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Coexpression cluster:C1591

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Full id: C1591_CD4_CD19_CD8_Natural_Neutrophils_peripheral_Peripheral



Phase1 CAGE Peaks

Hg19::chr10:70092889..70092902,+p@chr10:70092889..70092902
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Hg19::chr13:25885831..25885836,+p@chr13:25885831..25885836
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Hg19::chr1:245025039..245025045,-p@chr1:245025039..245025045
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Hg19::chr1:245025688..245025704,-p@chr1:245025688..245025704
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Hg19::chr7:104719134..104719139,+p@chr7:104719134..104719139
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell9.72e-32168
angioblastic mesenchymal cell9.72e-32168
hematopoietic cell3.91e-29177
hematopoietic oligopotent progenitor cell6.99e-29161
hematopoietic multipotent progenitor cell6.99e-29161
leukocyte1.07e-28136
hematopoietic lineage restricted progenitor cell6.21e-25120
nongranular leukocyte1.02e-24115
myeloid cell1.13e-17108
common myeloid progenitor1.13e-17108
classical monocyte1.12e-1542
CD14-positive, CD16-negative classical monocyte1.12e-1542
myeloid leukocyte2.48e-1572
myeloid lineage restricted progenitor cell2.07e-1466
defensive cell7.53e-1448
phagocyte7.53e-1448
granulocyte monocyte progenitor cell1.53e-1367
macrophage dendritic cell progenitor2.88e-1361
monopoietic cell7.46e-1359
monocyte7.46e-1359
monoblast7.46e-1359
promonocyte7.46e-1359
nucleate cell2.74e-1155
lymphocyte1.19e-1053
common lymphoid progenitor1.19e-1053
lymphoid lineage restricted progenitor cell2.61e-1052
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.23e-1498
blood island2.23e-1498
adult organism2.32e-13114
neural tube3.73e-1356
neural rod3.73e-1356
future spinal cord3.73e-1356
neural keel3.73e-1356
regional part of nervous system3.63e-1253
regional part of brain3.63e-1253
hemolymphoid system9.33e-12108
regional part of forebrain1.48e-1141
forebrain1.48e-1141
anterior neural tube1.48e-1141
future forebrain1.48e-1141
bone marrow3.11e-1076
bone element4.06e-1082
brain grey matter4.32e-1034
gray matter4.32e-1034
nervous system1.33e-0989
telencephalon2.20e-0934
regional part of telencephalon2.63e-0932
brain3.44e-0968
future brain3.44e-0968
central nervous system4.17e-0981
cerebral hemisphere9.13e-0932
neurectoderm1.16e-0886
immune system2.91e-0893
neural plate2.80e-0782
presumptive neural plate2.80e-0782
cerebral cortex7.04e-0725
pallium7.04e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.