MCL coexpression mm9:1061

Phase1 CAGE Peaks

	Short description
Mm9::chr11:118337140..118337150,+	p@chr11:118337140..118337150 +
Mm9::chr13:63252868..63252890,+	p@chr13:63252868..63252890 +
Mm9::chr16:4549406..4549436,-	p@chr16:4549406..4549436 -
Mm9::chr1:166467691..166467700,-	p@chr1:166467691..166467700 -
Mm9::chr3:101471524..101471547,+	p@chr3:101471524..101471547 +
Mm9::chr3:107714196..107714218,-	p@chr3:107714196..107714218 -
Mm9::chr5:73729793..73729815,-	p2@Ociad2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016284	alanine aminopeptidase activity	0.0200421603531313
GO:0004179	membrane alanyl aminopeptidase activity	0.0200421603531313
GO:0043450	alkene biosynthetic process	0.0200421603531313
GO:0019370	leukotriene biosynthetic process	0.0200421603531313
GO:0006691	leukotriene metabolic process	0.0200421603531313
GO:0043449	alkene metabolic process	0.0200421603531313
GO:0046456	icosanoid biosynthetic process	0.0229015595172475
GO:0006690	icosanoid metabolic process	0.0250444610025648
GO:0004177	aminopeptidase activity	0.0274508806678439
GO:0008235	metalloexopeptidase activity	0.0367067000739442
GO:0006633	fatty acid biosynthetic process	0.0374582636576044
GO:0046394	carboxylic acid biosynthetic process	0.0374582636576044
GO:0016053	organic acid biosynthetic process	0.0374582636576044
GO:0008238	exopeptidase activity	0.0447628310266275

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	1.65e-11	9
epithelial cell of alimentary canal	1.65e-11	9
intestinal crypt stem cell	6.78e-07	3

Uber Anatomy

Ontology term	p-value	n
intestine	3.42e-40	31
gastrointestinal system	8.40e-32	47
mucosa	1.94e-20	15
intestinal mucosa	1.59e-17	13
anatomical wall	1.59e-17	13
wall of intestine	1.59e-17	13
gastrointestinal system mucosa	1.59e-17	13
epithelium of mucosa	1.65e-11	9
gastrointestinal system epithelium	1.65e-11	9
intestinal epithelium	1.65e-11	9
organ component layer	2.45e-11	24
digestive system	3.09e-09	116
digestive tract	3.09e-09	116
primitive gut	3.09e-09	116
simple columnar epithelium	4.14e-09	11
endoderm-derived structure	6.26e-09	118
endoderm	6.26e-09	118
presumptive endoderm	6.26e-09	118
small intestine	5.98e-08	4
subdivision of digestive tract	6.27e-08	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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