MCL coexpression mm9:922

Phase1 CAGE Peaks

	Short description
Mm9::chr11:97011339..97011398,-	p1@Tbkbp1
Mm9::chr12:27100064..27100079,-	p2@Rnf144a
Mm9::chr16:95680624..95680630,-	p@chr16:95680624..95680630 -
Mm9::chr16:95680889..95680991,-	p1@Erg
Mm9::chr18:38146824..38146828,-	p@chr18:38146824..38146828 -
Mm9::chr18:38158368..38158425,-	p1@Arap3
Mm9::chr18:38159171..38159194,-	p@chr18:38159171..38159194 -
Mm9::chr6:72254313..72254324,+	p8@Sftpb

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0035024	negative regulation of Rho protein signal transduction	0.0271624509120334
GO:0035021	negative regulation of Rac protein signal transduction	0.0271624509120334
GO:0008060	ARF GTPase activator activity	0.0271624509120334
GO:0050828	regulation of liquid surface tension	0.0271624509120334
GO:0035020	regulation of Rac protein signal transduction	0.0271624509120334
GO:0051058	negative regulation of small GTPase mediated signal transduction	0.0271624509120334
GO:0030336	negative regulation of cell migration	0.0429612841110319
GO:0005100	Rho GTPase activator activity	0.0429612841110319
GO:0016601	Rac protein signal transduction	0.0429612841110319
GO:0051271	negative regulation of cell motility	0.0429612841110319
GO:0007585	respiratory gaseous exchange	0.0429612841110319
GO:0040013	negative regulation of locomotion	0.0429612841110319

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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