MCL coexpression mm9:825

Phase1 CAGE Peaks

	Short description
Mm9::chr15:6336759..6336785,+	p1@Dab2
Mm9::chr15:6372301..6372327,+	p@chr15:6372301..6372327 +
Mm9::chr15:6374201..6374212,+	p@chr15:6374201..6374212 +
Mm9::chr15:6374660..6374664,+	p@chr15:6374660..6374664 +
Mm9::chr15:6385332..6385355,-	p@chr15:6385332..6385355 -
Mm9::chr15:6385439..6385449,+	p@chr15:6385439..6385449 +
Mm9::chr15:6389228..6389240,+	p@chr15:6389228..6389240 +
Mm9::chr9:62692398..62692419,+	p6@Cln6
Mm9::chr9:62693807..62693811,+	p8@Cln6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031987	locomotion during locomotory behavior	0.00552222860125881
GO:0045851	pH reduction	0.00552222860125881
GO:0051452	cellular pH reduction	0.00552222860125881
GO:0051453	regulation of cellular pH	0.00552222860125881
GO:0007042	lysosomal lumen acidification	0.00552222860125881
GO:0030641	cellular hydrogen ion homeostasis	0.00591651141402709
GO:0006907	pinocytosis	0.00591651141402709
GO:0045862	positive regulation of proteolysis	0.00862777305743479
GO:0055067	monovalent inorganic cation homeostasis	0.0092022015204295
GO:0030004	cellular monovalent inorganic cation homeostasis	0.0092022015204295
GO:0001573	ganglioside metabolic process	0.0092022015204295
GO:0005788	endoplasmic reticulum lumen	0.0092022015204295
GO:0006687	glycosphingolipid metabolic process	0.010617342979341
GO:0030162	regulation of proteolysis	0.0119174408521997
GO:0007588	excretion	0.0119174408521997
GO:0007040	lysosome organization and biogenesis	0.0119174408521997
GO:0006664	glycolipid metabolic process	0.0119174408521997
GO:0006898	receptor-mediated endocytosis	0.0119174408521997
GO:0006885	regulation of pH	0.0119174408521997
GO:0006022	aminoglycan metabolic process	0.0119174408521997
GO:0030203	glycosaminoglycan metabolic process	0.0119174408521997
GO:0007033	vacuole organization and biogenesis	0.0119174408521997
GO:0006672	ceramide metabolic process	0.0137976292243873
GO:0046519	sphingoid metabolic process	0.01437174251759
GO:0005905	coated pit	0.0171053084570357
GO:0006665	sphingolipid metabolic process	0.0222768700319768
GO:0008203	cholesterol metabolic process	0.0326687356933175
GO:0016125	sterol metabolic process	0.0337359571224111
GO:0051247	positive regulation of protein metabolic process	0.0337359571224111
GO:0044432	endoplasmic reticulum part	0.0367361909616291
GO:0003008	system process	0.0408793113802752
GO:0042803	protein homodimerization activity	0.0424400708242353
GO:0030003	cellular cation homeostasis	0.0424400708242353
GO:0055080	cation homeostasis	0.0424400708242353
GO:0007601	visual perception	0.0424400708242353
GO:0050953	sensory perception of light stimulus	0.0424400708242353
GO:0001701	in utero embryonic development	0.044259385893427
GO:0008202	steroid metabolic process	0.0493293550094
GO:0055082	cellular chemical homeostasis	0.0493293550094
GO:0006873	cellular ion homeostasis	0.0493293550094
GO:0016043	cellular component organization and biogenesis	0.0493293550094
GO:0006643	membrane lipid metabolic process	0.0494317164474651

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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