MCL coexpression mm9:3121

Phase1 CAGE Peaks

	Short description
Mm9::chr17:85025798..85025852,+	p1@Dync2li1
Mm9::chr5:122714387..122714464,-	p1@Tctn1
Mm9::chr6:55153375..55153453,+	p1@Fam188b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021956	central nervous system interneuron axonogenesis	0.00315507654069492
GO:0007389	pattern specification process	0.00315507654069492
GO:0032990	cell part morphogenesis	0.00315507654069492
GO:0030030	cell projection organization and biogenesis	0.00315507654069492
GO:0048858	cell projection morphogenesis	0.00315507654069492
GO:0021523	somatic motor neuron differentiation	0.00405390596887041
GO:0021904	dorsoventral neural tube patterning	0.00442207940659197
GO:0000902	cell morphogenesis	0.00442207940659197
GO:0032989	cellular structure morphogenesis	0.00442207940659197
GO:0021517	ventral spinal cord development	0.00442207940659197
GO:0021522	spinal cord motor neuron differentiation	0.00442207940659197
GO:0021515	cell differentiation in spinal cord	0.00472903868446856
GO:0021532	neural tube patterning	0.00498873928580061
GO:0021955	central nervous system neuron axonogenesis	0.00521130806984765
GO:0008589	regulation of smoothened signaling pathway	0.00648465028861927
GO:0021510	spinal cord development	0.00658579247715281
GO:0042384	cilium biogenesis	0.0066750094529573
GO:0021954	central nervous system neuron development	0.00945444941444193
GO:0021537	telencephalon development	0.00972377690978215
GO:0021953	central nervous system neuron differentiation	0.00972377690978215
GO:0007224	smoothened signaling pathway	0.0108030119282221
GO:0009653	anatomical structure morphogenesis	0.0113409857519361
GO:0007368	determination of left/right symmetry	0.0113409857519361
GO:0009855	determination of bilateral symmetry	0.0113409857519361
GO:0009799	determination of symmetry	0.0113409857519361
GO:0009953	dorsal/ventral pattern formation	0.0133943795193287
GO:0030031	cell projection biogenesis	0.0143961183162794
GO:0001841	neural tube formation	0.0148858579396324
GO:0001839	neural plate morphogenesis	0.0148858579396324
GO:0001840	neural plate development	0.0148858579396324
GO:0001838	embryonic epithelial tube formation	0.0148858579396324
GO:0021915	neural tube development	0.0164410198034808
GO:0016331	morphogenesis of embryonic epithelium	0.0179010678781001
GO:0048856	anatomical structure development	0.0231036180869506
GO:0030900	forebrain development	0.0231036180869506
GO:0001701	in utero embryonic development	0.0265317845739987
GO:0002009	morphogenesis of an epithelium	0.0265317845739987
GO:0007275	multicellular organismal development	0.0265317845739987
GO:0003002	regionalization	0.0291509628980074
GO:0016043	cellular component organization and biogenesis	0.0291509628980074
GO:0035239	tube morphogenesis	0.0291509628980074
GO:0007409	axonogenesis	0.0296056635183185
GO:0048667	neuron morphogenesis during differentiation	0.0299041014782157
GO:0048812	neurite morphogenesis	0.0299041014782157
GO:0007420	brain development	0.0324449225963009
GO:0000904	cellular morphogenesis during differentiation	0.0324449225963009
GO:0031175	neurite development	0.0330781690028371
GO:0048598	embryonic morphogenesis	0.0330781690028371
GO:0035295	tube development	0.0330781690028371
GO:0032502	developmental process	0.0340595106086465
GO:0048666	neuron development	0.0340595106086465
GO:0043009	chordate embryonic development	0.0340595106086465
GO:0009792	embryonic development ending in birth or egg hatching	0.0340595106086465
GO:0007417	central nervous system development	0.0344667770223854
GO:0030182	neuron differentiation	0.0405273721558926
GO:0048699	generation of neurons	0.0452166221412793
GO:0009966	regulation of signal transduction	0.0466591344530326
GO:0022008	neurogenesis	0.0468153418192806

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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