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UBERON:0002148

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Name:locus ceruleus
Namespace:FANTOM
Definition:"The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." [GAID:577, GO:0021703, Wikipedia:Locus_ceruleus]
Xrefs:
links:

ABA:LC
BM:Pons-LC
BTO:0001408
EFO:0001963
FMA:72478
GAID:577
[ 200px-Gray709.png 200px-Gray709.png]
MA:0001017
MESH:A.08.186.211.132.659.473
ncithesaurus:Locus_Coeruleus
NIF_GrossAnatomy:birnlex_905
SCTID:369016004
TAO:0000539

ZFA:0000539
Synonyms: "blue nucleus" EXACT [NIF_GrossAnatomy:birnlex_905]
"caerulean nucleus" EXACT []
"locus caeruleus" EXACT [NIF_GrossAnatomy:birnlex_905]
"locus cinereus" RELATED [BTO:0001408]
"locus coeruleu" EXACT []
"locus coeruleus" EXACT []
"nucleus caeruleus" EXACT [FMA:72478, FMA:TA]
"nucleus of locus caeruleus" EXACT []
"nucleus pigmentosus pontis" EXACT [NIF_GrossAnatomy:birnlex_905]
"substantia ferruginea" EXACT [NIF_GrossAnatomy:birnlex_905]
Comments:TODO - check ZFA/pons. also GO says part of dorsorostral pons
Alt_id: UBERON:FMA_72478-MA_0001017-ZFA_0000539
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0006331(brainstem nucleus),UBERON:0009662(hindbrain nucleus)
part_of:UBERON:0003023(pontine tegmentum)



Children

is a:FF:10362-105F2 (locus coeruleus, newborn, donor10223)
derives from:FF:0011487 (human locus coeruleus- adult sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002148 (locus ceruleus), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.29e-195FFCP PHASE1:Hg19::chr2:237146889..237146895,-#_3d8b1683908909bb5c96d7128eaafc12p@chr2:237146889..237146895, -
3.29e-195FFCP PHASE2:Hg19::chr2:237146889..237146895,-#_3d8b1683908909bb5c96d7128eaafc12p@chr2:237146889..237146895, -
4.22e-98FFCP PHASE2:Hg19::chr16:49601912..49601949,-#_db86f2cb1a96bb56e633f22bc7b91265p@chr16:49601912..49601949, -
4.22e-98FFCP PHASE1:Hg19::chr16:49601912..49601949,-#_db86f2cb1a96bb56e633f22bc7b91265p@chr16:49601912..49601949, -
1.16e-78FFCP PHASE2:Hg19::chr2:108602711..108602722,+#_5cfb487dc97ea73eaed3f5dab587e0b3p3@SLC5A7
1.16e-78FFCP PHASE1:Hg19::chr2:108602711..108602722,+#_5cfb487dc97ea73eaed3f5dab587e0b3p3@SLC5A7
2.84e-66FFCP PHASE2:Hg19::chr17:7559346..7559354,+#_cf05b1af1b1b4be6cf78f45dd7793749p@chr17:7559346..7559354, +
2.84e-66FFCP PHASE1:Hg19::chr17:7559346..7559354,+#_cf05b1af1b1b4be6cf78f45dd7793749p@chr17:7559346..7559354, +
3.58e-57FFCP PHASE1:Hg19::chr2:234077664..234077672,+#_0284385191acdfa85c84706163956e91p@chr2:234077664..234077672, +
3.58e-57FFCP PHASE2:Hg19::chr2:234077664..234077672,+#_0284385191acdfa85c84706163956e91p@chr2:234077664..234077672, +
6.36e-57FFCP PHASE1:Hg19::chr9:87427873..87427884,+#_ac6a7447c13c77f9d47596e37c127659p67@NTRK2
6.36e-57FFCP PHASE2:Hg19::chr9:87427873..87427884,+#_ac6a7447c13c77f9d47596e37c127659p67@NTRK2
8.47e-57FFCP PHASE1:Hg19::chr11:30751827..30751838,+#_0d825f42857458efbe964527bd6cee77p@chr11:30751827..30751838, +
8.47e-57FFCP PHASE1:Hg19::chr5:75379091..75379100,+#_0d825f42857458efbe964527bd6cee77p6@SV2C
8.47e-57FFCP PHASE2:Hg19::chr11:30751827..30751838,+#_0d825f42857458efbe964527bd6cee77p@chr11:30751827..30751838, +
8.47e-57FFCP PHASE2:Hg19::chr5:75379091..75379100,+#_0d825f42857458efbe964527bd6cee77p6@SV2C
1.13e-56FFCP PHASE2:Hg19::chr4:117675601..117675614,+#_d69cf710999970f6c66b5c01219803a1p@chr4:117675601..117675614, +
1.13e-56FFCP PHASE1:Hg19::chr4:117675601..117675614,+#_d69cf710999970f6c66b5c01219803a1p@chr4:117675601..117675614, +
1.5e-56FFCP PHASE1:Hg19::chr9:135089670..135089681,-#_50ec54165d4393a3d4f86b403e2ce298p@chr9:135089670..135089681, -
1.5e-56FFCP PHASE2:Hg19::chr10:133878269..133878278,+#_50ec54165d4393a3d4f86b403e2ce298p@chr10:133878269..133878278, +
1.5e-56FFCP PHASE2:Hg19::chr9:135089670..135089681,-#_50ec54165d4393a3d4f86b403e2ce298p@chr9:135089670..135089681, -
1.5e-56FFCP PHASE1:Hg19::chr10:133878269..133878278,+#_50ec54165d4393a3d4f86b403e2ce298p@chr10:133878269..133878278, +
2.0e-56FFCP PHASE1:Hg19::chr7:94297970..94297982,+#_a9b6497ab975a4080818d825a3a530c4p@chr7:94297970..94297982, +
2.0e-56FFCP PHASE2:Hg19::chr7:94297970..94297982,+#_a9b6497ab975a4080818d825a3a530c4p@chr7:94297970..94297982, +
1.46e-50FFCP PHASE1:Hg19::chr5:71505323..71505333,+#_9f8ed49c2029a57e1a1359966c9c355cp@chr5:71505323..71505333, +
1.46e-50FFCP PHASE2:Hg19::chr5:71505323..71505333,+#_9f8ed49c2029a57e1a1359966c9c355cp@chr5:71505323..71505333, +
1.88e-50FFCP PHASE2:Hg19::chr18:5577640..5577652,-#_9a9853cd63769d497647b0dd91c68668p14@EPB41L3
1.88e-50FFCP PHASE1:Hg19::chr18:5577640..5577652,-#_9a9853cd63769d497647b0dd91c68668p14@EPB41L3
2.74e-50FFCP PHASE1:Hg19::chr4:114303795..114303800,+#_18dd88540353a6cae4d6954231981097p51@ANK2
2.74e-50FFCP PHASE2:Hg19::chr4:114303795..114303800,+#_18dd88540353a6cae4d6954231981097p51@ANK2
2.74e-50FFCP PHASE1:Hg19::chr11:20621167..20621170,+#_18dd88540353a6cae4d6954231981097p6@SLC6A5
2.74e-50FFCP PHASE2:Hg19::chr11:20621167..20621170,+#_18dd88540353a6cae4d6954231981097p6@SLC6A5
4.0e-50FFCP PHASE1:Hg19::chr22:37213554..37213565,-#_d4e94024d70e649ceec4b8cb54a352afp4@PVALB
4.0e-50FFCP PHASE2:Hg19::chr22:37213554..37213565,-#_d4e94024d70e649ceec4b8cb54a352afp4@PVALB
4.52e-50FFCP PHASE1:Hg19::chr6:56820018..56820029,+#_cdfc6057e90243fb00fe5f41ad1e316ap16@BEND6
4.52e-50FFCP PHASE2:Hg19::chr6:56820018..56820029,+#_cdfc6057e90243fb00fe5f41ad1e316ap16@BEND6
4.52e-50FFCP PHASE2:Hg19::chr2:218873244..218873256,-#_cdfc6057e90243fb00fe5f41ad1e316ap@chr2:218873244..218873256, -
4.52e-50FFCP PHASE1:Hg19::chr2:218873244..218873256,-#_cdfc6057e90243fb00fe5f41ad1e316ap@chr2:218873244..218873256, -
5.15e-50FFCP PHASE2:Hg19::chr3:183979132..183979143,-#_47cf2de29319ca7128c9d30101cadb82p8@CAMK2N2
5.15e-50FFCP PHASE1:Hg19::chr3:183979132..183979143,-#_47cf2de29319ca7128c9d30101cadb82p8@CAMK2N2
6.61e-50FFCP PHASE1:Hg19::chr11:81982984..81982991,+#_36e4bc5c54a633773e58ff0cd116e0bcp@chr11:81982984..81982991, +
6.61e-50FFCP PHASE1:Hg19::chr8:82354790..82354800,-#_36e4bc5c54a633773e58ff0cd116e0bcp@chr8:82354790..82354800, -
6.61e-50FFCP PHASE1:Hg19::chr22:26565113..26565124,+#_36e4bc5c54a633773e58ff0cd116e0bcp7@SEZ6L
6.61e-50FFCP PHASE2:Hg19::chr8:82354790..82354800,-#_36e4bc5c54a633773e58ff0cd116e0bcp@chr8:82354790..82354800, -
6.61e-50FFCP PHASE2:Hg19::chr22:26565113..26565124,+#_36e4bc5c54a633773e58ff0cd116e0bcp7@SEZ6L
6.61e-50FFCP PHASE2:Hg19::chr11:81982984..81982991,+#_36e4bc5c54a633773e58ff0cd116e0bcp@chr11:81982984..81982991, +
8.5e-50FFCP PHASE1:Hg19::chr1:160113171..160113182,+#_60c63187bf07fee3df102cd3506918acp@chr1:160113171..160113182, +
8.5e-50FFCP PHASE2:Hg19::chr1:160113171..160113182,+#_60c63187bf07fee3df102cd3506918acp@chr1:160113171..160113182, +
1.4e-49FFCP PHASE1:Hg19::chr6:55039307..55039326,+#_7799de21633b1ae17d729a5393397391p1@HCRTR2
1.4e-49FFCP PHASE2:Hg19::chr6:55039307..55039326,+#_7799de21633b1ae17d729a5393397391p1@HCRTR2
1.8e-49FFCP PHASE1:Hg19::chr8:23127683..23127694,+#_109181f582bf2385abfdc68742e0a480p8@R3HCC1
1.8e-49FFCP PHASE2:Hg19::chr8:23127683..23127694,+#_109181f582bf2385abfdc68742e0a480p8@R3HCC1
3.19e-45FFCP PHASE2:Hg19::chr15:60296481..60296492,+#_de7582d09019595f426068d0774d08f8p7@FOXB1
3.19e-45FFCP PHASE1:Hg19::chr15:60296481..60296492,+#_de7582d09019595f426068d0774d08f8p7@FOXB1
5.0e-45FFCP PHASE2:Hg19::chr3:58372039..58372043,+#_cdaa1235671df331a858d86a88f21302p@chr3:58372039..58372043, +
5.0e-45FFCP PHASE1:Hg19::chr3:58372039..58372043,+#_cdaa1235671df331a858d86a88f21302p@chr3:58372039..58372043, +
7.83e-45FFCP PHASE1:Hg19::chr1:160112787..160112798,+#_f5567ccb61b6fce43a8b8238a2647b32p12@ATP1A2
7.83e-45FFCP PHASE2:Hg19::chr1:160112787..160112798,+#_f5567ccb61b6fce43a8b8238a2647b32p12@ATP1A2
9.79e-45FFCP PHASE2:Hg19::chr22:29885906..29885916,+#_51226ae0fa555d20f1cd01ae2cd61c0cp@chr22:29885906..29885916, +
9.79e-45FFCP PHASE1:Hg19::chr8:28748765..28748785,+#_51226ae0fa555d20f1cd01ae2cd61c0cp10@HMBOX1
9.79e-45FFCP PHASE2:Hg19::chr8:28748765..28748785,+#_51226ae0fa555d20f1cd01ae2cd61c0cp10@HMBOX1
9.79e-45FFCP PHASE1:Hg19::chr22:29885906..29885916,+#_51226ae0fa555d20f1cd01ae2cd61c0cp@chr22:29885906..29885916, +
2.39e-44FFCP PHASE2:Hg19::chr17:42983463..42983466,-#_6db22ee563bd769922d90d23c2401e70p45@GFAP
2.39e-44FFCP PHASE1:Hg19::chr18:74691000..74691005,-#_6db22ee563bd769922d90d23c2401e70p@chr18:74691000..74691005, -
2.39e-44FFCP PHASE1:Hg19::chr17:42983463..42983466,-#_6db22ee563bd769922d90d23c2401e70p45@GFAP
2.39e-44FFCP PHASE2:Hg19::chr18:74691000..74691005,-#_6db22ee563bd769922d90d23c2401e70p@chr18:74691000..74691005, -
2.98e-44FFCP PHASE1:Hg19::chr7:12544061..12544073,+#_6dc935613ba7df6b985ac500d9afa61bp1@ENST00000424453
2.98e-44FFCP PHASE2:Hg19::chr7:12544061..12544073,+#_6dc935613ba7df6b985ac500d9afa61bp1@ENST00000424453
3.72e-44FFCP PHASE2:Hg19::chr13:70682590..70682601,-#_43a4a94ee0570742248abd9eed5706e9p3@KLHL1
3.72e-44FFCP PHASE1:Hg19::chr13:70682590..70682601,-#_43a4a94ee0570742248abd9eed5706e9p3@KLHL1
4.65e-44FFCP PHASE1:Hg19::chr8:81639875..81639889,-#_29fb75c7cd408ce76bde5d637374baa4p@chr8:81639875..81639889, -
4.65e-44FFCP PHASE2:Hg19::chr8:81639875..81639889,-#_29fb75c7cd408ce76bde5d637374baa4p@chr8:81639875..81639889, -
4.89e-41FFCP PHASE2:Hg19::chr12:72332618..72332632,+#_ee18646db8aa96d3b4c4eb4202febd37p1@TPH2
4.89e-41FFCP PHASE1:Hg19::chr12:72332618..72332632,+#_ee18646db8aa96d3b4c4eb4202febd37p1@TPH2
1.34e-40FFCP PHASE2:Hg19::chr14:62010202..62010207,-#_39c8a0ec234dcd6133d4838f4cd2b478p@chr14:62010202..62010207, -
1.34e-40FFCP PHASE1:Hg19::chr14:62010202..62010207,-#_39c8a0ec234dcd6133d4838f4cd2b478p@chr14:62010202..62010207, -
1.64e-40FFCP PHASE1:Hg19::chr8:24775490..24775500,+#_4a490c88fbc1ee3b5e6a45232a44fcd7p@chr8:24775490..24775500, +
1.64e-40FFCP PHASE2:Hg19::chr8:24775490..24775500,+#_4a490c88fbc1ee3b5e6a45232a44fcd7p@chr8:24775490..24775500, +
2.01e-40FFCP PHASE2:Hg19::chr4:67195068..67195099,-#_805112659dded9d1af7af3008b5a5c40p@chr4:67195068..67195099, -
2.01e-40FFCP PHASE1:Hg19::chr4:67195068..67195099,-#_805112659dded9d1af7af3008b5a5c40p@chr4:67195068..67195099, -
2.46e-40FFCP PHASE1:Hg19::chr1:155291376..155291428,+#_47c9b69f9dbb4ea60409f7d19b064cbbp6@RUSC1
2.46e-40FFCP PHASE2:Hg19::chr1:155291376..155291428,+#_47c9b69f9dbb4ea60409f7d19b064cbbp6@RUSC1
2.46e-40FFCP PHASE1:Hg19::chr19:35789028..35789044,+#_47c9b69f9dbb4ea60409f7d19b064cbbp@chr19:35789028..35789044, +
2.46e-40FFCP PHASE2:Hg19::chr19:35789028..35789044,+#_47c9b69f9dbb4ea60409f7d19b064cbbp@chr19:35789028..35789044, +
3.01e-40FFCP PHASE1:Hg19::chr1:24645071..24645074,+#_13badbbfec036da9148c7d20b56ef664p@chr1:24645071..24645074, +
3.01e-40FFCP PHASE2:Hg19::chr1:24645071..24645074,+#_13badbbfec036da9148c7d20b56ef664p@chr1:24645071..24645074, +
5.49e-40FFCP PHASE1:Hg19::chr6:33161034..33161047,-#_a8ead261893d870e58eeb6dccde62927p@chr6:33161034..33161047, -
5.49e-40FFCP PHASE2:Hg19::chr6:33161034..33161047,-#_a8ead261893d870e58eeb6dccde62927p@chr6:33161034..33161047, -
5.49e-40FFCP PHASE1:Hg19::chr2:179739649..179739660,-#_a8ead261893d870e58eeb6dccde62927p@chr2:179739649..179739660, -
5.49e-40FFCP PHASE2:Hg19::chr2:179739649..179739660,-#_a8ead261893d870e58eeb6dccde62927p@chr2:179739649..179739660, -
6.7e-40FFCP PHASE1:Hg19::chr6:151670422..151670433,+#_3985747ae8d07c3ee1ddba19fbe928cap@chr6:151670422..151670433, +
6.7e-40FFCP PHASE2:Hg19::chr6:151670422..151670433,+#_3985747ae8d07c3ee1ddba19fbe928cap@chr6:151670422..151670433, +
2.27e-37FFCP PHASE1:Hg19::chr11:121976070..121976081,-#_6ec942f19eeff98e77bfe71db2d2c05dp4@ENST00000534195
2.27e-37FFCP PHASE2:Hg19::chr11:121976070..121976081,-#_6ec942f19eeff98e77bfe71db2d2c05dp4@ENST00000534195
2.73e-37FFCP PHASE2:Hg19::chr2:25720514..25720525,-#_318a3ce7e6705d493a6e3a992a4d87d2p16@DTNB
2.73e-37FFCP PHASE1:Hg19::chr2:25720514..25720525,-#_318a3ce7e6705d493a6e3a992a4d87d2p16@DTNB
3.28e-37FFCP PHASE2:Hg19::chr17:42984370..42984375,-#_52931458b0cf44b41d92583125fc8af4p42@GFAP
3.28e-37FFCP PHASE2:Hg19::chr17:11144580..11144595,+#_52931458b0cf44b41d92583125fc8af4p2@SHISA6
3.28e-37FFCP PHASE1:Hg19::chr17:42984370..42984375,-#_52931458b0cf44b41d92583125fc8af4p42@GFAP
3.28e-37FFCP PHASE1:Hg19::chr17:11144580..11144595,+#_52931458b0cf44b41d92583125fc8af4p2@SHISA6

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