MCL coexpression mm9:730

Phase1 CAGE Peaks

	Short description
Mm9::chr14:118412218..118412229,-	p@chr14:118412218..118412229 -
Mm9::chr14:118429907..118429909,-	p@chr14:118429907..118429909 -
Mm9::chr14:118451457..118451475,-	p1@Dct
Mm9::chr15:10930471..10930491,+	p1@Slc45a2
Mm9::chr15:10930503..10930518,+	p2@Slc45a2
Mm9::chr19:29772395..29772417,+	p1@Mlana
Mm9::chr4:80480108..80480125,+	p1@Tyrp1
Mm9::chr4:80480190..80480199,+	p5@Tyrp1
Mm9::chr4:80480202..80480217,+	p3@Tyrp1
Mm9::chr6:97941770..97941784,+	p4@Mitf

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006583	melanin biosynthetic process from tyrosine	6.78820209071475e-09
GO:0006582	melanin metabolic process	1.35741721685762e-08
GO:0042438	melanin biosynthetic process	1.35741721685762e-08
GO:0006570	tyrosine metabolic process	2.42608404590985e-08
GO:0009072	aromatic amino acid family metabolic process	1.46956811269265e-07
GO:0046148	pigment biosynthetic process	1.46956811269265e-07
GO:0048066	pigmentation during development	1.77004589903175e-07
GO:0042440	pigment metabolic process	1.90510097451336e-07
GO:0019748	secondary metabolic process	4.64698917360445e-07
GO:0006725	aromatic compound metabolic process	7.9118639122626e-06
GO:0006520	amino acid metabolic process	4.92698596534237e-05
GO:0006519	amino acid and derivative metabolic process	0.000103407251882155
GO:0009308	amine metabolic process	0.000150135472305523
GO:0006807	nitrogen compound metabolic process	0.000173712652337567
GO:0019752	carboxylic acid metabolic process	0.000310035712120609
GO:0006082	organic acid metabolic process	0.000310035712120609
GO:0004167	dopachrome isomerase activity	0.000991906161063647
GO:0043437	butanoic acid metabolic process	0.000991906161063647
GO:0043438	acetoacetic acid metabolic process	0.000991906161063647
GO:0044249	cellular biosynthetic process	0.00161887872627728
GO:0009058	biosynthetic process	0.00377523513334822
GO:0032438	melanosome organization and biogenesis	0.00409565704379738
GO:0048753	pigment granule organization and biogenesis	0.00409565704379738
GO:0033059	cellular pigmentation	0.0070626860823427
GO:0016863	intramolecular oxidoreductase activity, transposing C

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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