MCL coexpression mm9:690

Phase1 CAGE Peaks

	Short description
Mm9::chr10:52111412..52111416,+	p1@Nepn
Mm9::chr11:96184567..96184569,+	p8@Hoxb3
Mm9::chr13:48757894..48757908,+	p5@Barx1
Mm9::chr13:48758072..48758117,-	p@chr13:48758072..48758117 -
Mm9::chr13:48758276..48758291,+	p1@Barx1
Mm9::chr13:48758328..48758335,+	p4@Barx1
Mm9::chr13:48758358..48758415,+	p2@Barx1
Mm9::chr13:48758431..48758443,+	p3@Barx1
Mm9::chr2:62318547..62318556,-	p2@Gcg
Mm9::chr3:122393672..122393673,+	p@chr3:122393672..122393673 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007267	cell-cell signaling	0.0416563664909537
GO:0030878	thyroid gland development	0.0416563664909537
GO:0050796	regulation of insulin secretion	0.0416563664909537
GO:0005667	transcription factor complex	0.0416563664909537
GO:0043565	sequence-specific DNA binding	0.0416563664909537
GO:0030178	negative regulation of Wnt receptor signaling pathway	0.0416563664909537
GO:0046883	regulation of hormone secretion	0.0416563664909537
GO:0044451	nucleoplasm part	0.0416563664909537
GO:0030111	regulation of Wnt receptor signaling pathway	0.0416563664909537
GO:0030073	insulin secretion	0.0416563664909537
GO:0005654	nucleoplasm	0.0416563664909537
GO:0030072	peptide hormone secretion	0.0427696953751431
GO:0002790	peptide secretion	0.0427696953751431
GO:0031981	nuclear lumen	0.0427696953751431
GO:0030855	epithelial cell differentiation	0.0427696953751431
GO:0015833	peptide transport	0.0427696953751431
GO:0046879	hormone secretion	0.0427696953751431
GO:0031974	membrane-enclosed lumen	0.0427696953751431
GO:0043233	organelle lumen	0.0427696953751431
GO:0035270	endocrine system development	0.0459066551200862
GO:0003700	transcription factor activity	0.0459066551200862
GO:0051046	regulation of secretion	0.0459066551200862

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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