MCL coexpression mm9:261

Phase1 CAGE Peaks

	Short description
Mm9::chr11:102214546..102214569,-	p@chr11:102214546..102214569 -
Mm9::chr11:102214630..102214658,-	p@chr11:102214630..102214658 -
Mm9::chr11:102218475..102218486,-	p@chr11:102218475..102218486 -
Mm9::chr11:95238906..95238922,+	p@chr11:95238906..95238922 +
Mm9::chr13:47201101..47201115,-	p10@Dek
Mm9::chr14:69860634..69860655,-	p@chr14:69860634..69860655 -
Mm9::chr14:69861633..69861672,-	p@chr14:69861633..69861672 -
Mm9::chr14:69862027..69862070,-	p@chr14:69862027..69862070 -
Mm9::chr14:69867395..69867407,-	p@chr14:69867395..69867407 -
Mm9::chr15:103079752..103079774,-	p@chr15:103079752..103079774 -
Mm9::chr16:32630179..32630192,+	p@chr16:32630179..32630192 +
Mm9::chr16:32630197..32630206,+	p@chr16:32630197..32630206 +
Mm9::chr17:47735613..47735657,+	p@chr17:47735613..47735657 +
Mm9::chr18:64616946..64616963,-	p@chr18:64616946..64616963 -
Mm9::chr1:134254052..134254079,-	p@chr1:134254052..134254079 -
Mm9::chr1:134254118..134254132,-	p@chr1:134254118..134254132 -
Mm9::chr1:134254201..134254237,-	p@chr1:134254201..134254237 -
Mm9::chr1:134257248..134257260,-	p@chr1:134257248..134257260 -
Mm9::chr2:131014815..131014832,+	p@chr2:131014815..131014832 +
Mm9::chr2:131019004..131019012,+	p@chr2:131019004..131019012 +
Mm9::chr2:163453686..163453707,-	p@chr2:163453686..163453707 -
Mm9::chr3:100276521..100276540,-	p@chr3:100276521..100276540 -
Mm9::chr3:121948828..121948839,+	p7@Gclm
Mm9::chr3:36466826..36466850,-	p@chr3:36466826..36466850 -
Mm9::chr3:84284193..84284220,+	p@chr3:84284193..84284220 +
Mm9::chr4:118859919..118859942,-	p@chr4:118859919..118859942 -
Mm9::chr4:135748823..135748835,+	p@chr4:135748823..135748835 +
Mm9::chr4:46409733..46409745,-	p@chr4:46409733..46409745 -
Mm9::chr7:134362245..134362250,-	p9@Sept1
Mm9::chr8:108298224..108298257,-	p@chr8:108298224..108298257 -
Mm9::chrX:146988548..146988561,+	p3@Alas2
Mm9::chrX:147001144..147001172,+	p2@Alas2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005381	iron ion transmembrane transporter activity	0.000456819144618196
GO:0051301	cell division	0.000733726995788518
GO:0016538	cyclin-dependent protein kinase regulator activity	0.0026114002127088
GO:0006873	cellular ion homeostasis	0.0026114002127088
GO:0055082	cellular chemical homeostasis	0.0026114002127088
GO:0006879	cellular iron ion homeostasis	0.0026114002127088
GO:0055072	iron ion homeostasis	0.0026114002127088
GO:0046915	transition metal ion transmembrane transporter activity	0.0026114002127088
GO:0050801	ion homeostasis	0.00265023647613552
GO:0015082	di-, tri-valent inorganic cation transmembrane transporter activity	0.00374559201860592
GO:0048878	chemical homeostasis	0.00404491782573569
GO:0019725	cellular homeostasis	0.00404491782573569
GO:0007049	cell cycle	0.00798705738009567
GO:0019887	protein kinase regulator activity	0.0081313237622078
GO:0048250	mitochondrial iron ion transport	0.0081313237622078
GO:0035229	positive regulation of glutamate-cysteine ligase activity	0.0081313237622078
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	0.0081313237622078
GO:0035227	regulation of glutamate-cysteine ligase activity	0.0081313237622078
GO:0051351	positive regulation of ligase activity	0.0081313237622078
GO:0042592	homeostatic process	0.00854684043983682
GO:0019207	kinase regulator activity	0.00959426906029585
GO:0051882	mitochondrial depolarization	0.0106522111007838
GO:0016749	N-succinyltransferase activity	0.0106522111007838
GO:0004357	glutamate-cysteine ligase activity	0.0106522111007838
GO:0004998	transferrin receptor activity	0.0106522111007838
GO:0051340	regulation of ligase activity	0.0106522111007838
GO:0051900	regulation of mitochondrial depolarization	0.0106522111007838
GO:0017109	glutamate-cysteine ligase complex	0.0106522111007838
GO:0003870	5-aminolevulinate synthase activity	0.0106522111007838
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.010902254789028
GO:0051188	cofactor biosynthetic process	0.010902254789028
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.0110021371492729
GO:0030003	cellular cation homeostasis	0.0120011801332138
GO:0055080	cation homeostasis	0.0123224510919724
GO:0007144	female meiosis I	0.012520457965269
GO:0016748	succinyltransferase activity	0.012520457965269
GO:0051881	regulation of mitochondrial membrane potential	0.012520457965269
GO:0042541	hemoglobin biosynthetic process	0.0156168431581143
GO:0001940	male pronucleus	0.0156168431581143
GO:0022890	inorganic cation transmembrane transporter activity	0.0156168431581143
GO:0043085	positive regulation of catalytic activity	0.0159305284196433
GO:0001556	oocyte maturation	0.0171492062413345
GO:0020027	hemoglobin metabolic process	0.0171492062413345
GO:0001939	female pronucleus	0.0171492062413345
GO:0006534	cysteine metabolic process	0.0171492062413345
GO:0022402	cell cycle process	0.0172638545631914
GO:0006750	glutathione biosynthetic process	0.0196984864028533
GO:0007067	mitosis	0.0210190108072703
GO:0000087	M phase of mitotic cell cycle	0.0210190108072703
GO:0065008	regulation of biological quality	0.0210850417664668
GO:0048599	oocyte development	0.0232427130231152
GO:0009994	oocyte differentiation	0.0232427130231152
GO:0007143	female meiosis	0.0232427130231152
GO:0051186	cofactor metabolic process	0.0232427130231152
GO:0006783	heme biosynthetic process	0.0308229493562097
GO:0000278	mitotic cell cycle	0.0318412966535553
GO:0000279	M phase	0.0332048536694561
GO:0006779	porphyrin biosynthetic process	0.0339407523590761
GO:0033014	tetrapyrrole biosynthetic process	0.0339407523590761
GO:0045120	pronucleus	0.0359335298015824
GO:0065007	biological regulation	0.0388170245174001
GO:0000096	sulfur amino acid metabolic process	0.0390459646284324
GO:0042168	heme metabolic process	0.0390459646284324
GO:0050790	regulation of catalytic activity	0.0390459646284324
GO:0022403	cell cycle phase	0.0390459646284324
GO:0009069	serine family amino acid metabolic process	0.0390459646284324
GO:0051899	membrane depolarization	0.0390459646284324
GO:0033013	tetrapyrrole metabolic process	0.0400006848200994
GO:0006778	porphyrin metabolic process	0.0400006848200994
GO:0046873	metal ion transmembrane transporter activity	0.0400006848200994
GO:0006749	glutathione metabolic process	0.0411607496894537
GO:0048477	oogenesis	0.0448395069175333
GO:0065009	regulation of a molecular function	0.0456768811291409
GO:0006839	mitochondrial transport	0.0456938762583261

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
subdivision of trunk	3.94e-11	66
abdomen element	1.42e-10	49
abdominal segment element	1.42e-10	49
abdominal segment of trunk	1.42e-10	49
abdomen	1.42e-10	49
spleen	1.10e-09	6
cavity lining	1.10e-09	6
serous membrane	1.10e-09	6
gastrointestinal system mesentery	1.10e-09	6
stomach region	1.10e-09	6
mesentery	1.10e-09	6
gastrointestinal system serosa	1.10e-09	6
mesentery of stomach	1.10e-09	6
gut mesentery	1.10e-09	6
dorsal mesentery	1.10e-09	6
dorsal mesogastrium	1.10e-09	6
peritoneal cavity	1.10e-09	6
spleen primordium	1.10e-09	6
foregut	2.86e-09	80
trunk region element	6.02e-08	79
intraembryonic coelom	3.58e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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