617455e-05 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000155941073147859 |
GO:0006302 | double-strand break repair | 0.00017663550546281 |
GO:0007346 | regulation of progression through mitotic cell cycle | 0.00017663550546281 |
GO:0003896 | DNA primase activity | 0.000179382546341777 |
GO:0006350 | transcription | 0.00018759465755886 |
GO:0004386 | helicase activity | 0.000188673765015375 |
GO:0051052 | regulation of DNA metabolic process | 0.000190095688629298 |
GO:0010212 | response to ionizing radiation | 0.000190095688629298 |
GO:0019222 | regulation of metabolic process | 0.000199818676757546 |
GO:0044454 | nuclear chromosome part | 0.000249708036459689 |
GO:0016070 | RNA metabolic process | 0.000304170447340138 |
GO:0009219 | pyrimidine deoxyribonucleotide metabolic process | 0.000304170447340138 |
GO:0006269 | DNA replication, synthesis of RNA primer | 0.000304170447340138 |
GO:0006287 | base-excision repair, gap-filling | 0.000304170447340138 |
GO:0009221 | pyrimidine deoxyribonucleotide biosynthetic process | 0.000304170447340138 |
GO:0051327 | M phase of meiotic cell cycle | 0.000317638958272158 |
GO:0007126 | meiosis | 0.000317638958272158 |
GO:0032553 | ribonucleotide binding | 0.000322225484646875 |
GO:0032555 | purine ribonucleotide binding | 0.000322225484646875 |
GO:0051321 | meiotic cell cycle | 0.000322225484646875 |
GO:0016787 | hydrolase activity | 0.00036832978815441 |
GO:0051276 | chromosome organization and biogenesis | 0.000434618134789887 |
GO:0033261 | regulation of progression through S phase | 0.000434618134789887 |
GO:0009263 | deoxyribonucleotide biosynthetic process | 0.000434618134789887 |
GO:0007090 | regulation of S phase of mitotic cell cycle | 0.000434618134789887 |
GO:0017076 | purine nucleotide binding | 0.000447185330812165 |
GO:0044446 | intracellular organelle part | 0.000452490315714532 |
GO:0044422 | organelle part | 0.000476756506158463 |
GO:0031323 | regulation of cellular metabolic process | 0.000509064906395719 |
GO:0003899 | DNA-directed RNA polymerase activity | 0.000611674994291507 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.00062545611014525 |
GO:0043228 | non-membrane-bound organelle | 0.00062545611014525 |
GO:0006338 | chromatin remodeling | 0.000764183637789637 |
GO:0051325 | interphase | 0.00101846235749989 |
GO:0051329 | interphase of mitotic cell cycle | 0.00101846235749989 |
GO:0000724 | double-strand break repair via homologous recombination | 0.00103935725970721 |
GO:0000725 | recombinational repair | 0.00103935725970721 |
GO:0008156 | negative regulation of DNA replication | 0.00103935725970721 |
GO:0001833 | inner cell mass cell proliferation | 0.00103935725970721 |
GO:0008283 | cell proliferation | 0.00124176142498293 |
GO:0016772 | transferase activity, transferring phosphorus-containing groups | 0.00124176142498293 |
GO:0044428 | nuclear part | 0.00125774878889427 |
GO:0006268 | DNA unwinding during replication | 0.00125774878889427 |
GO:0032508 | DNA duplex unwinding | 0.00125774878889427 |
GO:0032392 | DNA geometric change | 0.00125774878889427 |
GO:0032774 | RNA biosynthetic process | 0.00130999379615391 |
GO:0009262 | deoxyribonucleotide metabolic process | 0.00154009768440277 |
GO:0010165 | response to X-ray | 0.0018616474005412 |
GO:0001832 | blastocyst growth | 0.00255981425810372 |
GO:0006342 | chromatin silencing | 0.00255981425810372 |
GO:0031507 | heterochromatin formation | 0.00255981425810372 |
GO:0000775 | chromosome, pericentric region | 0.00280641356419977 |
GO:0051053 | negative regulation of DNA metabolic process | 0.00292845902660106 |
GO:0045814 | negative regulation of gene expression, epigenetic | 0.00334349102180072 |
GO:0010467 | gene expression | 0.00412730926283443 |
GO:0006284 | base-excision repair | 0.00424107610063794 |
GO:0006221 | pyrimidine nucleotide biosynthetic process | 0.0047221593430035 |
GO:0006220 | pyrimidine nucleotide metabolic process | 0.00516254453655152 |
GO:0003678 | DNA helicase activity | 0.00516254453655152 |
GO:0006730 | one-carbon compound metabolic process | 0.00516254453655152 |
GO:0031570 | DNA integrity checkpoint | 0.00555857942310869 |
GO:0016585 | chromatin remodeling complex | 0.00555857942310869 |
GO:0003697 | single-stranded DNA binding | 0.00555857942310869 |
GO:0009117 | nucleotide metabolic process | 0.00614601939436519 |
GO:0055086 | nucleobase, nucleoside and nucleotide metabolic process | 0.00785722532512364 |
GO:0016740 | transferase activity | 0.00787910142428621 |
GO:0009314 | response to radiation | 0.00839170878106891 |
GO:0000075 | cell cycle checkpoint | 0.0087002153863223 |
GO:0016458 | gene silencing | 0.0087002153863223 |
GO:0003682 | chromatin binding | 0.0087002153863223 |
GO:0007127 | meiosis I | 0.0087002153863223 |
GO:0006996 | organelle organization and biogenesis | 0.0087002153863223 |
GO:0042772 | DNA damage response, signal transduction resulting in transcription | 0.0087002153863223 |
GO:0031508 | centric heterochromatin formation | 0.0087002153863223 |
GO:0009177 | pyrimidine deoxyribonucleoside monophosphate biosynthetic process | 0.0087002153863223 |
GO:0009157 | deoxyribonucleoside monophosphate biosynthetic process | 0.0087002153863223 |
GO:0051171 | regulation of nitrogen compound metabolic process | 0.0087002153863223 |
GO:0051383 | kinetochore organization and biogenesis | 0.0087002153863223 |
GO:0043515 | kinetochore binding | 0.0087002153863223 |
GO:0009162 | deoxyribonucleoside monophosphate metabolic process | 0.0087002153863223 |
GO:0009176 | pyrimidine deoxyribonucleoside monophosphate metabolic process | 0.0087002153863223 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 0.0087002153863223 |
GO:0004170 | dUTP diphosphatase activity | 0.0087002153863223 |
GO:0048478 | replication fork protection | 0.0087002153863223 |
GO:0006231 | dTMP biosynthetic process | 0.0087002153863223 |
GO:0042083 | 5,10-methylenetetrahydrofolate-dependent methyltransferase activity | 0.0087002153863223 |
GO:0045004 | DNA replication proofreading | 0.0087002153863223 |
GO:0019740 | nitrogen utilization | 0.0087002153863223 |
GO:0046073 | dTMP metabolic process | 0.0087002153863223 |
GO:0031055 | chromatin remodeling at centromere | 0.0087002153863223 |
GO:0006545 | glycine biosynthetic process | 0.0087002153863223 |
GO:0004799 | thymidylate synthase activity | 0.0087002153863223 |
GO:0006808 | regulation of nitrogen utilization | 0.0087002153863223 |
GO:0004146 | dihydrofolate reductase activity | 0.0087002153863223 |
GO:0043626 | PCNA complex | 0.0087002153863223 |
GO:0045875 | negative regulation of sister chromatid cohesion | 0.0087002153863223 |
GO:0030337 | DNA polymerase processivity factor activity | 0.0087002153863223 |
GO:0007063 | regulation of sister chromatid cohesion | 0.0087002153863223 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.00880140301853096 |
GO:0045449 | regulation of transcription | 0.00932692971064166 |
GO:0050794 | regulation of cellular process | 0.00947024922444374 |
GO:0006351 | transcription, DNA-dependent | 0.00956051246705678 |
GO:0005635 | nuclear envelope | 0.00993403381199426 |
GO:0001824 | blastocyst development | 0.00994799621884025 |
GO:0000792 | heterochromatin | 0.0131324804534796 |
GO:0050789 | regulation of biological process | 0.0131324804534796 |
GO:0009165 | nucleotide biosynthetic process | 0.0135724520300108 |
GO:0016569 | covalent chromatin modification | 0.0136850101753674 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0150981133449953 |
GO:0009189 | deoxyribonucleoside diphosphate biosynthetic process | 0.0150981133449953 |
GO:0004798 | thymidylate kinase activity | 0.0150981133449953 |
GO:0009197 | pyrimidine deoxyribonucleoside diphosphate biosynthetic process | 0.0150981133449953 |
GO:0047429 | nucleoside-triphosphate diphosphatase activity | 0.0150981133449953 |
GO:0009196 | pyrimidine deoxyribonucleoside diphosphate metabolic process | 0.0150981133449953 |
GO:0006233 | dTDP biosynthetic process | 0.0150981133449953 |
GO:0009130 | pyrimidine nucleoside monophosphate biosynthetic process | 0.0150981133449953 |
GO:0009129 | pyrimidine nucleoside monophosphate metabolic process | 0.0150981133449953 |
GO:0009138 | pyrimidine nucleoside diphosphate metabolic process | 0.0150981133449953 |
GO:0010225 | response to UV-C | 0.0150981133449953 |
GO:0009139 | pyrimidine nucleoside diphosphate biosynthetic process | 0.0150981133449953 |
GO:0046072 | dTDP metabolic process | 0.0150981133449953 |
GO:0043414 | biopolymer methylation | 0.0162039160043243 |
GO:0040029 | regulation of gene expression, epigenetic | 0.0168730682349682 |
GO:0010468 | regulation of gene expression | 0.0172913426464061 |
GO:0032259 | methylation | 0.018140221160066 |
GO:0004527 | exonuclease activity | 0.018140221160066 |
GO:0051028 | mRNA transport | 0.0196343655688497 |
GO:0048589 | developmental growth | 0.0198511959057177 |
GO:0043566 | structure-specific DNA binding | 0.0198511959057177 |
GO:0009202 | deoxyribonucleoside triphosphate biosynthetic process | 0.0198511959057177 |
GO:0006235 | dTTP biosynthetic process | 0.0198511959057177 |
GO:0007141 | male meiosis I | 0.0198511959057177 |
GO:0000076 | DNA replication checkpoint | 0.0198511959057177 |
GO:0046075 | dTTP metabolic process | 0.0198511959057177 |
GO:0009211 | pyrimidine deoxyribonucleoside triphosphate metabolic process | 0.0198511959057177 |
GO:0010216 | maintenance of DNA methylation | 0.0198511959057177 |
GO:0009212 | pyrimidine deoxyribonucleoside triphosphate biosynthetic process | 0.0198511959057177 |
GO:0046125 | pyrimidine deoxyribonucleoside metabolic process | 0.0198511959057177 |
GO:0031573 | intra-S DNA damage checkpoint | 0.0198511959057177 |
GO:0000212 | meiotic spindle organization and biogenesis | 0.0198511959057177 |
GO:0032297 | negative regulation of DNA replication initiation | 0.0198511959057177 |
GO:0030174 | regulation of DNA replication initiation | 0.0198511959057177 |
GO:0045143 | homologous chromosome segregation | 0.0198511959057177 |
GO:0007089 | traversing start control point of mitotic cell cycle | 0.0198511959057177 |
GO:0009148 | pyrimidine nucleoside triphosphate biosynthetic process | 0.0198511959057177 |
GO:0051236 | establishment of RNA localization | 0.0198511959057177 |
GO:0050657 | nucleic acid transport | 0.0198511959057177 |
GO:0050658 | RNA transport | 0.0198511959057177 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0198511959057177 |
GO:0006403 | RNA localization | 0.0202484670395594 |
GO:0005643 | nuclear pore | 0.0202484670395594 |
GO:0044464 | cell part | 0.0202484670395594 |
GO:0005623 | cell | 0.0202484670395594 |
GO:0016043 | cellular component organization and biogenesis | 0.0202484670395594 |
GO:0043234 | protein complex | 0.0202484670395594 |
GO:0065002 | intracellular protein transport across a membrane | 0.0222611536446463 |
GO:0015931 | nucleobase, nucleoside, nucleotide and nucleic acid transport | 0.0229557736592968 |
GO:0046930 | pore complex | 0.0235048772467655 |
GO:0016568 | chromatin modification | 0.0235048772467655 |
GO:0051567 | histone H3-K9 methylation | 0.0235048772467655 |
GO:0003689 | DNA clamp loader activity | 0.0235048772467655 |
GO:0033205 | cytokinesis during cell cycle | 0.0235048772467655 |
GO:0033170 | DNA-protein loading ATPase activity | 0.0235048772467655 |
GO:0009133 | nucleoside diphosphate biosynthetic process | 0.0235048772467655 |
GO:0009120 | deoxyribonucleoside metabolic process | 0.0235048772467655 |
GO:0009186 | deoxyribonucleoside diphosphate metabolic process | 0.0235048772467655 |
GO:0006346 | methylation-dependent chromatin silencing | 0.0235048772467655 |
GO:0005663 | DNA replication factor C complex | 0.0235048772467655 |
GO:0005721 | centric heterochromatin | 0.0235048772467655 |
GO:0045931 | positive regulation of progression through mitotic cell cycle | 0.0235048772467655 |
GO:0009628 | response to abiotic stimulus | 0.0235048772467655 |
GO:0044453 | nuclear membrane part | 0.0259789772887451 |
GO:0009892 | negative regulation of metabolic process | 0.0267945879902005 |
GO:0000074 | regulation of progression through cell cycle | 0.0271116267554325 |
GO:0031965 | nuclear membrane | 0.0272822106528812 |
GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0279963129673401 |
GO:0001556 | oocyte maturation | 0.0283112397968595 |
GO:0009200 | deoxyribonucleoside triphosphate metabolic process | 0.0283112397968595 |
GO:0007062 | sister chromatid cohesion | 0.0283112397968595 |
GO:0000785 | chromatin | 0.032805469237265 |
GO:0065007 | biological regulation | 0.0328542136216438 |
GO:0000080 | G1 phase of mitotic cell cycle | 0.0331104184081896 |
GO:0009070 | serine family amino acid biosynthetic process | 0.0331104184081896 |
GO:0006213 | pyrimidine nucleoside metabolic process | 0.0331104184081896 |
GO:0051318 | G1 phase | 0.0331104184081896 |
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | 0.0381178251218692 |
GO:0007131 | meiotic recombination | 0.0381178251218692 |
GO:0045132 | meiotic chromosome segregation | 0.0381178251218692 |
GO:0032991 | macromolecular complex | 0.0383161317982588 |
GO:0006886 | intracellular protein transport | 0.0416380833161427 |
GO:0006544 | glycine metabolic process | 0.0420047285588263 |
GO:0048599 | oocyte development | 0.0420047285588263 |
GO:0010332 | response to gamma radiation | 0.0420047285588263 |
GO:0009994 | oocyte differentiation | 0.0420047285588263 |
GO:0005652 | nuclear lamina | 0.0420047285588263 |
GO:0005677 | chromatin silencing complex | 0.0420047285588263 |
GO:0004730 | pseudouridylate synthase activity | 0.0420047285588263 |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 0.0466557972357244 |
GO:0007140 | male meiosis | 0.0466557972357244 |
GO:0000922 | spindle pole | 0.0466557972357244 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |