MCL coexpression mm9:1039
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0008470 | isovaleryl-CoA dehydrogenase activity | 0.00807997794267702 |
| GO:0006573 | valine metabolic process | 0.00807997794267702 |
| GO:0008442 | 3-hydroxyisobutyrate dehydrogenase activity | 0.00807997794267702 |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 0.00807997794267702 |
| GO:0050662 | coenzyme binding | 0.00807997794267702 |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | 0.00807997794267702 |
| GO:0004316 | 3-oxoacyl-[acyl-carrier-protein] reductase activity | 0.00807997794267702 |
| GO:0009062 | fatty acid catabolic process | 0.00807997794267702 |
| GO:0016491 | oxidoreductase activity | 0.00874906374718147 |
| GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 0.00887057747633578 |
| GO:0048037 | cofactor binding | 0.00887057747633578 |
| GO:0005739 | mitochondrion | 0.0116250181027593 |
| GO:0004312 | fatty-acid synthase activity | 0.0124266493749851 |
| GO:0046395 | carboxylic acid catabolic process | 0.0129222992076651 |
| GO:0016054 | organic acid catabolic process | 0.0129222992076651 |
| GO:0009081 | branched chain family amino acid metabolic process | 0.0141322160224741 |
| GO:0006098 | pentose-phosphate shunt | 0.0143549637651335 |
| GO:0006740 | NADPH regeneration | 0.0143549637651335 |
| GO:0016290 | palmitoyl-CoA hydrolase activity | 0.0186930827713556 |
| GO:0005829 | cytosol | 0.0190751224128284 |
| GO:0044444 | cytoplasmic part | 0.0190751224128284 |
| GO:0016291 | acyl-CoA thioesterase activity | 0.0190751224128284 |
| GO:0006739 | NADP metabolic process | 0.0196471368667866 |
| GO:0003995 | acyl-CoA dehydrogenase activity | 0.0206530341095781 |
| GO:0016289 | CoA hydrolase activity | 0.0206530341095781 |
| GO:0044248 | cellular catabolic process | 0.021631562070282 |
| GO:0019752 | carboxylic acid metabolic process | 0.0236493803871915 |
| GO:0006082 | organic acid metabolic process | 0.0236493803871915 |
| GO:0051287 | NAD binding | 0.0236493803871915 |
| GO:0006769 | nicotinamide metabolic process | 0.0236493803871915 |
| GO:0019362 | pyridine nucleotide metabolic process | 0.0249616164641196 |
| GO:0044242 | cellular lipid catabolic process | 0.0279736970247396 |
| GO:0009056 | catabolic process | 0.0279736970247396 |
| GO:0006733 | oxidoreduction coenzyme metabolic process | 0.0303189034023962 |
| GO:0006767 | water-soluble vitamin metabolic process | 0.0358678919018525 |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | 0.0375416456033633 |
| GO:0031072 | heat shock protein binding | 0.0417177120662889 |
| GO:0006007 | glucose catabolic process | 0.0425852196503891 |
| GO:0046365 | monosaccharide catabolic process | 0.0425852196503891 |
| GO:0019320 | hexose catabolic process | 0.0425852196503891 |
| GO:0046164 | alcohol catabolic process | 0.0438838185182793 |
| GO:0051082 | unfolded protein binding | 0.0440697942513917 |
| GO:0050660 | FAD binding | 0.0440697942513917 |
| GO:0006766 | vitamin metabolic process | 0.0452432408623376 |
| GO:0044275 | cellular carbohydrate catabolic process | 0.0470712521752496 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| epithelial tube | 2.02e-09 | 47 |
| exocrine gland | 6.99e-08 | 25 |
| exocrine system | 6.99e-08 | 25 |
| digestive tract diverticulum | 3.62e-07 | 23 |
| sac | 3.62e-07 | 23 |
| liver | 5.93e-07 | 22 |
| epithelial sac | 5.93e-07 | 22 |
| digestive gland | 5.93e-07 | 22 |
| epithelium of foregut-midgut junction | 5.93e-07 | 22 |
| anatomical boundary | 5.93e-07 | 22 |
| hepatobiliary system | 5.93e-07 | 22 |
| foregut-midgut junction | 5.93e-07 | 22 |
| hepatic diverticulum | 5.93e-07 | 22 |
| liver primordium | 5.93e-07 | 22 |
| septum transversum | 5.93e-07 | 22 |
| liver bud | 5.93e-07 | 22 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.8002 |
| MA0004.1 | 0.481116 |
| MA0006.1 | 2.30634 |
| MA0007.1 | 0.465969 |
| MA0009.1 | 0.92425 |
| MA0014.1 | 0.694761 |
| MA0017.1 | 0.337808 |
| MA0019.1 | 1.753 |
| MA0024.1 | 0.880057 |
| MA0025.1 | 1.15921 |
| MA0027.1 | 2.57545 |
| MA0028.1 | 0.321735 |
| MA0029.1 | 0.858105 |
| MA0030.1 | 0.864739 |
| MA0031.1 | 0.828781 |
| MA0038.1 | 0.62758 |
| MA0040.1 | 0.936879 |
| MA0041.1 | 0.404721 |
| MA0042.1 | 0.391504 |
| MA0043.1 | 1.02178 |
| MA0046.1 | 0.960497 |
| MA0048.1 | 0.128106 |
| MA0050.1 | 0.520357 |
| MA0051.1 | 0.636645 |
| MA0052.1 | 0.945011 |
| MA0055.1 | 0.0406078 |
| MA0056.1 | 0 |
| MA0057.1 | 0.376102 |
| MA0058.1 | 0.384683 |
| MA0059.1 | 0.397033 |
| MA0060.1 | 1.90283 |
| MA0061.1 | 2.05557 |
| MA0063.1 | 0 |
| MA0066.1 | 0.616444 |
| MA0067.1 | 1.27078 |
| MA0068.1 | 0.771749 |
| MA0069.1 | 0.945354 |
| MA0070.1 | 0.93557 |
| MA0071.1 | 0.519509 |
| MA0072.1 | 0.927016 |
| MA0073.1 | 4.19963e-05 |
| MA0074.1 | 0.580087 |
| MA0076.1 | 0.356883 |
| MA0077.1 | 0.905143 |
| MA0078.1 | 0.670113 |
| MA0081.1 | 0.420276 |
| MA0083.1 | 1.02098 |
| MA0084.1 | 1.59945 |
| MA0087.1 | 0.977537 |
| MA0088.1 | 0.0841779 |
| MA0089.1 | 0 |
| MA0090.1 | 0.446539 |
| MA0091.1 | 0.494398 |
| MA0092.1 | 0.446857 |
| MA0093.1 | 0.329976 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.568369 |
| MA0101.1 | 1.0468 |
| MA0103.1 | 0.348572 |
| MA0105.1 | 1.5116 |
| MA0106.1 | 0.677988 |
| MA0107.1 | 0.906859 |
| MA0108.2 | 0.763162 |
| MA0109.1 | 0 |
| MA0111.1 | 0.460823 |
| MA0113.1 | 0.649407 |
| MA0114.1 | 0.719313 |
| MA0115.1 | 1.0246 |
| MA0116.1 | 0.836994 |
| MA0117.1 | 0.992087 |
| MA0119.1 | 0.40661 |
| MA0122.1 | 1.01209 |
| MA0124.1 | 1.21735 |
| MA0125.1 | 1.14291 |
| MA0130.1 | 0 |
| MA0131.1 | 0.735438 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.05845 |
| MA0136.1 | 0.600242 |
| MA0139.1 | 0.202522 |
| MA0140.1 | 0.568252 |
| MA0141.1 | 0.964041 |
| MA0142.1 | 0.814115 |
| MA0143.1 | 0.665982 |
| MA0144.1 | 0.262477 |
| MA0145.1 | 1.05551 |
| MA0146.1 | 1.57153 |
| MA0147.1 | 1.38091 |
| MA0148.1 | 0.49752 |
| MA0149.1 | 0.411562 |
| MA0062.2 | 0.167299 |
| MA0035.2 | 0.573016 |
| MA0039.2 | 1.37408 |
| MA0138.2 | 0.727395 |
| MA0002.2 | 0.205289 |
| MA0137.2 | 0.957645 |
| MA0104.2 | 1.17226 |
| MA0047.2 | 0.626803 |
| MA0112.2 | 1.5617 |
| MA0065.2 | 0.305574 |
| MA0150.1 | 0.465855 |
| MA0151.1 | 0 |
| MA0152.1 | 0.626912 |
| MA0153.1 | 1.07519 |
| MA0154.1 | 0.397336 |
| MA0155.1 | 0.336768 |
| MA0156.1 | 0.356017 |
| MA0157.1 | 0.781683 |
| MA0158.1 | 0 |
| MA0159.1 | 0.284457 |
| MA0160.1 | 0.50056 |
| MA0161.1 | 0 |
| MA0162.1 | 0.55478 |
| MA0163.1 | 0.28052 |
| MA0164.1 | 0.600609 |
| MA0080.2 | 0.343316 |
| MA0018.2 | 0.610433 |
| MA0099.2 | 0.721008 |
| MA0079.2 | 0.16158 |
| MA0102.2 | 1.65195 |
| MA0258.1 | 1.27611 |
| MA0259.1 | 1.34223 |
| MA0442.1 | 0 |
