MCL coexpression mm9:675

Phase1 CAGE Peaks

	Short description
Mm9::chr15:99330556..99330579,-	p@chr15:99330556..99330579 -
Mm9::chr17:57220593..57220605,-	p@chr17:57220593..57220605 -
Mm9::chr18:82731161..82731209,+	p@chr18:82731161..82731209 +
Mm9::chr18:82742205..82742279,+	p@chr18:82742205..82742279 +
Mm9::chr18:82753528..82753641,+	p3@Mbp
Mm9::chr18:82753680..82753700,+	p8@Mbp
Mm9::chr18:82753753..82753769,+	p14@Mbp
Mm9::chr18:82753804..82753847,+	p7@Mbp
Mm9::chrX:133365641..133365660,+	p8@Plp1
Mm9::chrX:133366600..133366616,+	p@chrX:133366600..133366616 +
Mm9::chrX:133367911..133367925,+	p7@Plp1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043209	myelin sheath	4.0221668700022e-06
GO:0042552	myelination	4.08249937305224e-05
GO:0007272	ensheathment of neurons	4.08249937305224e-05
GO:0008366	axon ensheathment	4.08249937305224e-05
GO:0001508	regulation of action potential	5.35752627084294e-05
GO:0022010	myelination in the central nervous system	0.00104875128158972
GO:0032291	ensheathment of axons in the central nervous system	0.00104875128158972
GO:0019226	transmission of nerve impulse	0.00126698256405069
GO:0019911	structural constituent of myelin sheath	0.0016313461917299
GO:0007267	cell-cell signaling	0.00211767085705616
GO:0042759	long-chain fatty acid biosynthetic process	0.00266932932585364
GO:0014003	oligodendrocyte development	0.00305852272406418
GO:0048709	oligodendrocyte differentiation	0.00479273862666581
GO:0021782	glial cell development	0.00479273862666581
GO:0065008	regulation of biological quality	0.00479273862666581
GO:0007399	nervous system development	0.00479273862666581
GO:0001676	long-chain fatty acid metabolic process	0.00604358963983972
GO:0010001	glial cell differentiation	0.015482504587328
GO:0042063	gliogenesis	0.0158243052701531
GO:0044459	plasma membrane part	0.0214488081593173
GO:0006633	fatty acid biosynthetic process	0.0216866710636755
GO:0016053	organic acid biosynthetic process	0.0216866710636755
GO:0046394	carboxylic acid biosynthetic process	0.0216866710636755
GO:0048731	system development	0.0216866710636755
GO:0048469	cell maturation	0.0216866710636755
GO:0050877	neurological system process	0.0221309831303422
GO:0021700	developmental maturation	0.024066419993433
GO:0003008	system process	0.024066419993433
GO:0005886	plasma membrane	0.0242892758101357
GO:0048856	anatomical structure development	0.0242892758101357
GO:0007275	multicellular organismal development	0.0294463485289453
GO:0006631	fatty acid metabolic process	0.0365464137225575
GO:0007268	synaptic transmission	0.0420490122393708
GO:0032787	monocarboxylic acid metabolic process	0.0451609585678168
GO:0032502	developmental process	0.0451609585678168
GO:0007417	central nervous system development	0.0465238823906946
GO:0008610	lipid biosynthetic process	0.0465238823906946

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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