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Coexpression cluster:C1155

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Full id: C1155_Hepatocyte_Intestinal_Prostate_liver_colon_small_Retinal



Phase1 CAGE Peaks

Hg19::chr11:74870848..74870885,+p3@SLCO2B1
Hg19::chr11:74870889..74870902,+p5@SLCO2B1
Hg19::chr11:74870904..74870913,+p10@SLCO2B1
Hg19::chr1:209827344..209827383,-p@chr1:209827344..209827383
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Hg19::chr22:50738736..50738785,-p@chr22:50738736..50738785
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Hg19::chr6:126221034..126221056,+p13@NCOA7
Hg19::chr6:170190148..170190182,+p1@C6orf208


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0016998cell wall catabolic process0.0139189274041004
GO:0010382cell wall metabolic process0.0139189274041004
GO:0007047cell wall organization and biogenesis0.0139189274041004
GO:0045229external encapsulating structure organization and biogenesis0.0139189274041004



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell6.62e-07254
Uber Anatomy
Ontology termp-valuen
organ3.32e-16511
organ part4.15e-13219
subdivision of digestive tract2.52e-11129
endodermal part of digestive tract2.52e-11129
endoderm-derived structure5.77e-11169
endoderm5.77e-11169
presumptive endoderm5.77e-11169
neural plate7.16e-1186
presumptive neural plate7.16e-1186
adult organism8.74e-11115
pre-chordal neural plate3.88e-1061
neurectoderm5.69e-1090
multi-tissue structure5.95e-10347
digestive system8.15e-10155
digestive tract8.15e-10155
primitive gut8.15e-10155
neural tube8.54e-1057
neural rod8.54e-1057
future spinal cord8.54e-1057
neural keel8.54e-1057
mixed endoderm/mesoderm-derived structure1.00e-09130
regional part of brain3.51e-0959
central nervous system6.32e-0982
anterior neural tube1.15e-0842
regional part of nervous system1.21e-0894
nervous system1.21e-0894
regional part of forebrain1.36e-0841
forebrain1.36e-0841
future forebrain1.36e-0841
brain2.33e-0869
future brain2.33e-0869
cerebral hemisphere5.16e-0832
head7.11e-08123
gray matter7.61e-0834
brain grey matter7.61e-0834
sac8.13e-0826
telencephalon8.23e-0834
digestive tract diverticulum8.71e-0823
multi-cellular organism1.22e-07659
regional part of telencephalon1.56e-0733
abdomen element1.62e-0755
abdominal segment element1.62e-0755
epithelium of foregut-midgut junction1.75e-0725
anatomical boundary1.75e-0725
hepatobiliary system1.75e-0725
foregut-midgut junction1.75e-0725
septum transversum1.75e-0725
anterior region of body1.81e-07129
craniocervical region1.81e-07129
epithelial sac2.73e-0725
hepatic diverticulum3.03e-0722
liver primordium3.03e-0722
embryo5.21e-07612
foregut6.04e-0798
anatomical system6.89e-07625
neocortex8.00e-0720
Disease
Ontology termp-valuen
carcinoma5.10e-08106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.