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{{CL
{{CL
|id=CL:0000632
|alt_id=
|name=hepatic stellate cell
|namespace=cell
|def="A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
|xref=BTO:0002741;;FMA:67763
|is_a=CL:0000057;;CL:0000327
|synonym="fat-storing cell" RELATED [];;"hepatic perisinusoidal cell" EXACT [];;"Ito cell" EXACT [];;"lipocyte" RELATED [];;"perisinusoidal cell" EXACT [];;"vitamin A-storing cells" RELATED [PMID:12808230]
|comment=Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
|comment=Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
|subset=
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000632
|is_a=CL:0000057 ;;CL:0000327
|is_obsolete=
|located_in=
|located_in=
|name=hepatic stellate cell
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0002107
|part_of=UBERON:0002107
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl
|subset=
|synonym="fat-storing cell" RELATED [];;"hepatic perisinusoidal cell" EXACT [];;"ito cell" EXACT [];;"lipocyte" RELATED [];;"perisinusoidal cell" EXACT [];;"vitamin A-storing cells" RELATED [PMID:12808230]
|union_of=
|xref=BTO:0002741;;FMA:67763
}}
}}

Latest revision as of 16:35, 12 September 2014

Name:hepatic stellate cell
Namespace:FANTOM
Definition:"A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
Xrefs:
links:

BTO:0002741

FMA:67763
Synonyms: "fat-storing cell" RELATED []
"hepatic perisinusoidal cell" EXACT []
"ito cell" EXACT []
"lipocyte" RELATED []
"perisinusoidal cell" EXACT []
"vitamin A-storing cells" RELATED [PMID:12808230]
Comments:Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell)
part_of:UBERON:0002107(liver)



Children


is a:FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1)
derives from:FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.07e-86FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7bp@chr2:156282978..156282979, +
3.07e-86FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7bp@chrX:45409736..45409738, +
3.07e-86FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7bp@chr17:15914532..15914535, +
3.07e-86FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7bp@chr4:50498164..50498166, +
3.07e-86FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7bp@chr2:156282978..156282979, +
3.07e-86FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7bp@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7bp1@Mup20
3.07e-86FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7bp@chr4:50498164..50498166, +
3.07e-86FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7bp1@Mup20
3.07e-86FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7bp@chrX:45409736..45409738, +
3.07e-86FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7bp@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7bp@chr17:15914532..15914535, +
2.19e-53FFCP PHASE1:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160dp75@IGFBP5
2.19e-53FFCP PHASE2:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160dp75@IGFBP5
7.47e-44FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302fp@chr6:31268117..31268151, -
7.47e-44FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302fp@chr3:127483562..127483571, +
7.47e-44FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302fp@chr7:129965112..129965151, +
7.47e-44FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302fp7@Rbm18
7.47e-44FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302fp@chr7:129965112..129965151, +
7.47e-44FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302fp@chr19:39390004..39390011, +
7.47e-44FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302fp7@Rbm18
7.47e-44FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302fp@chr6:31268117..31268151, -
7.47e-44FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302fp@chrX:166354085..166354088, +
7.47e-44FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302fp@chr8:42092122..42092137, -
7.47e-44FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302fp@chr19:39390004..39390011, +
7.47e-44FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302fp@chr5:114824802..114824807, +
7.47e-44FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302fp@chr7:111614187..111614200, +
7.47e-44FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302fp@chr8:42092122..42092137, -
7.47e-44FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302fp@chr5:114824802..114824807, +
7.47e-44FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302fp@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302fp@chr11:48686060..48686062, +
7.47e-44FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302fp@chr3:127483562..127483571, +
7.47e-44FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302fp@chr7:111614187..111614200, +
7.47e-44FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302fp@chr11:48686060..48686062, +
7.47e-44FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302fp@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302fp@chrX:166354085..166354088, +
3.19e-38FFCP PHASE1:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709p@chr1:153091885..153091892, -
3.19e-38FFCP PHASE2:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709p@chr1:153091885..153091892, -
4.27e-34FFCP PHASE1:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3ebp15@DAK
4.27e-34FFCP PHASE1:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3ebp10@WT1-AS
4.27e-34FFCP PHASE2:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3ebp15@DAK
4.27e-34FFCP PHASE2:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3ebp10@WT1-AS
4.66e-34FFCP PHASE1:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125p10@LRRN4
4.66e-34FFCP PHASE2:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125p10@LRRN4
5.96e-34FFCP PHASE1:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853p@chr20:54998100..54998106, +
5.96e-34FFCP PHASE2:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853p@chr4:10057464..10057469, +
5.96e-34FFCP PHASE2:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853p@chr2:112009644..112009652, +
5.96e-34FFCP PHASE2:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853p@chr17:10560452..10560487, -
5.96e-34FFCP PHASE1:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853p@chr13:46542969..46542977, +
5.96e-34FFCP PHASE2:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853p@chr6:3759217..3759221, +
5.96e-34FFCP PHASE2:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853p@chr13:46542969..46542977, +
5.96e-34FFCP PHASE2:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853p@chr20:54998100..54998106, +
5.96e-34FFCP PHASE1:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853p@chr9:21499446..21499456, -
5.96e-34FFCP PHASE1:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853p@chr4:37636545..37636557, -
5.96e-34FFCP PHASE2:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853p@chr9:21499446..21499456, -
5.96e-34FFCP PHASE1:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853p2@AK123249
5.96e-34FFCP PHASE2:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853p@chr4:37636545..37636557, -
5.96e-34FFCP PHASE1:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853p1@AB527600
5.96e-34FFCP PHASE1:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853p@chr16:46766272..46766280, -
5.96e-34FFCP PHASE1:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853p@chr13:38275506..38275512, -
5.96e-34FFCP PHASE2:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853p2@AK123249
5.96e-34FFCP PHASE2:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853p@chr13:38275506..38275512, -
5.96e-34FFCP PHASE1:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853p@chr17:10560452..10560487, -
5.96e-34FFCP PHASE1:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853p@chr6:3759217..3759221, +
5.96e-34FFCP PHASE2:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853p1@AB527600
5.96e-34FFCP PHASE1:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853p@chr4:10057464..10057469, +
5.96e-34FFCP PHASE2:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853p@chr16:46766272..46766280, -
5.96e-34FFCP PHASE1:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853p@chr2:112009644..112009652, +
1.08e-33FFCP PHASE1:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9p9@RNF214
1.08e-33FFCP PHASE2:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9p9@RNF214
2.87e-30FFCP PHASE1:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220p@chr10:124988598..124988600, +
2.87e-30FFCP PHASE2:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220p@chr10:124988598..124988600, +
2.87e-30FFCP PHASE2:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220p7@Cd200r3
2.87e-30FFCP PHASE1:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220p7@Cd200r3
5.62e-30FFCP PHASE2:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042p30@Dab2ip
5.62e-30FFCP PHASE1:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042p30@Dab2ip
5.62e-30FFCP PHASE2:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr16:18733244..18733286, -
5.62e-30FFCP PHASE2:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113257676..113257683, +
5.62e-30FFCP PHASE1:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr16:18733244..18733286, -
5.62e-30FFCP PHASE1:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113257676..113257683, +
5.62e-30FFCP PHASE2:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr17:29604869..29604892, -
5.62e-30FFCP PHASE1:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042p1@ENSMUST00000164855
5.62e-30FFCP PHASE1:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr17:29604869..29604892, -
5.62e-30FFCP PHASE2:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113254075..113254086, -
5.62e-30FFCP PHASE2:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042p1@ENSMUST00000164855
5.62e-30FFCP PHASE1:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr1:87792029..87792037, -
5.62e-30FFCP PHASE2:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr8:89139298..89139300, +
5.62e-30FFCP PHASE1:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr8:89139298..89139300, +
5.62e-30FFCP PHASE2:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr1:87792029..87792037, -
5.62e-30FFCP PHASE1:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113254075..113254086, -
1.1e-29FFCP PHASE2:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627p@chr2:122090551..122090560, +
1.1e-29FFCP PHASE1:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627p@chr2:122090551..122090560, +
3.11e-27FFCP PHASE1:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6bp@chr2:27296691..27296699, -
3.11e-27FFCP PHASE2:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6bp@chr2:27296691..27296699, -
2.62e-23FFCP PHASE1:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130p7@ATF7
2.62e-23FFCP PHASE2:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130p@chr21:22496435..22496437, -
2.62e-23FFCP PHASE2:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130p7@ATF7
2.62e-23FFCP PHASE1:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130p@chr21:22496435..22496437, -
3.06e-23FFCP PHASE1:Mm9::chr4:61443256..61443260,-#_11f0a9b190f7fb77ea7ffa6ae4c2ef92p2@Mup12, p2@Mup16, p2@Mup17, p2@Mup19, p2@Mup9
3.06e-23FFCP PHASE1:Mm9::chr3:89539611..89539638,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92p@chr3:89539611..89539638, +

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